Derrick J Rossi

Derrick J Rossi

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Derrick J Rossi

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Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

Cell Stem Cell 2019 06 18;24(6):944-957.e5. Epub 2019 Apr 18.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193011
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http://dx.doi.org/10.1016/j.stem.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597014PMC
June 2019

Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation.

Nat Commun 2019 02 6;10(1):616. Epub 2019 Feb 6.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, 20892, MD, USA.

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http://dx.doi.org/10.1038/s41467-018-08202-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365540PMC
February 2019

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.

Cell 2018 06 14;174(1):156-171.e16. Epub 2018 Jun 14.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089614PMC
June 2018

Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

J Biol Chem 2018 05 28;293(19):7300-7314. Epub 2018 Mar 28.

From the Department of Dermatology and Harvard Skin Disease Research Center and

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http://dx.doi.org/10.1074/jbc.RA117.000775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950021PMC
May 2018

Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells.

Sci Adv 2017 12 6;3(12):e1701211. Epub 2017 Dec 6.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cell and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.170
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http://dx.doi.org/10.1126/sciadv.1701211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721728PMC
December 2017

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

Blood 2017 08 14;130(5):619-624. Epub 2017 Jun 14.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-09-738591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542850PMC
August 2017

A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells.

Stem Cell Reports 2017 06 4;8(6):1563-1572. Epub 2017 May 4.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2-373, Seattle, WA 98109, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.stemcr.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469918PMC
June 2017

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.

J Clin Invest 2017 Jun 8;127(6):2433-2437. Epub 2017 May 8.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI92030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451245PMC
June 2017

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells.

Stem Cells 2016 10 17;34(10):2501-2511. Epub 2016 Jul 17.

Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard University, Cambridge, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064874PMC
http://dx.doi.org/10.1002/stem.2435DOI Listing
October 2016

DNA Damage and Aging Around the Clock.

Trends Mol Med 2016 08 23;22(8):635-637. Epub 2016 Jun 23.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969220PMC
August 2016

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Sci Transl Med 2016 07;8(347):347ra93

Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://stm.sciencemag.org/content/scitransmed/8/347/347ra93.
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http://dx.doi.org/10.1126/scitranslmed.aaf6038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024536PMC
July 2016

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis.

Cell Rep 2016 Mar 17;14(12):2809-18. Epub 2016 Mar 17.

Division of Molecular Hematology, Department of Laboratory Medicine, Medical Faculty, Lund University, Klinikgatan 26, BMC B12, 22184 Lund, Sweden; Hemato-Linné, Lund University, 22184 Lund, Sweden; StemTherapy, Lund University, 22184 Lund, Sweden; Lund Stem Cell Center, Lund University, 22184 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819906PMC
March 2016

Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells.

Exp Hematol 2015 Sep 2;43(9):756-9. Epub 2015 Jul 2.

Stem Cell Transplantation Program, Division of Hematology and Oncology, Boston Children's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.exphem.2015.05.007DOI Listing
September 2015

Genome editing for human gene therapy.

Methods Enzymol 2014 ;546:273-95

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA; Harvard Stem Cell Institute, Sherman Fairchild Biochemistry, Cambridge, Massachusetts, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00013-1DOI Listing
July 2015

Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells.

Curr Opin Hematol 2015 Jul;22(4):317-23

aDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge bProgram in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital cDepartment of Dermatology, and Program of Excellence in Glycosciences, Brigham & Women's Hospital, Harvard Medical School dDivision of Hematology, Department of Medicine, Brigham & Women's Hospital eDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston fHarvard Stem Cell Institute, Cambridge, Massachusetts, USA *Jungmin Lee and Brad Dykstra contributed equally to the writing of this manuscript.

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http://dx.doi.org/10.1097/MOH.0000000000000147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459525PMC
July 2015

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.

Cell Stem Cell 2015 Jun;16(6):613-25

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02116, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469343PMC
June 2015

Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells.

Stem Cell Reports 2013 15;1(3):266-80. Epub 2013 Aug 15.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA ; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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http://dx.doi.org/10.1016/j.stemcr.2013.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849420PMC
May 2015

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.

Blood 2015 Mar 5;125(13):2075-8. Epub 2015 Feb 5.

Stem Cell Group, University College London Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-08-596734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467872PMC
March 2015

Transcription factor-mediated reprogramming toward hematopoietic stem cells.

EMBO J 2015 Mar 20;34(6):694-709. Epub 2015 Feb 20.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA Department of Pediatrics, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Cambridge, MA, USA

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http://dx.doi.org/10.15252/embj.201490804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369309PMC
March 2015

Epigenetic regulation of hematopoietic stem cell aging.

Exp Cell Res 2014 Dec 28;329(2):192-9. Epub 2014 Sep 28.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children׳s Hospital, MA 02116, USA.

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http://dx.doi.org/10.1016/j.yexcr.2014.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250347PMC
December 2014

Growth hormone receptor signaling is dispensable for HSC function and aging.

