Dieter Edbauer

Dieter Edbauer

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Dieter Edbauer

Dieter Edbauer

Publications by authors named "Dieter Edbauer"

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Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3.

Authors:
Yoshihiro Nihei Kohji Mori Georg Werner Thomas Arzberger Qihui Zhou Barham Khosravi Julia Japtok Andreas Hermann Andreas Sommacal Markus Weber Frits Kamp Brigitte Nuscher Dieter Edbauer Christian Haass

Acta Neuropathol 2019 Oct 23. Epub 2019 Oct 23.

German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-019-02082-0DOI Listing
October 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Authors:
Samira Parhizkar Thomas Arzberger Matthias Brendel Gernot Kleinberger Maximilian Deussing Carola Focke Brigitte Nuscher Monica Xiong Alireza Ghasemigharagoz Natalie Katzmarski Susanne Krasemann Stefan F Lichtenthaler Stephan A Müller Alessio Colombo Laura Sebastian Monasor Sabina Tahirovic Jochen Herms Michael Willem Nadine Pettkus Oleg Butovsky Peter Bartenstein Dieter Edbauer Axel Rominger Ali Ertürk Stefan A Grathwohl Jonas J Neher David M Holtzman Melanie Meyer-Luehmann Christian Haass

Nat Neurosci 2019 02 7;22(2):191-204. Epub 2019 Jan 7.

Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://www.nature.com/articles/s41593-018-0296-9
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http://dx.doi.org/10.1038/s41593-018-0296-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417433PMC
February 2019

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Authors:
Janine Diehl-Schmid Abigail Licata Oliver Goldhardt Hans Förstl Igor Yakushew Markus Otto Sarah Anderl-Straub Ambros Beer Albert Christian Ludolph Georg Bernhard Landwehrmeyer Johannes Levin Adrian Danek Klaus Fliessbach Annika Spottke Klaus Fassbender Epameinondas Lyros Johannes Prudlo Bernd Joachim Krause Alexander Volk Dieter Edbauer Matthias Leopold Schroeter Alexander Drzezga Johannes Kornhuber Martin Lauer Timo Grimmer

Transl Psychiatry 2019 01 31;9(1):54. Epub 2019 Jan 31.

Department of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41398-019-0381-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355852PMC
January 2019

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.

Authors:
Petra Frick Chantal Sellier Ian R A Mackenzie Chieh-Yu Cheng Julie Tahraoui-Bories Cecile Martinat R Jeroen Pasterkamp Johannes Prudlo Dieter Edbauer Mustapha Oulad-Abdelghani Regina Feederle Nicolas Charlet-Berguerand Manuela Neumann

Acta Neuropathol Commun 2018 08 3;6(1):72. Epub 2018 Aug 3.

German Center for Neurodegenerative Diseases (DZNE), Otfried-Müllerstr. 23, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1186/s40478-018-0579-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091050PMC
August 2018

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

Authors:
Carina Lehmer Martin H Schludi Linnea Ransom Johanna Greiling Michaela Junghänel Nicole Exner Henrick Riemenschneider Julie van der Zee Christine Van Broeckhoven Patrick Weydt Michael T Heneka Dieter Edbauer

EMBO Mol Med 2018 06;10(6)

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201708558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991575PMC
June 2018

Proteomics and neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity.

Authors:
Hannelore Hartmann Daniel Hornburg Mareike Czuppa Jakob Bader Meike Michaelsen Daniel Farny Thomas Arzberger Matthias Mann Felix Meissner Dieter Edbauer

Life Sci Alliance 2018 May 16;1(2):e201800070. Epub 2018 May 16.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238541PMC
May 2018

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Authors:
Eva Benito Cemil Kerimoglu Binu Ramachandran Tonatiuh Pena-Centeno Gaurav Jain Roman Manuel Stilling Md Rezaul Islam Vincenzo Capece Qihui Zhou Dieter Edbauer Camin Dean André Fischer

Cell Rep 2018 Apr;23(2):546-554

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Strasse 3A, 37075 Göttingen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Von Siebold Strasse 5, 37075 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912949PMC
April 2018

RNA versus protein toxicity in C9orf72 ALS/FTLD.

Authors:
Thomas Arzberger Martin H Schludi Carina Lehmer Bettina Schmid Dieter Edbauer

Acta Neuropathol 2018 03 15;135(3):475-479. Epub 2018 Feb 15.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1823-1DOI Listing
March 2018

Atrophy in the Thalamus But Not Cerebellum Is Specific for FTD and ALS Patients - An Atlas-Based Volumetric MRI Study.

