Didier Mazel

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Didier Mazel

Publications by authors named "Didier Mazel"

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75Publications

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Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation.

Biotechnol Bioeng 2018 Jan 16;115(1):184-191. Epub 2017 Oct 16.

Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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January 2018

Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality.

Nucleic Acids Res 2017 Oct;45(18):10555-10563

B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, Arnoldstraße 18, 01307 Dresden, Germany.

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October 2017

Genomic Plasticity of Vibrio cholerae.

Int Microbiol 2017 Sep;20(3):138-148

Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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September 2017

An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.

BMC Biotechnol 2017 Jul 14;17(1):62. Epub 2017 Jul 14.

Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Institut Pasteur, 75015, Paris, France.

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July 2017

The Proximity of Ribosomal Protein Genes to Enhances Fitness in the Absence of Multifork Replication.

MBio 2017 02 28;8(1). Epub 2017 Feb 28.

Département Génomes et Génétique, Institut Pasteur, Unité Plasticité du Génome Bactérien, Paris, France

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February 2017

Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria.

Nat Ecol Evol 2016 Nov 7;1(1):10. Epub 2016 Nov 7.

Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.

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November 2016

Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites.

Nucleic Acids Res 2016 09 5;44(16):7792-803. Epub 2016 Aug 5.

Institut Pasteur, Bacterial Genome Plasticity Unit, 75724 Paris, France CNRS UMR3525, 75724 Paris, France.

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September 2016

A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.

Sci Adv 2016 Apr 22;2(4):e1501914. Epub 2016 Apr 22.

Bacterial Genome Plasticity, Department of Genomes and Genetics, Institut Pasteur, Paris 75015, France.; CNRS UMR 3525, Paris 75015, France.

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April 2016

The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae.

PLoS One 2014 10;9(3):e91194. Epub 2014 Mar 10.

Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France; CNRS, UMR 3525, Paris, France.

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March 2016

Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.

Nat Commun 2016 Mar 10;7:10937. Epub 2016 Mar 10.

Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, 28 Rue du Dr Roux, 75015 Paris, France.

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March 2016

A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters.

Environ Microbiol 2015 Nov 27;17(11):4189-99. Epub 2015 Jan 27.

Ifremer, Unité Physiologie Fonctionnelle des Organismes Marins, ZI de la Pointe du Diable, CS 10070, F-29280, Plouzané, France.

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November 2015

Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron.

J Bacteriol 2015 Jul 20;197(13):2150-9. Epub 2015 Apr 20.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France CNRS, UMR3525, Paris, France

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July 2015

Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity.

PLoS Genet 2015 Apr 13;11(4):e1005156. Epub 2015 Apr 13.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France; Centre National de la Recherche Scientifique UMR3525, Paris, France.

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April 2015

Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.

Res Microbiol 2014 Jul-Aug;165(6):476-80. Epub 2014 Jun 16.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, 25 rue du docteur Roux, 75015 Paris, France; CNRS, UMR3525, Paris, France.

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March 2015

Management of multipartite genomes: the Vibrio cholerae model.

Curr Opin Microbiol 2014 Dec;22:120-6

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France

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December 2014

VIBRIO 2014 meeting report.

Res Microbiol 2014 Dec 22;165(10):857-64. Epub 2014 Oct 22.

Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, UK.

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December 2014

SOS, the formidable strategy of bacteria against aggressions.

FEMS Microbiol Rev 2014 Nov 30;38(6):1126-45. Epub 2014 Jun 30.

Institut Pasteur, Département Génomes et Génétique, Unité Plasticité du Génome Bactérien, Paris, France; CNRS, UMR3525, Paris, France.

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November 2014

Shuffling of DNA cassettes in a synthetic integron.

Methods Mol Biol 2013 ;1073:169-74

Bacterial Genome Plasticity Unit, Institut Pasteur, Paris, France.

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March 2014

Fuse or die: how to survive the loss of Dam in Vibrio cholerae.

Mol Microbiol 2014 Feb 7;91(4):665-78. Epub 2014 Jan 7.

Department of Genomes and Genetics, Institut Pasteur, F-75015, Paris, France; CNRS, UMR3525, F-75015, Paris, France.

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February 2014

Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.

Nucleic Acids Res 2014 Feb 6;42(4):2366-79. Epub 2013 Dec 6.

Département Génomes et Génétique, Unité Plasticité du Génome Bactérien, Institut Pasteur, 75015 Paris, France and Centre National de la Recherche Scientifique, CNRS, UMR3525 Paris, France.

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February 2014

RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae.

PLoS Genet 2013 11;9(4):e1003421. Epub 2013 Apr 11.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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July 2013

Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance.

Antibiotics (Basel) 2013 May 30;2(2):288-315. Epub 2013 May 30.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Paris 75015, France.

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May 2013

Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons.

J Bacteriol 2013 May 8;195(10):2270-83. Epub 2013 Mar 8.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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May 2013

Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.

