Publications by authors named "Dierk Niessing"

51Publications

Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.

EMBO J 2020 Aug 6;39(16):e103373. Epub 2020 Jul 6.

Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians Universitaet Muenchen, Planegg/Munich, Germany.

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http://dx.doi.org/10.15252/embj.2019103373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429739PMC
August 2020

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.

Nucleic Acids Res 2020 07;48(13):7385-7403

Institute for Molecular Biosciences, Goethe University Frankfurt and Center for Biomolecular Magnetic Resonance (BMRZ), 60438 Frankfurt, Germany.

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http://dx.doi.org/10.1093/nar/gkaa465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367199PMC
July 2020

The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life.

RNA Biol 2020 09 31;17(9):1228-1238. Epub 2020 May 31.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health , Neuherberg, Germany.

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http://dx.doi.org/10.1080/15476286.2020.1761639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549692PMC
September 2020

Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization.

Biotechnol J 2020 Apr 17:e2000010. Epub 2020 Apr 17.

Technische Universität München, Lehrstuhl für Bioverfahrenstechnik, Boltzmannstraße 15, Garching, 85748, Germany.

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http://dx.doi.org/10.1002/biot.202000010DOI Listing
April 2020

Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.

Mol Pharm 2020 May 13;17(5):1663-1673. Epub 2020 Apr 13.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 300308 Tianjin, China.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00098DOI Listing
May 2020

Defining and expanding the phenotype of -associated developmental epileptic encephalopathy.

Neurol Genet 2019 Dec 10;5(6):e373. Epub 2019 Dec 10.

Department of Epilepsy Genetics and Precision Medicine (K.J.M., E.G., G.R., R.S.M.), The Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Institute for Regional Health Services (K.J.M., E.G., R.S.M.), University of Southern Denmark, Odense; Institute of Human Genetics (D.M., R. Jamra, A.F., J.R.L.), University of Leipzig Medical Center, Germany; Institute of Structural Biology (R. Janowski, D.N.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Paediatric Radiology (C.R.), University of Leipzig Medical Center, Germany; Department of Epilepsy, Sleep and Pediatric Neurophysiology (J.T.), Lyon University Hospital, France; Neuropediatric Unit (A.-L.P., D.M.V., G.L.), Lyon University Hospital, France; Department of Medical Genetics (N.C., G.L.), Lyon University Hospital, France; GenDev Team (N.C.), CNRS UMR 5292, INSERM U1028, CNRL and University of Lyon, France; Department of Genetics (E.B.), University Medical Center Utrecht, The Netherlands; Department of Child Neurology (K.G.), Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands; Department of Paediatrics (A.P.B.), Copenhagen University Hospital Rigshospitalet, Denmark; Baylor College of Medicine (S.M., K.N.), Children's Hospital of San Antonio; Undiagnosed Diseases Program (G.B., C.P.), Genetic Services of Western Australia, Department of Health, Government of Western Australia, Perth; Western Australian Register of Developmental Anomalies (G.B., D.G.), Australia; Telethon Kids Institute and the School of Paediatrics and Child Health (G.B.), University of Western Australia, Perth; Linear Clinical Research (L.D.), WA, Australia; Center of Human Genetics (S.S), Jena University Hospital, Germany; Department of Neuropediatrics (A.D.), Jena University Hospital, Germany; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Division of Neuropediatrics (A.M.), University of Leipzig Medical Center, Germany; Amplexa Genetics (H.H.), Odense, Denmark; Clinic for Children (H.H.), Værløse, Denmark; Center for Integrative Brain Research (G.M.), Seattle Children's Research Institute, WA; Department of Pediatrics (G.M.), University of Washington, Seattle; Medical Genetics Unit (F.B.), Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; Istituto Dermopatico dell'Immacolata (F.B.), IDI-IRCCS, Rome, Italy; Institute of Human Genetics (T.B., M.H.), University Medical Center Hamburg-Eppendorf, Germany; Childrens Hospital (J.D.), University Medical Center Hamburg-Eppendorf, Germany; University of Copenhagen (G.R.), Denmark; Institute for Human Genetics (P.M.), University Hospital Magdeburg, Germany; Children's Hospital A. Meyer (R.G., A.V.), University of Florence, Italy; and Institute of Pharmaceutical Biotechnology (D.N.), Ulm University, Germany.