Authors:
Sonja Schönecker Christiane Neuhofer Markus Otto Albert Ludolph Jan Kassubek Bernhard Landwehrmeyer Sarah Anderl-Straub Elisa Semler Janine Diehl-Schmid Catharina Prix Christian Vollmar Juan Fortea Hans-Jürgen Huppertz Thomas Arzberger Dieter Edbauer Berend Feddersen Marianne Dieterich Matthias L Schroeter Alexander E Volk Klaus Fließbach Anja Schneider Johannes Kornhuber Manuel Maler Johannes Prudlo Holger Jahn Tobias Boeckh-Behrens Adrian Danek Thomas Klopstock Johannes Levin

Front Aging Neurosci 2018 15;10:45. Epub 2018 Mar 15.

Department of Neurology, Ludwig Maximilians Universität München, Munich, Germany.

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http://dx.doi.org/10.3389/fnagi.2018.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863593PMC
March 2018

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Authors:
Qiang Guo Carina Lehmer Antonio Martínez-Sánchez Till Rudack Florian Beck Hannelore Hartmann Manuela Pérez-Berlanga Frédéric Frottin Mark S Hipp F Ulrich Hartl Dieter Edbauer Wolfgang Baumeister Rubén Fernández-Busnadiego

Cell 2018 02 1;172(4):696-705.e12. Epub 2018 Feb 1.

Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035389PMC
February 2018

Targeting RNA G-quadruplexes as new treatment strategy for ALS/FTD.

Authors:
Martin H Schludi Dieter Edbauer

EMBO Mol Med 2018 01;10(1):4-6

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

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http://dx.doi.org/10.15252/emmm.201708572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760851PMC
January 2018

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

Authors:
Martin H Schludi Lore Becker Lillian Garrett Tania F Gendron Qihui Zhou Franziska Schreiber Bastian Popper Leda Dimou Tim M Strom Juliane Winkelmann Anne von Thaden Kristin Rentzsch Stephanie May Meike Michaelsen Benjamin M Schwenk Jing Tan Benedikt Schoser Marianne Dieterich Leonard Petrucelli Sabine M Hölter Wolfgang Wurst Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Thomas Klopstock Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2017 08 13;134(2):241-254. Epub 2017 Apr 13.

German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-017-1711-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508040PMC
August 2017

Poly-GP in cerebrospinal fluid links -associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.

Authors:
Carina Lehmer Patrick Oeckl Jochen H Weishaupt Alexander E Volk Janine Diehl-Schmid Matthias L Schroeter Martin Lauer Johannes Kornhuber Johannes Levin Klaus Fassbender Bernhard Landwehrmeyer Martin H Schludi Thomas Arzberger Elisabeth Kremmer Andrew Flatley Regina Feederle Petra Steinacker Patrick Weydt Albert C Ludolph Dieter Edbauer Markus Otto

EMBO Mol Med 2017 07;9(7):859-868

Department of Neurology, Ulm University Hospital, Ulm, Germany

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http://dx.doi.org/10.15252/emmm.201607486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494528PMC
July 2017

Antibodies inhibit transmission and aggregation of poly-GA dipeptide repeat proteins.

Authors:
Qihui Zhou Carina Lehmer Meike Michaelsen Kohji Mori Dominik Alterauge Dirk Baumjohann Martin H Schludi Johanna Greiling Daniel Farny Andrew Flatley Regina Feederle Stephanie May Franziska Schreiber Thomas Arzberger Christoph Kuhm Thomas Klopstock Andreas Hermann Christian Haass Dieter Edbauer

EMBO Mol Med 2017 05;9(5):687-702

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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http://dx.doi.org/10.15252/emmm.201607054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412769PMC
May 2017

Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.

Authors:
Bahram Khosravi Hannelore Hartmann Stephanie May Christoph Möhl Helena Ederle Meike Michaelsen Martin H Schludi Dorothee Dormann Dieter Edbauer

Hum Mol Genet 2017 Feb;26(4):790-800

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany.

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http://dx.doi.org/10.1093/hmg/ddw432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409121PMC
February 2017

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.

