Publications by authors named "Diana J Leeming"

71Publications

Localized inhibition of platelets and platelet derived growth factor by a matrix targeted glycan mimetic significantly attenuates liver fibrosis.

Authors:
Harsha Kabra Tanaya Walimbe Kate Stuart Camille Indey Swati Jalgaonkar Elvis Ikwa Taylor Skurnac Julia Chen Andrew Woolley Nicholas M Snead Nathan Bachtell Diana J Leeming Morten Karsdal Glenn Prestwich Alyssa Panitch John Paderi

Biomaterials 2020 Nov 17:120538. Epub 2020 Nov 17.

Symic Bio, USA.

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November 2020

Combining biomarkers of clot resolution and alveolar basement membrane destruction predicts mortality in the ECLIPSE COPD cohort.

Authors:
Jannie M B Sand Sarah R Rønnow Lasse L Langholm Morten A Karsdal Tina Manon-Jensen Ruth Tal-Singer Bruce E Miller Jørgen Vestbo Diana J Leeming

Respir Med 2020 11 2;173:106185. Epub 2020 Oct 2.

Nordic Bioscience A/S, Herlev, Denmark.

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November 2020

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.

Authors:
Alison E John Rebecca H Graves K Tao Pun Giovanni Vitulli Ellen J Forty Paul F Mercer Josie L Morrell John W Barrett Rebecca F Rogers Maryam Hafeji Lloyd I Bibby Elaine Gower Valerie S Morrison Yim Man James A Roper Jeni C Luckett Lee A Borthwick Ben S Barksby Rachel A Burgoyne Rory Barnes Joelle Le David J Flint Susan Pyne Anthony Habgood Louise A Organ Chitra Joseph Rochelle C Edwards-Pritchard Toby M Maher Andrew J Fisher Natasja Stæhr Gudmann Diana J Leeming Rachel C Chambers Pauline T Lukey Richard P Marshall Simon J F Macdonald R Gisli Jenkins Robert J Slack

Nat Commun 2020 09 16;11(1):4659. Epub 2020 Sep 16.

Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK.

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September 2020

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort.

Authors:
Sarah R Rønnow Lasse L Langholm Morten A Karsdal Tina Manon-Jensen Ruth Tal-Singer Bruce E Miller Jørgen Vestbo Diana J Leeming Jannie M B Sand

Respir Res 2020 Jul 30;21(1):202. Epub 2020 Jul 30.

Nordic Bioscience A/S, Herlev, Denmark.

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July 2020

Serum Type XIX Collagen is Significantly Elevated in Non-Small Cell Lung Cancer: A Preliminary Study on Biomarker Potential.

Authors:
Jeppe Thorlacius-Ussing Tina Manon-Jensen Shu Sun Diana J Leeming Jannie M Sand Morten Karsdal Nicholas Willumsen

Cancers (Basel) 2020 Jun 9;12(6). Epub 2020 Jun 9.

Biomarkers and Research, Nordic Bioscience A/S, 2730 Herlev, Denmark.

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June 2020

Collagen biology and non-invasive biomarkers of liver fibrosis.

Authors:
Morten A Karsdal Samuel J Daniels Signe Holm Nielsen Cecilie Bager Daniel G K Rasmussen Rohit Loomba Rambabu Surabattula Ida Falk Villesen Yi Luo Diane Shevell Natasja S Gudmann Mette J Nielsen Jacob George Rose Christian Diana J Leeming Detlef Schuppan

Liver Int 2020 04 19;40(4):736-750. Epub 2020 Feb 19.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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April 2020

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.

Authors:
Giuseppe Mazza Andrea Telese Walid Al-Akkad Luca Frenguelli Ana Levi Martina Marrali Lisa Longato Kessarin Thanapirom Maria Giovanna Vilia Benedetta Lombardi Claire Crowley Mark Crawford Morten A Karsdal Diana J Leeming Giusi Marrone Katrin Bottcher Benjamin Robinson Armando Del Rio Hernandez Domenico Tamburrino Gabriele Spoletini Massimo Malago Andrew R Hall Jasminka Godovac-Zimmermann Tu Vinh Luong Paolo De Coppi Massimo Pinzani Krista Rombouts

Cells 2019 12 28;9(1). Epub 2019 Dec 28.

Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.

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December 2019

Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis.

Authors:
Samuel J Daniels Diana J Leeming Sönke Detlefsen Maria F Bruun Sara T Hjuler Kim Henriksen Peter Hein Aleksander Krag Morten A Karsdal Mette Juul Nielsen Sarah Brockbank Simon Cruwys

Am J Physiol Gastrointest Liver Physiol 2020 03 6;318(3):G410-G418. Epub 2020 Jan 6.

Innovative Medicines Unit, Grünenthal, Aachen, Germany.

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March 2020

Safety profile of autologous macrophage therapy for liver cirrhosis.

Authors:
Francesca Moroni Benjamin J Dwyer Catriona Graham Chloe Pass Laura Bailey Lisa Ritchie Donna Mitchell Alison Glover Audrey Laurie Stuart Doig Emily Hargreaves Alasdair R Fraser Marc L Turner John D M Campbell Neil W A McGowan Jacqueline Barry Joanna K Moore Peter C Hayes Diana J Leeming Mette J Nielsen Kishwar Musa Jonathan A Fallowfield Stuart J Forbes

Nat Med 2019 10 7;25(10):1560-1565. Epub 2019 Oct 7.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.

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October 2019

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.