Blood 2014 Nov 1;124(20):3076-80. Epub 2014 Oct 1.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA; Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA; and.

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http://www.bloodjournal.org/content/early/2014/10/01/blood-2
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http://www.bloodjournal.org/content/124/20/3076.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-05-57
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http://dx.doi.org/10.1182/blood-2014-05-575308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231418PMC
November 2014

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell Stem Cell 2014 Nov 6;15(5):643-52. Epub 2014 Nov 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269831PMC
November 2014

Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

Cell Stem Cell 2014 Jul 8;15(1):37-50. Epub 2014 May 8.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stem.2014.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082747PMC
July 2014

Fgd5 identifies hematopoietic stem cells in the murine bone marrow.

J Exp Med 2014 Jun 23;211(7):1315-31. Epub 2014 Jun 23.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138 Program in Cellular and Molecular Medicine, Division of Hematology/Oncology and Division of Transfusion Medicine, Department of Laboratory Medicine, Boston Children's Hospital, MA 02116 Department of Pediatrics, Department of Neurobiology, Harvard Medical School, Boston MA 02115 Harvard Stem Cell Institute, Cambridge, MA 02138

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http://www.idi.harvard.edu/uploads/investigators/Gazit_et_al
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http://www.jem.org/lookup/doi/10.1084/jem.20130428
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http://dx.doi.org/10.1084/jem.20130428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076584PMC
June 2014

Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.

Cell 2014 Apr;157(3):549-64

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, MA 02116, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060823PMC
April 2014

Human iPSC-based modeling of late-onset disease via progerin-induced aging.

Cell Stem Cell 2013 Dec;13(6):691-705

The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA; Gerstner Sloan-Kettering Graduate School, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909130049
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http://dx.doi.org/10.1016/j.stem.2013.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153390PMC
December 2013

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.

Nat Biotechnol 2013 Oct 8;31(10):898-907. Epub 2013 Sep 8.

1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Department of Cardiology, Children's Hospital Boston, Boston, Massachusetts, USA. [4] Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, USA. [5] Boston and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [6].

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http://dx.doi.org/10.1038/nbt.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058317PMC
October 2013

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

Cell Stem Cell 2013 Apr 14;12(4):413-25. Epub 2013 Feb 14.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02116, USA.

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http://www.idi.harvard.edu/uploads/investigators/Beerman_et_
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http://linkinghub.elsevier.com/retrieve/pii/S193459091300020
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http://dx.doi.org/10.1016/j.stem.2013.01.017DOI Listing
April 2013

Gene Expression Commons: an open platform for absolute gene expression profiling.

PLoS One 2012 18;7(7):e40321. Epub 2012 Jul 18.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040321PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399844PMC
March 2013

Reprogramming human fibroblasts to pluripotency using modified mRNA.

Nat Protoc 2013 Mar 21;8(3):568-82. Epub 2013 Feb 21.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2013.019DOI Listing
March 2013

Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA.

Curr Protoc Stem Cell Biol 2012 ;Chapter 4:Unit4A.5

Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/9780470151808.sc04a05s21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397830PMC
September 2012

DNA-damage-induced differentiation in hematopoietic stem cells.

Cell 2012 Mar;148(5):847-8

Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children's Hospital Boston, Boston, MA 02116, USA.

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http://dx.doi.org/10.1016/j.cell.2012.02.011DOI Listing
March 2012

Reactive oxygen species resulting from mitochondrial mutation diminishes stem and progenitor cell function.

Cell Metab 2012 Jan;15(1):2-3

Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.12.008DOI Listing
January 2012

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

Proc Natl Acad Sci U S A 2011 Dec 28;108(50):20012-7. Epub 2011 Nov 28.

Institute for Stem Cell Biology and Regenerative Medicine, Ludwig Center for Stem Cell Research, and Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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http://www.pnas.org/content/108/50/20012.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1116110108
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http://dx.doi.org/10.1073/pnas.1116110108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250139PMC
December 2011

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

Nat Cell Biol 2011 May 17;13(5):541-9. Epub 2011 Apr 17.

Department of Ob/Gyn and Center for Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.

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http://www.nature.com/articles/ncb2239
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http://dx.doi.org/10.1038/ncb2239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987913PMC
May 2011

DNA damage response in adult stem cells: pathways and consequences.

Nat Rev Mol Cell Biol 2011 03 9;12(3):198-202. Epub 2011 Feb 9.

Immune Disease Institute, the Program in Cellular and Molecular Medicine, Childrens Hospital Boston, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrm3060DOI Listing
March 2011

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Nature 2010 Sep 15;467(7313):338-42. Epub 2010 Aug 15.

Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature09367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956609PMC
September 2010

Stem cells and the aging hematopoietic system.

Curr Opin Immunol 2010 Aug 23;22(4):500-6. Epub 2010 Jul 23.

Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coi.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817978PMC
August 2010

Differential DNA damage response in stem and progenitor cells.