Authors:
Yu Ohki Andrea Wenninger-Weinzierl Alexander Hruscha Kazuhide Asakawa Koichi Kawakami Christian Haass Dieter Edbauer Bettina Schmid

Mol Neurodegener 2017 01 14;12(1). Epub 2017 Jan 14.

German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str.17, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s13024-016-0146-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237533PMC
January 2017

Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD.

Authors:
Renate K Hukema Fréderike W Riemslagh Shamiram Melhem Herma C van der Linde Lies-Anne W F M Severijnen Dieter Edbauer Alex Maas Nicolas Charlet-Berguerand Rob Willemsen John C van Swieten

Acta Neuropathol Commun 2016 12 9;4(1):129. Epub 2016 Dec 9.

Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40478-016-0401-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148842PMC
December 2016

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Authors:
Benjamin M Schwenk Hannelore Hartmann Alperen Serdaroglu Martin H Schludi Daniel Hornburg Felix Meissner Denise Orozco Alessio Colombo Sabina Tahirovic Meike Michaelsen Franziska Schreiber Simone Haupt Michael Peitz Oliver Brüstle Clemens Küpper Thomas Klopstock Markus Otto Albert C Ludolph Thomas Arzberger Peer-Hendrik Kuhn Dieter Edbauer

EMBO J 2016 11 12;35(21):2350-2370. Epub 2016 Sep 12.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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http://dx.doi.org/10.15252/embj.201694221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090220PMC
November 2016

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.

Authors:
Kohji Mori Yoshihiro Nihei Thomas Arzberger Qihui Zhou Ian R Mackenzie Andreas Hermann Frank Hanisch Frits Kamp Brigitte Nuscher Denise Orozco Dieter Edbauer Christian Haass

EMBO Rep 2016 09 26;17(9):1314-25. Epub 2016 Jul 26.

Biomedical Center (BMC), Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE), Munich, Germany Munich Cluster for System Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.15252/embr.201541724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007570PMC
September 2016

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

Authors:
Yong-Jie Zhang Tania F Gendron Jonathan C Grima Hiroki Sasaguri Karen Jansen-West Ya-Fei Xu Rebecca B Katzman Jennifer Gass Melissa E Murray Mitsuru Shinohara Wen-Lang Lin Aliesha Garrett Jeannette N Stankowski Lillian Daughrity Jimei Tong Emilie A Perkerson Mei Yue Jeannie Chew Monica Castanedes-Casey Aishe Kurti Zizhao S Wang Amanda M Liesinger Jeremy D Baker Jie Jiang Clotilde Lagier-Tourenne Dieter Edbauer Don W Cleveland Rosa Rademakers Kevin B Boylan Guojun Bu Christopher D Link Chad A Dickey Jeffrey D Rothstein Dennis W Dickson John D Fryer Leonard Petrucelli

Nat Neurosci 2016 05 21;19(5):668-677. Epub 2016 Mar 21.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1038/nn.4272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138863PMC
May 2016

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.

Authors:
Jie Jiang Qiang Zhu Tania F Gendron Shahram Saberi Melissa McAlonis-Downes Amanda Seelman Jennifer E Stauffer Paymaan Jafar-Nejad Kevin Drenner Derek Schulte Seung Chun Shuying Sun Shuo-Chien Ling Brian Myers Jeffery Engelhardt Melanie Katz Michael Baughn Oleksandr Platoshyn Martin Marsala Andy Watt Charles J Heyser M Colin Ard Louis De Muynck Lillian M Daughrity Deborah A Swing Lino Tessarollo Chris J Jung Arnaud Delpoux Daniel T Utzschneider Stephen M Hedrick Pieter J de Jong Dieter Edbauer Philip Van Damme Leonard Petrucelli Christopher E Shaw C Frank Bennett Sandrine Da Cruz John Ravits Frank Rigo Don W Cleveland Clotilde Lagier-Tourenne

Neuron 2016 05 21;90(3):535-50. Epub 2016 Apr 21.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860075PMC
May 2016

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

Authors:
Marc Suárez-Calvet Manuela Neumann Thomas Arzberger Claudia Abou-Ajram Eva Funk Hannelore Hartmann Dieter Edbauer Elisabeth Kremmer Christoph Göbl Moritz Resch Benjamin Bourgeois Tobias Madl Stefan Reber Daniel Jutzi Marc-David Ruepp Ian R A Mackenzie Olaf Ansorge Dorothee Dormann Christian Haass

Acta Neuropathol 2016 Apr 19;131(4):587-604. Epub 2016 Feb 19.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen Strasse 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-016-1544-2DOI Listing
April 2016

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD.

