Publications by authors named "Dieter Hartmann"

69Publications

Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice.

J Biol Chem 2014 Apr 18;289(14):9611-22. Epub 2014 Feb 18.

From the Dipartimento di Scienze Farmaceutiche, University of Perugia, Perugia 06126, Italy.

View Article and Find Full Text PDF
April 2014

Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues.

Histochem Cell Biol 2013 Nov 17;140(5):533-47. Epub 2013 Apr 17.

Molecular Genetics, Life and Medical Sciences (LIMES)-Institute, University of Bonn, Carl-Troll-Str. 31, 53115, Bonn, Germany.

View Article and Find Full Text PDF
November 2013

Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.

Biochim Biophys Acta 2012 Jul 20;1822(7):1137-46. Epub 2012 Mar 20.

University of Perugia, D.S.E.E.A., Institute of Food Chemistry, Biochemistry, Physiology and Nutrition, Italy.

View Article and Find Full Text PDF
July 2012

Astroparticle physics: A multi-messenger story.

Nature 2011 Jul 20;475(7356):303-4. Epub 2011 Jul 20.

View Article and Find Full Text PDF
July 2011

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy.

Hum Mol Genet 2011 Jul 22;20(14):2760-9. Epub 2011 Apr 22.

Laboratory of Biological Psychology, Department of Psychology, University of Leuven, Tiensestraat 102, Leuven, Belgium.

View Article and Find Full Text PDF
July 2011

Keratins regulate yolk sac hematopoiesis and vasculogenesis through reduced BMP-4 signaling.

Eur J Cell Biol 2010 Apr 25;89(4):299-306. Epub 2010 Jan 25.

Institute of Physiological Chemistry, Division of Cell Biochemistry, Bonner Forum Biomedizin and LIMES-Institute, Rheinische Friedrich-Wilhelms-Universität, Nussallee 11, 53115 Bonn, Germany.

View Article and Find Full Text PDF
April 2010

Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.

J Biol Chem 2009 Nov 30;284(48):33549-60. Epub 2009 Sep 30.

Institute of Genetics, Division of Molecular Genetics, University of Bonn, Römerstrasse 164, 53117 Bonn, Germany.

View Article and Find Full Text PDF
November 2009

Vinblastine and doxorubicin administration to pregnant mice affects brain development and behaviour in the offspring.

Neurotoxicology 2009 Jul 5;30(4):647-57. Epub 2009 May 5.

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
July 2009

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.

J Biol Chem 2009 Apr 11;284(17):11738-47. Epub 2009 Feb 11.

Center for Human Genetics, Katholieke Universiteit Leuven (K. U. Leuven), Department for Developmental and Molecular Genetics, and Laboratory of Membrane Trafficking, Vlaams Instituut voor Biotechnologie (VIB), K. U. Leuven, B-3000 Leuven, Belgium.

View Article and Find Full Text PDF
April 2009

Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

Curr Alzheimer Res 2008 Apr;5(2):187-201

Dept. of Anatomy, Division of Neuroanatomy, University of Bonn, Nussallee 10, D-53115 Bonn, Federal Republic Germany.

View Article and Find Full Text PDF
April 2008

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.

Nat Immunol 2006 Dec 29;7(12):1293-8. Epub 2006 Oct 29.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA.

View Article and Find Full Text PDF
December 2006

BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease.

Neurodegener Dis 2004 ;1(4-5):168-74

Neuronal Cell Biology and Gene Transfer Laboratory, Department of Human Genetics, KU Leuven and VIB4, Leuven, Belgium.

View Article and Find Full Text PDF
September 2006

(Make) stick and cut loose--disintegrin metalloproteases in development and disease.

Birth Defects Res C Embryo Today 2006 Mar;78(1):24-46

Laboratory for Neuronal Cell Biology and Gene Transfer, Department for Human Genetics, K.U. Leuven and Flanders Interuniversity Institute for Biotechnology, Leuven/Flanders, Belgium.

View Article and Find Full Text PDF
March 2006

Supernova neutrino nucleosynthesis of light elements with neutrino oscillations.

Phys Rev Lett 2006 Mar 7;96(9):091101. Epub 2006 Mar 7.

Astronomical Institute, Graduate School of Science, Tohoku University, Miyagi 980-8578, Japan.

