Publications by authors named "Didier Picard"

75Publications

Implementation of liquid chromatography-high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial.

Anal Chim Acta 2020 Apr 2;1105:28-44. Epub 2020 Jan 2.

Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2019.12.062DOI Listing
April 2020

Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling.

Nat Commun 2019 04 23;10(1):1833. Epub 2019 Apr 23.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211, Genève, Switzerland.

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http://dx.doi.org/10.1038/s41467-019-09800-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478910PMC
April 2019

A scoring approach for multi-platform acquisition in metabolomics.

J Chromatogr A 2019 May 10;1592:47-54. Epub 2019 Jan 10.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CMU - Rue Michel Servet 1, 1211 Geneva, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.01.023DOI Listing
May 2019

ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1.

Life Sci Alliance 2018 Jun 7;1(3):e201800055. Epub 2018 Jun 7.

Département de Biologie Cellulaire and Institute of Genetics and Genomics of Geneva, Université de Genève, Genève, Switzerland.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238530PMC
June 2018

Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes.

Sci Rep 2018 02 12;8(1):2801. Epub 2018 Feb 12.

Département de Biologie Cellulaire, Université de Genève, 30 Quai Ernest-Ansermet, Sciences III, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1038/s41598-018-21210-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809404PMC
February 2018

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.

Cell Stress Chaperones 2018 07 1;23(4):467-482. Epub 2018 Feb 1.

Département de Biologie Cellulaire, Université de Genève, 1211, Geneva 4, Switzerland.

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http://dx.doi.org/10.1007/s12192-018-0877-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045531PMC
July 2018

Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry.

PLoS One 2017 8;12(12):e0189403. Epub 2017 Dec 8.

Département de Biologie Cellulaire, Université de Genève, Sciences III, Genève, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189403PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722324PMC
January 2018

Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23.

PLoS One 2017 26;12(6):e0180035. Epub 2017 Jun 26.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, Genève 4, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484504PMC
September 2017

H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

Transcription 2017 03 8;8(2):126-132. Epub 2017 Feb 8.

a Département de Biologie Cellulaire , Université de Genève , Genève , Switzerland.

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http://dx.doi.org/10.1080/21541264.2017.1285852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423472PMC
March 2017

Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers.

Mol Cell 2016 10 29;64(2):334-346. Epub 2016 Sep 29.

Département de Biologie Cellulaire, Université de Genève, 1211 Genève 4, Switzerland; Institute of Genetics and Genomics of Geneva, Université de Genève, 1211 Genève 4, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.08.034DOI Listing
October 2016

LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP.

Nucleic Acids Res 2016 Oct 20;44(18):8655-8670. Epub 2016 Jun 20.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland

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http://dx.doi.org/10.1093/nar/gkw522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062963PMC
October 2016

Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.

J Med Chem 2016 07 28;59(13):6344-52. Epub 2016 Jun 28.

Département de Biologie Cellulaire, Université de Genève , Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00591DOI Listing
July 2016

Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis.

Adv Cancer Res 2016 23;129:1-30. Epub 2015 Oct 23.

Département de Biologie Cellulaire, Université de Genève, Sciences III, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2015.08.001DOI Listing
September 2016

A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation.

Mol Cell Biol 2016 Apr 31;36(8):1310-21. Epub 2016 Mar 31.

Département de Biologie Cellulaire, Université de Genève, Sciences III, Geneva, Switzerland

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http://dx.doi.org/10.1128/MCB.01099-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836269PMC
April 2016

Minireview: Tipping the balance: ligand-independent activation of steroid receptors.

Mol Endocrinol 2015 Mar 27;29(3):349-63. Epub 2015 Jan 27.

Département de Biologie Cellulaire, Université de Genève, Sciences III, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1210/me.2014-1315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414756PMC
March 2015

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells.

Trends Cell Biol 2014 Aug 11;24(8):455-63. Epub 2014 Apr 11.

Department of Cell Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.tcb.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670877PMC
August 2014

Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.

J Med Chem 2014 Mar 3;57(6):2524-35. Epub 2014 Mar 3.