Cell Stem Cell 2010 Aug;7(2):145-7

Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.stem.2010.07.006DOI Listing
August 2010

Controlling stem cell fate one substrate at a time.

Nat Immunol 2010 Mar;11(3):193-4

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http://dx.doi.org/10.1038/ni0310-193DOI Listing
March 2010

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.

Proc Natl Acad Sci U S A 2010 Mar 18;107(12):5465-70. Epub 2010 Mar 18.

Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1000834107
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http://dx.doi.org/10.1073/pnas.1000834107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851806PMC
March 2010

Niche recycling through division-independent egress of hematopoietic stem cells.

J Exp Med 2009 Nov 2;206(12):2837-50. Epub 2009 Nov 2.

Institute of Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford, CA 94305, USA.

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http://dx.doi.org/10.1084/jem.20090778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806613PMC
November 2009

Stem cells and aging in the hematopoietic system.

Mech Ageing Dev 2009 Jan-Feb;130(1-2):46-53. Epub 2008 Apr 8.

Department of Pathology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.mad.2008.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992834PMC
April 2009

Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.

Proc Natl Acad Sci U S A 2009 Apr 7;106(17):7034-9. Epub 2009 Apr 7.

Department of Pathology and Immune Disease Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0813296106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678457PMC
April 2009

Hematopoietic stem cells and the aging hematopoietic system.

Semin Hematol 2008 Oct;45(4):218-24

Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1053/j.seminhematol.2008.07.010DOI Listing
October 2008

Deciphering developmental stages of adult myelopoiesis.

Cell Cycle 2008 Mar;7(6):706-13

Institution for Experimental Medical Science, Immunology Section, Lund University, Lund, Sweden

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http://dx.doi.org/10.4161/cc.7.6.5565DOI Listing
March 2008

Stems cells and the pathways to aging and cancer.

Cell 2008 Feb;132(4):681-96

Immune Disease Institute, Harvard Stem Cell Institute, and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2008.01.036DOI Listing
February 2008

Transcriptional instability is not a universal attribute of aging.

Aging Cell 2007 Dec 8;6(6):775-82. Epub 2007 Oct 8.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2007.00337.xDOI Listing
December 2007

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

Cell Cycle 2007 Oct 18;6(19):2371-6. Epub 2007 Jul 18.

Department of Pathology, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.4161/cc.6.19.4759DOI Listing
October 2007

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

Cell Stem Cell 2007 Oct;1(4):428-42

Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC I13, 221 84 Lund, Sweden; Immunology Unit, Institution for Experimental Medical Science, Lund University, BMC I13, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1016/j.stem.2007.07.005DOI Listing
October 2007

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Nature 2007 Jun;447(7145):725-9

Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature05862DOI Listing
June 2007

Hematopoietic stem cell aging: mechanism and consequence.

Exp Gerontol 2007 May 31;42(5):385-90. Epub 2007 Jan 31.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.exger.2006.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892213PMC
May 2007

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.

Am J Pathol 2006 Aug;169(2):338-46

Stanford University School of Medicine, B257 Beckman Center, Stanford, CA 94305-5323, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698791PMC
http://dx.doi.org/10.2353/ajpath.2006.060312DOI Listing
August 2006

Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors.

Cell Cycle 2006 Jun 1;5(11):1135-9. Epub 2006 Jun 1.

Institute of Cancer and Stem Cell Biology and Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507427PMC
http://dx.doi.org/10.4161/cc.5.11.2772DOI Listing
June 2006

Pten, tumorigenesis, and stem cell self-renewal.

Cell 2006 Apr;125(2):229-31

Department of Pathology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2006.04.006DOI Listing
April 2006

Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning.

J Exp Med 2006 Jan 27;203(1):73-85. Epub 2005 Dec 27.

Department of Pathology, Institute of Cancer and Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20051714
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http://dx.doi.org/10.1084/jem.20051714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118067PMC
January 2006

Cell intrinsic alterations underlie hematopoietic stem cell aging.

Proc Natl Acad Sci U S A 2005 Jun 20;102(26):9194-9. Epub 2005 Jun 20.

Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0503280102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1153718PMC
June 2005

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

Gastroenterology 2004 Oct;127(4):1030-7

Molecular Cancer Biology Research Program, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2004.07.059DOI Listing
October 2004

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

Neuron 2003 Sep;39(6):919-35

Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.neuron.2003.08.017DOI Listing
September 2003

The histidine triad protein Hint is not required for murine development or Cdk7 function.

Mol Cell Biol 2003 Jun;23(11):3929-35

Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, 00014 University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155213PMC
http://dx.doi.org/10.1128/mcb.23.11.3929-3935.2003DOI Listing
June 2003

Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription.

J Cell Sci 2002 Nov;115(Pt 22):4275-84

Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 63, Haartmaninkatu 8, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1242/jcs.00121DOI Listing
November 2002

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

Proc Natl Acad Sci U S A 2002 Sep 6;99(19):12327-32. Epub 2002 Sep 6.

Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, P.O. Box 63, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.192301399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129444PMC
September 2002