Didier Leroy

Didier Leroy

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Didier Leroy

Didier Leroy

Publications by authors named "Didier Leroy"

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Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay.

Malar J 2019 Dec 18;18(1):427. Epub 2019 Dec 18.

Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland.

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http://dx.doi.org/10.1186/s12936-019-3056-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918666PMC
December 2019

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum.

Int J Parasitol Drugs Drug Resist 2019 04 22;9:93-99. Epub 2019 Feb 22.

Department of Immunology & Infection, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK; Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market Centre, Capper Street, London, WC1E 6JB, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22113207183018
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http://dx.doi.org/10.1016/j.ijpddr.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403410PMC
April 2019

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.

Nat Med 2017 Aug;23(8):917-928

Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747363PMC
August 2017

How to tackle antimalarial resistance?

Authors:
Didier Leroy

EMBO Mol Med 2017 02;9(2):133-134

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.15252/emmm.201607295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286390PMC
February 2017

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.

Trends Parasitol 2016 09 18;32(9):669-681. Epub 2016 May 18.

Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2016.04.017DOI Listing
September 2016

Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila.

PLoS One 2016 7;11(3):e0150909. Epub 2016 Mar 7.

Center for Research on Intracellular Bacteria (CRIB), Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780729PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.

J Antimicrob Chemother 2016 May 16;71(5):1148-58. Epub 2016 Feb 16.

Dipartimento di Malattie Infettive, Parassitarie, Immunomediate, Istituto Superiore di Sanità, Rome, Italy

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http://dx.doi.org/10.1093/jac/dkv493DOI Listing
May 2016

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.

Cell Host Microbe 2016 Jan 31;19(1):114-26. Epub 2015 Dec 31.

Division of Pharmacology and Drug Discovery, Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723716PMC
January 2016

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Malar J 2015 May 22;14:213. Epub 2015 May 22.

Malaria Parasite Molecular Laboratory, Centre for Sustainable Malaria Control, Department of Biochemistry, University of Pretoria, Private Bag x20, Hatfield, Pretoria, 0028, South Africa.

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http://dx.doi.org/10.1186/s12936-015-0718-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449569PMC
May 2015

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.

Nat Commun 2015 Mar 24;6:6555. Epub 2015 Mar 24.

Rheumatology Laboratory, Centre Hospitalier Universitaire Vaudois, Ave Pierre Decker 4, 1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/ncomms7555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382995PMC
March 2015

Defining the biology component of the drug discovery strategy for malaria eradication.

Trends Parasitol 2014 Oct 15;30(10):478-90. Epub 2014 Aug 15.

Medicines for Malaria Venture (MMV), PO Box 1826, 20 route de Pré-Bois, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.1016/j.pt.2014.07.004DOI Listing
October 2014

Antimalarial drug discovery - the path towards eradication.

Parasitology 2014 Jan 17;141(1):128-39. Epub 2013 Jul 17.

Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois - PO Box 1826, 1215 Geneva 15, Switzerland.

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http://www.journals.cambridge.org/abstract_S0031182013000826
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http://dx.doi.org/10.1017/S0031182013000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884835PMC
January 2014

Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes.

J Parasitol Res 2012 15;2012:927148. Epub 2012 Mar 15.

Malaria Discovery Performance Unit, GlaxoSmithKline R&D, Tres Cantos Medicine Development Campus, C/Severo Ochoa No. 2, Tres Cantos, 28760 Madrid, Spain.

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http://dx.doi.org/10.1155/2012/927148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317192PMC
August 2012

The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies.

Malar J 2012 Mar 16;11:70. Epub 2012 Mar 16.

The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
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http://dx.doi.org/10.1186/1475-2875-11-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315749PMC
March 2012

Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?

Malar J 2012 Feb 6;11:34. Epub 2012 Feb 6.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston 4006, Queensland, Australia.

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http://dx.doi.org/10.1186/1475-2875-11-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293736PMC
February 2012

Challenges in antimalarial drug discovery.

Future Med Chem 2011 Sep;3(11):1401-12

Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.4155/fmc.11.91DOI Listing
September 2011

Finding new hits in neglected disease projects: target or phenotypic based screening?

Curr Top Med Chem 2011 ;11(10):1284-91

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, Sir James Black Centre, University of Dundee, UK.

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http://dx.doi.org/10.2174/156802611795429176DOI Listing
August 2011

Drugging the Plasmodium kinome: the benefits of academia-industry synergy.

Trends Pharmacol Sci 2008 May 18;29(5):241-9. Epub 2008 Apr 18.

Merck-Serono International S.A., Geneva Research Center, 9, Chemin des Mines, Case postale 54, CH-1211 Genève 20, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S016561470800070
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http://dx.doi.org/10.1016/j.tips.2008.02.005DOI Listing
May 2008

G protein-coupled receptor-mediated ERK1/2 phosphorylation: towards a generic sensor of GPCR activation.

J Recept Signal Transduct Res 2007 ;27(1):83-97

Department of Molecular Screening and Cellular Pharmacology, Serono Pharmaceutical Research Institute, CH-1228 Plan-les-Ouates, Geneva, Switzerland.

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http://www.tandfonline.com/doi/full/10.1080/1079989060111224
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http://dx.doi.org/10.1080/10799890601112244DOI Listing
May 2007

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha.

J Biol Chem 2004 Oct 28;279(43):44731-9. Epub 2004 Jul 28.

Serono Pharmaceutical Research Institute, Serono International S.A., Plan-les-Ouates 1228, Geneva CH1228, Switzerland.

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http://dx.doi.org/10.1074/jbc.M407669200DOI Listing
October 2004

Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha.

Nucleic Acids Res 2003 Oct;31(19):5714-22

Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, CH-1066 Epalinges s/Lausanne, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC206448PMC
http://dx.doi.org/10.1093/nar/gkg737DOI Listing
October 2003