Publications by authors named "Diane Mathis"

100Publications

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.

Cell 2020 Oct 17;183(1):62-75.e17. Epub 2020 Sep 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.08.039DOI Listing
October 2020

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance.

Nat Commun 2020 04 2;11(1):1625. Epub 2020 Apr 2.

Department of Biological Chemistry and Molecular Pharmacology Blavatnik Institute at Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-020-15448-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118133PMC
April 2020

Visceral adipose tissue Tregs and the cells that nurture them.

Immunol Rev 2020 05 12;295(1):114-125. Epub 2020 Mar 12.

Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/imr.12850DOI Listing
May 2020

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.

Proc Natl Acad Sci U S A 2020 03 26;117(10):5402-5408. Epub 2020 Feb 26.

Department of Immunology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1922559117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071852PMC
March 2020

Microbial bile acid metabolites modulate gut RORγ regulatory T cell homeostasis.

Nature 2020 01 25;577(7790):410-415. Epub 2019 Dec 25.

Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1865-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274525PMC
January 2020

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.

Proc Natl Acad Sci U S A 2019 Dec 10. Epub 2019 Dec 10.

Department of Immunology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1914848116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936428PMC
December 2019

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

J Clin Invest 2019 08 5;129(9):3717-3731. Epub 2019 Aug 5.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI122445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715391PMC
August 2019

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.

Sci Immunol 2019 05;4(35)

Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/sciimmunol.aaw3658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648660PMC
May 2019

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.

J Exp Med 2019 06 15;216(6):1328-1344. Epub 2019 Apr 15.

Department of Immunology, Harvard Medical School, Boston, MA

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http://www.jem.org/lookup/doi/10.1084/jem.20182002
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http://dx.doi.org/10.1084/jem.20182002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547863PMC
June 2019

Methods of Isolation and Analysis of TREG Immune Infiltrates from Injured and Dystrophic Skeletal Muscle.

Methods Mol Biol 2019 ;1899:229-237

UCL Research Department for Surgical Biotechnologies & Institute for Immunity and Transplantation, University College London, London, UK.

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http://link.springer.com/10.1007/978-1-4939-8938-6_16
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http://dx.doi.org/10.1007/978-1-4939-8938-6_16DOI Listing
June 2019

Organismal immunometabolism: advances in both directions.

Authors:
Diane Mathis

Nat Rev Immunol 2019 02;19(2):83-84

Department of Immunology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41577-018-0118-zDOI Listing
February 2019

Molecular diversification of regulatory T cells in nonlymphoid tissues.

Sci Immunol 2018 09;3(27)

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aat5861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219455PMC
September 2018

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.

Cell 2018 07 7;174(2):285-299.e12. Epub 2018 Jun 7.

Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046274PMC
July 2018

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.

Nat Immunol 2018 06;19(6):645

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-018-0104-4DOI Listing
June 2018

T cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration.

Proc Natl Acad Sci U S A 2018 03 23;115(11):E2585-E2593. Epub 2018 Feb 23.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1800618115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856564PMC
March 2018

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.

Nat Immunol 2018 03 12;19(3):291-301. Epub 2018 Feb 12.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-018-0051-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069633PMC
March 2018

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.

Proc Natl Acad Sci U S A 2018 01 21;115(2):E253-E262. Epub 2017 Dec 21.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1718599115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777076PMC
January 2018

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

Nat Immunol 2017 Nov 11;18(11):1238-1248. Epub 2017 Sep 11.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679728PMC
November 2017

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

Proc Natl Acad Sci U S A 2017 09 24;114(37):E7776-E7785. Epub 2017 Aug 24.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1707381114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604023PMC
September 2017

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.

Proc Natl Acad Sci U S A 2017 09 22;114(36):9671-9676. Epub 2017 Aug 22.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1712280114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594701PMC
September 2017

, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.

Proc Natl Acad Sci U S A 2017 04 10;114(17):E3472-E3480. Epub 2017 Apr 10.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1700946114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410798PMC
April 2017

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Cell 2017 03 2;168(6):1135-1148.e12. Epub 2017 Mar 2.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396461PMC
March 2017

Mining the Human Gut Microbiota for Immunomodulatory Organisms.

Cell 2017 02 16;168(5):928-943.e11. Epub 2017 Feb 16.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.022DOI Listing
February 2017

The transcriptional regulator Aire binds to and activates super-enhancers.

Nat Immunol 2017 03 30;18(3):263-273. Epub 2017 Jan 30.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310976PMC
March 2017

Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes.

Proc Natl Acad Sci U S A 2016 12 21;113(49):14103-14108. Epub 2016 Nov 21.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1616710113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150376PMC
December 2016

IL-33, Imprimatur of Adipocyte Thermogenesis.