Authors:
Dieter Edbauer Christian Haass

Curr Opin Neurobiol 2016 Feb 8;36:99-106. Epub 2015 Nov 8.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany; Biomedical Center (BMC), Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.conb.2015.10.009DOI Listing
February 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Authors:
Daniel Fleck Matthias Voss Ben Brankatschk Camilla Giudici Heike Hampel Benjamin Schwenk Dieter Edbauer Akio Fukumori Harald Steiner Elisabeth Kremmer Martina Haug-Kröper Moritz J Rossner Regina Fluhrer Michael Willem Christian Haass

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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http://www.jbc.org/content/291/1/318.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.697995
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http://dx.doi.org/10.1074/jbc.M115.697995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697167PMC
January 2016

Three novel presenilin 1 mutations marking the wide spectrum of age at onset and clinical patterns in familial Alzheimer's disease.

Authors:
Sigrun Roeber Felix Müller-Sarnowski Julia Kress Dieter Edbauer Tanja Kuhlmann Frank Tüttelmann Christoph Schindler Pia Winter Thomas Arzberger Ulrich Müller Adrian Danek Hans A Kretzschmar

J Neural Transm (Vienna) 2015 Dec 8;122(12):1715-9. Epub 2015 Sep 8.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 23, 81377, Munich, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00702-015-14
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http://link.springer.com/10.1007/s00702-015-1450-0
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http://dx.doi.org/10.1007/s00702-015-1450-0DOI Listing
December 2015

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Authors:
Ian R A Mackenzie Petra Frick Friedrich A Grässer Tania F Gendron Leonard Petrucelli Neil R Cashman Dieter Edbauer Elisabeth Kremmer Johannes Prudlo Dirk Troost Manuela Neumann

Acta Neuropathol 2015 Dec 15;130(6):845-61. Epub 2015 Sep 15.

German Center for Neurodegenerative Diseases (DZNE), Otfried-Müllerstr. 23, 72076, Tübingen, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00401-015-14
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http://link.springer.com/10.1007/s00401-015-1476-2
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http://dx.doi.org/10.1007/s00401-015-1476-2DOI Listing
December 2015

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

Authors:
Marka van Blitterswijk Tania F Gendron Matthew C Baker Mariely DeJesus-Hernandez NiCole A Finch Patricia H Brown Lillian M Daughrity Melissa E Murray Michael G Heckman Jie Jiang Clotilde Lagier-Tourenne Dieter Edbauer Don W Cleveland Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen Leonard Petrucelli Bradley F Boeve Neill R Graff-Radford Kevin B Boylan Dennis W Dickson Rosa Rademakers

Acta Neuropathol 2015 Dec 5;130(6):863-76. Epub 2015 Oct 5.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00401-015-14
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http://link.springer.com/10.1007/s00401-015-1480-6
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http://dx.doi.org/10.1007/s00401-015-1480-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655160PMC
December 2015

Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing.

Authors:
Martin H Schludi Stephanie May Friedrich A Grässer Kristin Rentzsch Elisabeth Kremmer Clemens Küpper Thomas Klopstock Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2015 Oct 18;130(4):537-55. Epub 2015 Jun 18.

German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81337, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-015-1450-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575390PMC
October 2015

Erratum to: Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing.

Authors:
Martin H Schludi Stephanie May Friedrich A Grässer Kristin Rentzsch Elisabeth Kremmer Clemens Küpper Thomas Klopstock Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2015 Oct;130(4):557-8

German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81337, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-015-1464-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713950PMC
October 2015

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

Authors:
Tania F Gendron Marka van Blitterswijk Kevin F Bieniek Lillian M Daughrity Jie Jiang Beth K Rush Otto Pedraza John A Lucas Melissa E Murray Pamela Desaro Amelia Robertson Karen Overstreet Colleen S Thomas Julia E Crook Monica Castanedes-Casey Linda Rousseau Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen Bradley F Boeve Neill R Graff-Radford Rosa Rademakers Clotilde Lagier-Tourenne Dieter Edbauer Don W Cleveland Dennis W Dickson Leonard Petrucelli Kevin B Boylan

Acta Neuropathol 2015 Oct 8;130(4):559-73. Epub 2015 Sep 8.

Department of Neurology, Mayo Clinic, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1474-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575385PMC
October 2015

Brain banks still yield high interest rates.

