Diane Nepomuceno

Diane Nepomuceno

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Diane Nepomuceno

Diane Nepomuceno

Publications by authors named "Diane Nepomuceno"

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36Publications

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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.

J Pharmacol Exp Ther 2015 Mar 12;352(3):590-601. Epub 2015 Jan 12.

Janssen Research & Development, LLC, San Diego, California (P.B., S.Y., B.T.S., T.P.L., D.N., B.L., M.W., J.S., N.C., T.L., C.D.); and Indiana University School of Medicine, Indianapolis, Indiana (P.L.J., A.S., S.D.F.).

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http://dx.doi.org/10.1124/jpet.114.220392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352589PMC
March 2015

The discovery of potent selective NPY Y(2) antagonists.

Bioorg Med Chem Lett 2013 Jul 22;23(14):4141-4. Epub 2013 May 22.

Janssen Research & Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.038DOI Listing
July 2013

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

Bioorg Med Chem Lett 2011 Sep 18;21(18):5552-6. Epub 2011 Jul 18.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.136DOI Listing
September 2011

Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.

Bioorg Med Chem Lett 2011 Jan 24;21(1):42-4. Epub 2010 Nov 24.

Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.078DOI Listing
January 2011

Indole- and benzothiophene-based histamine H3 antagonists.

Bioorg Med Chem Lett 2010 Nov 27;20(21):6226-30. Epub 2010 Aug 27.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121-1126, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.08.103DOI Listing
November 2010

2-Aryloxymethylmorpholine histamine H(3) antagonists.

Bioorg Med Chem Lett 2008 Nov 24;18(21):5796-9. Epub 2008 Sep 24.

Johnson & Johnson Pharmaceutical Research & Development L.L.C., San Diego, CA 92121-1126, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.09.077DOI Listing
November 2008

2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.

Bioorg Med Chem Lett 2008 Mar 30;18(6):2103-8. Epub 2008 Jan 30.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.090DOI Listing
March 2008

G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.

Neuroendocrinology 2005 13;82(3-4):139-50. Epub 2006 Jan 13.

Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1159/000091267DOI Listing
June 2006

A novel form of neurotensin post-translationally modified by arginylation.

J Biol Chem 2005 Oct 8;280(42):35089-97. Epub 2005 Aug 8.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M502567200DOI Listing
October 2005

Recent progress in relaxin-3-related research.

Ann N Y Acad Sci 2005 May;1041:47-60

Johnson & Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121.

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http://dx.doi.org/10.1196/annals.1282.009DOI Listing
May 2005

Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.

Neuroendocrinology 2004 26;80(5):298-307. Epub 2005 Jan 26.

Neuroscience Group, Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1159/000083656DOI Listing
April 2005

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.

Eur J Pharmacol 2005 Apr 20;513(3):181-92. Epub 2005 Apr 20.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.ejphar.2005.03.013DOI Listing
April 2005

Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species.

J Pharmacol Exp Ther 2005 Jan 14;312(1):83-95. Epub 2004 Sep 14.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1124/jpet.104.073486DOI Listing
January 2005

INSL5 is a high affinity specific agonist for GPCR142 (GPR100).

J Biol Chem 2005 Jan 2;280(1):292-300. Epub 2004 Nov 2.

Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, USA.

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http://dx.doi.org/10.1074/jbc.M409916200DOI Listing
January 2005

Novel non-peptidic neuropeptide Y Y2 receptor antagonists.

Bioorg Med Chem Lett 2004 Mar;14(5):1239-42

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2003.12.057DOI Listing
March 2004