Detlef Schuppan

Detlef Schuppan

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Detlef Schuppan

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Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices.

Biochim Biophys Acta Mol Basis Dis 2020 Jan 30;1866(1):165582. Epub 2019 Oct 30.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165582DOI Listing
January 2020

PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices.

Biochem Pharmacol 2019 Nov 5;169:113633. Epub 2019 Sep 5.

Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen 9713AV, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113633DOI Listing
November 2019

Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer.

Am J Physiol Gastrointest Liver Physiol 2019 Oct 21. Epub 2019 Oct 21.

Gastroenterology, BIDMC and Harvard Medical School, United States.

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http://dx.doi.org/10.1152/ajpgi.00041.2019DOI Listing
October 2019

Targeting myeloid cells in the tumor sustaining microenvironment.

Cell Immunol 2019 Sep 2;343:103713. Epub 2017 Nov 2.

Department of Dermatology, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2017.10.013DOI Listing
September 2019

Clinical Guide and Update on Porphyrias.

Gastroenterology 2019 08 11;157(2):365-381.e4. Epub 2019 May 11.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.04.050DOI Listing
August 2019

Deletion of organic cation transporter Oct3 promotes hepatic fibrosis via upregulation of TGFβ.

Am J Physiol Gastrointest Liver Physiol 2019 Aug 26;317(2):G195-G202. Epub 2019 Jun 26.

1st Department of Internal Medicine, Gastroenterology, and Hepatology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1152/ajpgi.00088.2019DOI Listing
August 2019

Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma.

Clin Chem Lab Med 2019 Jul;57(8):1207-1217

Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Celiac Disease Center-Comer Children's Hospital, Chicago, IL, USA.

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2019-0088DOI Listing
July 2019

Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E.

Gastroenterology 2019 07 15;157(1):109-118.e5. Epub 2019 May 15.

Institute of Translational Immunology, University Medical Center, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193463
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http://dx.doi.org/10.1053/j.gastro.2019.03.046DOI Listing
July 2019

α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages.

Macromol Biosci 2019 07 7;19(7):e1900162. Epub 2019 Jun 7.

Institutes of Organic Chemistry, Johannes Gutenberg-University of Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201900162DOI Listing
July 2019

Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway inflammation.

Eur J Nutr 2019 Jun 29;58(4):1507-1514. Epub 2018 Mar 29.

Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00394-018-1681-6DOI Listing
June 2019

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis.

Hepatology 2019 May;69(5):2241-2257

Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany.

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http://doi.wiley.com/10.1002/hep.30333
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http://dx.doi.org/10.1002/hep.30333DOI Listing
May 2019

Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI.

Nanoscale 2019 May;11(19):9769-9779

Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany.

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http://xlink.rsc.org/?DOI=C9NR00943D
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http://dx.doi.org/10.1039/c9nr00943dDOI Listing
May 2019

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo.

Sci Rep 2019 May 16;9(1):7505. Epub 2019 May 16.

Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine 700 Albany Street, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/s41598-019-43837-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522598PMC
May 2019

Influence of low FODMAP and gluten-free diets on disease activity and intestinal microbiota in patients with non-celiac gluten sensitivity.

Clin Nutr 2019 04 4;38(2):697-707. Epub 2018 Apr 4.

Medical Department 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; Hector Center of Excellence for Nutrition, Exercise and Sports, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.1016/j.clnu.2018.03.017DOI Listing
April 2019

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Nat Rev Gastroenterol Hepatol 2019 03;16(3):145-159

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41575-018-0082-xDOI Listing
March 2019

Management of celiac disease in daily clinical practice.

Eur J Intern Med 2019 03 5;61:15-24. Epub 2018 Dec 5.

Institute for Translational Immunology, Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183046
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http://dx.doi.org/10.1016/j.ejim.2018.11.012DOI Listing
March 2019

Cirrhosis risk score of the donor organ predicts early fibrosis progression after liver transplantation.

J Gastrointestin Liver Dis 2019 Mar;28(1):53-61

Institute of Translational Immunology, Liver Fibrosis Center, University Medical Center Mainz, Germany;Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.15403/jgld.2014.1121.281.crrDOI Listing
March 2019

Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions.

Am J Physiol Gastrointest Liver Physiol 2019 02 12;316(2):G291-G303. Epub 2018 Dec 12.

Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology, and Immunology, Medical University of Vienna , Vienna , Austria.

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http://dx.doi.org/10.1152/ajpgi.00261.2018DOI Listing
February 2019

Wheat amylase-trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice.

J Allergy Clin Immunol 2019 01 21;143(1):201-212.e4. Epub 2018 Mar 21.

Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.jaci.2018.02.041DOI Listing
January 2019

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile.

