Dimpy Koul

Dimpy Koul

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Dimpy Koul

Dimpy Koul

Publications by authors named "Dimpy Koul"

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BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening.

Am J Cancer Res 2019 1;9(11):2428-2441. Epub 2019 Nov 1.

Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center Houston, Texas, USA.

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November 2019

Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma.

Cancer Res 2019 Oct 15;79(19):5088-5101. Epub 2019 Aug 15.

Brain Tumor Center, Departments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0325DOI Listing
October 2019

Wild-type defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs.

Am J Cancer Res 2019 1;9(8):1734-1745. Epub 2019 Aug 1.

Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726980PMC
August 2019

APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death.

Oncotarget 2017 Aug 21;8(33):54285-54296. Epub 2017 Apr 21.

Brain Tumor Center, Departments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.17348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589580PMC
August 2017

MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.

Mol Cancer Ther 2016 07 22;15(7):1656-68. Epub 2016 Apr 22.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936927PMC
July 2016

Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis.

Neuro Oncol 2013 Jul 15;15(7):829-39. Epub 2013 Mar 15.

Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.1093/neuonc/not024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688008PMC
July 2013

Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells.

Cancer Res 2013 May 14;73(10):3062-74. Epub 2013 Mar 14.

Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655088PMC
May 2013

Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy.

Neuro Oncol 2011 Jul 8;13(7):748-58. Epub 2011 Jun 8.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1093/neuonc/nor037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129270PMC
July 2011

Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway.

Cancer 2011 Jun 14;117(11):2386-97. Epub 2010 Dec 14.

Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.25796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116027PMC
June 2011

Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.

Neuro Oncol 2010 Jun 15;12(6):559-69. Epub 2010 Feb 15.

Department of Neuro-Oncology, Unit 100, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/neuonc/nop058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940638PMC
June 2010

PTEN signaling pathways in glioblastoma.

Authors:
Dimpy Koul

Cancer Biol Ther 2008 Sep 8;7(9):1321-5. Epub 2008 Sep 8.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cbt.7.9.6954DOI Listing
September 2008

Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells.

Clin Cancer Res 2008 Apr;14(7):1997-2005

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1533DOI Listing
April 2008

PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.

Mol Cell Biochem 2007 Jun 18;300(1-2):77-87. Epub 2007 Jan 18.

Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s11010-006-9371-8DOI Listing
June 2007

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.

Biochem Biophys Res Commun 2006 Nov 25;350(2):463-71. Epub 2006 Sep 25.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.09.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703012PMC
November 2006

Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.

Mol Cancer Ther 2006 Mar;5(3):637-44

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 1002, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0453DOI Listing
March 2006

Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro.

Breast Cancer Res 2005 6;7(5):R699-707. Epub 2005 Jul 6.

Medicine Endocrinology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1186/bcr1276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242134PMC
February 2006

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.

Mol Cancer Ther 2005 Nov;4(11):1681-8

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 100, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0258DOI Listing
November 2005

Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma.

Cancer Res 2005 Mar;65(5):1678-86

Department of Neurological Surgery (Brain Tumor Research Center), University of California, School of Medicine, San Francisco, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2921DOI Listing
March 2005

Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer.

Clin Cancer Res 2004 Dec;10(23):8068-76

Department of Experimental Therapeutics-Unit 422, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1107DOI Listing
December 2004

Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.

Int J Oncol 2004 Feb;24(2):409-17

The Brain Tumor Center, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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February 2004

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

J Biol Chem 2003 Oct 17;278(41):40057-66. Epub 2003 Jul 17.

Department of Molecular Therapeutics, Division of Cancer Medicine, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M303621200DOI Listing
October 2003

MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.

Int J Oncol 2002 Sep;21(3):469-75

Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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September 2002

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.

Oncogene 2002 Apr;21(15):2357-64

Department of Neuro-Oncology, Box 100, The Brain Tumor Center, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, TX 77030, USA.

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http://www.nature.com/articles/1205296
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1205296DOI Listing
April 2002

Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region.

Biochem Biophys Res Commun 2002 Mar;292(2):422-6

Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1006/bbrc.2002.6662DOI Listing
March 2002