Publications by authors named "Dinesh Khanna"

100Publications

UCLA Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 Reflux Scale correlates with impaired Esophageal Scintigraphy findings in Systemic Sclerosis.

J Rheumatol 2021 Jan 15. Epub 2021 Jan 15.

Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Radiology Department, San Carlo Hospital, Potenza, Italy; Department of Rheumatology, Kocaeli University, Kocaeli, Turkey; University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA. Address correspondence to Giuseppina Abignano MD PhD, Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Via Potito Petrone snc, 85100 Potenza, (Italy);

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January 2021

Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial.

Lancet Respir Med 2021 01;9(1):96-106

National Heart and Lung Institute, Imperial College London, London, UK; National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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January 2021

Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.

Arthritis Res Ther 2021 Jan 6;23(1):10. Epub 2021 Jan 6.

Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA.

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January 2021

Rheumatoid arthritis-associated interstitial lung disease: Current update on prevalence, risk factors, and pharmacologic treatment.

Curr Treatm Opt Rheumatol 2020 Dec 1;6(4):337-353. Epub 2020 Sep 1.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School; Boston, Massachusetts, USA.

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December 2020

New composite endpoint in early diffuse cutaneous systemic sclerosis: revisiting the provisional American College of Rheumatology Composite Response Index in Systemic Sclerosis.

Ann Rheum Dis 2020 Nov 30. Epub 2020 Nov 30.

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

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November 2020

Rituximab for the treatment of systemic sclerosis-interstitial lung disease.

Rheumatology (Oxford) 2020 Nov 27. Epub 2020 Nov 27.

Scleroderma Program, University of Michigan, Ann Arbor, MI, USA.

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November 2020

Emerging drugs for the treatment of scleroderma: a review of recent phase 2 and 3 trials.

Expert Opin Emerg Drugs 2020 12 26;25(4):455-466. Epub 2020 Oct 26.

Division of Rheumatology, Department of Internal Medicine, University of Michigan , Ann Arbor, MI, USA.

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December 2020

STRATUS, a Phase II Study of Abituzumab in Patients with Systemic Sclerosis-associated Interstitial Lung Disease.

J Rheumatol 2020 Oct 1. Epub 2020 Oct 1.

From the University of Michigan, Ann Arbor, MI, USA; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Royal Brompton Hospital, London, UK; Scleroderma Research Consultants, LLC, Aiken, SC, USA; EMD Serono Inc., Billerica, MA, USA; University College London Medical School, Royal Free Hospital, London, UK. The STRATUS study was sponsored by Merck KGaA (for all study sites residing in countries outside of the USA) or EMD Serono Research and Development Institute, Inc., Billerica, MA, USA* (for study sites residing within the USA). Medical writing assistance was provided by Dan Booth (Bioscript Science, Macclesfield, UK) and funded by Merck KGaA. The STRATUS study was funded by Merck KGaA, Darmstadt, Germany and EMD Serono Research Institute Inc. (a business of Merck KGaA, Darmstadt, Germany). Merck KGaA authors were involved in the study design, collection, analysis and interpretation of the data, and in the writing of and decision to submit the manuscript. Address correspondence to Dr Dinesh Khanna, Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI 48109, USA. Email:

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October 2020

Dissecting the cellular mechanism of prostacyclin analogue iloprost in reversing vascular dysfunction in scleroderma.

Arthritis Rheumatol 2020 Oct 1. Epub 2020 Oct 1.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.

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October 2020

Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis.

Semin Arthritis Rheum 2020 10 17;50(5):891-896. Epub 2020 Jun 17.

Stanford University School of Medicine and Palo Alto VA Health Care System, Department of Immunology and Rheumatology and Dermatology (by courtesy), USA. Electronic address:

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October 2020

Response to: 'Riociguat in systemic sclerosis: a potential for disease modification' by Jain and Dhir.

Ann Rheum Dis 2020 Jul 15. Epub 2020 Jul 15.

Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.

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July 2020

Management of systemic sclerosis: the first five years.

Curr Opin Rheumatol 2020 05;32(3):228-237

Department of Internal Medicine, Division of Rheumatology, Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA.

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May 2020

Management of systemic sclerosis-associated interstitial lung disease in the current era.

Int J Rheum Dis 2020 02;23(2):137-139

Scleroderma Program, University of Michigan, Ann Arbor, MI, USA.

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February 2020

Psychometric validation of the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU®) patient-reported outcome instrument.

Arthritis Res Ther 2020 01 6;22(1). Epub 2020 Jan 6.

Department of Internal Medicine, University of Michigan Scleroderma Program, Suite 7C27, 300 North Ingalls Street, Ann Arbor, MI, USA.

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January 2020

Fatigue and its Association with Social Participation, Functioning and Quality of Life in Systemic Sclerosis.

Arthritis Care Res (Hoboken) 2019 Dec 16. Epub 2019 Dec 16.

University of Michigan, Division of Rheumatology, 300 North Ingalls Street, SPC 5422, Suite 7C27, Ann Arbor, Michigan, United States.