View Article and Find Full Text PDF
March 2006

Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.

Mol Cell Biol 2006 Jan;26(2):605-16

Experimental Mouse Genetics, Center for Human Genetics, KU Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49, bus 602, B-3000 Leuven, Belgium.

View Article and Find Full Text PDF
January 2006

Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.

Mol Cell Biol 2005 Nov;25(21):9324-39

Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D-23845 Borstel, Germany.

View Article and Find Full Text PDF
November 2005

Astrophysics: swift progress.

Nature 2005 Aug;436(7053):923-5

View Article and Find Full Text PDF
August 2005

Constraining the spectrum of supernova neutrinos from nu-process induced light element synthesis.

Phys Rev Lett 2005 Jun 15;94(23):231101. Epub 2005 Jun 15.

Astronomical Institute, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.

View Article and Find Full Text PDF
June 2005

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.

J Biol Chem 2005 Sep 29;280(35):30797-806. Epub 2005 Jun 29.

Center for Human Genetics, Katholieke Universiteit Leuven and Flanders Interuniversity Institute for Biotechnology VIB4, Herestraat 49, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
September 2005

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

Proc Natl Acad Sci U S A 2005 Jun 15;102(26):9182-7. Epub 2005 Jun 15.

Biochemical Institute and Department of Dermatology, Christian-Albrechts-University Kiel, D-24098 Kiel, Germany.

View Article and Find Full Text PDF
June 2005

The pH dependency of the binding of drugs to plasma proteins in man.

Ther Drug Monit 2005 Feb;27(1):71-85

Food and Drug Administration, Center for Drug Evaluation and Research, Office of Clinical Pharmacology and Biopharmaceutics, Rockville, Maryland 20852, USA.

View Article and Find Full Text PDF
February 2005

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.

Proc Natl Acad Sci U S A 2005 Feb 21;102(5):1719-24. Epub 2005 Jan 21.

Neuronal Cell Biology, Flanders Interuniversity Institute for Biotechnology and Katholieke Universiteit Leuven, Leuven B-3000, Belgium.

View Article and Find Full Text PDF
February 2005

Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice.

Eur J Neurosci 2004 Nov;20(10):2749-56

Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55099 Mainz, Germany.

View Article and Find Full Text PDF
November 2004

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.

Neurobiol Dis 2004 Nov;17(2):260-72

Neuronal Cell Biology and Gene Transfer, Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB4) and K.U. Leuven, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
November 2004

Limited redundancy of the proprotein convertase furin in mouse liver.

J Biol Chem 2004 Dec 7;279(51):53442-50. Epub 2004 Oct 7.

Experimental Mouse Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, B-3000 Leuven, Belgium.

View Article and Find Full Text PDF
December 2004

Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.

J Cell Biol 2004 Jun 14;165(6):893-902. Epub 2004 Jun 14.

Dept. of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

View Article and Find Full Text PDF
June 2004

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

Hum Mol Genet 2004 Jul 5;13(13):1321-31. Epub 2004 May 5.

Neuronal Cell Biology Laboratory, Center for Human Genetics CB 4, University Hospital, Catholic University of Leuven, Belgium.

View Article and Find Full Text PDF
July 2004

Presenilins in memory, Alzheimer's disease, and therapy.

Neuron 2004 Apr;42(2):189-92

Laboratory for Neuronal Cell Biology and Gene Transfer, Center for Human Genetics, Vib4, K.U.Leuven, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
April 2004

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.

J Cell Biol 2004 Mar;164(5):769-79

Cell Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA.

View Article and Find Full Text PDF
March 2004

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

J Biol Chem 2004 Feb 24;279(6):4241-9. Epub 2003 Nov 24.

Cell Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

View Article and Find Full Text PDF
February 2004

Gene therapy: prospects for glycolipid storage diseases.

Philos Trans R Soc Lond B Biol Sci 2003 May;358(1433):921-5

Institut für Physiologische Chemie, Rheinische-Friedrich-Wilhelms Universität, Bonn 53115, Germany.

View Article and Find Full Text PDF
May 2003

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Hum Mol Genet 2002 Oct;11(21):2615-24

Center for Human Genetics KU Leuven and Flanders Interuniversity Institute for Biotechnology, VIB 4 KU Leuven, VIB 7 (Celgen), Herestraat 49, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
October 2002