PLoS Pathog 2012 14;8(6):e1002778. Epub 2012 Jun 14.

Department of Immunology, Medicine and Microbiology, University of Washington, Seattle, Washington, United States of America.

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November 2012

Antibiotics as physiological stress inducers and bacterial response to the challenge.

Curr Opin Microbiol 2012 Oct 9;15(5):553-4. Epub 2012 Oct 9.

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October 2012

Replicative resolution of integron cassette insertion.

Nucleic Acids Res 2012 Sep 26;40(17):8361-70. Epub 2012 Jun 26.

Institut Pasteur, Unité Plasticité du Génome Bactérien, CNRS UMR3525, Paris 75724, France.

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September 2012

Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase.

J Bacteriol 2012 Apr 27;194(7):1659-67. Epub 2012 Jan 27.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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April 2012

Genome engineering in Vibrio cholerae: a feasible approach to address biological issues.

PLoS Genet 2012 Jan 12;8(1):e1002472. Epub 2012 Jan 12.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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January 2012

High-level gene cassette transcription prevents integrase expression in class 1 integrons.

J Bacteriol 2011 Oct 19;193(20):5675-82. Epub 2011 Aug 19.

INSERM, Équipe Avenir, Limoges, France.

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October 2011

Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.

Antimicrob Agents Chemother 2011 May 7;55(5):2438-41. Epub 2011 Feb 7.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, 25 rue du Dr. Roux, F-75015 Paris, France.

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May 2011

Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids.

Environ Microbiol 2011 Feb 6;13(2):296-306. Epub 2010 Sep 6.

Laboratoire de Génétique et Pathologie, IFREMER, 3790 La Tremblade, France.

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February 2011

Integrons.

Annu Rev Genet 2010 ;44:141-66

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, F-75015 Paris, France.

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January 2011

Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation.

PLoS Genet 2010 Oct 21;6(10):e1001165. Epub 2010 Oct 21.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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October 2010

Folded DNA in action: hairpin formation and biological functions in prokaryotes.

Microbiol Mol Biol Rev 2010 Dec;74(4):570-88

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, F-75015 Paris, France.

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December 2010

Vibrio aestuarianus zinc metalloprotease causes lethality in the Pacific oyster Crassostrea gigas and impairs the host cellular immune defenses.

Fish Shellfish Immunol 2010 Nov 17;29(5):753-8. Epub 2010 Jul 17.

UMR 100 IFREMER Physiologie et Ecophysiologie des Mollusques Marins, Centre de Brest, B.P. 70, 29280 Plouzané, France.

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November 2010

Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation.

PLoS Genet 2010 Oct 21;6(10):e1001165. Epub 2010 Oct 21.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.

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October 2010

The synthetic integron: an in vivo genetic shuffling device.

Nucleic Acids Res 2010 Aug 9;38(15):e153. Epub 2010 Jun 9.

Institut Pasteur, Département Génomes et Génétique, Paris, France.

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August 2010

Cellular pathways controlling integron cassette site folding.

EMBO J 2010 Aug 13;29(15):2623-34. Epub 2010 Jul 13.

Institut Pasteur, Unité Plasticité du Génome Bactérien, Paris, France.

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August 2010

An end-joining repair mechanism in Escherichia coli.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):2141-6. Epub 2010 Jan 19.

Departement d'Immunologie, Unité de Génétique Moléculaire des Levures, Institut Pasteur, 75015 Paris, France.

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February 2010

The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity.

Nucleic Acids Res 2010 Jan 13;38(2):559-69. Epub 2009 Nov 13.

Institut Pasteur, Unité Plasticité du Génome Bactérien, CNRS URA 2171, 25 rue du Dr Roux, 75724 Paris, France.

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January 2010

Inverse correlation between promoter strength and excision activity in class 1 integrons.

PLoS Genet 2010 Jan 8;6(1):e1000793. Epub 2010 Jan 8.

Université de Limoges, Faculté de Médecine, EA3175, Limoges, France.

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January 2010

Structural features of single-stranded integron cassette attC sites and their role in strand selection.

PLoS Genet 2009 Sep 4;5(9):e1000632. Epub 2009 Sep 4.

Institut Pasteur, Unité Plasticité du Génome Bactérien, CNRS URA 2171, Paris, France.

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September 2009

Translation regulation of integrons gene cassette expression by the attC sites.

Mol Microbiol 2009 Jun 26;72(6):1475-86. Epub 2009 May 26.

Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Service de Bactériologie-Virologie, Université Paris VII, 2 rue Ambroise Paré, 75010 Paris, France.

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June 2009

The SOS response controls integron recombination.

Science 2009 May;324(5930):1034

Université de Limoges, Faculté de Médecine, EA3175, INSERM, Equipe Avenir, 87000 Limoges, France.

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May 2009

Construction of an improved RP4 (RK2)-based conjugative system.

Res Microbiol 2008 Sep-Oct;159(7-8):545-9. Epub 2008 Jun 27.

