Publications by authors named "Dillon Mintoff"

9 Publications

  • Page 1 of 1

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects.

Int J Dermatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Dermatology, Liverpool Hospital, University of New South Wales, Sydney, NSW, Australia.

Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.15910DOI Listing
September 2021

Clinical Dermatology and COVID-19 Pandemic: Narrative Review.

Indian J Dermatol 2021 May-Jun;66(3):246-255

Department of KPC Medical College and Hospital, Kolkata, West Bengal, India.

The coronavirus disease of 2019 (COVID-19) pandemic has radical repercussions on every aspect of medical science, including dermatology. The magnitude of the impact on clinical dermatology cannot be overemphasized. Dermatologists have been forced to modify and reconsider the way they consult patients. Teledermatology has come up in a big way, with most of the clinicians resorting to technology and software-based consultations. Management of different dermatological conditions like papulosquamous disorders, vesiculobullous disorders, malignancies, etc., needs to be modified as per the different recommendations proposed by expert panels. This review is an attempt to highlight the impact of this destructive pandemic on various aspects of clinical dermatology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.ijd_463_21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375546PMC
August 2021

A novel SPINK5 donor splice site variant in a child with Netherton syndrome.

Mol Genet Genomic Med 2021 03 3;9(3):e1611. Epub 2021 Feb 3.

Institute of Human Genetics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

Background: Netherton syndrome (NS) is a genodermatosis caused by loss-of-function mutations in SPINK5, resulting in aberrant LEKTI expression.

Method: Next-generation sequencing of SPINK5 (NM_001127698.1) was carried out and functional studies were performed by immunofluorescence microscopy of a lesional skin biopsy using anti-LEKTI antibodies.

Results: We describe a novel SPINK5 likely pathogenic donor splice site variant (NM_001127698.1:c.2015+5G>A) in a patient with NS and confirm its functional significance by demonstrating complete loss of LEKTI expression in lesional skin by immunofluorescence analysis.

Conclusion: The 2015+5G>A is a novel, likely pathogenic variant in NS. Herein we review and assimilate documented SPINK5 pathogenic variants and discuss possible genotype-phenotype associations in NS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.1611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104165PMC
March 2021

Papillomatosis cutis lymphostatica and 'Ski-Jump' nails.

Pediatr Dermatol 2021 Jan 18;38(1):332-333. Epub 2020 Nov 18.

Department of Dermatology, Mater Dei Hospital, Msida, Malta.

Papillomatosis cutis lymphostatica is an uncommon condition usually associated with lymphedema. "Ski-jump" nails are upward sloping concave nails that can be an important diagnostic sign which may be overlooked in the setting of lymphedema. A diagnosis of papillomatosis cutis lymphostatica should be suspected in patients presenting with persistent, bland papilliform plaques, supported by the additional presence of "ski-jump" nails.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.14457DOI Listing
January 2021

Gorlin-Goltz Syndrome: A Rare Syndrome Presenting as an Even Rarer Case with Numerous Features and Complications.

Skinmed 2019 1;17(5):324-327. Epub 2019 Sep 1.

Department of Dermatology, Sir Paul Boffa Hospital, Malta;

A 76-year-old woman with intellectual deficit presented with a small, pearly, telangiectatic raised lesion on the left cheek, together with an ulcerated lesion on the right side of the nose (Figure 1), which were clinically diagnosed as basal cell carcinomas (BCCs.) These were treated with cryotherapy. The patient had had a right hemimandibulectomy (Figure 1), and she showed frontal and temporal bossing and a wide nasal bridge.
View Article and Find Full Text PDF

Download full-text PDF

Source
May 2020

Psoriasis: Keratinocytes or Immune Cells - Which Is the Trigger?

Dermatology 2019 19;235(2):91-100. Epub 2018 Dec 19.

Dermatology Department, Erasme Hospital, Université Libre de Bruxelles - ULB, Brussels, Belgium.

Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood.

Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease - a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495291DOI Listing
June 2019

Relationship of Hyperglycaemia, Hypoglycaemia, and Glucose Variability to Atherosclerotic Disease in Type 2 Diabetes.

J Diabetes Res 2018 22;2018:7464320. Epub 2018 Jul 22.

Mater Dei Hospital and University of Malta, Msida, Malta.

Objective: Type 2 diabetes mellitus (T2DM) is known to be associated with increased cardiovascular risk. The aim of this study was therefore to investigate the independent effects of hyperglycaemia, hypoglycaemia, and glucose variability on microvascular and macrovascular disease in T2DM.

Methods: Subjects with T2DM of <10 years duration and on stable antiglycaemic treatment underwent carotid intima-media thickness (CIMT), ankle-brachial index (ABI), albumin-creatinine ratio (ACR), and HbA measurement, as well as 72-hour continuous glucose monitoring. Macrovascular disease was defined as one or more of the following: history of ischaemic heart disease (IHD), cerebrovascular accident (CVA), ABI < 0.9, or abnormal CIMT.

Results: The study population comprised 121 subjects with T2DM (89 males : 32 females). The mean age was 62.6 years, and the mean DM duration was 3.7 years. Macrovascular disease was present in 71 patients (58.7%). In multivariate logistic regression analysis, body surface area (BSA) (OR 18.88 (95% CI 2.20-156.69), = 0.006) and duration of blood glucose (BG) < 3.9 mmol/L (OR 1.12 (95% CI 1.014-1.228), = 0.024) were independent predictors of macrovascular disease. BSA (OR 12.6 (95% CI 1.70-93.54), = 0.013) and duration of BG < 3.9 mmol/L (OR 1.09 (95% CI 1.003-1.187), = 0.041) were independent predictors of abnormal CIMT. Area under the curve for BG > 7.8 mmol/L ( = 15.83, = 0.005) was the sole independent predictor of albuminuria in generalised linear regression.

Conclusions: This study demonstrates that hypoglycaemia is associated with the occurrence of atherosclerotic disease while hyperglycaemia is associated with microvascular disease in a Caucasian population with T2DM of recent duration.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/7464320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081537PMC
December 2018

Psoriasis and Microbiota: A Systematic Review.

Diseases 2018 Jun 2;6(2). Epub 2018 Jun 2.

Dermatology Department, Erasmus Medical Center, 3000 Rotterdam, The Netherlands.

Background: Recent advances have highlighted the crucial role of microbiota in the pathophysiology of chronic inflammatory diseases as well as its impact on the efficacy of therapeutic agents. Psoriasis is a chronic, multifactorial inflammatory skin disorder, which has a microbiota distinct from healthy, unaffected skin.

Aim: Through an extensive review of the literature, we aim to discuss the skin and gut microbiota and redefine their role in the pathogenesis of psoriasis.

Conclusions: Unfortunately, the direct link between the skin microbiota and the pathogenesis of psoriasis remains to be clearly established. Apart from improving the course of psoriasis, selective modulation of the microbiota may increase the efficacy of medical treatments as well as attenuate their side effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/diseases6020047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023392PMC
June 2018

An unusual cause of hemiplegia post-percutaneous coronary intervention.

Br J Hosp Med (Lond) 2016 Nov;77(11):660

Chairman and Consultant Cardiologist in the Department of Cardiology, Mater Dei Hospital, and Visiting Senior Lecturer, University of Malta, Malta.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.12968/hmed.2016.77.11.660DOI Listing
November 2016
-->