Mr. Dinesh Bhandari, M.Sc. - Public Helath Research Laboratory, Institute of Medicine, Tribhuvan University, Nepal - Research Officer

Mr. Dinesh Bhandari

M.Sc.

Public Helath Research Laboratory, Institute of Medicine, Tribhuvan University, Nepal

Research Officer

काठमाडौँ | Nepal

Main Specialties: Epidemiology, Medical Microbiology, Public Health

Additional Specialties: Microbiology and immunology, Infectious disease epidemiology and Public Health

ORCID logohttps://orcid.org/0000-0002-0979-1406

Mr. Dinesh Bhandari, M.Sc. - Public Helath Research Laboratory, Institute of Medicine, Tribhuvan University, Nepal - Research Officer

Mr. Dinesh Bhandari

M.Sc.

Introduction

Primary Affiliation: Public Helath Research Laboratory, Institute of Medicine, Tribhuvan University, Nepal - काठमाडौँ , Nepal

Specialties:

Additional Specialties:

Research Interests:

Education

Jan 2010 - Apr 2015
Tribhuvan University - Trichandra Multiple Campus
M.sc.
Medical Microbiology
Feb 2018
University of Adelaide
PhD Fellow
Faculty of Health and Medical Sciences, School of Public Health

Experience

Sep 2017 - Dec 2017
Institute of Environmental Science and Research Ltd
Research Assistant
Apr 2014 - Sep 2017
Tribhuvan University Institute of Medicine
Health Research Officer
Public Health Research Laboratory

Publications

16Publications

226Reads

74Profile Views

10PubMed Central Citations

Assessing the effect of climate factors on childhood diarrhoea burden in Kathmandu, Nepal.

Int J Hyg Environ Health 2020 Jan 17;223(1):199-206. Epub 2019 Sep 17.

The University of Adelaide, School of Public Health, Adelaide, South Australia, Australia. Electronic address:

Introduction: This study was undertaken to assess the effect of climate variability on diarrhoeal disease burden among children under 5 years of age living in Kathmandu, Nepal. The researchers sought to predict future risk of childhood diarrhoea under different climate change scenarios to advance the evidence base available to public health decision-makers, and the Nepalese infection control division, in planning for climate impacts.

Methods: A time series study was conducted using the monthly case count of diarrhoeal disease (2003-2013) among children under 5 years of age living in Kathmandu, Nepal. A quasi Poisson generalised linear equation with distributed lag linear model was fitted to estimate the lagged effect of monthly maximum temperature and rainfall on childhood diarrhoea. The environmental framework of comparative risk assessment was used to assess the environmental burden of diarrhoea within this population.

Results: A total of 219,774 cases of diarrhoeal disease were recorded during the study period with a median value of 1286 cases per month. The results of a regression model revealed that the monthly count of diarrhoea cases increased by 8.1% (RR: 1.081; 95% CI: 1.02-1.14) per 1?°C increase in maximum temperature above the monthly average recorded within that month. Similarly, rainfall was found to have significant effect on the monthly diarrhoea count, with a 0.9% (RR; 1.009; 95% CI: 1.004-1.015) increase in cases for every 10?mm increase in rainfall above the monthly cumulative value recorded within that month. It was estimated that 7.5% (95% CI: 2.2%-12.5%) of the current burden of diarrhoea among children under 5 years of age could be attributed to climatic factors (maximum temperature), and projected that 1357 (UI: 410-2274) additional cases of childhood diarrhoea could be climate attributable by the year 2050 under low-risk scenario (0.9?°C increase in maximum temperature).

Conclusion: It is estimated that there exists a significant association (p?

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijheh.2019.09.002DOI Listing
January 2020
53 Reads
1 Citation
4.379 Impact Factor

Detection of Pathogenic Viruses, Pathogen Indicators, and Fecal-Source Markers within Tanker Water and Their Sources in the Kathmandu Valley, Nepal.

Pathogens 2019 Jun 19;8(2). Epub 2019 Jun 19.

Interdisciplinary Center for River Basin Environment, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan.

Tanker water is used extensively for drinking as well as domestic purposes in the Kathmandu Valley of Nepal. This study aimed to investigate water quality in terms of microbial contamination and determine sources of fecal pollution within these waters. Thirty-one samples from 17 tanker filling stations (TFSs) and 30 water tanker (WT) samples were collected during the dry and wet seasons of 2016. was detected in 52% of the 31 TFS samples and even more frequently in WT samples. Of the six pathogenic viruses tested, enteroviruses, noroviruses of genogroup II (NoVs-GII), human adenoviruses (HAdVs), and group A rotaviruses were detected using quantitative PCR (qPCR) at 10, five, four, and two TFSs, respectively, whereas Aichi virus 1 and NoVs-GI were not detected at any sites. Index viruses, such as pepper mild mottle virus and tobacco mosaic virus, were detected using qPCR in 77% and 95% out of 22 samples, respectively, all of which were positive for at least one of the tested pathogenic viruses. At least one of the four human-associated markers tested (i.e., BacHum, HAdVs, and JC and BK polyomaviruses) was detected using qPCR in 39% of TFS samples. Ruminant-associated markers were detected at three stations, and pig- and chicken-associated markers were found at one station each of the suburbs. These findings indicate that water supplied by TFSs is generally of poor quality and should be improved, and proper management of WTs should be implemented.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens8020081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630610PMC
June 2019
3 Reads

Co-Infection by Waterborne Enteric Viruses in Children with Gastroenteritis in Nepal.

Healthcare (Basel) 2019 Jan 13;7(1). Epub 2019 Jan 13.