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http://dx.doi.org/10.1212/NXG.0000000000000373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927360PMC
December 2019

Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.

J Struct Biol 2018 12 1;204(3):519-522. Epub 2018 Oct 1.

Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2018.09.013DOI Listing
December 2018

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.

Cell 2018 04;173(3):706-719.e13

Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy); 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.004DOI Listing
April 2018

mRNA transport in fungal top models.

Wiley Interdiscip Rev RNA 2018 01 10;9(1). Epub 2017 Oct 10.

Centre of Excellence on Plant Sciences, Institute for Microbiology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.

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http://doi.wiley.com/10.1002/wrna.1453
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http://dx.doi.org/10.1002/wrna.1453DOI Listing
January 2018

Evidence for Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution.

Toxins (Basel) 2017 09 16;9(9). Epub 2017 Sep 16.

Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Schönleutnerstr 8, 85764 Oberschleißheim, Germany.

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http://www.mdpi.com/2072-6651/9/9/288
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http://dx.doi.org/10.3390/toxins9090288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618221PMC
September 2017

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.

Sci Rep 2017 04 21;7(1):1051. Epub 2017 Apr 21.

Munich Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41598-017-01031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430869PMC
April 2017

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.

Nat Struct Mol Biol 2017 02 16;24(2):152-161. Epub 2017 Jan 16.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

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http://www.nature.com/articles/nsmb.3351
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http://dx.doi.org/10.1038/nsmb.3351DOI Listing
February 2017

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.

Acta Crystallogr F Struct Biol Commun 2016 10 22;72(Pt 10):743-749. Epub 2016 Sep 22.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1107/S2053230X16013686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053159PMC
October 2016

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.

Nat Commun 2016 Mar 24;7:11032. Epub 2016 Mar 24.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg DE-85764, Germany.

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http://dx.doi.org/10.1038/ncomms11032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603727PMC
March 2016

RNA recognition by Roquin in posttranscriptional gene regulation.

Wiley Interdiscip Rev RNA 2016 07 4;7(4):455-69. Epub 2016 Feb 4.

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1002/wrna.1333DOI Listing
July 2016

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.

Elife 2016 Jan 8;5. Epub 2016 Jan 8.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.7554/eLife.11297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764581PMC
January 2016

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.

ACS Chem Biol 2016 Apr 19;11(4):1001-11. Epub 2016 Jan 19.

Cancer Drug Development Group, German Cancer Research Center (DKFZ) , Im Neunheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acschembio.5b00755DOI Listing
April 2016

ASH1 mRNP-core factors form stable complexes in absence of cargo RNA at physiological conditions.

RNA Biol 2015 ;12(3):233-7

a Institute of Structural Biology ; Helmholtz Zentrum München - German Center for Environmental Health ; Neuherberg , Germany.

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http://dx.doi.org/10.1080/15476286.2015.1017217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615642PMC
December 2015

Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast.

RNA Biol 2014 31;11(8):998-1009. Epub 2014 Oct 31.

a Institute of Structural Biology; Helmholtz Zentrum München - German Center for Environmental Health ; Neuherberg , Germany.

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http://dx.doi.org/10.4161/rna.29946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615550PMC
August 2015

mRNA transport meets membrane traffic.

Trends Genet 2014 Sep 7;30(9):408-17. Epub 2014 Aug 7.

Heinrich Heine University Düsseldorf, Institute for Microbiology, Cluster of Excellence on Plant Sciences, 40204 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.07.002DOI Listing
September 2014

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.

Nat Struct Mol Biol 2014 Aug 13;21(8):671-8. Epub 2014 Jul 13.

1] Biomolecular NMR Spectroscopy, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. [2] Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1038/nsmb.2855DOI Listing
August 2014

In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation.

J Cell Biol 2013 Dec;203(6):971-84

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1083/jcb.201302095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871432PMC
December 2013

Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.

PLoS One 2013 10;8(12):e82065. Epub 2013 Dec 10.

