Dinakantha Kumararatne

Dinakantha Kumararatne

UNVERIFIED PROFILE

Are you Dinakantha Kumararatne?   Register this Author

Register author
Dinakantha Kumararatne

Dinakantha Kumararatne

Publications by authors named "Dinakantha Kumararatne"

Are you Dinakantha Kumararatne?   Register this Author

60Publications

2025Reads

21Profile Views

A First Unexplained Invasive Encapsulated Bacterial Infection in Young Adults is Associated with High Mortality and Readmission Rates.

Authors:
Niall Jackson Tommy Sutton Luke Bedford Sanja Ugrinovic Dinakantha Kumararatne Effrossyni Gkrania-Klotsas

Clin Infect Dis 2019 Jun 3. Epub 2019 Jun 3.

Cambridge University Hospitals, Immunology, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/cid/ciz470DOI Listing
June 2019

Reply.

Authors:
Vian Azzu Mariana Fonseca Lucinda Kennard Adam Duckworth Nasreen Moini Maria Qurashi Rebecca Brais Sue Davies Ania Manson Emily Staples Dinakantha S Kumararatne William J H Griffiths

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2508-2509

The Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaip.2019.06.015DOI Listing
June 2019

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Authors:
Maria Elena Maccari Hassan Abolhassani Asghar Aghamohammadi Alessandro Aiuti Olga Aleinikova Catherine Bangs Safa Baris Federica Barzaghi Helen Baxendale Matthew Buckland Siobhan O Burns Caterina Cancrini Andrew Cant Pascal Cathébras Marina Cavazzana Anita Chandra Francesca Conti Tanya Coulter Lisa A Devlin J David M Edgar Saul Faust Alain Fischer Marina Garcia-Prat Lennart Hammarström Maximilian Heeg Stephen Jolles Elif Karakoc-Aydiner Gerhard Kindle Ayca Kiykim Dinakantha Kumararatne Bodo Grimbacher Hilary Longhurst Nizar Mahlaoui Tomas Milota Fernando Moreira Despina Moshous Anna Mukhina Olaf Neth Benedicte Neven Alexandra Nieters Peter Olbrich Ahmet Ozen Jana Pachlopnik Schmid Capucine Picard Seraina Prader William Rae Janine Reichenbach Stephan Rusch Sinisa Savic Alessia Scarselli Raphael Scheible Anna Sediva Svetlana O Sharapova Anna Shcherbina Mary Slatter Pere Soler-Palacin Aurelie Stanislas Felipe Suarez Francesca Tucci Annette Uhlmann Joris van Montfrans Klaus Warnatz Anthony Peter Williams Phil Wood Sven Kracker Alison Mary Condliffe Stephan Ehl

Front Immunol 2018 16;9:543. Epub 2018 Mar 16.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00
Publisher Site
http://dx.doi.org/10.3389/fimmu.2018.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863269PMC
May 2019

Liver disease is common in patients with common variable immunodeficiency and predicts mortality in the presence of cirrhosis or portal hypertension.

Authors:
Vian Azzu Mariana Fonseca Adam Duckworth Lucinda Kennard Nasreen Moini Maria Qurashi Rebecca Brais Sue Davies Ania Manson Emily Staples Dinakantha S Kumararatne William J H Griffiths

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2484-2486.e3. Epub 2019 Apr 24.

The Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaip.2019.04.016DOI Listing
April 2019

Correction to: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

Authors:
Katharina Schütz Diana Alecsandru Bodo Grimbacher Jamanda Haddock Annemarie Bruining Gertjan Driessen Esther de Vries Peter M van Hagen Ieneke Hartmann Francesco Fraioli Cinzia Milito Milica Mitrevski Isabella Quinti Goffredo Serra Peter Kelleher Michael Loebinger Jiri Litzman Vera Postranecka Vojtech Thon Judith Babar Alison M Condliffe Andrew Exley Dinakantha Kumararatne Nick Screaton Alison Jones Maria P Bondioni Vassilios Lougaris Alessandro Plebani Annarosa Soresina Cesare Sirignano Giuseppe Spadaro Nermeen Galal Luis I Gonzalez-Granado Sabine Dettmer Robert Stirling Helen Chapel Mary Lucas Smita Patel Claire-Michele Farber Isabelle Meyts Arpan K Banerjee Scott Hackett John R Hurst Klaus Warnatz Benjamin Gathmann Jürgen Weidemann Daniel Berthold Ulrich Baumann

J Clin Immunol 2019 Feb;39(2):225-227

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10875-019-00609-4DOI Listing
February 2019

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

Authors:
Katharina Schütz Diana Alecsandru Bodo Grimbacher Jamanda Haddock Annemarie Bruining Gertjan Driessen Esther de Vries Peter M van Hagen Ieneke Hartmann Francesco Fraioli Cinzia Milito Milica Mitrevski Isabella Quinti Goffredo Serra Peter Kelleher Michael Loebinger Jiri Litzman Vera Postranecka Vojtech Thon Judith Babar Alison M Condliffe Andrew Exley Dinakantha Kumararatne Nick Screaton Alison Jones Maria P Bondioni Vassilios Lougaris Alessandro Plebani Annarosa Soresina Cesare Sirignano Giuseppe Spadaro Nermeen Galal Luis I Gonzalez-Granado Sabine Dettmer Robert Stirling Helen Chapel Mary Lucas Smita Patel Claire-Michele Farber Isabelle Meyts Arpan K Banerjee Scott Hackett John R Hurst Klaus Warnatz Benjamin Gathmann Ulrich Baumann

J Clin Immunol 2019 Jan 13;39(1):45-54. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s10875-018-0577-9
Publisher Site
http://dx.doi.org/10.1007/s10875-018-0577-9DOI Listing
January 2019

Novel Mutation in a Patient With APLAID and Cutis Laxa.

