Publications by authors named "Dieter Weichenhan"

83Publications

AmpliconDesign - an interactive web server for the design of high-throughput targeted DNA methylation assays.

Epigenetics 2020 Oct 24:1-7. Epub 2020 Oct 24.

Section Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) , Heidelberg, Germany.

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http://dx.doi.org/10.1080/15592294.2020.1834921DOI Listing
October 2020

Epigenomic technologies for precision oncology.

Semin Cancer Biol 2020 Aug 18. Epub 2020 Aug 18.

German Cancer Research Center Heidelberg, Cancer Epigenomics (B370), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2020.08.004DOI Listing
August 2020

Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study.

J Thorac Oncol 2020 Aug 7;15(8):1338-1350. Epub 2020 Apr 7.

Translational Lung Research Centre Heidelberg, Member of the German Centre for Lung Research (Deutsches Zentrum für Lungenforschung), Heidelberg, Germany; Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jtho.2020.03.023DOI Listing
August 2020

Neuronal ensemble-specific DNA methylation strengthens engram stability.

Nat Commun 2020 01 31;11(1):639. Epub 2020 Jan 31.

Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, INF 366, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41467-020-14498-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994722PMC
January 2020

Identification of Ppar-modulated miRNA hubs that target the fibrotic tumor microenvironment.

Proc Natl Acad Sci U S A 2020 01 23;117(1):454-463. Epub 2019 Dec 23.

Department for Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany;

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http://dx.doi.org/10.1073/pnas.1909145117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955372PMC
January 2020

Longitudinal trends of serum IgE and IL5RA expression throughout childhood are associated with asthma but not with persistent wheeze.

Allergy 2019 10 21;74(10):2002-2006. Epub 2019 May 21.

Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, associated partner of the German Center for Lung Research (DZL), Berlin, Germany.

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http://dx.doi.org/10.1111/all.13837DOI Listing
October 2019

Generation of Whole Genome Bisulfite Sequencing Libraries from Very Low DNA Input.

Methods Mol Biol 2019 ;1956:229-248

Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9151-8_10DOI Listing
July 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444093PMC
December 2018

Early-onset childhood atopic dermatitis is related to NLRP2 repression.

J Allergy Clin Immunol 2018 04 9;141(4):1482-1485.e16. Epub 2017 Dec 9.

Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.018DOI Listing
April 2018

Tagmentation-Based Library Preparation for Low DNA Input Whole Genome Bisulfite Sequencing.

Methods Mol Biol 2018 ;1708:105-122

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/978-1-4939-7481-8_6
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http://dx.doi.org/10.1007/978-1-4939-7481-8_6DOI Listing
July 2018

Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.

Circulation 2017 Oct 24;136(16):1528-1544. Epub 2017 Aug 24.

From Department of Internal Medicine III, Institute for Cardiomyopathies, University of Heidelberg, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., R.N., C.S., S.M., D.M.-B., A.A., H.H., D.B.H., M.M.-H., T.W., H.A.K.); Siemens Healthcare GmbH, Strategy and Innovation, Erlangen, Germany (C.D., M.W., A.E.P.); Department of Bioinformatics, University of Saarland, Saarbrücken, Germany (A.K.); German Centre for Cardiovascular Research, Berlin, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., D.S., M.M.-H., T.W., J.B., H.A.K.); Institute for Molecular Cardiology and Epigenetics, University of Heidelberg, Germany (D.S., J.B.); Funktionelle Genomanalyse, Deutsches Krebsforschungszentrum, Heidelberg, Germany (A.B.); Department of Cardiac Surgery, University of Heidelberg, Germany (A.R.); Siemens AG, Corporate Technology, Vienna, Austria (D.P.); Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Austria (D.P.); and Division of Epigenomics and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany (D.W., C.P.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027355DOI Listing
October 2017

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications.

J Allergy Clin Immunol 2018 02 6;141(2):741-753. Epub 2017 Apr 6.

Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig-Halle, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.03.017DOI Listing
February 2018

Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms.

J Allergy Clin Immunol 2016 Feb 15;137(2):610-3. Epub 2015 Aug 15.

Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany; Core Facility Studies, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.06.040DOI Listing
February 2016

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Cell Stem Cell 2014 Oct 21;15(4):507-522. Epub 2014 Aug 21.

Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://www.cell.com/cms/attachment/2035154136/2050496774/mmc
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http://www-huber.embl.de/pub/pdf/CabezasWallscheid2014.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S193459091400301
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http://dx.doi.org/10.1016/j.stem.2014.07.005DOI Listing
October 2014

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

Mol Cell 2014 Aug 31;55(4):604-14. Epub 2014 Jul 31.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; The German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.06.031DOI Listing
August 2014

Tagmentation-based whole-genome bisulfite sequencing.

Nat Protoc 2013 Oct 26;8(10):2022-32. Epub 2013 Sep 26.

Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://www.nature.com/doifinder/10.1038/nprot.2013.118
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http://dx.doi.org/10.1038/nprot.2013.118DOI Listing
October 2013

The evolving epigenome.

Hum Mol Genet 2013 Oct 29;22(R1):R1-6. Epub 2013 Jul 29.

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http://dx.doi.org/10.1093/hmg/ddt348DOI Listing
October 2013

S151A δ-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice.

Eur J Hum Genet 2014 Jan 22;22(1):119-25. Epub 2013 May 22.

1] Department of Cardiology, Angiology and Pneumology, University Hospital, Heidelberg, Germany [2] DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/ejhg.2013.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865419PMC
January 2014

Enrichment of methylated DNA by methyl-CpG immunoprecipitation.

Methods Mol Biol 2013 ;971:201-12

Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-62703-269-8_11DOI Listing
June 2013

DNA methylation changes in cells regrowing after fractioned ionizing radiation.

Radiother Oncol 2011 Oct 23;101(1):116-21. Epub 2011 Jun 23.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01678140110024
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http://dx.doi.org/10.1016/j.radonc.2011.05.048DOI Listing
October 2011

Genome-wide epigenetic modifications in cancer.

Prog Drug Res 2011 ;67:25-49

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066002PMC
http://dx.doi.org/10.1007/978-3-7643-8989-5_2DOI Listing
January 2011

Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation.

Cardiovasc Res 2010 Jun 18;86(3):452-60. Epub 2010 Jan 18.

Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/cvr/cvq009DOI Listing
June 2010

A mouse translocation associated with Caspr5-2 disruption and perinatal lethality.

Mamm Genome 2008 Oct-Dec;19(10-12):675-86. Epub 2008 Oct 24.

Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00335-008-9148-3DOI Listing
March 2009

Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice.

Comp Med 2007 Dec;57(6):546-53

Department of Medicine III, Otto-Meyerhof-Zentrum, University of Heidelberg, Heidelberg, Germany.

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December 2007

Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia.

J Mol Med (Berl) 2008 Mar 7;86(3):281-9. Epub 2007 Nov 7.

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-007-0275-1DOI Listing
March 2008

New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene.

Mamm Genome 2006 Jul 14;17(7):723-31. Epub 2006 Jul 14.

Institut für Biologie, Zentrum für medizinische Struktur- und Zellbiologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.

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http://dx.doi.org/10.1007/s00335-005-0157-1DOI Listing
July 2006

Large-scale mutation screening in patients with dilated or hypertrophic cardiomyopathy: a pilot study using DGGE.

J Mol Med (Berl) 2006 Aug 20;84(8):682-91. Epub 2006 May 20.

Innere Medizin III, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-006-0056-2DOI Listing
August 2006

Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice.

Physiol Genomics 2006 May;25(3):387-92

Division of Cardiology, Department of Medicine III, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1152/physiolgenomics.00010.2006DOI Listing
May 2006

Early diagnostic marker panel determination for microarray based clinical studies.

Stat Appl Genet Mol Biol 2005 26;4:Article9. Epub 2005 Apr 26.

Max Planck Institute for Molecular Genetics, Berlin.

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http://dx.doi.org/10.2202/1544-6115.1109DOI Listing
May 2006

Calcification of myocardial necrosis is common in mice.

Virchows Arch 2006 May 7;448(5):630-8. Epub 2005 Oct 7.

Department of Medicine III, Division of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00428-005-0071-7DOI Listing
May 2006

S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

Mol Ther 2005 Dec 15;12(6):1120-9. Epub 2005 Sep 15.

Medizinische Universitätsklinik und Poliklinik III, Otto Meyerhof Zentrum, Universität zu Heidelberg, INF 350, 69115 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ymthe.2005.08.002DOI Listing
December 2005

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

J Clin Invest 2004 Dec;114(11):1550-63

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1172/JCI21454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529280PMC
December 2004

An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands.

Genome Res 2002 Oct;12(10):1591-8

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1101/gr.197402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187524PMC
October 2002