Authors:
Diane Mathis

Cell 2016 Aug;166(4):794-795

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163100
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http://dx.doi.org/10.1016/j.cell.2016.07.051DOI Listing
August 2016

Network pharmacology of JAK inhibitors.

Proc Natl Acad Sci U S A 2016 08 11;113(35):9852-7. Epub 2016 Aug 11.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1610253113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024632PMC
August 2016

Tissue Tregs.

Annu Rev Immunol 2016 05;34:609-33

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115; email: , ,

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http://www.annualreviews.org/doi/10.1146/annurev-immunol-032
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http://dx.doi.org/10.1146/annurev-immunol-032712-095948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942112PMC
May 2016

Promiscuity Promotes Tolerance.

J Immunol 2016 Apr;196(7):2913-4

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.

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http://dx.doi.org/10.4049/jimmunol.1600225DOI Listing
April 2016

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

Immunity 2016 Feb 9;44(2):355-67. Epub 2016 Feb 9.

Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764071PMC
February 2016

Unstable FoxP3+ T regulatory cells in NZW mice.

Proc Natl Acad Sci U S A 2016 Feb 14;113(5):1345-50. Epub 2016 Jan 14.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1524660113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747713PMC
February 2016

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.

Proc Natl Acad Sci U S A 2015 Dec 16;112(48):14942-7. Epub 2015 Nov 16.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1520393112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672803PMC
December 2015

Immunological contributions to adipose tissue homeostasis.

Semin Immunol 2015 Sep 24;27(5):315-21. Epub 2015 Nov 24.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10445323150006
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http://dx.doi.org/10.1016/j.smim.2015.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681639PMC
September 2015

Rapid, high efficiency isolation of pancreatic ß-cells.

Sci Rep 2015 Sep 2;5:13681. Epub 2015 Sep 2.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://www.nature.com/articles/srep13681
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http://dx.doi.org/10.1038/srep13681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557033PMC
September 2015

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.

Science 2015 Aug 13;349(6251):993-7. Epub 2015 Aug 13.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, MA, USA. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaa9420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700932PMC
August 2015

Aire controls gene expression in the thymic epithelium with ordered stochasticity.

Nat Immunol 2015 Sep 3;16(9):942-9. Epub 2015 Aug 3.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632529PMC
September 2015

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):E4448-57. Epub 2015 Jul 27.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1512081112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538633PMC
August 2015

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.

Cell Metab 2015 Apr;21(4):543-57

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747251PMC
April 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.

Semin Immunol 2015 Feb 25;27(1):51-7. Epub 2015 Mar 25.

Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.smim.2015.03.003DOI Listing
February 2015

Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.

Science 2015 May 19;348(6234):589-94. Epub 2015 Mar 19.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaa7017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710357PMC
May 2015

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.

Proc Natl Acad Sci U S A 2015 Feb 3;112(7):2139-44. Epub 2015 Feb 3.

Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1424993112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343112PMC
February 2015

Population dynamics of islet-infiltrating cells in autoimmune diabetes.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1511-6. Epub 2015 Jan 20.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1423769112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321317PMC
February 2015

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects.

Proc Natl Acad Sci U S A 2015 Jan 30;112(2):482-7. Epub 2014 Dec 30.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1423486112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299242PMC
January 2015

Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.

Proc Natl Acad Sci U S A 2014 Nov 31;111(46):16466-71. Epub 2014 Oct 31.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1419337111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246343PMC
November 2014

Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.

J Immunol 2014 Nov 29;193(9):4485-96. Epub 2014 Sep 29.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; and

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http://dx.doi.org/10.4049/jimmunol.1401280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201955PMC
November 2014

Intersection of population variation and autoimmunity genetics in human T cell activation.

Science 2014 Sep;345(6202):1254665

Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1254665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751028PMC
September 2014

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11419-24. Epub 2014 Jul 21.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1410854111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128122PMC
August 2014

Type 1 diabetes in NOD mice unaffected by mast cell deficiency.

Diabetes 2014 Nov 10;63(11):3827-34. Epub 2014 Jun 10.

Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany

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http://dx.doi.org/10.2337/db14-0372DOI Listing
November 2014

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.

Proc Natl Acad Sci U S A 2014 May 21;111(18):6696-701. Epub 2014 Apr 21.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1405634111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020091PMC
May 2014

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

Immunity 2014 Apr;40(4):569-81

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070748PMC
April 2014

Interindividual variation in human T regulatory cells.

Proc Natl Acad Sci U S A 2014 Mar 7;111(12):E1111-20. Epub 2014 Mar 7.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1401343111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970507PMC
March 2014

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.

Proc Natl Acad Sci U S A 2014 Jan 16;111(4):1491-6. Epub 2014 Jan 16.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1323535111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910647PMC
January 2014

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis.