Authors:
Dieter Edbauer Thomas Arzberger

J Neural Transm (Vienna) 2015 Jul;122(7):935-6

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http://dx.doi.org/10.1007/s00702-015-1422-4DOI Listing
July 2015

Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits.

Authors:
Jeannie Chew Tania F Gendron Mercedes Prudencio Hiroki Sasaguri Yong-Jie Zhang Monica Castanedes-Casey Chris W Lee Karen Jansen-West Aishe Kurti Melissa E Murray Kevin F Bieniek Peter O Bauer Ena C Whitelaw Linda Rousseau Jeannette N Stankowski Caroline Stetler Lillian M Daughrity Emilie A Perkerson Pamela Desaro Amelia Johnston Karen Overstreet Dieter Edbauer Rosa Rademakers Kevin B Boylan Dennis W Dickson John D Fryer Leonard Petrucelli

Science 2015 Jun 14;348(6239):1151-4. Epub 2015 May 14.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/science.aaa9344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692360PMC
June 2015

A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD.

Authors:
Renate K Hukema Fréderike W Riemslagh Shamiram Melhem Herma C van der Linde Lies-Anne Wfm Severijnen Dieter Edbauer Alex Maas Nicolas Charlet-Berguerand Rob Willemsen John C van Swieten

Acta Neuropathol Commun 2014 Dec 13;2:166. Epub 2014 Dec 13.

Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40478-014-0166-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271461PMC
December 2014

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.

Authors:
Stephanie May Daniel Hornburg Martin H Schludi Thomas Arzberger Kristin Rentzsch Benjamin M Schwenk Friedrich A Grässer Kohji Mori Elisabeth Kremmer Julia Banzhaf-Strathmann Matthias Mann Felix Meissner Dieter Edbauer

Acta Neuropathol 2014 Oct 14;128(4):485-503. Epub 2014 Aug 14.

German Center for Neurodegenerative Diseases (DZNE), Munich, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-014-1329-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159571PMC
October 2014

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

Authors:
Julia Banzhaf-Strathmann Eva Benito Stephanie May Thomas Arzberger Sabina Tahirovic Hans Kretzschmar André Fischer Dieter Edbauer

EMBO J 2014 Aug 7;33(15):1667-80. Epub 2014 Jul 7.

German Center for Neurodegenerative Diseases, Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.15252/embj.201387576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194100PMC
August 2014

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Authors:
Johnathan Cooper-Knock Matthew J Walsh Adrian Higginbottom J Robin Highley Mark J Dickman Dieter Edbauer Paul G Ince Stephen B Wharton Stuart A Wilson Janine Kirby Guillaume M Hautbergue Pamela J Shaw

Brain 2014 Jul 27;137(Pt 7):2040-51. Epub 2014 May 27.

1 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK

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http://dx.doi.org/10.1093/brain/awu120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065024PMC
July 2014

The ER under rapid fire.

Authors:
Benjamin M Schwenk Dieter Edbauer

EMBO J 2014 Jun 30;33(11):1195-7. Epub 2014 Apr 30.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany Biochemistry, Adolf Butenandt Institute Ludwig-Maximilians University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

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http://emboj.embopress.org/cgi/doi/10.1002/embj.201488692
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http://dx.doi.org/10.1002/embj.201488692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198023PMC
June 2014

Good guy or bad guy: the opposing roles of microRNA 125b in cancer.

Authors:
Julia Banzhaf-Strathmann Dieter Edbauer

Cell Commun Signal 2014 Apr 28;12:30. Epub 2014 Apr 28.

German Center for Neurodegenerative Diseases, Site Munich, Schillerstr, 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1186/1478-811X-12-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011766PMC
April 2014

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.

Authors:
Benjamin M Schwenk Christina M Lang Sebastian Hogl Sabina Tahirovic Denise Orozco Kristin Rentzsch Stefan F Lichtenthaler Casper C Hoogenraad Anja Capell Christian Haass Dieter Edbauer

EMBO J 2014 Mar 19;33(5):450-67. Epub 2013 Dec 19.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1002/embj.201385857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989627PMC
March 2014

Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability.

Authors:
Malcolm Proudfoot Nick J Gutowski Dieter Edbauer David A Hilton Mark Stephens Julia Rankin Ian R A Mackenzie

Acta Neuropathol 2014 Mar 21;127(3):451-8. Epub 2014 Jan 21.