Authors:
João Farela Neves Rainer Doffinger Gabriela Barcena-Morales Catarina Martins Olivier Papapietro Vincent Plagnol James Curtis Marta Martins Dinakantha Kumararatne Ana Isabel Cordeiro Conceição Neves Luis Miguel Borrego Matilda Katan Sergey Nejentsev

Front Immunol 2018 14;9:2863. Epub 2018 Dec 14.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
https://www.frontiersin.org/article/10.3389/fimmu.2018.02863
Publisher Site
http://dx.doi.org/10.3389/fimmu.2018.02863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302768PMC
December 2018

Biallelic mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation.

Authors:
Delphine Cuchet-Lourenço Davide Eletto Changxin Wu Vincent Plagnol Olivier Papapietro James Curtis Lourdes Ceron-Gutierrez Chris M Bacon Scott Hackett Badr Alsaleem Mailis Maes Miguel Gaspar Ali Alisaac Emma Goss Eman AlIdrissi Daniela Siegmund Harald Wajant Dinakantha Kumararatne Mofareh S AlZahrani Peter D Arkwright Mario Abinun Rainer Doffinger Sergey Nejentsev

Science 2018 08 19;361(6404):810-813. Epub 2018 Jul 19.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1126/science.aar2641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529353PMC
August 2018

Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated exons.

Authors:
Alexandre Bolze Bertrand Boisson Barbara Bosch Alexander Antipenko Matthieu Bouaziz Paul Sackstein Malik Chaker-Margot Vincent Barlogis Tracy Briggs Elena Colino Aurora C Elmore Alain Fischer Ferah Genel Angela Hewlett Maher Jedidi Jadranka Kelecic Renate Krüger Cheng-Lung Ku Dinakantha Kumararatne Alain Lefevre-Utile Sam Loughlin Nizar Mahlaoui Susanne Markus Juan-Miguel Garcia Mathilde Nizon Matias Oleastro Malgorzata Pac Capucine Picard Andrew J Pollard Carlos Rodriguez-Gallego Caroline Thomas Horst Von Bernuth Austen Worth Isabelle Meyts Maurizio Risolino Licia Selleri Anne Puel Sebastian Klinge Laurent Abel Jean-Laurent Casanova

Proc Natl Acad Sci U S A 2018 08 2;115(34):E8007-E8016. Epub 2018 Aug 2.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065;

View Article

Download full-text PDF

 Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1805437115
Publisher Site
http://dx.doi.org/10.1073/pnas.1805437115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112730PMC
August 2018

Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation.

Authors:
Kesava A Ramakrishnan William Rae Gabriela Barcenas-Morales Yifang Gao Reuben J Pengelly Sanjay V Patel Dinakantha S Kumararatne Sarah Ennis Rainer Döffinger Saul N Faust Anthony P Williams

J Allergy Clin Immunol 2018 04 7;141(4):1479-1482.e6. Epub 2017 Dec 7.

Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom; Department of Allergy, Asthma and Clinical Immunology, University Hospital Southampton, Southampton, United Kingdom; CRUK NIHR Experimental Cancer Medicine Centre, Southampton, United Kingdom; WISH Laboratory University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaci.2017.11.014DOI Listing
April 2018

Liver transplantation in adults with liver disease due to common variable immunodeficiency leads to early recurrent disease and poor outcome.

Authors:
Vian Azzu Joshua E Elias Adam Duckworth Susan Davies Rebecca Brais Dinakantha S Kumararatne Alexander E S Gimson William J H Griffiths

Liver Transpl 2018 02;24(2):171-181

The Liver Unit, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/lt.24979DOI Listing
February 2018

Prescribing Immunoglobulin Replacement Therapy for Patients with Non-classical and Secondary Antibody Deficiency: an Analysis of the Practice of Clinical Immunologists in the UK and Republic of Ireland.

Authors:
John David M Edgar Alex G Richter Aarnoud P Huissoon Dinakantha S Kumararatne Helen E Baxendale Claire A Bethune Tomaz Garcez Siraj A Misbah Ricardo U Sorensen

J Clin Immunol 2018 02 8;38(2):204-213. Epub 2018 Feb 8.

Clinical Professor of Pediatrics, Department of Pediatrics, Louisiana State University Health Science Center, New Orleans, Louisiana, USA & Honorary Professor, Faculty of Medicine, University of La Frontera, Temuco, Chile.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10875-017-0469-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840253PMC
February 2018

BCG induced lupus vulgaris: an unexpected adverse event.

Authors:
Elaine Pace Spadaro John Xuereb Dingli Rainer Doffinger Kumararatne Dinakantha Alexandra Betts David Pace

Arch Dis Child 2018 01 11;103(1):71-72. Epub 2017 Mar 11.

Department of Child and Adolescent Health, Mater Dei Hospital, Msida, Malta.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/archdischild-2016-312338DOI Listing
January 2018

Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper-IgM but can be prevented by early hematopoietic stem cell transplantation.

Authors:
Vian Azzu Lucinda Kennard Beatriz Morillo-Gutierrez Mary Slatter J David M Edgar Dinakantha S Kumararatne William J H Griffiths

J Allergy Clin Immunol 2018 01 26;141(1):405-408.e7. Epub 2017 Jul 26.

Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaci.2017.06.036DOI Listing
January 2018

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection.