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December 2019

Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

Am J Respir Crit Care Med 2020 03;201(6):650-660

Northwestern Scleroderma Program, Feinberg School of Medicine, Chicago, Illinois.

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March 2020

Drug initiation and escalation strategies of vasodilator therapies for Raynaud's phenomenon: can we treat to target?

Rheumatology (Oxford) 2020 03;59(3):464-466

Royal National Hospital for Rheumatic Diseases, Royal United Hospitals, UK.

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March 2020

Reliability, construct validity and responsiveness to change of the PROMIS-29 in systemic sclerosis-associated interstitial lung disease.

Clin Exp Rheumatol 2019 Jul-Aug;37 Suppl 119(4):49-56. Epub 2019 Sep 4.

University of Michigan Scleroderma Program, Division of Rheumatology Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

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October 2019

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Arthritis Res Ther 2019 09 3;21(1):202. Epub 2019 Sep 3.

Division of Rheumatology/Department of Internal Medicine, University of Michigan Scleroderma Program, Suite 7C27, 300 North Ingalls Street, SPC 5422, Ann Arbor, MI, 48109, USA.

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September 2019

Development and Pilot Testing of MyGoutCare: A Novel Web-Based Platform to Educate Patients With Gout.

J Clin Rheumatol 2020 Dec;26(8):320-326

From the Department of Medicine, Division of Rheumatology.

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December 2020

2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus.

Ann Rheum Dis 2019 09 5;78(9):1151-1159. Epub 2019 Aug 5.

Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île deFrance, Cochin Hospital, Université Paris Descartes-Sorbonne Paris Cité, INSERM U1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France

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September 2019

Impact of the revised haemodynamic definition on the diagnosis of pulmonary hypertension in patients with systemic sclerosis.

Eur Respir J 2019 08 22;54(2). Epub 2019 Aug 22.

Division of Rheumatology and Scleroderma Program, Dept of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

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August 2019

Management of systemic sclerosis-associated interstitial lung disease.

Curr Opin Rheumatol 2019 05;31(3):241-249

Department of Internal Medicine, Division of Rheumatology, Scleroderma Program.

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May 2019

Cyclophosphamide for Systemic Sclerosis-related Interstitial Lung Disease: A Comparison of Scleroderma Lung Study I and II.

J Rheumatol 2019 10 15;46(10):1316-1325. Epub 2019 Feb 15.

From the Department of Medicine and Department of Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California; Department of Biomathematics, University of California, Los Angeles, California; Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Rheumatology, Oslo University Hospital, Oslo, Norway.

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October 2019

Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma.

Proc Natl Acad Sci U S A 2019 02 12;116(9):3695-3702. Epub 2019 Feb 12.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109;

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February 2019

Performance of Anti-Topoisomerase I Antibody Testing by Multiple-Bead, Enzyme-Linked Immunosorbent Assay and Immunodiffusion in a University Setting.

J Clin Rheumatol 2020 Apr;26(3):115-118

From the University of Michigan Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan.

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April 2020

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2019 07 15;46(7):721-726. Epub 2018 Dec 15.

From the Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, Toronto; University Health Network, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Division of Rheumatology, Department of Medicine, University of Michigan, Ann Arbor, Michigan; University of California, Los Angeles, Los Angeles; University of California, San Francisco, California; Brigham and Women's Hospital, Boston; Harvard Medical School, Boston, Massachusetts; Medical University of South Carolina, Charleston, South Carolina; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Hospital Clínic, Barcelona, Spain; AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris; Université Paris Descartes-Sorbonne Paris Cité, Paris; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin; Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin; University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece; Department of Medicine, University of Cambridge, Cambridge, UK; University of Pisa, Pisa, Italy; Medical University of Vienna, Vienna, Austria.

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July 2019

Diagnosis of pulmonary hypertension.

Eur Respir J 2019 01 24;53(1). Epub 2019 Jan 24.

Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.

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January 2019

Longitudinal Assessment of Patient-reported Outcome Measures in Systemic Sclerosis Patients with Gastroesophageal Reflux Disease - Scleroderma Clinical Trials Consortium.

J Rheumatol 2019 01 15;46(1):78-84. Epub 2018 Nov 15.

From the Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Biostatistics, and Division of Rheumatology, University of Michigan, Ann Arbor Michigan, USA; Division of Rheumatology, University of Florence, Florence, Italy; Division of Rheumatology, Ghent University Hospital, Faculty of Internal Medicine, Ghent University, Ghent, Belgium; Rheumatology Unit, Royal Adelaide Hospital, Discipline of Medicine, University of Adelaide, Adelaide, Australia; Department of Medicine, and Division of Rheumatology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

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January 2019

Reply.

Arthritis Rheumatol 2019 02 29;71(2):327-328. Epub 2018 Dec 29.

Columbia University Medical Center, New York, NY.

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February 2019

Burden of Gastrointestinal Symptoms in the United States: Results of a Nationally Representative Survey of Over 71,000 Americans.

Am J Gastroenterol 2018 11 15;113(11):1701-1710. Epub 2018 Oct 15.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.

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November 2018

Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial.