Department of Neurology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK,

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http://dx.doi.org/10.1007/s00401-014-1245-7DOI Listing
March 2014

FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD.

Authors:
Denise Orozco Dieter Edbauer

J Mol Med (Berl) 2013 Dec 24;91(12):1343-54. Epub 2013 Aug 24.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1007/s00109-013-1077-2DOI Listing
December 2013

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Authors:
Ian R Mackenzie Thomas Arzberger Elisabeth Kremmer Dirk Troost Stefan Lorenzl Kohji Mori Shih-Ming Weng Christian Haass Hans A Kretzschmar Dieter Edbauer Manuela Neumann

Acta Neuropathol 2013 Dec 6;126(6):859-79. Epub 2013 Oct 6.

Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00401-013-1181-yDOI Listing
December 2013

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Authors:
Kohji Mori Thomas Arzberger Friedrich A Grässer Ilse Gijselinck Stephanie May Kristin Rentzsch Shih-Ming Weng Martin H Schludi Julie van der Zee Marc Cruts Christine Van Broeckhoven Elisabeth Kremmer Hans A Kretzschmar Christian Haass Dieter Edbauer

Acta Neuropathol 2013 Dec 17;126(6):881-93. Epub 2013 Oct 17.

Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-013-1189-3DOI Listing
December 2013

Staufen2 regulates neuronal target RNAs.

Authors:
Jacki E Heraud-Farlow Tejaswini Sharangdhar Xiao Li Philipp Pfeifer Stefanie Tauber Denise Orozco Alexandra Hörmann Sabine Thomas Anetta Bakosova Ashley R Farlow Dieter Edbauer Howard D Lipshitz Quaid D Morris Martin Bilban Michael Doyle Michael A Kiebler

Cell Rep 2013 Dec 19;5(6):1511-8. Epub 2013 Dec 19.

Department of Neuronal Cell Biology, Center for Brain Research, 1090 Vienna, Austria; Department of Anatomy and Cell Biology, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.039DOI Listing
December 2013

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

Authors:
Daniel Fleck Frauke van Bebber Alessio Colombo Chiara Galante Benjamin M Schwenk Linnea Rabe Heike Hampel Bozidar Novak Elisabeth Kremmer Sabina Tahirovic Dieter Edbauer Stefan F Lichtenthaler Bettina Schmid Michael Willem Christian Haass

J Neurosci 2013 May;33(18):7856-69

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3372-12.2
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http://dx.doi.org/10.1523/JNEUROSCI.3372-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618983PMC
May 2013

Promoter DNA methylation regulates progranulin expression and is altered in FTLD.

Authors:
Julia Banzhaf-Strathmann Rainer Claus Oliver Mücke Kristin Rentzsch Julie van der Zee Sebastiaan Engelborghs Peter P De Deyn Marc Cruts Christine van Broeckhoven Christoph Plass Dieter Edbauer

Acta Neuropathol Commun 2013 May 13;1:16. Epub 2013 May 13.

German Center for Neurodegenerative Diseases (DZNE), University of Munich, Schillerstr, 44, Munich 80336, Germany.

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http://dx.doi.org/10.1186/2051-5960-1-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893557PMC
May 2013

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Authors:
Kohji Mori Sven Lammich Ian R A Mackenzie Ignasi Forné Sonja Zilow Hans Kretzschmar Dieter Edbauer Jonathan Janssens Gernot Kleinberger Marc Cruts Jochen Herms Manuela Neumann Christine Van Broeckhoven Thomas Arzberger Christian Haass

Acta Neuropathol 2013 Mar 5;125(3):413-23. Epub 2013 Feb 5.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-013-1088-7DOI Listing
March 2013

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Authors:
Kohji Mori Shih-Ming Weng Thomas Arzberger Stephanie May Kristin Rentzsch Elisabeth Kremmer Bettina Schmid Hans A Kretzschmar Marc Cruts Christine Van Broeckhoven Christian Haass Dieter Edbauer

Science 2013 Mar 7;339(6125):1335-8. Epub 2013 Feb 7.

Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Munich, Germany.