Department of Cell Biology, University of Geneva , and ‡Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences of the Universities of Geneva and Lausanne , 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1021/jm401801tDOI Listing
March 2014

Preface to Hsp90.

Authors:
Didier Picard

Biochim Biophys Acta 2012 Mar;1823(3):605-6

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http://dx.doi.org/10.1016/j.bbamcr.2012.02.004DOI Listing
March 2012

Multidirectional interplay between nuclear receptors and microRNAs.

Curr Opin Pharmacol 2010 Dec 7;10(6):637-42. Epub 2010 Sep 7.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.coph.2010.08.009DOI Listing
December 2010

CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP.

Genes Dev 2010 Apr;24(7):708-19

Département de Biologie Cellulaire, Université de Genève, Sciences III, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1101/gad.568410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849127PMC
April 2010

Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility.

Biochim Biophys Acta 2010 Jun 16;1803(6):641-9. Epub 2009 Dec 16.

Département de Biologie Cellulaire, Université de Genève, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.bbamcr.2009.11.012DOI Listing
June 2010

The unfolding stories of GPR30, a new membrane-bound estrogen receptor.

J Endocrinol 2010 Feb 18;204(2):105-14. Epub 2009 Sep 18.

Department of Pharmaco-Biology, University of Calabria, 87030 Rende, Italy.

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https://joe.bioscientifica.com/view/journals/joe/204/2/105.x
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http://dx.doi.org/10.1677/JOE-09-0242DOI Listing
February 2010

miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA.

Mol Cell Biol 2009 Jul 4;29(13):3783-90. Epub 2009 May 4.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1128/MCB.01875-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698751PMC
July 2009

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.

Mol Biochem Parasitol 2009 Apr;164(2):147-52

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.molbiopara.2008.12.011DOI Listing
April 2009

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF.

EMBO J 2009 Mar 15;28(5):523-32. Epub 2009 Jan 15.

Département de Biologie Cellulaire, Sciences III, Université de Genève, Genève, Switzerland.

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http://dx.doi.org/10.1038/emboj.2008.304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657575PMC
March 2009

A stress protein interface of innate immunity.

Authors:
Didier Picard

EMBO Rep 2008 Dec 14;9(12):1193-5. Epub 2008 Nov 14.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1038/embor.2008.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603461PMC
December 2008

Genomics of signaling crosstalk of estrogen receptor alpha in breast cancer cells.

PLoS One 2008 Mar 26;3(3):e1859. Epub 2008 Mar 26.

Département de Biologie Cellulaire, Université de Genève, Genève, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001859PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268000PMC
March 2008

p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity.

Mol Cell Biol 2008 May 24;28(10):3446-56. Epub 2008 Mar 24.

Département de Biologie Cellulaire, Université de Genève, Sciences III, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1128/MCB.02246-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423160PMC
May 2008

The glucocorticoid responses are shaped by molecular chaperones.

Mol Cell Endocrinol 2007 Sep 2;275(1-2):2-12. Epub 2007 Jun 2.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.mce.2007.05.018DOI Listing
September 2007

Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.

Dig Dis Sci 2007 Aug 3;52(8):1924-33. Epub 2007 Apr 3.

Centre Médico-Chirurgical Rond-Point-Plainpalais et Département de biologie cellulaire, Unité de recherche des maladies prédisposant aux cancers gastro-intestinaux, Université de Genève, Genève, Switzerland.

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http://dx.doi.org/10.1007/s10620-006-9435-3DOI Listing
August 2007

2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex.

Exp Cell Res 2006 Nov 3;312(19):3949-58. Epub 2006 Sep 3.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.yexcr.2006.08.026DOI Listing
November 2006

The Hsp90 cochaperone p23 is essential for perinatal survival.

Mol Cell Biol 2006 Dec 25;26(23):8976-83. Epub 2006 Sep 25.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1128/MCB.00734-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636834PMC
December 2006

Chaperoning steroid hormone action.