Authors:
Yvonne Huber Daniel Pfirrmann Ines Gebhardt Christian Labenz Nadine Gehrke Beate K Straub Christian Ruckes Heike Bantel Eugenio Belda Karine Clément Diana J Leeming Morten A Karsdal Peter R Galle Perikles Simon Jörn M Schattenberg

Aliment Pharmacol Ther 2019 10 25;50(8):930-939. Epub 2019 Jul 25.

Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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October 2019

Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.

Authors:
Louise A Organ Anne-Marie R Duggan Eunice Oballa Sarah C Taggart Juliet K Simpson Arthur R Kang'ombe Rebecca Braybrooke Philip L Molyneaux Bernard North Yakshitha Karkera Diana J Leeming Morten A Karsdal Carmel B Nanthakumar William A Fahy Richard P Marshall R Gisli Jenkins Toby M Maher

Respir Res 2019 Jul 12;20(1):148. Epub 2019 Jul 12.

NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK.

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July 2019

Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART.

Authors:
Leona Dold Mette J Nielsen Michael Praktiknjo Carolynne Schwarze-Zander Christoph Boesecke Robert Schierwagen Raphael Mohr Jan-Christian Wasmuth Christian Jansen Jenny Bischoff Jürgen Kurt Rockstroh Morten A Karsdal Ulrich Spengler Jonel Trebicka Diana J Leeming

PLoS One 2019 11;14(7):e0219526. Epub 2019 Jul 11.

Nordic Bioscience, Fibrosis Biology and Biomarkers, Herlev, Denmark.

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February 2020

Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography.

Authors:
Cyrielle Caussy Meera Bhargava Ida F Villesen Natasja S Gudmann Diana J Leeming Morten A Karsdal Claire Faulkner Denny Bao Amy Liu Min-Tzu Lo Ricki Bettencourt Shirin Bassirian Lisa Richards David A Brenner Chi-Hua Chen Claude B Sirlin Rohit Loomba

Hepatology 2019 07 29;70(1):127-141. Epub 2019 Apr 29.

NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA.

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July 2019

Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue.

Authors:
Samuel J Daniels Diana J Leeming Sönke Detlefsen Maria F Bruun Sara T Hjuler Kim Henriksen Peter Hein Morten A Karsdal Sarah Brockbank Simon Cruwys

Biomed Pharmacother 2019 Mar 7;111:926-933. Epub 2019 Jan 7.

Innovative Medicines Unit, Grünenthal, Aachen, Germany. Electronic address:

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March 2019

Enhanced processing of von Willebrand factor reflects disease severity and discriminates severe portal hypertension in cirrhosis.

Authors:
Lasse L Langholm Tina Manon-Jensen Morten A Karsdal Flemming Bendtsen Diana J Leeming Søren Møller

Eur J Gastroenterol Hepatol 2019 Aug;31(8):1040-1048

Clinical Physiology, Center of Functional Imaging and Research, Faculty of Health Sciences, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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August 2019

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis.

Authors:
Signe Holm Nielsen Christoffer Tengryd Andreas Edsfeldt Susanne Brix Federica Genovese Eva Bengtsson Morten Karsdal Diana J Leeming Jan Nilsson Isabel Goncalves

J Am Heart Assoc 2018 11;7(21):e009193

3 Experimental Cardiovascular Research Unit Department of Clinical Sciences, Malmö Lund University Malmö Sweden.

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November 2018

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial.

Authors:
Gideon M Hirschfield Olivier Chazouillères Joost P Drenth Douglas Thorburn Stephen A Harrison Charles S Landis Marlyn J Mayo Andrew J Muir James F Trotter Diana J Leeming Morten A Karsdal Mark J Jaros Lei Ling Kathline H Kim Stephen J Rossi Ransi M Somaratne Alex M DePaoli Ulrich Beuers

J Hepatol 2019 03 9;70(3):483-493. Epub 2018 Nov 9.

Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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March 2019

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile.

Authors:
Morten A Karsdal Sara T Hjuler Yi Luo Daniel G K Rasmussen Mette J Nielsen Signe Holm Nielsen Diana J Leeming Zachary Goodman Robert H Arch Keyur Patel Detlef Schuppan

Am J Physiol Gastrointest Liver Physiol 2019 01 30;316(1):G25-G31. Epub 2018 Aug 30.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University , Mainz , Germany.

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January 2019

ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis.

Authors:
Samuel J Daniels Diana J Leeming Mohammed Eslam Ahmed M Hashem Mette J Nielsen Aleksander Krag Morten A Karsdal Jane I Grove Indra Neil Guha Takumi Kawaguchi Takuji Torimura Duncan McLeod Jun Akiba Philip Kaye Bastiaan de Boer Guruprasad P Aithal Leon A Adams Jacob George

Hepatology 2019 03;69(3):1075-1086

Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, Australia.

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March 2019

High turnover of extracellular matrix reflected by specific protein fragments measured in serum is associated with poor outcomes in two metastatic breast cancer cohorts.

Authors:
Allan Lipton Kim Leitzel Suhail M Ali Hyma V Polimera Vinod Nagabhairu Eric Marks Angelique E Richardson Laura Krecko Ayesha Ali Wolfgang Koestler Francisco J Esteva Diana J Leeming Morten A Karsdal Nicholas Willumsen

Int J Cancer 2018 12 29;143(11):3027-3034. Epub 2018 Sep 29.

Nordic Bioscience A/S, Herlev, Denmark.

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December 2018