Institut Pasteur, Unité Plasticité du Génome Bactérien, CNRS URA 2171, 25 rue du Dr Roux, 75724 Paris, France.

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December 2008

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus.

Appl Environ Microbiol 2008 Dec 3;74(23):7108-17. Epub 2008 Oct 3.

Institut Pasteur, Unité Plasticité du Génome Bactérien, CNRS URA 2171, Paris, France.

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December 2008

Synonymous genes explore different evolutionary landscapes.

PLoS Genet 2008 Nov 14;4(11):e1000256. Epub 2008 Nov 14.

Unité Plasticité du Génome Bactérien, Institut Pasteur, CNRS URA 2171, Paris, France.

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November 2008

Correlation between detection of a plasmid and high-level virulence of Vibrio nigripulchritudo, a pathogen of the shrimp Litopenaeus stylirostris.

Appl Environ Microbiol 2008 May 21;74(10):3038-47. Epub 2008 Mar 21.

Laboratoire de Génétique et Pathologie, Ifremer, 17390 La Tremblade, France.

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May 2008

Identification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency.

Nucleic Acids Res 2007 20;35(19):6475-89. Epub 2007 Sep 20.

Unité Plasticité du Génome Bactérien, CNRS URA 2171 and Laboratoire de Biochimie et Biophysique des Macromolécules, CNRS URA 2185, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris 75724, France.

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December 2007

Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7.

J Bacteriol 2007 Apr 26;189(7):2712-9. Epub 2007 Jan 26.

Laboratoire de Génétique des Procaryotes, Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, 12 Rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium.

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April 2007

Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection.

Mol Microbiol 2007 Mar;63(6):1588-605

Division of Clinical Integrative Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, S1-26A, Toronto, Ontario, M4N 3N5, Canada.

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March 2007

Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7.

J Bacteriol 2007 Apr 26;189(7):2712-9. Epub 2007 Jan 26.

Laboratoire de Génétique des Procaryotes, Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, 12 Rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium.

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April 2007

Integrons: agents of bacterial evolution.

Authors:
Didier Mazel

Nat Rev Microbiol 2006 Aug;4(8):608-20

Unité Plasticité du Génome Bactérien- CNRS URA 2171, Department Génomes et Génétique, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France.

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August 2006

Structural basis for broad DNA-specificity in integron recombination.

Nature 2006 Apr;440(7088):1157-62

Laboratoire de Biochimie et Biophysique des Macromolécules, Département de Biologie Structurale et Chimie, CNRS URA 2171, Institut Pasteur, 75724 Paris Cedex 15, France.

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April 2006

Integron cassette insertion: a recombination process involving a folded single strand substrate.

EMBO J 2005 Dec 8;24(24):4356-67. Epub 2005 Dec 8.

Unité Postulante Plasticité du Génome Bactérien, CNRS URA 2171, Institut Pasteur, Paris, France.

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December 2005

The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.

Mol Cell 2005 Aug;19(4):559-66

Centre de Génétique Moléculaire, CNRS UPR2167, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France.

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August 2005

Comparative study of class 1 integron and Vibrio cholerae superintegron integrase activities.

J Bacteriol 2005 Mar;187(5):1740-50

Unité Postulante Plasticité du Génome Bactérien, CNRS URA 2171, Département Structure et Dynamique des Génomes, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, France.

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March 2005

A new family of conditional replicating plasmids and their cognate Escherichia coli host strains.

Res Microbiol 2004 Jul-Aug;155(6):455-61

Unité Postulante Plasticité du Génome Bactérien, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, France.

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November 2004

Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron.

Antimicrob Agents Chemother 2003 Oct;47(10):3326-31

Unité de Programmation Moléculaire et Toxicologie Génétique, CNRS URA 1444, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 75724, Paris, France.

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October 2003

Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae.

Genome Res 2003 Mar;13(3):428-42

Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 75724 Paris, France.

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March 2003

The role of integrons in antibiotic resistance gene capture.

Int J Med Microbiol 2002 Jul;292(2):115-25

Department of Microbiology, Division of Clinical Integrative Biology, Sunnybrook and Women's College Hospital Health Sciences Centre Research Institute, Toronto, Canada.

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July 2002

Bacterial resistance evolution by recruitment of super-integron gene cassettes.

Mol Microbiol 2002 Mar;43(6):1657-69

Unité de Programmation Moléculaire et Toxicologie Génétique, CNRS URA 1444, Département des Biotechnologies, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France.

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March 2002

A multigene family in Calothrix sp. PCC 7601 encodes phycocyanin, the major component of the cyanobacterial light-harvesting antenna

Mol Gen Genet 1988 02;211(2):296-304

Unité de Physiologie Microbienne, CNRS UA 1129, Département de Biochimie et Génétique Moléculaire, Institut Pasteur, 28 rue du Dr Roux, F-75724, Paris Cedex 15, France

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February 1988