Authors:
Davide Eletto Siobhan O Burns Ivan Angulo Vincent Plagnol Kimberly C Gilmour Frances Henriquez James Curtis Miguel Gaspar Karolin Nowak Vanessa Daza-Cajigal Dinakantha Kumararatne Rainer Doffinger Adrian J Thrasher Sergey Nejentsev

Nat Commun 2016 12 23;7:13992. Epub 2016 Dec 23.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196432PMC
December 2016

Common variable immunodeficiency and natural killer cell lymphopenia caused by Ets-binding site mutation in the IL-2 receptor γ (IL2RG) gene promoter.

Authors:
Anita Chandra Fang Zhang Kimberly C Gilmour David Webster Vincent Plagnol Dinakantha S Kumararatne Siobhan O Burns Sergey Nejentsev Adrian J Thrasher

J Allergy Clin Immunol 2016 Mar 31;137(3):940-2.e4. Epub 2015 Oct 31.

Molecular and Cellular Immunology, Institute of Child Health, University College London, London, United Kingdom; Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaci.2015.08.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774944PMC
March 2016

Emergence of host-adapted Enteritidis through rapid evolution in an immunocompromised host.

Authors:
Elizabeth J Klemm Effrossyni Gkrania-Klotsas James Hadfield Jessica L Forbester Simon R Harris Christine Hale Jennifer N Heath Thomas Wileman Simon Clare Leanne Kane David Goulding Thomas D Otto Sally Kay Rainer Doffinger Fiona J Cooke Andrew Carmichael Andrew Ml Lever Julian Parkhill Calman A MacLennan Dinakantha Kumararatne Gordon Dougan Robert A Kingsley

Nat Microbiol 2016 03 25;1(3). Epub 2016 Jan 25.

The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nmicrobiol.2015.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843968PMC
March 2016

Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency.

Authors:
Jacob M Rosenberg Jordan V Price Gabriela Barcenas-Morales Lourdes Ceron-Gutierrez Sophie Davies Dinakantha S Kumararatne Rainer Döffinger Paul J Utz

J Allergy Clin Immunol 2016 Jan 11;137(1):204-213.e3. Epub 2015 Sep 11.

Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, Calif; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, Calif. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaci.2015.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715746PMC
January 2016

The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1.

Authors:
Mark Depner Sebastian Fuchs Jan Raabe Natalie Frede Cristina Glocker Rainer Doffinger Effrossyni Gkrania-Klotsas Dinakantha Kumararatne T Prescott Atkinson Harry W Schroeder Tim Niehues Gregor Dückers Asbjørg Stray-Pedersen Ulrich Baumann Reinhold Schmidt Jose L Franco Julio Orrego Moshe Ben-Shoshan Christine McCusker Cristina Miuki Abe Jacob Magda Carneiro-Sampaio Lisa A Devlin J David M Edgar Paul Henderson Richard K Russell Anne-Bine Skytte Suranjith L Seneviratne Jennifer Wanders Hans Stauss Isabelle Meyts Leen Moens Milos Jesenak Robin Kobbe Stephan Borte Michael Borte Dowain A Wright David Hagin Troy R Torgerson Bodo Grimbacher

J Clin Immunol 2016 Jan 25;36(1):73-84. Epub 2015 Nov 25.

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Engesser Straße 4, 79108, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10875-015-0214-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718942PMC
January 2016

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

Authors:
Elizabeth J Klemm Effrossyni Gkrania-Klotsas James Hadfield Jessica L Forbester Simon R Harris Christine Hale Jennifer N Heath Thomas Wileman Simon Clare Leanne Kane David Goulding Thomas D Otto Sally Kay Rainer Doffinger Fiona J Cooke Andrew Carmichael Andrew M L Lever Julian Parkhill Calman A MacLennan Dinakantha Kumararatne Gordon Dougan Robert A Kingsley

Nat Microbiol 2016 Jan 25;1:15023. Epub 2016 Jan 25.

The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nmicrobiol.2015.23DOI Listing
January 2016

The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency.

Authors:
Jeremy M Woodward Effrossyni Gkrania-Klotsas Anthony Yk Cordero-Ng Aloysious Aravinthan Betty N Bandoh Hongxiang Liu Susan Davies Hongyi Zhang Philip Stevenson Martin D Curran Dinakantha Kumararatne

Am J Gastroenterol 2015 Feb 27;110(2):320-7. Epub 2015 Jan 27.

Department of Clinical Biochemistry and Immunology, Cambridge University Hospitals NHS Foundation Trust and Cambridge University Medical School, Cambridge, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ajg.2014.432DOI Listing
February 2015

Pneumococcal polysaccharide vaccine responses are impaired in a subgroup of children with cystic fibrosis.

Authors:
Michael J Browning Michael T C Lim Priti Kenia Michelle Whittle Rainer Doffinger Gabriela Barcenas-Morales Dinakantha Kumararatne Maria Viskaduraki Christopher O'Callaghan Erol A Gaillard

J Cyst Fibros 2014 Dec 11;13(6):632-8. Epub 2014 Mar 11.

Institute for Lung Health, NIHR Leicester Respiratory Biomedical Research Unit, Leicester LE1 9HN, UK; Department of Infection Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, UK; Children's Hospital, Leicester Royal Infirmary, Leicester LE1 5WW, UK. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jcf.2014.02.002DOI Listing
December 2014

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.

Authors:
Benjamin Gathmann Nizar Mahlaoui Laurence Gérard Eric Oksenhendler Klaus Warnatz Ilka Schulze Gerhard Kindle Taco W Kuijpers Rachel T van Beem David Guzman Sarita Workman Pere Soler-Palacín Javier De Gracia Torsten Witte Reinhold E Schmidt Jiri Litzman Eva Hlavackova Vojtech Thon Michael Borte Stephan Borte Dinakantha Kumararatne Conleth Feighery Hilary Longhurst Matthew Helbert Anna Szaflarska Anna Sediva Bernd H Belohradsky Alison Jones Ulrich Baumann Isabelle Meyts Necil Kutukculer Per Wågström Nermeen Mouftah Galal Joachim Roesler Evangelia Farmaki Natalia Zinovieva Peter Ciznar Efimia Papadopoulou-Alataki Kirsten Bienemann Sirje Velbri Zoya Panahloo Bodo Grimbacher

J Allergy Clin Immunol 2014 Jul 28;134(1):116-26. Epub 2014 Feb 28.