Am J Physiol Gastrointest Liver Physiol 2019 01 30;316(1):G25-G31. Epub 2018 Aug 30.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1152/ajpgi.00158.2018DOI Listing
January 2019

Celiac disease and endocrine autoimmunity - the genetic link.

Autoimmun Rev 2018 Dec 12;17(12):1169-1175. Epub 2018 Oct 12.

Institute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany; Division of Gastroenterology and the Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15689972183023
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http://dx.doi.org/10.1016/j.autrev.2018.05.013DOI Listing
December 2018

Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany.

Aliment Pharmacol Ther 2018 11 4;48(10):1109-1116. Epub 2018 Oct 4.

Department of Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://doi.wiley.com/10.1111/apt.14976
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http://dx.doi.org/10.1111/apt.14976DOI Listing
November 2018

Liver fibrosis: Direct antifibrotic agents and targeted therapies.

Matrix Biol 2018 08 12;68-69:435-451. Epub 2018 Apr 12.

Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/j.matbio.2018.04.006DOI Listing
August 2018

Celiac Disease and Glandular Autoimmunity.

Nutrients 2018 Jun 25;10(7). Epub 2018 Jun 25.

Institute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany.

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http://dx.doi.org/10.3390/nu10070814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073228PMC
June 2018

Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation.

Matrix Biol 2018 03 6;66:34-49. Epub 2017 Nov 6.

Institute of Translational Immunology, Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.11.002DOI Listing
March 2018

IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.

EBioMedicine 2018 Mar 17;29:92-103. Epub 2018 Feb 17.

Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183003
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http://dx.doi.org/10.1016/j.ebiom.2018.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925448PMC
March 2018

The immune contexture of hepatocellular carcinoma predicts clinical outcome.

Sci Rep 2018 03 29;8(1):5351. Epub 2018 Mar 29.

Institute of Translational Immunology and Research Centre for Immunotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1038/s41598-018-21937-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876395PMC
March 2018

[Drug therapy in coeliac disease - "from bench to bedside"].

Z Gastroenterol 2018 02 7;56(2):151-164. Epub 2017 Nov 7.

Institut für Translationale Immunologie, Universitätsmedizin Mainz, Deutschland.

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http://dx.doi.org/10.1055/s-0043-121345DOI Listing
February 2018

Determinants of fibrosis progression and regression in NASH.

J Hepatol 2018 02 14;68(2):238-250. Epub 2017 Nov 14.

Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/j.jhep.2017.11.012DOI Listing
February 2018

Optimized Mouse Models for Liver Fibrosis.

Methods Mol Biol 2017 ;1559:279-296

Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6786-5_19DOI Listing
January 2018

Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis.

Antioxid Redox Signal 2018 Jan 25;28(2):87-109. Epub 2017 Jul 25.

1 Institute of Translational Immunology, University Medical Center, Johannes Gutenberg-University , Mainz, Germany .

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http://dx.doi.org/10.1089/ars.2016.6953DOI Listing
January 2018

Fresh water, marine and terrestrial cyanobacteria display distinct allergen characteristics.

Sci Total Environ 2018 Jan 1;612:767-774. Epub 2017 Sep 1.

Max Planck Institute for Chemistry, Multiphase Chemistry Department, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2017.08.069DOI Listing
January 2018

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

Oncotarget 2017 Dec 18;8(70):115667-115680. Epub 2017 Dec 18.

Department of Internal Medicine, Gastroenterology and Hepatology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.23372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777802PMC
December 2017

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.

Gut 2017 09 10;66(9):1697-1708. Epub 2017 Jan 10.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/gutjnl-2016-312473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561383PMC
September 2017

Functional restoration of CD56 NK cells facilitates immune control via IL-15 and NKG2D in patients under antiviral treatment for chronic hepatitis B.

Hepatol Int 2017 Sep 20;11(5):419-428. Epub 2017 Jun 20.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Avenue, Wuhan, 430030, China.

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http://link.springer.com/10.1007/s12072-017-9803-4
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http://dx.doi.org/10.1007/s12072-017-9803-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606950PMC
September 2017

Early inflammatory players in cutanous fibrosis.

J Dermatol Sci 2017 Sep 15;87(3):228-235. Epub 2017 Jun 15.

Department of Dermatology, Division for Experimental and Translational Research, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Research Center for Immune Therapy, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.

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http://dx.doi.org/10.1016/j.jdermsci.2017.06.009DOI Listing
September 2017

Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis.

Br J Pharmacol 2017 Sep 11;174(18):3107-3117. Epub 2017 Aug 11.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1111/bph.13945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573419PMC
September 2017

Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin.

J Dermatol Sci 2017 Sep 13;87(3):285-291. Epub 2017 Jul 13.

Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2017.07.001DOI Listing
September 2017

Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma.

J Hepatol 2017 08 6;67(2):282-292. Epub 2017 Mar 6.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany; Department of General, Visceral and Thoracic Surgery, German Armed Forces Central Hospital, Koblenz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.02.024DOI Listing
August 2017

Effects of nintedanib on the microvascular architecture in a lung fibrosis model.

Angiogenesis 2017 Aug 10;20(3):359-372. Epub 2017 Mar 10.

Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 13, 55128, Mainz, Germany.

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http://dx.doi.org/10.1007/s10456-017-9543-zDOI Listing
August 2017

Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis.

Int J Mol Sci 2017 Jul 14;18(7). Epub 2017 Jul 14.

Department of Neurology, University Hospital Muenster, 48149 Muenster, Germany.

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http://dx.doi.org/10.3390/ijms18071526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536015PMC
July 2017

Fibrosis evaluation by transient elastography in alcoholic liver disease: Is the histological scoring system impacting cutoff values?

Hepatology 2017 05 3;65(5):1758-1761. Epub 2017 Apr 3.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.29075DOI Listing
May 2017

Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells.

Gastroenterology 2017 04 16;152(5):1100-1113.e12. Epub 2016 Dec 16.

Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.12.006DOI Listing
April 2017

Biomarkers of Hepatic Fibrosis in Chronic Hepatitis C: A Comparison of 10 Biomarkers Using 2 Different Assays for Hyaluronic Acid.

J Clin Gastroenterol 2017 Mar;51(3):268-277

*Institute for Liver & Digestive Health, University College London ‡Department of Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London †Public Health Sciences and Medical Statistics, University of Southampton, Southampton, UK §Department of Medicine 1, University of Erlangen, Erlangen ¶Institute of Molecular and Translational Medicine #Department of Medicine **Research Center for Immunology (FZI), University of Mainz, Mainz, Germany ∥Institute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner Hauptstrasse 48, 5020 Salzburg, Austria ††Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MCG.0000000000000581DOI Listing
March 2017

Noninvasive markers of liver fibrosis: on-treatment changes of serum markers predict the outcome of antifibrotic therapy.

Eur J Gastroenterol Hepatol 2017 Mar;29(3):289-296

aDivision of Medicine, Institute for Liver and Digestive Health, University College London bDepartment of Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London cDepartment of Public Health Sciences and Medical Statistics, Faculty of Medicine, University of Southampton, Southampton, UK dDepartment of Medicine 1, University of Erlangen, Erlangen eInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry fDepartment of Medicine, Research Center for Immunology (FZI), University of Mainz, Mainz, Germany gInstitute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Salzburg, Austria hDivision of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MEG.0000000000000789DOI Listing
March 2017

Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients.

Appl Environ Microbiol 2017 03 2;83(6). Epub 2017 Mar 2.

Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/AEM.03330-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335528PMC
March 2017

An extracellular proteasome releases endostatin from human collagen XVIII.

Angiogenesis 2017 Feb 5;20(1):125-137. Epub 2016 Dec 5.

Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1007/s10456-016-9533-6DOI Listing
February 2017

SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles.

J Control Release 2017 02 9;248:10-23. Epub 2016 Dec 9.

Institute of Translational Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 63, 55131 Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.12.006DOI Listing
February 2017

Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes.

Diabetologia 2017 Jan 8;60(1):50-59. Epub 2016 Sep 8.

Institute of Translational Immunology and Research Center of Immune Therapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1007/s00125-016-4094-1DOI Listing
January 2017

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy.

Am J Physiol Gastrointest Liver Physiol 2016 12 20;311(6):G1009-G1017. Epub 2016 Oct 20.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; and.

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http://dx.doi.org/10.1152/ajpgi.00283.2016DOI Listing
December 2016

Hepatocellular carcinoma in nonalcoholic fatty liver disease: A link between oxidative stress and T-cell suppression.

Hepatology 2016 11;64(5):1794-1797

Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1002/hep.28815DOI Listing
November 2016

Myeloid cell populations and fibrogenic parameters in bleomycin- and HOCl-induced fibrosis.

Exp Dermatol 2016 11;25(11):887-894

Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/exd.13124DOI Listing
November 2016

Dextran-based therapeutic nanoparticles for hepatic drug delivery.

Nanomedicine (Lond) 2016 Oct 15;11(20):2663-2677. Epub 2016 Sep 15.

Institute of Translational Immunology & Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.

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http://dx.doi.org/10.2217/nnm-2016-0156DOI Listing
October 2016

Nanoparticles and the immune system: challenges and opportunities.

Nanomedicine (Lond) 2016 10 20;11(20):2621-2624. Epub 2016 Sep 20.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.