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http://dx.doi.org/10.1126/science.1232927DOI Listing
March 2013

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

Authors:
Bettina Schmid Alexander Hruscha Sebastian Hogl Julia Banzhaf-Strathmann Katrin Strecker Julie van der Zee Mathias Teucke Stefan Eimer Jan Hegermann Maike Kittelmann Elisabeth Kremmer Marc Cruts Barbara Solchenberger Laura Hasenkamp Frauke van Bebber Christine Van Broeckhoven Dieter Edbauer Stefan F Lichtenthaler Christian Haass

Proc Natl Acad Sci U S A 2013 Mar 1;110(13):4986-91. Epub 2013 Mar 1.

German Center for Neurodegenerative Diseases, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1218311110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612625PMC
March 2013

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.

Authors:
Denise Orozco Sabina Tahirovic Kristin Rentzsch Benjamin M Schwenk Christian Haass Dieter Edbauer

EMBO Rep 2012 Aug 19;13(8):759-64. Epub 2012 Jun 19.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1038/embor.2012.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410390PMC
August 2012

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.

Authors:
Christina M Lang Katrin Fellerer Benjamin M Schwenk Peer-Hendrik Kuhn Elisabeth Kremmer Dieter Edbauer Anja Capell Christian Haass

J Biol Chem 2012 Jun 17;287(23):19355-65. Epub 2012 Apr 17.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.365098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365973PMC
June 2012

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Authors:
Brooke H Miller Zane Zeier Li Xi Thomas A Lanz Shibing Deng Julia Strathmann David Willoughby Paul J Kenny John D Elsworth Matthew S Lawrence Robert H Roth Dieter Edbauer Robin J Kleiman Claes Wahlestedt

Proc Natl Acad Sci U S A 2012 Feb 6;109(8):3125-30. Epub 2012 Feb 6.

Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.

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http://dx.doi.org/10.1073/pnas.1113793109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286960PMC
February 2012

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.

Authors:
Nikolaos Mellios Hiroki Sugihara Jorge Castro Abhishek Banerjee Chuong Le Arooshi Kumar Benjamin Crawford Julia Strathmann Daniela Tropea Stuart S Levine Dieter Edbauer Mriganka Sur

Nat Neurosci 2011 Sep 4;14(10):1240-2. Epub 2011 Sep 4.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nn.2909
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http://dx.doi.org/10.1038/nn.2909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183341PMC
September 2011

microRNA-34c is a novel target to treat dementias.

Authors:
Athanasios Zovoilis Hope Y Agbemenyah Roberto C Agis-Balboa Roman M Stilling Dieter Edbauer Pooja Rao Laurent Farinelli Ivana Delalle Andrea Schmitt Peter Falkai Sanaz Bahari-Javan Susanne Burkhardt Farahnaz Sananbenesi Andre Fischer

EMBO J 2011 Sep 23;30(20):4299-308. Epub 2011 Sep 23.

Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Göttingen, Germany.

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http://dx.doi.org/10.1038/emboj.2011.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199394PMC
September 2011

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

Authors:
Dorothee Dormann Ramona Rodde Dieter Edbauer Eva Bentmann Ingeborg Fischer Alexander Hruscha Manuel E Than Ian R A Mackenzie Anja Capell Bettina Schmid Manuela Neumann Christian Haass

EMBO J 2010 Aug 6;29(16):2841-57. Epub 2010 Jul 6.

DZNE-German Center for Neurodegenerative Diseases, Munich, Germany.

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http://dx.doi.org/10.1038/emboj.2010.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924641PMC
August 2010

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.

Authors:
Dieter Edbauer Joel R Neilson Kelly A Foster Chi-Fong Wang Daniel P Seeburg Matthew N Batterton Tomoko Tada Bridget M Dolan Phillip A Sharp Morgan Sheng

Neuron 2010 Feb;65(3):373-84

The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018398PMC
February 2010

Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation.

Authors:
Kelly A Foster Nathan McLaughlin Dieter Edbauer Marnie Phillips Andrew Bolton Martha Constantine-Paton Morgan Sheng

J Neurosci 2010 Feb;30(7):2676-85

Department of Basic Science, The Commonwealth Medical College, Scranton, Pennsylvania 18510, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4022-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840640PMC
February 2010

Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody.

Authors:
Dieter Edbauer Dongmei Cheng Matthew N Batterton Chi-Fong Wang Duc M Duong Michael B Yaffe Junmin Peng Morgan Sheng

Mol Cell Proteomics 2009 Apr 3;8(4):681-95. Epub 2008 Dec 3.

The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/mcp.M800233-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667352PMC
April 2009

Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons.