Center for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg and University of Freiburg, Freiburg, Germany; UCL Medical School Royal Free Campus and Royal Free Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jaci.2013.12.1077DOI Listing
July 2014

Towards a safety net for management of 22q11.2 deletion syndrome: guidelines for our times.

Authors:
Alex Habel Richard Herriot Dinakantha Kumararatne Jeremy Allgrove Kate Baker Helen Baxendale Frances Bu'Lock Helen Firth Andrew Gennery Anthony Holland Claire Illingworth Nigel Mercer Merel Pannebakker Andrew Parry Anne Roberts Beverly Tsai-Goodman

Eur J Pediatr 2014 Jun 3;173(6):757-65. Epub 2014 Jan 3.

North Thames Regional Cleft Unit, Great Ormond Street NHS Trust, Great Ormond Street, London, WC1N 3JH, UK,

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00431-013-2240-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032642PMC
June 2014

Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency.

Authors:
Monia Ouederni Ozden Sanal Aydan Ikinciogullari Ilhan Tezcan Figen Dogu Ithaisa Sologuren Sigifredo Pedraza-Sánchez Melike Keser Gonul Tanir Chris Nieuwhof Elena Colino Dinakantha Kumararatne Jacov Levy Necil Kutukculer Caner Aytekin Estefanía Herrera-Ramos Micah Bhatti Neslihan Karaca Ridha Barbouche Arnon Broides Ekaterini Goudouris José Luis Franco Nima Parvaneh Ismail Reisli Alexis Strickler Anna Shcherbina Ayper Somer Anthony Segal Alfonso Angel-Moreno José Luis Lezana-Fernandez Mohamed Bejaoui Miriam Bobadilla-Del Valle Salem Kachboura Timothy Sentongo Imen Ben-Mustapha Jacinta Bustamante Capucine Picard Anne Puel Stéphanie Boisson-Dupuis Laurent Abel Jean-Laurent Casanova Carlos Rodríguez-Gallego

Clin Infect Dis 2014 Jan 1;58(2):204-13. Epub 2013 Nov 1.

Pediatric Hematology-Immunology Unit, National Bone Marrow Transplantation Center, Tunis.

View Article

Download full-text PDF

 Source
http://cid.oxfordjournals.org/content/early/2013/11/01/cid.c
Web Search
http://cid.oxfordjournals.org/lookup/doi/10.1093/cid/cit722
Publisher Site
http://dx.doi.org/10.1093/cid/cit722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871796PMC
January 2014

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:
Ivan Angulo Oscar Vadas Fabien Garçon Edward Banham-Hall Vincent Plagnol Timothy R Leahy Helen Baxendale Tanya Coulter James Curtis Changxin Wu Katherine Blake-Palmer Olga Perisic Deborah Smyth Mailis Maes Christine Fiddler Jatinder Juss Deirdre Cilliers Gašper Markelj Anita Chandra George Farmer Anna Kielkowska Jonathan Clark Sven Kracker Marianne Debré Capucine Picard Isabelle Pellier Nada Jabado James A Morris Gabriela Barcenas-Morales Alain Fischer Len Stephens Phillip Hawkins Jeffrey C Barrett Mario Abinun Menna Clatworthy Anne Durandy Rainer Doffinger Edwin R Chilvers Andrew J Cant Dinakantha Kumararatne Klaus Okkenhaug Roger L Williams Alison Condliffe Sergey Nejentsev

Science 2013 Nov 17;342(6160):866-71. Epub 2013 Oct 17.

Department of Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1126/science.1243292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930011PMC
November 2013

Immune competence after alemtuzumab treatment of multiple sclerosis.

Authors:
Claire L McCarthy Orla Tuohy D Alastair S Compston Dinakantha S Kumararatne Alasdair J Coles Joanne L Jones

Neurology 2013 Sep 7;81(10):872-6. Epub 2013 Aug 7.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/WNL.0b013e3182a35215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885219PMC
September 2013

Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds.

Authors:
Carolina Prando Arina Samarina Jacinta Bustamante Stéphanie Boisson-Dupuis Aurelie Cobat Capucine Picard Zobaida AlSum Suliman Al-Jumaah Sami Al-Hajjar Husn Frayha Abdullah Alangari Hamoud Al-Mousa Khalid F Mobaireek Imen Ben-Mustapha Parisa Adimi Jacqueline Feinberg Maylis de Suremain Lucile Jannière Orchidée Filipe-Santos Nahal Mansouri Jean-Louis Stephan Revathy Nallusamy Dinakantha S Kumararatne Mohamad Reza Bloorsaz Meriem Ben-Ali Houda Elloumi-Zghal Jalel Chemli Jihene Bouguila Mohamed Bejaoui Emadia Alaki Tariq S AlFawaz Eman Al Idrissi Gehad ElGhazali Andrew J Pollard Belinda Murugasu Bee Wah Lee Rabih Halwani Mohammed Al-Zahrani Mohammed A Al Shehri Mofareh Al-Zahrani Ibrahim Bin-Hussain Seyed Alireza Mahdaviani Nima Parvaneh Laurent Abel Davood Mansouri Ridha Barbouche Saleh Al-Muhsen Jean-Laurent Casanova

Medicine (Baltimore) 2013 Mar;92(2):109-22

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York 10065, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/MD.0b013e31828a01f9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822760PMC
March 2013

LRBA gene deletion in a patient presenting with autoimmunity without hypogammaglobulinemia.