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http://dx.doi.org/10.2217/nnm-2016-0281DOI Listing
October 2016

Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy.

Nanomedicine (Lond) 2016 Oct 23;11(20):2735-2751. Epub 2016 Sep 23.

Institute of Translational Immunology & Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.2217/nnm-2016-0208DOI Listing
October 2016

Past, present and future of immunology in Mainz.

Cell Immunol 2016 10;308:1-6

Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2016.09.001DOI Listing
October 2016

Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease.

Am J Physiol Gastrointest Liver Physiol 2016 09 28;311(3):G571-80. Epub 2016 Jul 28.

Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts;

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http://dx.doi.org/10.1152/ajpgi.00185.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076000PMC
September 2016

Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge.

Am J Gastroenterol 2016 07 17;111(7):1014-22. Epub 2016 May 17.

Department of Pediatrics and Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands.

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http://www.nature.com/articles/ajg2016162
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http://dx.doi.org/10.1038/ajg.2016.162DOI Listing
July 2016

[Celiac disease : Pathogenesis, clinics, epidemiology, diagnostics, therapy].

Authors:
Detlef Schuppan

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016 Jul;59(7):827-35

Institut für Translationale Immunologie, Zentrum für Zöliakie und Dünndarmerkrankungen und Forschungszentrum für Immuntherapie (FZI), Universitätsmedizin, Johannes Gutenberg-Universität Mainz, Langenbeckstr.1, 55131, Mainz, Deutschland.

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http://dx.doi.org/10.1007/s00103-016-2364-1DOI Listing
July 2016

Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery.

Macromol Rapid Commun 2016 Jun 14;37(11):924-33. Epub 2016 Apr 14.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, D-55099, Mainz, Germany.

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http://dx.doi.org/10.1002/marc.201600046DOI Listing
June 2016

X-linked protoporphyria: Iron supplementation improves protoporphyrin overload, liver damage and anaemia.

Br J Haematol 2016 05 20;173(3):482-4. Epub 2015 Jul 20.

Department of Internal Medicine II, Klinikum Chemnitz, Chemnitz, Germany.

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http://dx.doi.org/10.1111/bjh.13612DOI Listing
May 2016

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.

FASEB J 2016 Apr 23;30(4):1599-609. Epub 2015 Dec 23.

*Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Gilead Sciences, Inc., Foster City, California, USA; and Institute of Translational Immunology, University Medical Center, Mainz, Germany

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http://www.fasebj.org/content/early/2015/12/22/fj.14-268425.
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http://www.fasebj.org/cgi/doi/10.1096/fj.14-268425
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http://dx.doi.org/10.1096/fj.14-268425DOI Listing
April 2016

Small bowel: from sideline to center stage in gastroenterology.

Dig Dis 2015 22;33(2):113-4. Epub 2015 Apr 22.

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http://dx.doi.org/10.1159/000371650DOI Listing
January 2016

Celiac disease and endocrine autoimmunity.

Dig Dis 2015 22;33(2):155-61. Epub 2015 Apr 22.

Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany.

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https://www.karger.com/Article/FullText/369535
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http://dx.doi.org/10.1159/000369535DOI Listing
January 2016

Wheat amylase trypsin inhibitors as nutritional activators of innate immunity.

Dig Dis 2015 22;33(2):260-3. Epub 2015 Apr 22.

Institute for Translational Immunology and Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1159/000371476DOI Listing
January 2016

Collagen and tissue turnover as a function of age: Implications for fibrosis.

J Hepatol 2016 Jan 22;64(1):103-9. Epub 2015 Aug 22.

Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jhep.2015.08.014DOI Listing
January 2016

Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced Gastric and Gastroesophageal Adenocarcinomas.

Oncology 2015 28;89(5):294-303. Epub 2015 Aug 28.

Department of Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, Metabolic Disorders, Oncology, Klinikum Chemnitz gGmbH, Chemnitz, Germany.

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https://www.karger.com/Article/FullText/437373
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http://dx.doi.org/10.1159/000437373DOI Listing
January 2016

In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles.

Adv Healthc Mater 2015 Dec 2;4(18):2809-15. Epub 2015 Dec 2.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/adhm.201500826DOI Listing
December 2015

Liver fibrosis: Common mechanisms and antifibrotic therapies.

Authors:
Detlef Schuppan

Clin Res Hepatol Gastroenterol 2015 Sep 17;39 Suppl 1:S51-9. Epub 2015 Jul 17.

Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2015.05.005DOI Listing
September 2015

Non-celiac wheat sensitivity: differential diagnosis, triggers and implications.

Best Pract Res Clin Gastroenterol 2015 Jun 8;29(3):469-76. Epub 2015 May 8.

Institute for Translational Immunology and Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.bpg.2015.04.002DOI Listing
June 2015