Publications by authors named "Dieter Edbauer"

81Publications

Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.

Authors:
Saskia Hutten Sinem Usluer Benjamin Bourgeois Francesca Simonetti Hana M Odeh Charlotte M Fare Mareike Czuppa Marian Hruska-Plochan Mario Hofweber Magdalini Polymenidou James Shorter Dieter Edbauer Tobias Madl Dorothee Dormann

Cell Rep 2020 Dec;33(12):108538

BioMedical Center (BMC), Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany; LMU Graduate School of Systemic Neurosciences (GSN), 82152 Planegg-Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

View Article and Find Full Text PDF
December 2020

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

Authors:
Georg Werner Markus Damme Martin Schludi Johannes Gnörich Karin Wind Katrin Fellerer Benedikt Wefers Wolfgang Wurst Dieter Edbauer Matthias Brendel Christian Haass Anja Capell

EMBO Rep 2020 Oct 14;21(10):e50241. Epub 2020 Sep 14.

Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

View Article and Find Full Text PDF
October 2020

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.

Authors:
Katherine D LaClair Qihui Zhou Meike Michaelsen Benedikt Wefers Monika S Brill Aleksandar Janjic Birgit Rathkolb Daniel Farny Mikolaj Cygan Martin Hrabe de Angelis Wolfgang Wurst Manuela Neumann Wolfgang Enard Thomas Misgeld Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2020 08 19;140(2):121-142. Epub 2020 Jun 19.

German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.

View Article and Find Full Text PDF
August 2020

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.

Authors:
Brigid K Jensen Martin H Schuldi Kevin McAvoy Katelyn A Russell Ashley Boehringer Bridget M Curran Karthik Krishnamurthy Xinmei Wen Thomas Westergard Le Ma Aaron R Haeusler Dieter Edbauer Piera Pasinelli Davide Trotti

EMBO Mol Med 2020 05 29;12(5):e10722. Epub 2020 Apr 29.

Jefferson Weinberg ALS Center, Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.

View Article and Find Full Text PDF
May 2020

Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.

Authors:
Bahram Khosravi Kathrine D LaClair Henrick Riemenschneider Qihui Zhou Frédéric Frottin Nikola Mareljic Mareike Czuppa Daniel Farny Hannelore Hartmann Meike Michaelsen Thomas Arzberger F Ulrich Hartl Mark S Hipp Dieter Edbauer

EMBO J 2020 04 16;39(8):e102811. Epub 2020 Mar 16.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

View Article and Find Full Text PDF
April 2020

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins.

Authors:
Masin Abo-Rady Norman Kalmbach Arun Pal Carina Schludi Antje Janosch Tanja Richter Petra Freitag Marc Bickle Anne-Karin Kahlert Susanne Petri Stefan Stefanov Hannes Glass Selma Staege Walter Just Rajat Bhatnagar Dieter Edbauer Andreas Hermann Florian Wegner Jared L Sterneckert

Stem Cell Reports 2020 03 20;14(3):390-405. Epub 2020 Feb 20.

Technische Universität Dresden, Center for Regenerative Therapies TU Dresden (CRTD), 01307 Dresden, Germany. Electronic address:

View Article and Find Full Text PDF
March 2020

Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.

Authors:
Qihui Zhou Nikola Mareljic Meike Michaelsen Samira Parhizkar Steffanie Heindl Brigitte Nuscher Daniel Farny Mareike Czuppa Carina Schludi Alexander Graf Stefan Krebs Helmut Blum Regina Feederle Stefan Roth Christian Haass Thomas Arzberger Arthur Liesz Dieter Edbauer

EMBO Mol Med 2020 02 20;12(2):e10919. Epub 2019 Dec 20.

German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany.

View Article and Find Full Text PDF
February 2020

Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3.

Authors:
Yoshihiro Nihei Kohji Mori Georg Werner Thomas Arzberger Qihui Zhou Barham Khosravi Julia Japtok Andreas Hermann Andreas Sommacal Markus Weber Frits Kamp Brigitte Nuscher Dieter Edbauer Christian Haass

Acta Neuropathol 2020 01 23;139(1):99-118. Epub 2019 Oct 23.

German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.

View Article and Find Full Text PDF
January 2020

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 06 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

View Article and Find Full Text PDF
June 2019

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Authors:
Janine Diehl-Schmid Abigail Licata Oliver Goldhardt Hans Förstl Igor Yakushew Markus Otto Sarah Anderl-Straub Ambros Beer Albert Christian Ludolph Georg Bernhard Landwehrmeyer Johannes Levin Adrian Danek Klaus Fliessbach Annika Spottke Klaus Fassbender Epameinondas Lyros Johannes Prudlo Bernd Joachim Krause Alexander Volk Dieter Edbauer Matthias Leopold Schroeter Alexander Drzezga Johannes Kornhuber Martin Lauer Timo Grimmer

Transl Psychiatry 2019 01 31;9(1):54. Epub 2019 Jan 31.