Authors:
Siobhan O Burns Helen L Zenner Vincent Plagnol James Curtis Kin Mok Michael Eisenhut Dinakantha Kumararatne Rainer Doffinger Adrian J Thrasher Sergey Nejentsev

J Allergy Clin Immunol 2012 Dec 14;130(6):1428-32. Epub 2012 Sep 14.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749120122
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2012.07.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930010PMC
December 2012

A robust model for read count data in exome sequencing experiments and implications for copy number variant calling.

Authors:
Vincent Plagnol James Curtis Michael Epstein Kin Y Mok Emma Stebbings Sofia Grigoriadou Nicholas W Wood Sophie Hambleton Siobhan O Burns Adrian J Thrasher Dinakantha Kumararatne Rainer Doffinger Sergey Nejentsev

Bioinformatics 2012 Nov 31;28(21):2747-54. Epub 2012 Aug 31.

UCL Genetics Institute, UCL, London, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/bts526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476336PMC
November 2012

Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology.

Authors:
Jordan S Orange Mark Ballow E Richard Stiehm Zuhair K Ballas Javier Chinen Maite De La Morena Dinakantha Kumararatne Terry O Harville Paul Hesterberg Majed Koleilat Sean McGhee Elena E Perez Jason Raasch Rebecca Scherzer Harry Schroeder Christine Seroogy Aarnoud Huissoon Ricardo U Sorensen Rohit Katial

J Allergy Clin Immunol 2012 Sep;130(3 Suppl):S1-24

Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.

View Article

Download full-text PDF

 Source
https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documen
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S009167491201103
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2012.07.002DOI Listing
September 2012

Specific antibody deficiency in children with chronic wet cough.

Authors:
Michael Teik Chung Lim Kayathrie Jeyarajah Philippa Jones Hitesh Pandya Rainer Doffinger Dinakantha Kumararatne Michael J Browning Erol A Gaillard

Arch Dis Child 2012 May 30;97(5):478-80. Epub 2012 Jan 30.

Department of Paediatrics, University Hospitals of Leicester, Leicester, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/archdischild-2011-300691DOI Listing
May 2012

Vaccine-derived poliomyelitis 12 years after infection.

Authors:
Calman A MacLennan Aarnoud P Huissoon Dinakantha S Kumararatne

N Engl J Med 2011 10;365(14):1355; author reply 1355

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1056/NEJMc1108814DOI Listing
October 2011

IRF8 mutations and human dendritic-cell immunodeficiency.

Authors:
Sophie Hambleton Sandra Salem Jacinta Bustamante Venetia Bigley Stéphanie Boisson-Dupuis Joana Azevedo Anny Fortin Muzlifah Haniffa Lourdes Ceron-Gutierrez Chris M Bacon Geetha Menon Céline Trouillet David McDonald Peter Carey Florent Ginhoux Laia Alsina Timothy J Zumwalt Xiao-Fei Kong Dinakantha Kumararatne Karina Butler Marjorie Hubeau Jacqueline Feinberg Saleh Al-Muhsen Andrew Cant Laurent Abel Damien Chaussabel Rainer Doffinger Eduardo Talesnik Anete Grumach Alberto Duarte Katia Abarca Dewton Moraes-Vasconcelos David Burk Albert Berghuis Frédéric Geissmann Matthew Collin Jean-Laurent Casanova Philippe Gros

N Engl J Med 2011 Jul 27;365(2):127-38. Epub 2011 Apr 27.

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1056/NEJMoa1100066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136554PMC
July 2011

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency.

Authors:
Venetia Bigley Muzlifah Haniffa Sergei Doulatov Xiao-Nong Wang Rachel Dickinson Naomi McGovern Laura Jardine Sarah Pagan Ian Dimmick Ignatius Chua Jonathan Wallis Jim Lordan Cliff Morgan Dinakantha S Kumararatne Rainer Doffinger Mirjam van der Burg Jacques van Dongen Andrew Cant John E Dick Sophie Hambleton Matthew Collin

J Exp Med 2011 Feb 17;208(2):227-34. Epub 2011 Jan 17.

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, England, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1084/jem.20101459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039861PMC
February 2011

Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries.