Authors:
Didier Picard

Trends Endocrinol Metab 2006 Aug 27;17(6):229-35. Epub 2006 Jun 27.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, CH 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.tem.2006.06.003DOI Listing
August 2006

Fungi and animals may share a common ancestor to nuclear receptors.

Proc Natl Acad Sci U S A 2006 May 24;103(18):7077-81. Epub 2006 Apr 24.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1073/pnas.0510080103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459020PMC
May 2006

The cell-specific activity of the estrogen receptor alpha may be fine-tuned by phosphorylation-induced structural gymnastics.

Nucl Recept Signal 2006 8;4:e005. Epub 2006 Feb 8.

Department of Cell Biology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1621/nrs.04005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402211PMC
May 2006

Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90.

Authors:
Didier Picard

Exp Cell Res 2006 Jan 11;312(2):198-204. Epub 2005 Nov 11.

European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2005.10.009DOI Listing
January 2006

The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

Mol Endocrinol 2006 Mar 20;20(3):631-46. Epub 2005 Oct 20.

Department of Pharmaco-Biology, University of Calabria, 87030 Rende (CS), Italy.

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http://dx.doi.org/10.1210/me.2005-0280DOI Listing
March 2006

A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha.

Biochem Biophys Res Commun 2005 Nov;337(1):133-7

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.bbrc.2005.09.025DOI Listing
November 2005

Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices.

Chemosphere 2005 Oct;61(2):259-66

Department of Biochemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1016/j.chemosphere.2005.01.080DOI Listing
October 2005

SPBP is a phosphoserine-specific repressor of estrogen receptor alpha.

Mol Cell Biol 2005 May;25(9):3421-30

Department of Cell Biology, Sciences III, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva 4, Switzerland.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.9.3421-3430.2005
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http://dx.doi.org/10.1128/MCB.25.9.3421-3430.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084313PMC
May 2005

TROD: T7 RNAi Oligo Designer.

Nucleic Acids Res 2004 Jul;32(Web Server issue):W121-3

Département de Biologie Cellulaire, Université de Genève, Sciences III, Quai Ernest-Ansermet 30, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1093/nar/gkh360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC441498PMC
July 2004

A web application to manage a database for liquid nitrogen tanks.

Immunol Cell Biol 2004 Jun;82(3):257-9

VisibilityWeb, 61, Chemin des Voirets, CH-1228 Plan-les-Ouates, Switzerland.

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http://doi.wiley.com/10.1046/j.1440-1711.2004.01232.x
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http://dx.doi.org/10.1046/j.1440-1711.2004.01232.xDOI Listing
June 2004

Hsp90 invades the outside.

Authors:
Didier Picard

Nat Cell Biol 2004 Jun;6(6):479-80

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http://dx.doi.org/10.1038/ncb0604-479DOI Listing
June 2004

The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.

EMBO J 2004 Feb 29;23(3):564-71. Epub 2004 Jan 29.

Département de Biologie Cellulaire, Université de Genève, Sciences III, Genève, Switzerland.

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http://dx.doi.org/10.1038/sj.emboj.7600078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271809PMC
February 2004

Cdc37 goes beyond Hsp90 and kinases.

Cell Stress Chaperones 2003 ;8(2):114-9

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514862PMC
http://dx.doi.org/10.1379/1466-1268(2003)008<0114:cgbhak>2.0.co;2DOI Listing
March 2004

The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.

Biol Chem 2002 Sep;383(9):1335-42

Département de Biologie Cellulaire, Université de Genève, Switzerland.

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http://dx.doi.org/10.1515/BC.2002.152DOI Listing
September 2002

Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells.

Mol Cell Endocrinol 2002 Jul;193(1-2):13-8

Department of Pharmaco-Biology, Facoltà di Farmacia, University of Calabria, I-87036 Rende, CS, Italy.

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http://dx.doi.org/10.1016/s0303-7207(02)00091-6DOI Listing
July 2002

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase.

Nucleic Acids Res 2002 May;30(10):e46

Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC115300PMC
http://dx.doi.org/10.1093/nar/30.10.e46DOI Listing
May 2002