Diego Pasini

Diego Pasini

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Diego Pasini

Diego Pasini

Publications by authors named "Diego Pasini"

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.

Mol Cell 2020 02 26;77(4):840-856.e5. Epub 2019 Dec 26.

Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy; Department of Health Sciences, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033561PMC
February 2020

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities.

Mol Cell 2019 06 24;74(5):1037-1052.e7. Epub 2019 Apr 24.

IEO European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy; University of Milan, Department of Health Sciences, Via A. di Rudinì, 8, 20142 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561742PMC
June 2019

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.

Nat Commun 2019 04 11;10(1):1679. Epub 2019 Apr 11.

IEO European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1038/s41467-019-09624-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459869PMC
April 2019

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

Cell Metab 2018 12 30;28(6):848-865.e6. Epub 2018 Aug 30.

Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142, Torino, Candiolo 10060, Italy; University of Torino, Department of Oncology, 10060, Torino, Candiolo, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183050
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http://dx.doi.org/10.1016/j.cmet.2018.08.006DOI Listing
December 2018

Mapping the Function of Polycomb Proteins.

Authors:
Diego Pasini

Methods Mol Biol 2016 ;1480:3-6

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-4939-6380-5_1DOI Listing
January 2018

EpiMINE, a computational program for mining epigenomic data.

Epigenetics Chromatin 2016 29;9:42. Epub 2016 Sep 29.

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1186/s13072-016-0095-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043526PMC
January 2018

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.

Circ Res 2018 01 12;122(2):231-245. Epub 2017 Dec 12.

From the IFOM, FIRC Institute of Molecular Oncology, Milan, Italy (M.F.M., C.G., M.C., F.P., E.D., A.T.); Department of Biomedicine, University of Basel, Switzerland (M.F.M.); Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland (C.G.); Cogentech, Milan, Italy (F.P.); Department of Experimental Oncology (E.L., D.P.) and Unit of Gynecological Oncology Research (M.L., U.C.), European Institute of Oncology, Milan, Italy; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (S.I.C., L.L.C., E.D.); Peptide Chemistry (N.O., D.J.), Structural Biology (S.K., R.G.), Experimental Histopathology (E.N.), Bioinformatics & Biostatistics Department (R.M.), and Immunity and Cancer Laboratory (D.P.C., A.T.), The Francis Crick Institute, London, United Kingdom; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY (A.M., J.J.); and Department of Oncology and Hemato-Oncology, University of Milan, Italy (E.D.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771688PMC
January 2018

Control of adult intestinal identity by the Polycomb repressive machinery.

Cell Cycle 2017 02 15;16(3):243-244. Epub 2016 Nov 15.

a Dpt. of Experimental Oncology , IRCCS - Istituto Europeo di Oncologia , Milan , Italy.

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http://dx.doi.org/10.1080/15384101.2016.1252582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345241PMC
February 2017

PRC2 preserves intestinal progenitors and restricts secretory lineage commitment.

EMBO J 2016 11 1;35(21):2301-2314. Epub 2016 Sep 1.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

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http://dx.doi.org/10.15252/embj.201694550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090213PMC
November 2016

The Dual Role of EPOP and Elongin BC in Controlling Transcriptional Activity.

Mol Cell 2016 11;64(4):637-638

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.009DOI Listing
November 2016

Emerging roles for Polycomb proteins in cancer.

Curr Opin Genet Dev 2016 02 2;36:50-8. Epub 2016 May 2.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Institucio Catalana de Recerca i Estudis Avancats, Pg Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.03.013DOI Listing
February 2016

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.

Cell Stem Cell 2016 Jan 29;18(1):91-103. Epub 2015 Oct 29.

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.09.019DOI Listing
January 2016

The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?

FEBS J 2015 May 11;282(9):1703-22. Epub 2014 Nov 11.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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http://openwetware.org/images/1/14/Scelfo_et_al_Polycomb_Rev
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http://doi.wiley.com/10.1111/febs.13112
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http://dx.doi.org/10.1111/febs.13112DOI Listing
May 2015

Expression-profiling of apoptosis induced by ablation of the long ncRNA TRPM2-AS in prostate cancer cell.