Department of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

View Article and Find Full Text PDF
January 2019

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Authors:
Samira Parhizkar Thomas Arzberger Matthias Brendel Gernot Kleinberger Maximilian Deussing Carola Focke Brigitte Nuscher Monica Xiong Alireza Ghasemigharagoz Natalie Katzmarski Susanne Krasemann Stefan F Lichtenthaler Stephan A Müller Alessio Colombo Laura Sebastian Monasor Sabina Tahirovic Jochen Herms Michael Willem Nadine Pettkus Oleg Butovsky Peter Bartenstein Dieter Edbauer Axel Rominger Ali Ertürk Stefan A Grathwohl Jonas J Neher David M Holtzman Melanie Meyer-Luehmann Christian Haass

Nat Neurosci 2019 02 7;22(2):191-204. Epub 2019 Jan 7.

Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

View Article and Find Full Text PDF
February 2019

Proteomics and neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity.

Authors:
Hannelore Hartmann Daniel Hornburg Mareike Czuppa Jakob Bader Meike Michaelsen Daniel Farny Thomas Arzberger Matthias Mann Felix Meissner Dieter Edbauer

Life Sci Alliance 2018 May 16;1(2):e201800070. Epub 2018 May 16.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

View Article and Find Full Text PDF
May 2018

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.

Authors:
Petra Frick Chantal Sellier Ian R A Mackenzie Chieh-Yu Cheng Julie Tahraoui-Bories Cecile Martinat R Jeroen Pasterkamp Johannes Prudlo Dieter Edbauer Mustapha Oulad-Abdelghani Regina Feederle Nicolas Charlet-Berguerand Manuela Neumann

Acta Neuropathol Commun 2018 08 3;6(1):72. Epub 2018 Aug 3.

German Center for Neurodegenerative Diseases (DZNE), Otfried-Müllerstr. 23, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
August 2018

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

Authors:
Carina Lehmer Martin H Schludi Linnea Ransom Johanna Greiling Michaela Junghänel Nicole Exner Henrick Riemenschneider Julie van der Zee Christine Van Broeckhoven Patrick Weydt Michael T Heneka Dieter Edbauer

EMBO Mol Med 2018 06;10(6)

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

View Article and Find Full Text PDF
June 2018

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Authors:
Eva Benito Cemil Kerimoglu Binu Ramachandran Tonatiuh Pena-Centeno Gaurav Jain Roman Manuel Stilling Md Rezaul Islam Vincenzo Capece Qihui Zhou Dieter Edbauer Camin Dean André Fischer

Cell Rep 2018 Apr;23(2):546-554

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Strasse 3A, 37075 Göttingen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Von Siebold Strasse 5, 37075 Göttingen, Germany. Electronic address:

View Article and Find Full Text PDF
April 2018

Atrophy in the Thalamus But Not Cerebellum Is Specific for FTD and ALS Patients - An Atlas-Based Volumetric MRI Study.

Authors:
Sonja Schönecker Christiane Neuhofer Markus Otto Albert Ludolph Jan Kassubek Bernhard Landwehrmeyer Sarah Anderl-Straub Elisa Semler Janine Diehl-Schmid Catharina Prix Christian Vollmar Juan Fortea Hans-Jürgen Huppertz Thomas Arzberger Dieter Edbauer Berend Feddersen Marianne Dieterich Matthias L Schroeter Alexander E Volk Klaus Fließbach Anja Schneider Johannes Kornhuber Manuel Maler Johannes Prudlo Holger Jahn Tobias Boeckh-Behrens Adrian Danek Thomas Klopstock Johannes Levin

Front Aging Neurosci 2018 15;10:45. Epub 2018 Mar 15.

Department of Neurology, Ludwig Maximilians Universität München, Munich, Germany.

View Article and Find Full Text PDF
March 2018

RNA versus protein toxicity in C9orf72 ALS/FTLD.

Authors:
Thomas Arzberger Martin H Schludi Carina Lehmer Bettina Schmid Dieter Edbauer

Acta Neuropathol 2018 03 15;135(3):475-479. Epub 2018 Feb 15.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.

View Article and Find Full Text PDF
March 2018

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Authors:
Qiang Guo Carina Lehmer Antonio Martínez-Sánchez Till Rudack Florian Beck Hannelore Hartmann Manuela Pérez-Berlanga Frédéric Frottin Mark S Hipp F Ulrich Hartl Dieter Edbauer Wolfgang Baumeister Rubén Fernández-Busnadiego

Cell 2018 02 1;172(4):696-705.e12. Epub 2018 Feb 1.

Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address:

View Article and Find Full Text PDF
February 2018

Targeting RNA G-quadruplexes as new treatment strategy for ALS/FTD.

Authors:
Martin H Schludi Dieter Edbauer

EMBO Mol Med 2018 01;10(1):4-6

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

View Article and Find Full Text PDF
January 2018

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

Authors:
Martin H Schludi Lore Becker Lillian Garrett Tania F Gendron Qihui Zhou Franziska Schreiber Bastian Popper Leda Dimou Tim M Strom Juliane Winkelmann Anne von Thaden Kristin Rentzsch Stephanie May Meike Michaelsen Benjamin M Schwenk Jing Tan Benedikt Schoser Marianne Dieterich Leonard Petrucelli Sabine M Hölter Wolfgang Wurst Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Thomas Klopstock Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2017 08 13;134(2):241-254. Epub 2017 Apr 13.

German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.

View Article and Find Full Text PDF
August 2017