Publications by authors named "Diana V Maslov"

3 Publications

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Utilization of Nivolumab in Adenoid Cystic Carcinoma After Progression on Platinum-Based Chemotherapy.

Perm J 2021 May;25

Ochsner Cancer Institute, New Orleans, LA.

Introduction: Adenoid cystic carcinoma (ACC) is a rare malignant neoplasm within the secretory glands of the head and neck. Clinical findings include a lump on the palate, tongue, or bottom of the mouth. Because symptoms can be mild, patients go for long periods of time without investigation. ACC is diagnosed using histology. Treatment is by surgical resection because there is no effective chemotherapy. Radiation can be effective adjuvant therapy, and proton therapy and stereotactic irradiation can be used for those who are ineligible for surgery. Immunotherapy has clinical activity for those with metastatic head and neck cancers who progress on proton therapy. This case reviews the use of immunotherapy in a patient with ACC.

Case Presentation: A man in his 20s presented with a 6-month history of nasal congestion, epistaxis, and sinus tenderness. Noncontrast computed tomography of the sinuses revealed a mass of the lateral wall of the nasal cavity, lateral wall of the maxillary sinus, and pterygoid plates. Positron emission tomography confirmed metastatic disease in the right iliac crest and right cervical lymph node; biopsy of the nasopharynx confirmed ACC. The patient received proton therapy and intensity-modulated radiotherapy and completed 2 Phase 1 trails but continued to have progressive disease. The patient started nivolumab and died 12 weeks later.

Conclusion: The patient recently received proton therapy, intensity-modulated radiotherapy, and completed 2 Phase 1 trials but continued to have progressive disease.
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http://dx.doi.org/10.7812/TPP/20.229DOI Listing
May 2021

COVID-19 and Cold Agglutinin Hemolytic Anemia.

TH Open 2020 Jul 20;4(3):e175-e177. Epub 2020 Aug 20.

Department of Haematology and Oncology, Ochsner Clinic Foundation, New Orleans, Louisiana, United States.

Novel coronavirus disease 2019 (COVID-19) has spread throughout the world and has infected close to 4 million people. It commonly presents with fever, cough, and fatigue. Due to the high inflammatory response, it is suggested that the coagulation cascade is enhanced causing thrombotic events for many patients. We describe a patient with clinical features of cerebrovascular accident, as well as documented blood clots in bilateral upper extremities. Labs revealed the presence of cold agglutinin hemolytic anemia. The association between cold agglutinin autoimmune hemolytic anemia and thrombotic events in COVID-19 patients has not been well investigated. The patient unfortunately passed away within 48 hours after admission. This case stresses the importance of considering a full workup to diagnose autoimmune hemolytic anemia (AIHA) in COVID-19 patients with thromboses and possible implications for management.
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http://dx.doi.org/10.1055/s-0040-1715791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440967PMC
July 2020

Chemotherapy Toxicity Confirms Diagnosis of Urachal Carcinoma.

Clin Genitourin Cancer 2019 10 2;17(5):e913-e915. Epub 2019 Jul 2.

Ochsner Cancer Institute, New Orleans, LA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.06.017DOI Listing
October 2019