Genom Data 2015 Mar 7;3:4-5. Epub 2014 Nov 7.

Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy ; Research Doctorate Program in Urology, Magna Graecia University, Catanzaro, Italy.

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http://dx.doi.org/10.1016/j.gdata.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535459PMC
March 2015

Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.

Mol Cell 2014 Jan 27;53(1):49-62. Epub 2013 Nov 27.

Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2013.10.030DOI Listing
January 2014

Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS.

Anal Chem 2013 Sep 16;85(17):8232-9. Epub 2013 Aug 16.

Centre for Epigenetics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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http://dx.doi.org/10.1021/ac401299wDOI Listing
September 2013

Regulation and function of DNA and histone methylations.

Curr Pharm Des 2013 ;19(4):719-33

Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16 20139 Milan, Italy.

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July 2013

Epigenetic methylations and their connections with metabolism.

Cell Mol Life Sci 2013 May 1;70(9):1495-508. Epub 2013 Mar 1.

Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1007/s00018-013-1293-5DOI Listing
May 2013

Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.

Nucleic Acids Res 2012 Apr 30;40(8):3403-18. Epub 2011 Dec 30.

Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1093/nar/gkr1290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333890PMC
April 2012

Epigenetic factors in cancer development: polycomb group proteins.

Future Oncol 2011 Jan;7(1):57-75

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, Milan, Italy.

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http://dx.doi.org/10.2217/fon.10.157DOI Listing
January 2011

Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.

Mol Cell Proteomics 2010 May 11;9(5):838-50. Epub 2010 Feb 11.

Centre for Epigenetics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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http://dx.doi.org/10.1074/mcp.M900489-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871418PMC
May 2010

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

Nature 2010 Mar;464(7286):306-10

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.

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http://www.nature.com/articles/nature08788
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http://dx.doi.org/10.1038/nature08788DOI Listing
March 2010

Polycomb complexes act redundantly to repress genomic repeats and genes.

Genes Dev 2010 Feb;24(3):265-76

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.

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http://dx.doi.org/10.1101/gad.544410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811828PMC
February 2010

A model for transmission of the H3K27me3 epigenetic mark.

Nat Cell Biol 2008 Nov 19;10(11):1291-300. Epub 2008 Oct 19.

Biotech Research & Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N., Denmark.

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http://www.nature.com/articles/ncb1787
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http://dx.doi.org/10.1038/ncb1787DOI Listing
November 2008

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.

PLoS Genet 2008 Aug 1;4(8):e1000145. Epub 2008 Aug 1.

Division of Nutritional Sciences, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475503PMC
August 2008

The polycomb repressive complex 2 is a potential target of SUMO modifications.

PLoS One 2008 Jul 16;3(7):e2704. Epub 2008 Jul 16.

Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002704PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442188PMC
July 2008

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

Genes Dev 2008 May;22(10):1345-55

Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1101/gad.470008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377189PMC
May 2008

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Nature 2007 Oct 22;449(7163):731-4. Epub 2007 Aug 22.

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nature06145DOI Listing
October 2007

The polycomb group protein Suz12 is required for embryonic stem cell differentiation.

Mol Cell Biol 2007 May 5;27(10):3769-79. Epub 2007 Mar 5.

Centre for Epigenetics and BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1128/MCB.01432-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899991PMC
May 2007

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

Genes Dev 2006 May 17;20(9):1123-36. Epub 2006 Apr 17.

Biotech Research and Innovation Centre (BRIC), 2100 Copenhagen Ø, Denmark.

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http://www.genesdev.org/cgi/doi/10.1101/gad.381706
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http://dx.doi.org/10.1101/gad.381706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472472PMC
May 2006

Polycomb group proteins in cell cycle progression and cancer.

Cell Cycle 2004 Apr 1;3(4):396-400. Epub 2004 Apr 1.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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April 2004

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

EMBO J 2003 Oct;22(20):5323-35

European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://emboj.embopress.org/cgi/doi/10.1093/emboj/cdg542
Publisher Site
http://dx.doi.org/10.1093/emboj/cdg542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC213796PMC
October 2003