Publications by authors named "Dieder Moechars"

38Publications

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils.

Authors:
Lien Veys Jessie Van Houcke Jeroen Aerts Sophie Van Pottelberge Michel Mahieu Audrey Coens Ronald Melki Dieder Moechars Louis De Muynck Lies De Groef

Front Aging Neurosci 2020 15;12:614587. Epub 2021 Jan 15.

Laboratory Neural Circuit Development and Regeneration, Department of Biology, KU Leuven, Leuven, Belgium.

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January 2021

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Authors:
Daniel Oehlrich Aldo Peschiulli Gary Tresadern Michiel Van Gool Juan Antonio Vega Ana Isabel De Lucas Sergio A Alonso de Diego Hana Prokopcova Nigel Austin Sven Van Brandt Michel Surkyn Michel De Cleyn Ann Vos Frederik J R Rombouts Gregor Macdonald Dieder Moechars Harrie J M Gijsen Andrés A Trabanco

ACS Med Chem Lett 2019 Aug 2;10(8):1159-1165. Epub 2019 Jul 2.

Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.

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August 2019

BACE2 distribution in major brain cell types and identification of novel substrates.

Authors:
Iryna Voytyuk Stephan A Mueller Julia Herber An Snellinx Dieder Moechars Geert van Loo Stefan F Lichtenthaler Bart De Strooper

Life Sci Alliance 2018 Jan 15;1(1):e201800026. Epub 2018 Feb 15.

Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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January 2018

Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice.

Authors:
Stijn Stroobants Nathalie G G Van Acker Frans W Verheijen Ilse Goris Guy F T Daneels Rachel Schot Elly Verbeek Michiel W M Knaapen An De Bondt Hinrich W Göhlmann Marion L A Crauwels Grazia M S Mancini Luc J Andries Dieder W E Moechars Rudi D'Hooge

Exp Neurol 2017 05 9;291:106-119. Epub 2017 Feb 9.

Laboratory of Biological Psychology, KU Leuven, Belgium.

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May 2017

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.

Authors:
Maarten Timmers Soraia Barão Bianca Van Broeck Ina Tesseur John Slemmon Katja De Waepenaert Jennifer Bogert Leslie M Shaw Sebastiaan Engelborghs Dieder Moechars Marc Mercken Luc Van Nueten Luc Tritsmans Bart de Strooper Johannes Rolf Streffer

J Alzheimers Dis 2017 ;56(4):1437-1449

Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.

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February 2018

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.

Authors:
Nicolas Malmanche Pierre Dourlen Marc Gistelinck Florie Demiautte Nichole Link Cloé Dupont Lies Vanden Broeck Elisabeth Werkmeister Philippe Amouyel Antonino Bongiovanni Hélène Bauderlique Dieder Moechars Anne Royou Hugo J Bellen Frank Lafont Patrick Callaerts Jean-Charles Lambert Bart Dermaut

Sci Rep 2017 01 23;7:40764. Epub 2017 Jan 23.

Inserm UMR1167, Laboratoire d'Excellence Distalz, Lille, F59000, France.

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January 2017

Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.

Authors:
Frederik J R Rombouts José-Ignacio Andrés Manuela Ariza José Manuel Alonso Nigel Austin Astrid Bottelbergs Lu Chen Vladimir Chupakhin Erna Cleiren Katleen Fierens Alberto Fontana Xavier Langlois Joseph E Leenaerts Jonas Mariën Carolina Martínez Lamenca Rhys Salter Mark E Schmidt Paula Te Riele Cindy Wintmolders Andrés A Trabanco Wei Zhang Gregor Macdonald Dieder Moechars

J Med Chem 2017 02 10;60(4):1272-1291. Epub 2017 Feb 10.

Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.

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February 2017

Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.

Authors:
Maarten Timmers Bianca Van Broeck Steven Ramael John Slemmon Katja De Waepenaert Alberto Russu Jennifer Bogert Hans Stieltjes Leslie M Shaw Sebastiaan Engelborghs Dieder Moechars Marc Mercken Enchi Liu Vikash Sinha John Kemp Luc Van Nueten Luc Tritsmans Johannes Rolf Streffer

Alzheimers Dement (N Y) 2016 Sep 24;2(3):202-212. Epub 2016 Aug 24.

Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium.

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September 2016

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

Authors:
Frederik J R Rombouts Gary Tresadern Oscar Delgado Carolina Martínez-Lamenca Michiel Van Gool Aránzazu García-Molina Sergio A Alonso de Diego Daniel Oehlrich Hana Prokopcova José Manuel Alonso Nigel Austin Herman Borghys Sven Van Brandt Michel Surkyn Michel De Cleyn Ann Vos Richard Alexander Gregor Macdonald Dieder Moechars Harrie Gijsen Andrés A Trabanco

J Med Chem 2015 Oct 10;58(20):8216-35. Epub 2015 Oct 10.

Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.

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October 2015

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future.

Authors:
Manuela Ariza Hartmuth C Kolb Dieder Moechars Frederik Rombouts José Ignacio Andrés

J Med Chem 2015 Jun 25;58(11):4365-82. Epub 2015 Feb 25.

∥Discovery Sciences, Janssen Research and Development, a Division of Janssen-Cilag, Jarama 75, 45007 Toledo, Spain.

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June 2015

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.

Authors:
Peter Borghgraef Clément Menuet Clara Theunis Justin V Louis Herman Devijver Hervé Maurin Caroline Smet-Nocca Guy Lippens Gerard Hilaire Harrie Gijsen Dieder Moechars Fred Van Leuven

PLoS One 2013 23;8(12):e84442. Epub 2013 Dec 23.

Experimental Genetics Group - LEGTEGG, KULeuven, Leuven, Belgium.

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October 2014

Inositol-related gene knockouts mimic lithium's effect on mitochondrial function.

Authors:
Lilach Toker Yuly Bersudsky Inbar Plaschkes Vered Chalifa-Caspi Gerard T Berry Roberto Buccafusca Dieder Moechars R H Belmaker Galila Agam

Neuropsychopharmacology 2014 Jan 8;39(2):319-28. Epub 2013 Aug 8.

1] Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel [2] Psychiatry Research Unit, Ben-Gurion University of the Negev, Beer-Sheva, Israel [3] Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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January 2014

Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.

Authors:
Jeanelle Portelli Leen Thielemans Luc Ver Donck Ellen Loyens Jessica Coppens Najat Aourz Jeroen Aerssens Katia Vermoesen Ralph Clinckers Anneleen Schallier Yvette Michotte Dieder Moechars Graham L Collingridge Zuner A Bortolotto Ilse Smolders

Neurotherapeutics 2012 Jul;9(3):658-72

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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July 2012

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.

Authors:
Gary Tresadern Francisca Delgado Oscar Delgado Harrie Gijsen Gregor J Macdonald Dieder Moechars Frederik Rombouts Richard Alexander John Spurlino Michiel Van Gool Juan Antonio Vega Andrés A Trabanco

Bioorg Med Chem Lett 2011 Dec 20;21(24):7255-60. Epub 2011 Oct 20.

Research Informatics & Integrative Genomics, Calle Jarama 75, Poligono Industrial, Toledo 45007, Spain.

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December 2011

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.

Authors:
Seon-Ah Chong Iryna Benilova Hamdy Shaban Bart De Strooper Herman Devijver Dieder Moechars Wolfgang Eberle Carmen Bartic Fred Van Leuven Geert Callewaert

Neurobiol Dis 2011 Dec 18;44(3):284-91. Epub 2011 Jul 18.

Bio-Electronic Systems, Imec, Kapeldreef 75, Leuven, Belgium.

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December 2011

Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.

Authors:
Elizabeth M McNeill Mariana Klöckner-Bormann Elizabeth C Roesler Lynn E Talton Dieder Moechars Margaret Clagett-Dame

Dev Biol 2011 May 16;353(2):331-43. Epub 2011 Mar 16.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin, Madison, WI 53706-1544, USA.

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May 2011

Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain.

Authors:
Sofie Celen Michel Koole Meri De Angelis Ivan Sannen Satish K Chitneni Jesus Alcazar Stefanie Dedeurwaerdere Dieder Moechars Mark Schmidt Alfons Verbruggen Xavier Langlois Koen Van Laere José Ignacio Andrés Guy Bormans

J Nucl Med 2010 Oct 16;51(10):1584-91. Epub 2010 Sep 16.

Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K.U. Leuven, Leuven, Belgium.

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October 2010

Nav2 is necessary for cranial nerve development and blood pressure regulation.

Authors:
Elizabeth M McNeill Kenneth P Roos Dieder Moechars Margaret Clagett-Dame

Neural Dev 2010 Feb 25;5. Epub 2010 Feb 25.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin, Madison, WI, USA.

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February 2010

Demonstration of vesicular glutamate transporter-1 in corticotroph cells in the anterior pituitary of the rat.

Authors:
Zsuzsa S Kocsis Csilla S Molnár Masahiko Watanabe Guy Daneels Dieder Moechars Zsolt Liposits Erik Hrabovszky

Neurochem Int 2010 Feb 16;56(3):479-86. Epub 2009 Dec 16.

Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary.

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February 2010

In vivo evidence for ligand-specific receptor activation in the central CRF system, as measured by local cerebral glucose utilization.

Authors:
Geoff Warnock Dieder Moechars Xavier Langlois Thomas Steckler

Peptides 2009 May 22;30(5):947-54. Epub 2009 Jan 22.

Dept. Psychiatry, RED Europe, Johnson & Johnson PRD, Beerse, Belgium.

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May 2009