Authors:
Ludovic de Beaucoudrey Arina Samarina Jacinta Bustamante Aurélie Cobat Stéphanie Boisson-Dupuis Jacqueline Feinberg Saleh Al-Muhsen Lucile Jannière Yoann Rose Maylis de Suremain Xiao-Fei Kong Orchidée Filipe-Santos Ariane Chapgier Capucine Picard Alain Fischer Figen Dogu Aydan Ikinciogullari Gonul Tanir Sami Al-Hajjar Suliman Al-Jumaah Husn H Frayha Zobaida AlSum Sulaiman Al-Ajaji Abdullah Alangari Abdulaziz Al-Ghonaium Parisa Adimi Davood Mansouri Imen Ben-Mustapha Judith Yancoski Ben-Zion Garty Carlos Rodriguez-Gallego Isabel Caragol Necil Kutukculer Dinakantha S Kumararatne Smita Patel Rainer Doffinger Andrew Exley Olle Jeppsson Janine Reichenbach David Nadal Yaryna Boyko Barbara Pietrucha Suzanne Anderson Michael Levin Liliane Schandené Kinda Schepers André Efira Françoise Mascart Masao Matsuoka Tatsunori Sakai Claire-Anne Siegrist Klara Frecerova Renate Blüetters-Sawatzki Jutta Bernhöft Joachim Freihorst Ulrich Baumann Darko Richter Filomeen Haerynck Frans De Baets Vas Novelli David Lammas Christiane Vermylen David Tuerlinckx Chris Nieuwhof Malgorzata Pac Walther H Haas Ingrid Müller-Fleckenstein Bernhard Fleckenstein Jacob Levy Revathi Raj Aileen Cleary Cohen David B Lewis Steven M Holland Kuender D Yang Xiaochuan Wang Xiaohong Wang Liping Jiang Xiqiang Yang Chaomin Zhu Yuanyuan Xie Pamela Pui Wah Lee Koon Wing Chan Tong-Xin Chen Gabriela Castro Ivelisse Natera Ana Codoceo Alejandra King Liliana Bezrodnik Daniela Di Giovani Maria Isabel Gaillard Dewton de Moraes-Vasconcelos Anete Sevciovic Grumach Alberto Jose da Silva Duarte Ruth Aldana Francisco Javier Espinosa-Rosales Mohammed Bejaoui Ahmed Aziz Bousfiha Jamila El Baghdadi Namik Ozbek Guzide Aksu Melike Keser Ayper Somer Nevin Hatipoglu Cigdem Aydogmus Suna Asilsoy Yildiz Camcioglu Saniye Gülle Tuba T Ozgur Meteran Ozen Matias Oleastro Andrea Bernasconi Setareh Mamishi Nima Parvaneh Sergio Rosenzweig Ridha Barbouche Sigifredo Pedraza Yu Lung Lau Mohammad S Ehlayel Claire Fieschi Laurent Abel Ozden Sanal Jean-Laurent Casanova

Medicine (Baltimore) 2010 Nov;89(6):381-402

Laboratory of Human Genetics of Infectious Diseases U980, Institut National de la Santé et de la Recherche Médicale, Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/MD.0b013e3181fdd832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129625PMC
November 2010

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

Authors:
Capucine Picard Horst von Bernuth Pegah Ghandil Maya Chrabieh Ofer Levy Peter D Arkwright Douglas McDonald Raif S Geha Hidetoshi Takada Jens C Krause C Buddy Creech Cheng-Lung Ku Stephan Ehl László Maródi Saleh Al-Muhsen Sami Al-Hajjar Abdulaziz Al-Ghonaium Noorbibi K Day-Good Steven M Holland John I Gallin Helen Chapel David P Speert Carlos Rodriguez-Gallego Elena Colino Ben-Zion Garty Chaim Roifman Toshiro Hara Hideto Yoshikawa Shigeaki Nonoyama Joseph Domachowske Andrew C Issekutz Mimi Tang Joanne Smart Simona Eva Zitnik Cyrille Hoarau Dinakantha S Kumararatne Adrian J Thrasher E Graham Davies Claire Bethune Nicolas Sirvent Dominique de Ricaud Yildiz Camcioglu Júlia Vasconcelos Margarida Guedes Artur Bonito Vitor Carlos Rodrigo Francisco Almazán Maria Méndez Juan Ignacio Aróstegui Laia Alsina Claudia Fortuny Janine Reichenbach James W Verbsky Xavier Bossuyt Rainer Doffinger Laurent Abel Anne Puel Jean-Laurent Casanova

Medicine (Baltimore) 2010 Nov;89(6):403-25

Study Center of Primary Immunodeficiencies, Assistance Publique Hôpitaux de Paris, Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/MD.0b013e3181fd8ec3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103888PMC
November 2010

Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

Authors:
Douglas R McDonald Frederick Goldman Oscar D Gomez-Duarte Andrew C Issekutz Dinakantha S Kumararatne Rainer Doffinger Raif S Geha

J Allergy Clin Immunol 2010 Aug;126(2):332-7, 337.e1-2

Division of Immunology, Children's Hospital, Boston, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749100081
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2010.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917474PMC
August 2010

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.

Authors:
Anne Puel Rainer Döffinger Angels Natividad Maya Chrabieh Gabriela Barcenas-Morales Capucine Picard Aurélie Cobat Marie Ouachée-Chardin Antoine Toulon Jacinta Bustamante Saleh Al-Muhsen Mohammed Al-Owain Peter D Arkwright Colm Costigan Vivienne McConnell Andrew J Cant Mario Abinun Michel Polak Pierre-François Bougnères Dinakantha Kumararatne László Marodi Amit Nahum Chaim Roifman Stéphane Blanche Alain Fischer Christine Bodemer Laurent Abel Desa Lilic Jean-Laurent Casanova

J Exp Med 2010 Feb 1;207(2):291-7. Epub 2010 Feb 1.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM), U550, 75015 Paris, France.

View Article

Download full-text PDF

 Source
http://www.jem.org/lookup/doi/10.1084/jem.20091983
Publisher Site
http://dx.doi.org/10.1084/jem.20091983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822614PMC
February 2010

Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency.

Authors:
Gerben Bouma Rainer Doffinger Smita Y Patel Emma Peskett Joanna C Sinclair Gabriela Barcenas-Morales Lourdes Cerron-Gutierrez Dinakantha S Kumararatne E Graham Davies Adrian J Thrasher Siobhan O Burns

Br J Haematol 2009 Oct 5;147(1):153-6. Epub 2009 Aug 5.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/j.1365-2141.2009.07838.xDOI Listing
October 2009

Clinical utility of ANA measured by ELISA compared with ANA measured by immunofluorescence.

Authors:
Gerald A Maguire Amel Ginawi Jeffrey Lee Anita Y N Lim Graham Wood Sally Houghton Dinakantha S Kumararatne Hill J S Gaston

Rheumatology (Oxford) 2009 Aug 2;48(8):1013-4. Epub 2009 Jun 2.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/rheumatology/kep137DOI Listing
August 2009

Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.