Authors:
Tomoko Tada Alyson Simonetta Matthew Batterton Makoto Kinoshita Dieter Edbauer Morgan Sheng

Curr Biol 2007 Oct 11;17(20):1752-8. Epub 2007 Oct 11.

The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1016/j.cub.2007.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194646PMC
October 2007

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

Authors:
Christoph Kaether Anja Capell Dieter Edbauer Edith Winkler Bozidar Novak Harald Steiner Christian Haass

EMBO J 2004 Dec 18;23(24):4738-48. Epub 2004 Nov 18.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535090PMC
December 2004

Identification of distinct gamma-secretase complexes with different APH-1 variants.

Authors:
Keiro Shirotani Dieter Edbauer Stefan Prokop Christian Haass Harald Steiner

J Biol Chem 2004 Oct 30;279(40):41340-5. Epub 2004 Jul 30.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M405768200DOI Listing
October 2004

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

Authors:
Dieter Edbauer Christoph Kaether Harald Steiner Christian Haass

J Biol Chem 2004 Sep 21;279(36):37311-5. Epub 2004 Jun 21.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406228200
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September 2004

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

Authors:
Keiro Shirotani Dieter Edbauer Marcus Kostka Harald Steiner Christian Haass

J Neurochem 2004 Jun;89(6):1520-7

Adolf-Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02447.xDOI Listing
June 2004

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

Authors:
Stefan Prokop Keiro Shirotani Dieter Edbauer Christian Haass Harald Steiner

J Biol Chem 2004 May 23;279(22):23255-61. Epub 2004 Mar 23.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M401789200DOI Listing
May 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

Authors:
Anja Capell Christoph Kaether Dieter Edbauer Keiro Shirotani Sabine Merkl Harald Steiner Christian Haass

J Biol Chem 2003 Dec 5;278(52):52519-23. Epub 2003 Nov 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C300435200
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http://dx.doi.org/10.1074/jbc.C300435200DOI Listing
December 2003

Gamma-secretase activity is associated with a conformational change of nicastrin.

Authors:
Keiro Shirotani Dieter Edbauer Anja Capell Julia Schmitz Harald Steiner Christian Haass

J Biol Chem 2003 May 18;278(19):16474-7. Epub 2003 Mar 18.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C300095200DOI Listing
May 2003

Reconstitution of gamma-secretase activity.

Authors:
Dieter Edbauer Edith Winkler Joerg T Regula Brigitte Pesold Harald Steiner Christian Haass

Nat Cell Biol 2003 May;5(5):486-8

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/ncb960DOI Listing
May 2003

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Authors:
Sven Lammich Masayasu Okochi Masatoshi Takeda Christoph Kaether Anja Capell Ann-Katrin Zimmer Dieter Edbauer Jochen Walter Harald Steiner Christian Haass

J Biol Chem 2002 Nov 9;277(47):44754-9. Epub 2002 Sep 9.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206872200DOI Listing
November 2002

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

Authors:
Harald Steiner Edith Winkler Dieter Edbauer Stefan Prokop Gabriele Basset Aya Yamasaki Marcus Kostka Christian Haass

J Biol Chem 2002 Oct 26;277(42):39062-5. Epub 2002 Aug 26.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C200469200DOI Listing
October 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Authors:
Christoph Kaether Sven Lammich Dieter Edbauer Michaela Ertl Jens Rietdorf Anja Capell Harald Steiner Christian Haass

J Cell Biol 2002 Aug 29;158(3):551-61. Epub 2002 Jul 29.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1083/jcb.200201123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840PMC
August 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Authors:
Tobias Moehlmann Edith Winkler Xuefeng Xia Dieter Edbauer Jill Murrell Anja Capell Christoph Kaether Hui Zheng Bernardino Ghetti Christian Haass Harald Steiner

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8025-30. Epub 2002 Jun 4.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.112686799
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http://dx.doi.org/10.1073/pnas.112686799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123014PMC
June 2002

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Authors:
Dieter Edbauer Edith Winkler Christian Haass Harald Steiner

Proc Natl Acad Sci U S A 2002 Jun 4;99(13):8666-71. Epub 2002 Jun 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.132277899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124353PMC
June 2002

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

Authors:
Dieter Edbauer Michael Willem Sven Lammich Harald Steiner Christian Haass

J Biol Chem 2002 Apr 23;277(16):13389-93. Epub 2002 Jan 23.

Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M111571200DOI Listing
April 2002