Dermot P B McGovern

Dermot P B McGovern

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Dermot P B McGovern

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The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience.

Inflamm Bowel Dis 2019 Aug;25(9):1541-1549

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ibd/izz016DOI Listing
August 2019

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups.

J Crohns Colitis 2019 Aug;13(8):1055-1066

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1093/ecco-jcc/jjz021DOI Listing
August 2019

Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease.

J Gastroenterol Hepatol 2019 Apr 30. Epub 2019 Apr 30.

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/jgh.14696DOI Listing
April 2019

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.

Cell Host Microbe 2019 Mar 5;25(3):377-388.e6. Epub 2019 Mar 5.

F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417942PMC
March 2019

A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study.

Inflamm Bowel Dis 2018 11;24(12):2550-2554

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.

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http://dx.doi.org/10.1093/ibd/izy215DOI Listing
November 2018

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics.

Inflamm Bowel Dis 2018 10;24(11):2413-2422

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1093/ibd/izy148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195175PMC
October 2018

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis.

Inflamm Bowel Dis 2018 07;24(8):1840-1848

Inflammatory Bowel Disease Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1093/ibd/izy083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128143PMC
July 2018

CX3CR1 mononuclear phagocytes control immunity to intestinal fungi.

Science 2018 01;359(6372):232-236

Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aao1503
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http://dx.doi.org/10.1126/science.aao1503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805464PMC
January 2018

CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway.

Sci Rep 2017 11 27;7(1):16351. Epub 2017 Nov 27.

Center for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41598-017-16753-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703874PMC
November 2017

Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.

Inflamm Bowel Dis 2017 08;23(8):1382-1393

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea; ‡Division of Hematology and Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; §Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; and ‖Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000001150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510223PMC
August 2017

Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis.

RMD Open 2017 16;3(2):e000437. Epub 2017 Aug 16.

Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1136/rmdopen-2017-000437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574426PMC
August 2017

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.

Gastroenterology 2017 07 9;153(1):219-232. Epub 2017 Apr 9.

F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484733PMC
July 2017

Reply.

Gastroenterology 2017 06 5;152(8):2083-2084. Epub 2017 May 5.

Department of Pediatrics and Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1053/j.gastro.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492261PMC
June 2017

The TNF family member TL1A induces IL-22 secretion in committed human T17 cells via IL-9 induction.

J Leukoc Biol 2017 03 12;101(3):727-737. Epub 2016 Oct 12.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://doi.wiley.com/10.1189/jlb.3A0316-129R
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http://dx.doi.org/10.1189/jlb.3A0316-129RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608031PMC
March 2017

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

J Immunol 2017 03 27;198(5):2133-2146. Epub 2017 Jan 27.

F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048;

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http://dx.doi.org/10.4049/jimmunol.1601293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322190PMC
March 2017

Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease.

Gastroenterology 2017 02 8;152(2):322-326. Epub 2016 Oct 8.

The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1053/j.gastro.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209278PMC
February 2017

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Gastroenterology 2017 01 28;152(1):206-217.e2. Epub 2016 Sep 28.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164948PMC
January 2017

Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.

Gastroenterology 2016 Dec 26;151(6):1096-1099.e4. Epub 2016 Aug 26.

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.08.025DOI Listing
December 2016

A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients.

Cell Mol Gastroenterol Hepatol 2016 Nov 2;2(6):750-766. Epub 2016 Jul 2.

Susan and Leonard Feinstein Inflammatory Bowel Disease Center, Department of Pediatrics, Icahn School of Medicine, Mount Sinai, New York.

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http://dx.doi.org/10.1016/j.jcmgh.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247316PMC
November 2016

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

Expert Rev Clin Immunol 2016 Oct 15;12(10):1091-107. Epub 2016 Jun 15.

b Cedars-Sinai Medical Center , F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Medical Genetics Research Institute , Los Angeles , CA , USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083126PMC
http://dx.doi.org/10.1080/1744666X.2016.1184972DOI Listing
October 2016

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Gastroenterology 2016 10 1;151(4):710-723.e2. Epub 2016 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037012PMC
October 2016

Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study.