Clin Exp Rheumatol 2018 Jul-Aug;36 Suppl 113(4):146-149. Epub 2018 Sep 30.

Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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January 2019

Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.

J Rheumatol 2019 02 1;46(2):176-183. Epub 2018 Oct 1.

From the Department of Medicine, Division of Rheumatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California; Department of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland; Department of Medicine, Division of Rheumatology, Boston University, Boston; Department of Medicine, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina; Department of Medicine, Division of Rheumatology, and Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, Colorado; Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, Illinois; Department of Medicine, Division of Rheumatology, New York University Medical Center, New York, New York; Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan; Department of Medicine, Division of Rheumatology, Albany Medical College, Albany, New York; Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Medicine, Division of Rheumatology, University of Texas, Houston, Texas; Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Medicine, Division of Rheumatology, University of Minnesota, Minneapolis, Minnesota; Department of Medicine, Divisions of Pulmonary and Rheumatology, Tulane University, New Orleans, Louisiana; Department of Epidemiology and Health Promotion, New York University, New York, New York; Department of Medicine, Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, D.C., USA.

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February 2019

Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts.

Ann Rheum Dis 2018 08 14;77(8):1208-1218. Epub 2018 May 14.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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August 2018

Practical suggestions on intravenous iloprost in Raynaud's phenomenon and digital ulcer secondary to systemic sclerosis: Systematic literature review and expert consensus.

Semin Arthritis Rheum 2019 Feb 4;48(4):686-693. Epub 2018 Apr 4.

Department of Experimental and Clinical Medicine, University of Florence & Department of Geriatric Medicine, Division of Rheumatology AOUC, Florence, Italy.

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February 2019

Monoclonal Gammopathy-Associated Scleromyxedema Presenting as Leonine Facies.

Arthritis Rheumatol 2018 10;70(10):1694

University of Michigan, Ann Arbor, MI.

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October 2018

The patient experience of Raynaud's phenomenon in systemic sclerosis.

Rheumatology (Oxford) 2019 01;58(1):18-26

Division of Rheumatology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

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January 2019

Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database.

Medicine (Baltimore) 2017 Dec;96(51):e8980

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD Division of Rheumatology, University of Texas-McGovern Medical School, Houston, TX Division of Rheumatology, University of Pittsburgh, PA Division of Rheumatology, Georgetown University School of Medicine, Washington, DC Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL Division of Rheumatology, Medical University of South Carolina, Charleston, SC Division of Rheumatology, University of Michigan, Ann Arbor, MI Division of Rheumatology, Robert Wood Johnson University, New Brunswick, NJ Division of Rheumatology, Hospital for Special Surgery, New York, NY Department of Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC Division of Rheumatology, Tulane University School of Medicine, New Orleans, LA Division of Rheumatology, University of California San Francisco, CA Division of Rheumatology, University of Pennsylvania, Philadelphia, PA Division of Rheumatology, Boston University School of Medicine, Boston, MA Division of Rheumatology, George Washington University, Washington, DC Division of Rheumatology, Stanford University School of Medicine, Stanford, CA Division of Rheumatology, University of Chicago Pritzker School of Medicine, Chicago, IL Division of Rheumatology, New York University Langone Medical Center, New York, NY National Human Genome Research Institute National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

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December 2017

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.

N Engl J Med 2018 01;378(1):35-47

From the Duke University Medical Center (K.M.S., O.C., E.W.S.C.) and RTI International (D.W.), Durham, and Rho Federal Systems Division, Chapel Hill (L.K.-E., A.P., B.E., S.C.) - all in North Carolina; National Institute of Allergy and Infectious Diseases, Bethesda, MD (E.A.G., B.W., L.M.G., J.S.G.); Colorado Blood Cancer Institute, Denver (P.A.M., R.A.N.); University of Texas McGovern Medical School (M.D.M.) and M.D. Anderson Cancer Center (C.H.) - both in Houston; Vanderbilt University, Nashville (L.J.C., K.P.); University of Michigan, Ann Arbor (D.K., J.R.S.); Case Western Reserve University and University Hospitals, Cleveland (R.J.F.); University of Alabama, Birmingham (S.M.); Boston University, Boston (R.W.S.); University of Virginia, Charlottesville (K.B.); University of Washington (M.H.W., D.E.F.) and the Fred Hutchinson Cancer Research Center (G.E.G., S.H.) - both in Seattle; University of California, Los Angeles, Los Angeles (J.G., S.K., D.E.F.); City of Hope National Medical Center, Duarte, CA (S.F.); Medical University of South Carolina, Charleston (R.M.S.); Mayo Clinic, Scottsdale, AZ (L.G.); University of Calgary, Calgary, AB, Canada (J.S., S.L.); Washington University, St. Louis (R.B.); Medical College of Wisconsin, Milwaukee (M.E.C., C.K.-T.); Ottawa Hospital Research Institute, Ottawa (C.B.); University of Pittsburgh, Pittsburgh (T.M., R.T.D.); and University of Toledo Medical Center, Toledo, OH (M.B.K.).

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January 2018