Authors:
Ulrich Salzer Chiara Bacchelli Sylvie Buckridge Qiang Pan-Hammarström Stephanie Jennings Vassilis Lougaris Astrid Bergbreiter Tina Hagena Jennifer Birmelin Alessandro Plebani A David B Webster Hans-Hartmut Peter Daniel Suez Helen Chapel Andrew McLean-Tooke Gavin P Spickett Stephanie Anover-Sombke Hans D Ochs Simon Urschel Bernd H Belohradsky Sanja Ugrinovic Dinakantha S Kumararatne Tatiana C Lawrence Are M Holm Jose L Franco Ilka Schulze Pascal Schneider E Michael Gertz Alejandro A Schäffer Lennart Hammarström Adrian J Thrasher H Bobby Gaspar Bodo Grimbacher

Blood 2009 Feb 3;113(9):1967-76. Epub 2008 Nov 3.

Department of Rheumatology and Clinical Immunology, University Hospital Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2008-02-141937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651012PMC
February 2009

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.

Authors:
Isabelle Isnardi Yen-Shing Ng Iva Srdanovic Roja Motaghedi Sergei Rudchenko Horst von Bernuth Shen-Ying Zhang Anne Puel Emmanuelle Jouanguy Capucine Picard Ben-Zion Garty Yildiz Camcioglu Rainer Doffinger Dinakantha Kumararatne Graham Davies John I Gallin Soichi Haraguchi Noorbibi K Day Jean-Laurent Casanova Eric Meffre

Immunity 2008 Nov;29(5):746-57

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, NY 10021, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.immuni.2008.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666307PMC
November 2008

IFN-gamma regulates Fas ligand expression in human CD4+ T lymphocytes and controls their anti-mycobacterial cytotoxic functions.

Authors:
Daniela Boselli Giuliana Losana Paola Bernabei Daniela Bosisio Pamela Drysdale Rolf Kiessling John S H Gaston David Lammas Jean-Laurent Casanova Dinakantha S Kumararatne Francesco Novelli

Eur J Immunol 2007 Aug;37(8):2196-204

Department of Medicine and Experimental Oncology, University of Turin, and Center for Experimental Research and Medical Studies, S. Giovanni Battista Hospital, Turin, Italy.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/eji.200636541
Publisher Site
http://dx.doi.org/10.1002/eji.200636541DOI Listing
August 2007

Tuberculous meningitis: protracted course and clinical response to interferon-gamma.

Authors:
J Brian S Coulter Richard L Baretto Connor L Mallucci Maria I Romano Laurance J Abernethy David M Isherwood Dinakantha S Kumararatne David A Lammas

Lancet Infect Dis 2007 Mar;7(3):225-32

Royal Liverpool Children's NHS Trust, Liverpool, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S1473-3099(07)70054-3DOI Listing
March 2007

Mendelian susceptibility to mycobacterial disease.

Authors:
Dinakantha S Kumararatne

Respiration 2006 ;73(3):280-2

View Article

Download full-text PDF

 Source
http://www.smw.ch/docs/pdf200x/2001/31/smw-09763.pdf
Web Search
https://www.orpha.net/data/patho/GB/uk-prpp.pdf
Web Search
http://www.karger.com/?doi=10.1159/000092083
Publisher Site
http://dx.doi.org/10.1159/000092083DOI Listing
October 2006

T cell-dependent activation of dendritic cells requires IL-12 and IFN-gamma signaling in T cells.

Authors:
Francesc Miro Cinzia Nobile Nicolas Blanchard Marianne Lind Orchidée Filipe-Santos Claire Fieschi Ariane Chapgier Guillaume Vogt Ludovic de Beaucoudrey Dinakantha S Kumararatne Françoise Le Deist Jean-Laurent Casanova Sebastian Amigorena Claire Hivroz

J Immunol 2006 Sep;177(6):3625-34

Institut National de la Santé et de la Recherche Médicale Unité 653, Institut Curie, Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4049/jimmunol.177.6.3625DOI Listing
September 2006

Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity.

Authors:
Rainer Doffinger Smita Y Patel Dinakantha S Kumararatne

Microbes Infect 2006 Apr 19;8(4):1141-50. Epub 2006 Jan 19.

Department of Clinical Biochemistry and Immunology, Box 109, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.micinf.2005.10.028DOI Listing
April 2006

Differential response to interferon-gamma therapy in a family with dominant negative partial interferon-gamma receptor1 deficiency.

Authors:
Anita E Smyth Paul Jackson David Lammas M Suhail Asghar Alistair D Crockard Jean-Laurent Casanova Dinakantha S Kumararatne J David M Edgar

Eur J Pediatr 2006 Jan 6;165(1):71-2. Epub 2005 Sep 6.

Department of Rheumatology, The Ulster Hospital, Belfast, and Department of Immunity and Infection, The Medical School, University of Birmingham, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00431-005-1739-3DOI Listing
January 2006

Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children.

Authors:
Philip M D Wood Claire Fieschi Capucine Picard Tom H M Ottenhoff Jean-Laurent Casanova Dinakantha S Kumararatne

Eur J Pediatr 2005 Dec 23;164(12):741-7. Epub 2005 Aug 23.

Department of Clinical Immunology and Allergy, St. James's University Hospital, Leeds, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00431-005-1745-5DOI Listing
December 2005

Epstein-Barr virus can establish infection in the absence of a classical memory B-cell population.