Inflamm Bowel Dis 2016 10;22(10):2311-6

*Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada; †Montreal Heart Institute, Montreal, Quebec, Canada; ‡Université de Montréal, Montreal, Quebec, Canada; §Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada; ‖Division of Gastroenterology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; ¶Section of Digestive Diseases, Yale University, New Haven, Connecticut; **Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; ††Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; ‡‡Translational Genomics Group, F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; §§Division of Gastroenterology, University of Chicago, Chicago, Illinois; and ‖‖Meyerhoff Inflammatory Bowel Diseases Center, Division of Gastroenterology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1097/MIB.0000000000000913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098421PMC
October 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1038/ncomms12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980482PMC
August 2016

TNFRSF1B Is Associated with ANCA in IBD.

Inflamm Bowel Dis 2016 06;22(6):1346-52

*Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Mount Sinai Hospital, Toronto, Ontario, Canada; ‡The Susan and Leonard Feinstein IBD Clinical Center, East New York, New York; and §Institute for Translational Genomics and Population Science, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1097/MIB.0000000000000771DOI Listing
June 2016

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.

Inflamm Bowel Dis 2016 Apr;22(4):862-9

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas; ‡Division of Hematology and Oncology, Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; and §Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220246PMC
April 2016

Sparse Inverse Covariance Estimation with L0 Penalty for Network Construction with Omics Data.

J Comput Biol 2016 Mar 1;23(3):192-202. Epub 2016 Feb 1.

1 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/cmb.2015.0102DOI Listing
March 2016

Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.

Inflamm Bowel Dis 2016 Jan;22(1):13-9

*Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; †Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea; ‡The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute; Cedars-Sinai Medical Center, Los Angeles, California; §Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ‖Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea; ¶Department of Life Science, Sogang University, Seoul, Korea; **Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; ††Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea; and ‡‡Human Genetics, Genome Institute of Singapore, Singapore.

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http://pdfs.journals.lww.com/ibdjournal/2016/01000/Identific
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http://dx.doi.org/10.1097/MIB.0000000000000584DOI Listing
January 2016

Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease.

Inflamm Bowel Dis 2016 Jan;22(1):20-7

*Department of Pediatrics and †Center for Research Informatics, The University of Chicago, Chicago, Illinois; ‡Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom; §Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; ‖Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; ¶F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; **Department of Genetics and Genomic Sciences and ††Zane Cohen Centre for Digestive Diseases, Department of Medicine, Mount Sinai Hospital, The University of Toronto, Toronto, Ontario, Canada; and ‡‡Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/MIB.0000000000000610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679526PMC
January 2016

Genetics of Inflammatory Bowel Diseases.

Gastroenterology 2015 Oct 7;149(5):1163-1176.e2. Epub 2015 Aug 7.

Departments of Genetics and Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://ac.els-cdn.com/S0016508511002009/1-s2.0-S001650851100
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http://www.cell.com/trends/immunology/pdf/S1471-4906(13)0005
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http://ac.els-cdn.com/S0016508502158963/1-s2.0-S001650850215
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http://dx.doi.org/10.1053/j.gastro.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915781PMC
October 2015

Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study.

J Cutan Med Surg 2015 Mar-Apr;19(2):125-31. Epub 2015 Mar 11.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CAWomen's College Hospital, Division of Gastroenterology, University of Toronto, Toronto, ONDepartment of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, CAMedical Genetics Research Institute, Cedars-Sinai Medical AU2 Center, Los Angeles, CA

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http://cms.sagepub.com/content/early/2015/03/06/7750.2014.14
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http://cms.sagepub.com/lookup/doi/10.2310/7750.2014.14053
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http://dx.doi.org/10.2310/7750.2014.14053DOI Listing
September 2015

Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico.

PLoS One 2014 26;9(9):e108204. Epub 2014 Sep 26.

Institute of Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178120PMC
June 2015

Multilevel regularized regression for simultaneous taxa selection and network construction with metagenomic count data.

