Dieter Edbauer

Dieter Edbauer

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Dieter Edbauer

Dieter Edbauer

Publications by authors named "Dieter Edbauer"

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Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Cell Rep 2018 Apr;23(2):546-554

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Strasse 3A, 37075 Göttingen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Von Siebold Strasse 5, 37075 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912949PMC
April 2018

RNA versus protein toxicity in C9orf72 ALS/FTLD.

Acta Neuropathol 2018 03 15;135(3):475-479. Epub 2018 Feb 15.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1823-1DOI Listing
March 2018

Targeting RNA G-quadruplexes as new treatment strategy for ALS/FTD.

EMBO Mol Med 2018 01;10(1):4-6

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

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http://dx.doi.org/10.15252/emmm.201708572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760851PMC
January 2018

Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.

Hum Mol Genet 2017 Feb;26(4):790-800

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany.

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http://dx.doi.org/10.1093/hmg/ddw432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409121PMC
February 2017

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.

EMBO Rep 2016 09 26;17(9):1314-25. Epub 2016 Jul 26.

Biomedical Center (BMC), Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE), Munich, Germany Munich Cluster for System Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.15252/embr.201541724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007570PMC
September 2016

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD.

Curr Opin Neurobiol 2016 Feb 8;36:99-106. Epub 2015 Nov 8.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany; Biomedical Center (BMC), Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.conb.2015.10.009DOI Listing
February 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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http://www.jbc.org/content/291/1/318.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.697995
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http://dx.doi.org/10.1074/jbc.M115.697995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697167PMC
January 2016

Brain banks still yield high interest rates.

J Neural Transm (Vienna) 2015 Jul;122(7):935-6

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http://dx.doi.org/10.1007/s00702-015-1422-4DOI Listing
July 2015

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

EMBO J 2014 Aug 7;33(15):1667-80. Epub 2014 Jul 7.

German Center for Neurodegenerative Diseases, Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.15252/embj.201387576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194100PMC
August 2014

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Brain 2014 Jul 27;137(Pt 7):2040-51. Epub 2014 May 27.

1 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK

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http://dx.doi.org/10.1093/brain/awu120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065024PMC
July 2014

The ER under rapid fire.

EMBO J 2014 Jun 30;33(11):1195-7. Epub 2014 Apr 30.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany Biochemistry, Adolf Butenandt Institute Ludwig-Maximilians University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

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http://emboj.embopress.org/cgi/doi/10.1002/embj.201488692
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http://dx.doi.org/10.1002/embj.201488692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198023PMC
June 2014

Good guy or bad guy: the opposing roles of microRNA 125b in cancer.

Cell Commun Signal 2014 Apr 28;12:30. Epub 2014 Apr 28.

German Center for Neurodegenerative Diseases, Site Munich, Schillerstr, 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1186/1478-811X-12-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011766PMC
April 2014

Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability.

Acta Neuropathol 2014 Mar 21;127(3):451-8. Epub 2014 Jan 21.

Department of Neurology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK,

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http://dx.doi.org/10.1007/s00401-014-1245-7DOI Listing
March 2014

FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD.

J Mol Med (Berl) 2013 Dec 24;91(12):1343-54. Epub 2013 Aug 24.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1007/s00109-013-1077-2DOI Listing
December 2013

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Acta Neuropathol 2013 Dec 6;126(6):859-79. Epub 2013 Oct 6.

Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00401-013-1181-yDOI Listing
December 2013

Staufen2 regulates neuronal target RNAs.

Cell Rep 2013 Dec 19;5(6):1511-8. Epub 2013 Dec 19.

Department of Neuronal Cell Biology, Center for Brain Research, 1090 Vienna, Austria; Department of Anatomy and Cell Biology, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.039DOI Listing
December 2013

Promoter DNA methylation regulates progranulin expression and is altered in FTLD.

Acta Neuropathol Commun 2013 May 13;1:16. Epub 2013 May 13.

German Center for Neurodegenerative Diseases (DZNE), University of Munich, Schillerstr, 44, Munich 80336, Germany.

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http://dx.doi.org/10.1186/2051-5960-1-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893557PMC
May 2013

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Science 2013 Mar 7;339(6125):1335-8. Epub 2013 Feb 7.

Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Munich, Germany.

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http://dx.doi.org/10.1126/science.1232927DOI Listing
March 2013

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.

EMBO Rep 2012 Aug 19;13(8):759-64. Epub 2012 Jun 19.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1038/embor.2012.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410390PMC
August 2012

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.

Nat Neurosci 2011 Sep 4;14(10):1240-2. Epub 2011 Sep 4.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nn.2909
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http://dx.doi.org/10.1038/nn.2909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183341PMC
September 2011

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.

Neuron 2010 Feb;65(3):373-84

The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018398PMC
February 2010

Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation.

J Neurosci 2010 Feb;30(7):2676-85

Department of Basic Science, The Commonwealth Medical College, Scranton, Pennsylvania 18510, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4022-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840640PMC
February 2010

Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody.

Mol Cell Proteomics 2009 Apr 3;8(4):681-95. Epub 2008 Dec 3.

The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/mcp.M800233-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667352PMC
April 2009

Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons.

Curr Biol 2007 Oct 11;17(20):1752-8. Epub 2007 Oct 11.

The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1016/j.cub.2007.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194646PMC
October 2007

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

EMBO J 2004 Dec 18;23(24):4738-48. Epub 2004 Nov 18.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535090PMC
December 2004

Identification of distinct gamma-secretase complexes with different APH-1 variants.

J Biol Chem 2004 Oct 30;279(40):41340-5. Epub 2004 Jul 30.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M405768200DOI Listing
October 2004

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

J Biol Chem 2004 Sep 21;279(36):37311-5. Epub 2004 Jun 21.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406228200
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http://dx.doi.org/10.1074/jbc.M406228200DOI Listing
September 2004

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

J Neurochem 2004 Jun;89(6):1520-7

Adolf-Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02447.xDOI Listing
June 2004

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

J Biol Chem 2004 May 23;279(22):23255-61. Epub 2004 Mar 23.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M401789200DOI Listing
May 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

J Biol Chem 2003 Dec 5;278(52):52519-23. Epub 2003 Nov 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C300435200
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http://dx.doi.org/10.1074/jbc.C300435200DOI Listing
December 2003

Gamma-secretase activity is associated with a conformational change of nicastrin.

J Biol Chem 2003 May 18;278(19):16474-7. Epub 2003 Mar 18.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C300095200DOI Listing
May 2003

Reconstitution of gamma-secretase activity.

Nat Cell Biol 2003 May;5(5):486-8

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/ncb960DOI Listing
May 2003

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

J Biol Chem 2002 Nov 9;277(47):44754-9. Epub 2002 Sep 9.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206872200DOI Listing
November 2002

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

J Biol Chem 2002 Oct 26;277(42):39062-5. Epub 2002 Aug 26.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C200469200DOI Listing
October 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

J Cell Biol 2002 Aug 29;158(3):551-61. Epub 2002 Jul 29.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1083/jcb.200201123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840PMC
August 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8025-30. Epub 2002 Jun 4.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.112686799
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http://dx.doi.org/10.1073/pnas.112686799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123014PMC
June 2002

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Proc Natl Acad Sci U S A 2002 Jun 4;99(13):8666-71. Epub 2002 Jun 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.132277899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124353PMC
June 2002

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

J Biol Chem 2002 Apr 23;277(16):13389-93. Epub 2002 Jan 23.

Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M111571200DOI Listing
April 2002