Institute of Structural Biology; Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany ; Gene Center and Department of Biochemistry, Ludwig-Maximilians-University, München, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858360PMC
September 2014

Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):E5049-58. Epub 2013 Dec 9.

Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum München- German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1073/pnas.1315289111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876240PMC
December 2013

Purification, crystallization and preliminary crystallographic analysis of the globular domain of the human type V myosin Myo5a.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Nov 17;69(Pt 11):1220-3. Epub 2013 Oct 17.

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1107/S1744309113025578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818037PMC
November 2013

Structural features of Argonaute-GW182 protein interactions.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):E3770-9. Epub 2013 Sep 16.

Biochemistry Center Regensburg, Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1073/pnas.1308510110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791723PMC
October 2013

Production of pure and functional RNA for in vitro reconstitution experiments.

Methods 2014 Feb 8;65(3):333-41. Epub 2013 Sep 8.

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.08.034DOI Listing
February 2014

Purification, crystallization and preliminary crystallographic analysis of Kar9p from Saccharomyces cerevisiae.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Oct 29;68(Pt 10):1251-4. Epub 2012 Sep 29.

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1107/S1744309112036342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497990PMC
October 2012

Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview.

Curr Protein Pept Sci 2012 Jun;13(4):284-93

Interfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474952PMC
http://dx.doi.org/10.2174/138920312801619493DOI Listing
June 2012

Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.

RNA Biol 2012 May 1;9(5):633-43. Epub 2012 May 1.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, München, Germany.

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http://dx.doi.org/10.4161/rna.19760DOI Listing
May 2012

Post-translational modifications regulate assembly of early spindle orientation complex in yeast.

J Biol Chem 2012 May 29;287(20):16238-45. Epub 2012 Mar 29.

Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1074/jbc.M112.347872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351353PMC
May 2012

Principles of mRNA transport in yeast.

Cell Mol Life Sci 2012 Jun 13;69(11):1843-53. Epub 2011 Dec 13.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, 81377, Munich, Germany.

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http://link.springer.com/10.1007/s00018-011-0902-4
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http://dx.doi.org/10.1007/s00018-011-0902-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350770PMC
June 2012

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast.

PLoS Biol 2011 Apr 19;9(4):e1000611. Epub 2011 Apr 19.

Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, München, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1000611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079584PMC
April 2011

The structure of the Myo4p globular tail and its function in ASH1 mRNA localization.

J Cell Biol 2010 May;189(3):497-510

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201002076
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http://dx.doi.org/10.1083/jcb.201002076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867299PMC
May 2010

X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface.

Proc Natl Acad Sci U S A 2009 Nov 21;106(44):18521-6. Epub 2009 Oct 21.

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Marchionini-Strasse 25, Munich 81377, Germany.

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http://dx.doi.org/10.1073/pnas.0907990106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765457PMC
November 2009

Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization.

RNA 2009 Nov 26;15(11):2002-12. Epub 2009 Aug 26.

Institute of Structural Biology, Helmholtz Zentrum München, Genome Research Center for Environmental Health, 81377 Munich, Germany.

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http://dx.doi.org/10.1261/rna.1753309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764475PMC
November 2009

Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells.

Plant Cell 2009 Jul 28;21(7):2090-106. Epub 2009 Jul 28.

Institute of Biochemical Plant Pathology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1105/tpc.108.061242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729594PMC
July 2009

Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.

EMBO Rep 2008 Aug 20;9(8):781-7. Epub 2008 Jun 20.

Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2008.112
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http://dx.doi.org/10.1038/embor.2008.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515214PMC
August 2008

Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes.

Proc Natl Acad Sci U S A 2007 Dec 4;104(50):19778-83. Epub 2007 Dec 4.

Institute of Structural Biology, GSF-National Research Center, 81377 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.0706780104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148375PMC
December 2007

She2p is a novel RNA binding protein with a basic helical hairpin motif.

Cell 2004 Nov;119(4):491-502

Laboratories of Molecular Biophysics and The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2004.10.018DOI Listing
November 2004

bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish.

Development 2003 Aug;130(16):3639-49

Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1242/dev.00558DOI Listing
August 2003

Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.

Genes Dev 2002 Oct;16(19):2576-82

Max-Planck-Institut für biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1101/gad.240002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187448PMC
October 2002