Bioinformatics 2015 Apr 20;31(7):1067-74. Epub 2014 Nov 20.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Molecular and Computational Biology Program, Department of Biological Sciences, USC, Los Angeles, CA 90089, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA and F. Widjaja Foundation - Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382903PMC
April 2015

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

Inflamm Bowel Dis 2015 Jan;21(1):1-7

1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea; 3Human Genetics Group, Genome Institute of Singapore, Singapore, Singapore; 4The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; 5Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 6Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 7Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 8Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea; 9Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea; 10Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Ansan, Korea; 11Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Korea; 12Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea; 13Department of Life Science, Sogang University, Seoul, Korea; 14Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; 15Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea; and 16Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and 17Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

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http://pdfs.journals.lww.com/ibdjournal/2015/01000/Immunochi
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http://dx.doi.org/10.1097/MIB.0000000000000268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331109PMC
January 2015

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism.

ISME J 2014 Nov 29;8(11):2193-206. Epub 2014 Apr 29.

1] Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/ismej.2014.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992076PMC
November 2014

The role of glycosylation in IBD.

Nat Rev Gastroenterol Hepatol 2014 Oct 10;11(10):588-600. Epub 2014 Jun 10.

Department of Biochemistry and Molecular Biology, University of Zagreb Faculty of Pharmacy and Biochemistry, Trg maršala Tita 14, 10000 Zagreb, Croatia.

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http://dx.doi.org/10.1038/nrgastro.2014.78DOI Listing
October 2014

A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease.

PLoS One 2013 19;8(11):e80702. Epub 2013 Nov 19.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834335PMC
August 2014

Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.

J Immunol 2014 Jul 16;193(2):940-9. Epub 2014 Jun 16.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095;

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http://dx.doi.org/10.4049/jimmunol.1400093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096688PMC
July 2014

Towards personalized care in IBD.

Nat Rev Gastroenterol Hepatol 2014 May 17;11(5):287-99. Epub 2013 Dec 17.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8730 Alden Drive, Suite E235, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1038/nrgastro.2013.242DOI Listing
May 2014

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

Gastroenterology 2014 Apr 11;146(4):1028-39. Epub 2014 Jan 11.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002656PMC
April 2014

Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.

Inflamm Bowel Dis 2014 Apr;20(4):646-51

*Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri; †Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri; ‡The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and §Medical Genetics Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/01.MIB.0000442838.21040.d7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180521PMC
April 2014

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients.

Inflamm Bowel Dis 2014 Mar;20(3):525-33

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California; ‡Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland; §Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; ‖Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut; ¶Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; **Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada; ††Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada; ‡‡Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California; and §§Medical Genetics Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/01.MIB.0000442011.60285.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046633PMC
March 2014

Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale.

Dig Dis Sci 2013 May 19;58(5):1313-21. Epub 2012 Dec 19.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8635 W. 3rd St. #960-Wv, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/s10620-012-2500-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161217PMC
May 2013

LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.

Expert Rev Clin Immunol 2012 Mar;8(3):227-9

Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Davis Building Room 4063, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1586/eci.12.11DOI Listing
March 2012

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.

Inflamm Bowel Dis 2011 Jan;17(1):171-8

Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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https://academic.oup.com/ibdjournal/article/17/1/171-178/463
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http://dx.doi.org/10.1002/ibd.21352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400263PMC
January 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

Immunogenetics 2009 Oct 30;61(10):663-71. Epub 2009 Sep 30.

Center for Genetics, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA.

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http://dx.doi.org/10.1007/s00251-009-0396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813946PMC
October 2009

MAGI2 genetic variation and inflammatory bowel disease.

Inflamm Bowel Dis 2009 Jan;15(1):75-83

Medical Genetics Institute & Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1002/ibd.20611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614310PMC
January 2009

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

Gastroenterology 2006 Oct 5;131(4):1190-6. Epub 2006 Aug 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK.

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http://dx.doi.org/10.1053/j.gastro.2006.08.008DOI Listing
October 2006