Dietmar Vestweber

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.

Authors:

Guorong Li Astrid F Nottebaum Mitchell Brigell Iris D Navarro Ute Ipe Sarthak Mishra Maria Gomez-Caraballo Heather Schmitt Brandi Soldo Steve Pakola Barbara Withers Kevin G Peters Dietmar Vestweber W Daniel Stamer

Invest Ophthalmol Vis Sci 2020 Dec;61(14):12

Department of Ophthalmology, Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States.

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December 2020

Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium.

Authors:

Timo Rademakers Marieke Goedhart Mark Hoogenboezem Alexander García Ponce Jos van Rijssel Maryna Samus Michael Schnoor Stefan Butz Stephan Huveneers Dietmar Vestweber Martijn A Nolte Carlijn Voermans Jaap D van Buul

Haematologica 2020 12 1;105(12):2746-2756. Epub 2020 Dec 1.

Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands.

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December 2020

EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.

Authors:

Maike Frye Simon Stritt Henrik Ortsäter Magda Hernandez Vasquez Mika Kaakinen Andres Vicente John Wiseman Lauri Eklund Jorge L Martínez-Torrecuadrada Dietmar Vestweber Taija Mäkinen

Elife 2020 09 8;9. Epub 2020 Sep 8.

Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden.

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September 2020

Extracellular Vesicle Transfer from Endothelial Cells Drives VE-Cadherin Expression in Breast Cancer Cells, Thereby Causing Heterotypic Cell Contacts.

Authors:

Maryam Rezaei Ana C Martins Cavaco Martin Stehling Astrid Nottebaum Katrin Brockhaus Michele F Caliandro Sonja Schelhaas Felix Schmalbein Dietmar Vestweber Johannes A Eble

Cancers (Basel) 2020 Aug 1;12(8). Epub 2020 Aug 1.

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany.

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August 2020

A molecular map of murine lymph node blood vascular endothelium at single cell resolution.

Authors:

Kevin Brulois Anusha Rajaraman Agata Szade Sofia Nordling Ania Bogoslowski Denis Dermadi Milladur Rahman Helena Kiefel Edward O'Hara Jasper J Koning Hiroto Kawashima Bin Zhou Dietmar Vestweber Kristy Red-Horse Reina E Mebius Ralf H Adams Paul Kubes Junliang Pan Eugene C Butcher

Nat Commun 2020 07 30;11(1):3798. Epub 2020 Jul 30.

Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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July 2020

The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1.

Authors:

Andreas Margraf Giulia Germena Hannes C A Drexler Jan Rossaint Nadine Ludwig Barbara Prystaj Sina Mersmann Katharina Thomas Helena Block Wiebke Gottschlich Chang Liu Peter W Krenn Hermann Haller Barbara Heitplatz Marika Meyer Zu Brickwedde Markus Moser Dietmar Vestweber Alexander Zarbock

Blood 2020 Nov;136(19):2200-2205

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.

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November 2020

Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin.

Authors:

Cao Nguyen Duong Dietmar Vestweber

Front Physiol 2020 21;11:519. Epub 2020 May 21.

Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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May 2020

Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.

Nat Cell Biol 2020 07 15;22(7):828-841. Epub 2020 Jun 15.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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July 2020

Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.

Authors:

Laura J Braun Rebekka I Stegmeyer Kerstin Schäfer Stefan Volkery Silke M Currie Birgit Kempe Astrid F Nottebaum Dietmar Vestweber

Blood 2020 Jul;136(5):627-639

Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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July 2020

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin.

Authors:

Ross O Smith Takeshi Ninchoji Emma Gordon Helder André Elisabetta Dejana Dietmar Vestweber Anders Kvanta Lena Claesson-Welsh

Elife 2020 Apr 21;9. Epub 2020 Apr 21.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory Uppsala University, Uppsala, Sweden.

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April 2020

Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch.

Authors:

Lukas Bergerhausen Julius Grosche Juliane Meißner Christina Hecker Michele F Caliandro Christoph Westerhausen Andrej Kamenac Maryam Rezaei Matthias Mörgelin Gereon Poschmann Dietmar Vestweber Eva-Maria Hanschmann Johannes A Eble

Antioxidants (Basel) 2020 Mar 10;9(3). Epub 2020 Mar 10.

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany.

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March 2020

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.

Authors:

Charlotte Owen-Woods Régis Joulia Anna Barkaway Loïc Rolas Bin Ma Astrid Fee Nottebaum Kenton P Arkill Monja Stein Tamara Girbl Matthew Golding David O Bates Dietmar Vestweber Mathieu-Benoit Voisin Sussan Nourshargh

J Clin Invest 2020 05;130(5):2301-2318

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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May 2020

Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System.

Authors:

Maryna Samus Yu-Tung Li Lydia Sorokin Klemens Rottner Dietmar Vestweber

J Neurosci 2020 02 7;40(7):1389-1404. Epub 2020 Jan 7.

Max-Planck Institute for Molecular Biomedicine, D48149 Münster, Germany,

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February 2020

Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation.

Authors:

Cao Nguyen Duong Astrid F Nottebaum Stefan Butz Stefan Volkery Dagmar Zeuschner Martin Stehling Dietmar Vestweber

Arterioscler Thromb Vasc Biol 2020 02 12;40(2):378-393. Epub 2019 Dec 12.

From the Department of Vascular Cell Biology (C.N.D., A.F.N., S.B., S.V., D.V.), Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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February 2020

Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.

Authors:

Benjamin R Thomson Isabel A Carota Tomokazu Souma Saily Soman Dietmar Vestweber Susan E Quaggin

Elife 2019 10 17;8. Epub 2019 Oct 17.

Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, United States.

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October 2019

Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.

Authors:

Hannes C A Drexler Matthias Vockel Christian Polaschegg Maike Frye Kevin Peters Dietmar Vestweber

Mol Cell Proteomics 2019 Oct 19;18(10):2058-2077. Epub 2020 Sep 19.

Department of Vascular Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149 Münster, Germany. Electronic address:

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October 2019

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.

Brain 2019 11;142(11):3411-3427

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany.

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November 2019

Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.

Authors:

Hannes C A Drexler Matthias Vockel Christian Polaschegg Maike Frye Kevin Peters Dietmar Vestweber

Mol Cell Proteomics 2019 10 19;18(10):2058-2077. Epub 2019 Aug 19.

Department of Vascular Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149 Münster, Germany

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October 2019

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.

Authors:

Yu-Tung Li Debashree Goswami Melissa Follmer Annette Artz Mariana Pacheco-Blanco Dietmar Vestweber

Elife 2019 08 6;8. Epub 2019 Aug 6.

Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Münster, Germany.

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August 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

Authors:

Laura J Braun Maren Zinnhardt Matthias Vockel Hannes C Drexler Kevin Peters Dietmar Vestweber

EMBO Rep 2019 07 14;20(7):e47046. Epub 2019 May 14.

Max Planck Institute of Molecular Biomedicine, Münster, Germany.

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July 2019

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