Interdisciplinary Center for River Basin Environment, University of Yamanashi, Yamanashi 400-8511, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/healthcare7010009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473710PMC
January 2019
6 Reads

Development of a Quantitative PCR Assay for Arcobacter spp. and its Application to Environmental Water Samples.

Microbes Environ 2018 Sep 6;33(3):309-316. Epub 2018 Sep 6.

Interdisciplinary Center for River Basin Environment, University of Yamanashi.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1264/jsme2.ME18052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167121PMC
September 2018
3 Reads
2.231 Impact Factor

Biofilm Production and Antimicrobial Resistance among Uropathogens in Pediatric Cases: a Hospital Based Study.

J Nepal Health Res Counc 2018 Jul 3;16(2):178-183. Epub 2018 Jul 3.

Department of Microbiology, Tri-Chandra Multiple Campus, Ghantaghar, Kathmandu, Nepal.

View Article

Download full-text PDF

Source
July 2018
7 Reads

Presence of Human Enteric Viruses, Protozoa, and Indicators of Pathogens in the Bagmati River, Nepal.

Pathogens 2018 Apr 6;7(2). Epub 2018 Apr 6.

Interdisciplinary Center for River Basin Environment, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens7020038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027487PMC
April 2018
10 Reads
1 Citation

Potential for Bacteriophage Endolysins to Supplement or Replace Antibiotics in Food Production and Clinical Care.

Antibiotics (Basel) 2018 Feb 27;7(1). Epub 2018 Feb 27.

Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch 8041, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antibiotics7010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872128PMC
February 2018
4 Reads
1 Citation

Next-generation sequencing identification of pathogenic bacterial genes and their relationship with fecal indicator bacteria in different water sources in the Kathmandu Valley, Nepal.

Sci Total Environ 2017 Dec 27;601-602:278-284. Epub 2017 May 27.

Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2017.05.105DOI Listing
December 2017
24 Reads
3 Citations
4.100 Impact Factor

A hospital based surveillance of metallo-beta-lactamase producing gram negative bacteria in Nepal by imipenem-EDTA disk method.

BMC Res Notes 2017 Jul 25;10(1):322. Epub 2017 Jul 25.

Department of Microbiology, Nepal Medical College and Teaching Hospital, Kathmandu University, Dhulikhel, Nepal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13104-017-2640-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526278PMC
July 2017
6 Reads
1 Citation

Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal.

BMC Ophthalmol 2016 Nov 29;16(1):209. Epub 2016 Nov 29.

Department of Microbiology, Trichandra Multiple College, Ghantaghar, Kathmandu, Nepal.

View Article

Download full-text PDF

Source
http://bmcophthalmol.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12886-016-0388-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129215PMC
November 2016
6 Reads
1.075 Impact Factor

Antibiotic Resistance: Evolution and Alternatives

Bhandari D, Thapa P, Tandukar S, Thapa K, Sherchand JB. Antibiotic resistance: evolution and alternatives. The Canadian journal of infection control : the official journal of the Community & Hospital Infection Control Association-Canada = Revue canadienne de prévention des infections / Association

Canadian Journal of Infection Control

Globally, infection control has been challenged by the rapid advent and dissemination of antibiotic resistant microorganisms. The 70-odd years’ history of post antibiotic era has shown that despite the fitness cost, microorganisms will continue to evolve and we now face a never-ending battle of bacterial resistance against the antibiotics of last resort that we have at our disposal. In this article, we give a brief overview of the discovery of antibiotics, the emergence of antibiotic resistance, and the alternative strategies that can be sought for the treatment of infections caused by multidrug resistant bacteria.

https://ipac-canada.org/photos/custom/CJIC/Vol31no3.pdf

View Article
September 2016
85 Reads

Prevalence of Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae Isolated From Urinary Tract Infected Patients.

J Nepal Health Res Counc 2016 May;14(33):111-115

Central Department of Biotechnology, Tribhuvan University, Kathmandu, Nepal.

View Article

Download full-text PDF

Source
May 2016
12 Reads

Enteric parasitic infection among HIV-infected patients visiting Tribhuvan University Teaching Hospital, Nepal.

BMC Res Notes 2016 Apr 6;9:204. Epub 2016 Apr 6.

Public Health Research Laboratory, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13104-016-2007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822322PMC
April 2016
13 Reads

Cyclospora Infection among School Children in Kathmandu, Nepal: Prevalence and Associated Risk Factors.

Trop Med Health 2015 Dec 20;43(4):211-6. Epub 2015 Aug 20.

Tribhuvan University Institute of Medicine, Public Health Research Laboratory and Microbiology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2149/tmh.2015-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689608PMC
December 2015
54 Reads
3 Citations

Top co-authors

Sarmila Tandukar
Sarmila Tandukar

Tribhuvan University Teaching Hospital

9
Jeevan B Sherchand
Jeevan B Sherchand

Public Health Research Laboratory

7
Rajani Ghaju Shrestha
Rajani Ghaju Shrestha

Public Health Research Laboratory

5
Eiji Haramoto
Eiji Haramoto

International Research Center for River Basin Environment

5
Pratigya Thapa
Pratigya Thapa

Tribhuvan University Tri-Chandra Multiple Campus

4
Hiramani Parajuli
Hiramani Parajuli

Tribhuvan University Tri-Chandra Multiple Campus

3
Dhiraj Shrestha
Dhiraj Shrestha

Tribhuvan University Tri-Chandra Multiple Campus

3
Ocean Thakali
Ocean Thakali

Institute of Medicine

3
Jeevan Bahadur Sherchand
Jeevan Bahadur Sherchand

Liverpool School of Tropical Medicine

3