Bioconjug Chem 2014 Jan 20;25(1):171-7. Epub 2013 Dec 20.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/bc4005014
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http://dx.doi.org/10.1021/bc4005014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016126PMC
January 2014

A gut feeling about arthritis.

Authors:
Diane Mathis

Elife 2013 Nov 5;2:e01608. Epub 2013 Nov 5.

Diane Mathis is at the Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States

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http://dx.doi.org/10.7554/eLife.01608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816613PMC
November 2013

Soluble factors secreted by T cells promote β-cell proliferation.

Diabetes 2014 Jan 2;63(1):188-202. Epub 2013 Oct 2.

Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db13-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868047PMC
January 2014

Regulatory T cells in nonlymphoid tissues.

Nat Immunol 2013 Oct 18;14(10):1007-13. Epub 2013 Sep 18.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.2683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708287PMC
October 2013

Differential splicing across immune system lineages.

Proc Natl Acad Sci U S A 2013 Aug 9;110(35):14324-9. Epub 2013 Aug 9.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1311839110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761616PMC
August 2013

Immunological goings-on in visceral adipose tissue.

Authors:
Diane Mathis

Cell Metab 2013 Jun;17(6):851-859

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264591PMC
June 2013

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.

J Exp Med 2013 Jun 6;210(6):1153-65. Epub 2013 May 6.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20122248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674700PMC
June 2013

The immune system's involvement in obesity-driven type 2 diabetes.

Semin Immunol 2012 Dec 18;24(6):436-42. Epub 2013 Jan 18.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.smim.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582811PMC
December 2012

Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.

Proc Natl Acad Sci U S A 2013 Jan 14;110(5):1833-8. Epub 2013 Jan 14.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1222023110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562810PMC
January 2013

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells.

Proc Natl Acad Sci U S A 2013 Jan 31;110(3):1023-8. Epub 2012 Dec 31.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1220688110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549117PMC
January 2013

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.

Nat Immunol 2012 Oct 9;13(10):972-80. Epub 2012 Sep 9.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.2420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698954PMC
October 2012

Consortium biology in immunology: the perspective from the Immunological Genome Project.

Nat Rev Immunol 2012 10 7;12(10):734-40. Epub 2012 Sep 7.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://escholarship.org/uc/item/57j375n0.pdf
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October 2012

Treg cells, life history, and diversity.

Cold Spring Harb Perspect Biol 2012 Sep 1;4(9):a007021. Epub 2012 Sep 1.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a007021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428763PMC
September 2012

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.

Nature 2012 Jun;486(7404):549-53

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature11132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387339PMC
June 2012

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.

Immunity 2012 May 10;36(5):731-41. Epub 2012 May 10.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386606PMC
May 2012

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.

Nat Immunol 2012 Feb 26;13(4):361-8. Epub 2012 Feb 26.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ni.2233
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http://dx.doi.org/10.1038/ni.2233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309063PMC
February 2012

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.

Proc Natl Acad Sci U S A 2012 Mar 15;109(10):3891-6. Epub 2012 Feb 15.

Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1200090109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309794PMC
March 2012

Thymic negative selection is functional in NOD mice.

J Exp Med 2012 Mar 13;209(3):623-37. Epub 2012 Feb 13.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20112593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302233PMC
March 2012

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.

Arthritis Res Ther 2012 Feb 7;14(1):R29. Epub 2012 Feb 7.

Center for Immunology and Department of Pediatrics, University of Minnesota, Medical Biosciences Building, 2101 6th St SE Minneapolis, MN, 55414, USA.

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http://dx.doi.org/10.1186/ar3732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392824PMC
February 2012

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):535-40. Epub 2011 Dec 27.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1119351109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258631PMC
January 2012

The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding.

Immunol Rev 2012 Jan;245(1):239-49

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://cbdm.hms.harvard.edu/assets/Publications/2012pub/ImmR
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http://dx.doi.org/10.1111/j.1600-065X.2011.01084.xDOI Listing
January 2012

Microbiota and autoimmune disease: the hosted self.

Cell Host Microbe 2011 Oct;10(4):297-301

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.chom.2011.09.007DOI Listing
October 2011

Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism.

Semin Immunol 2011 Dec 2;23(6):431-7. Epub 2011 Jul 2.

Department of Pathology, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.smim.2011.06.002DOI Listing
December 2011

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.

Proc Natl Acad Sci U S A 2011 Jul 27;108(28):11548-53. Epub 2011 Jun 27.

Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1108924108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136249PMC
July 2011

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

Arthritis Rheum 2011 Sep;63(9):2630-40

Joslin Diabetes Center and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://doi.wiley.com/10.1002/art.30425
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371645PMC
September 2011

A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice.

Proc Natl Acad Sci U S A 2011 May 4;108(21):8737-42. Epub 2011 May 4.

Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1105364108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102351PMC
May 2011