Authors:
Margaret Conacher Robin Callard Karen McAulay Helen Chapel David Webster Dinakantha Kumararatne Anita Chandra Gavin Spickett Paul A Hopwood Dorothy H Crawford

J Virol 2005 Sep;79(17):11128-34

Basic and Clinical Virology, University of Edinburgh, Royal (Dick) School of Veterinary Studies, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1128/JVI.79.17.11128-11134.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193576PMC
September 2005

Human immunodeficiencies that predispose to intracellular bacterial infections.

Authors:
Rainer Doffinger Smita Patel Dinakantha S Kumararatne

Curr Opin Rheumatol 2005 Jul;17(4):440-6

Department of Clinical Biochemistry and Immunology, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
http://pdfs.journals.lww.com/co-rheumatology/2005/07000/Huma
Web Search
http://dx.doi.org/10.1097/01.bor.0000166387.70475.ddDOI Listing
July 2005

Anti-interleukin-12 antibody treatment for Crohn disease: potential risk of invasive disease due to mycobacteria and salmonellae infection.

Authors:
Calman MacLennan David A Lammas Dinakantha S Kumararatne

Clin Infect Dis 2005 May;40(9):1381-2

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1086/429511DOI Listing
May 2005

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.

Authors:
Susan E Dorman Capucine Picard David Lammas Klaus Heyne Jaap T van Dissel Richard Baretto Sergio D Rosenzweig Melanie Newport Michael Levin Joachim Roesler Dinakantha Kumararatne Jean-Laurent Casanova Steven M Holland

Lancet 2004 Dec 11-17;364(9451):2113-21

Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, CRC B3-419, 10 Center Drive, MSC 1684, Bethesda, MD 20892-1684, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S0140-6736(04)17552-1DOI Listing
January 2005

Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.

Authors:
Calman MacLennan Claire Fieschi David A Lammas Capucine Picard Susan E Dorman Ozden Sanal Jenny M MacLennan Steven M Holland Tom H M Ottenhoff Jean-Laurent Casanova Dinakantha S Kumararatne

J Infect Dis 2004 Nov 7;190(10):1755-7. Epub 2004 Oct 7.

Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, Alabama, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1086/425021DOI Listing
November 2004

Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man.

Authors:
Calman MacLennan Glynis Dunn Aarnoud P Huissoon Dinakantha S Kumararatne Javier Martin Paula O'Leary Ronald A Thompson Husam Osman Philip Wood Philip Minor David J Wood Deenan Pillay

Lancet 2004 May;363(9420):1509-13

MRC Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S0140-6736(04)16150-3DOI Listing
May 2004

Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity.

Authors:
Rainer Döffinger Matthew R Helbert Gabriela Barcenas-Morales Kun Yang Stephanie Dupuis Lourdes Ceron-Gutierrez Clara Espitia-Pinzon Neil Barnes Graham Bothamley Jean-Laurent Casanova Hilary J Longhurst Dinakantha S Kumararatne

Clin Infect Dis 2004 Jan 4;38(1):e10-4. Epub 2003 Dec 4.

Department of Clinical Immunology and Biochemistry, Addenbrooke's Hospital, Cambridge, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1086/380453DOI Listing
January 2004

Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications.

Authors:
Claire Fieschi Stéphanie Dupuis Emilie Catherinot Jacqueline Feinberg Jacinta Bustamante Adrien Breiman Frédéric Altare Richard Baretto Françoise Le Deist Samer Kayal Hartmut Koch Darko Richter Martin Brezina Guzide Aksu Phil Wood Suliman Al-Jumaah Miquel Raspall Alberto José Da Silva Duarte David Tuerlinckx Jean-Louis Virelizier Alain Fischer Andrea Enright Jutta Bernhöft Aileen M Cleary Christiane Vermylen Carlos Rodriguez-Gallego Graham Davies Renate Blütters-Sawatzki Claire-Anne Siegrist Mohammad S Ehlayel Vas Novelli Walther H Haas Jacob Levy Joachim Freihorst Sami Al-Hajjar David Nadal Dewton De Moraes Vasconcelos Olle Jeppsson Necil Kutukculer Klara Frecerova Isabel Caragol David Lammas Dinakantha S Kumararatne Laurent Abel Jean-Laurent Casanova

J Exp Med 2003 Feb;197(4):527-35

Laboratory of Human Genetics of Infectious Diseases, University René Descartes INSERM U550, Necker Medical School, Paris, France.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193866PMC
http://dx.doi.org/10.1084/jem.20021769DOI Listing
February 2003

Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.

Authors:
Cheuk M Li Sarah J Campbell Dinakantha S Kumararatne Richard Bellamy Cyril Ruwende Keith P W J McAdam Adrian V S Hill David A Lammas

J Infect Dis 2002 Nov 29;186(10):1458-62. Epub 2002 Oct 29.

Division of Infection and Immunity, Medical Research Council (MRC) Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1086/344351DOI Listing
November 2002

Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.

Authors:
Capucine Picard Claire Fieschi Frédéric Altare Suliman Al-Jumaah Sami Al-Hajjar Jacqueline Feinberg Stéphanie Dupuis Claire Soudais Ibrahim Zaid Al-Mohsen Emmanuelle Génin David Lammas Dinakantha S Kumararatne Tony Leclerc Arash Rafii Husn Frayha Belinda Murugasu Lee Bee Wah Raja Sinniah Michael Loubser Emi Okamoto Abdulaziz Al-Ghonaium Haysam Tufenkeji Laurent Abel Jean-Laurent Casanova

Am J Hum Genet 2002 Feb 17;70(2):336-48. Epub 2001 Dec 17.

Laboratoire de Génétique Humaine des Maladies Infectieuses, Université René Descartes INSERM U550, Faculté de Médecine Necker, Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1086/338625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384913PMC
February 2002