Publications by authors named "Derin B Keskin"

61Publications

Acquired mechanisms of immune escape in cancer following immunotherapy.

Genome Med 2018 11 22;10(1):87. Epub 2018 Nov 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s13073-018-0598-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249768PMC
November 2018

TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

Eur J Immunol 2018 01 29;48(1):128-150. Epub 2017 Sep 29.

Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/eji.201747174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531858PMC
January 2018

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.

Immunity 2017 02;46(2):315-326

Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405381PMC
February 2017

Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.

Proc Natl Acad Sci U S A 2015 May 6;112(19):E2418. Epub 2015 Apr 6.

Department of Medical Oncology, Laboratory of Immunobiology, Cancer Vaccine Center, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1503931112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434774PMC
May 2015

Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2151-6. Epub 2015 Feb 2.

Department of Medical Oncology, Laboratory of Immunobiology, Cancer Vaccine Center, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1423482112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343122PMC
February 2015

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1517-22. Epub 2015 Jan 20.

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235

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http://www.pnas.org/content/112/5/1517.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1424829112
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http://dx.doi.org/10.1073/pnas.1424829112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321250PMC
February 2015

Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.

Front Immunol 2014 27;5:597. Epub 2014 Nov 27.

Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA , USA ; Department of Computer Science, Metropolitan College, Boston University , Boston, MA , USA ; Department of Medicine, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245923PMC
December 2014

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.

Front Immunol 2014 4;5:418. Epub 2014 Sep 4.

Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA , USA ; Department of Medicine, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154463PMC
September 2014

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.

Blood 2014 Jul 2;124(3):453-62. Epub 2014 Jun 2.

Cancer Vaccine Center and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1182/blood-2014-04-567933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102716PMC
July 2014

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

J Biol Chem 2014 Jul 21;289(27):18880-92. Epub 2014 May 21.

From the Department of Medical Oncology, Laboratory of Immunobiology, Dana-Farber Cancer Institute and Departments of Medicine and

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http://dx.doi.org/10.1074/jbc.M114.574996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081929PMC
July 2014

HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.

Database (Oxford) 2014 4;2014:bau031. Epub 2014 Apr 4.

Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Ave Louis Pasteur, Boston, MA 02115, USA, Department of Computer Science, Metropolitan College, Boston University, 808 Commonwealth Ave, Boston, MA 02215, USA, Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/database/bau031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975992PMC
August 2014

Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.

Clin Cancer Res 2012 Oct 21;18(20):5761-72. Epub 2012 Aug 21.

Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759991PMC
October 2012

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

BMC Bioinformatics 2011 30;12 Suppl 13:S6. Epub 2011 Nov 30.

Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1471-2105-12-S13-S6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278846PMC
August 2012

Impaired B cell development and function in the absence of IkappaBNS.

J Immunol 2011 Oct 7;187(8):3942-52. Epub 2011 Sep 7.

Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1002109
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http://dx.doi.org/10.4049/jimmunol.1002109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348541PMC
October 2011

Dana-Farber repository for machine learning in immunology.

J Immunol Methods 2011 Nov 18;374(1-2):18-25. Epub 2011 Jul 18.

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jim.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249226PMC
November 2011

MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.

J Immunol Methods 2011 Nov 2;374(1-2):53-61. Epub 2010 Dec 2.

Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jim.2010.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090484PMC
November 2011

Molecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap.

Anal Chem 2010 Nov 8;82(21):9090-9. Epub 2010 Oct 8.

Cancer Vaccine Center and Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1021/ac102387tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966287PMC
November 2010

Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid.

Ann Pharmacother 2010 Nov 5;44(11):1770-6. Epub 2010 Oct 5.

Center for Blistering Diseases, New England Baptist Hospital, Boston, MA, USA.

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http://journals.sagepub.com/doi/10.1345/aph.1P309
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http://dx.doi.org/10.1345/aph.1P309DOI Listing
November 2010

A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.

J Biol Chem 2010 Sep 8;285(38):29608-22. Epub 2010 Jul 8.

Cancer Vaccine Center, Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.126722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937992PMC
September 2010

Bioinformatic identification and characterization of human endothelial cell-restricted genes.

BMC Genomics 2010 May 28;11:342. Epub 2010 May 28.

Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1186/1471-2164-11-342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887814PMC
May 2010

Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products.

Autoimmun Rev 2010 Jun 24;9(8):553-9. Epub 2010 Mar 24.

Center for Blistering Diseases, Department of Medicine, New England Baptist Hospital, Boston, MA 02120, USA.

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http://dx.doi.org/10.1016/j.autrev.2010.03.003DOI Listing
June 2010

Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.

Clin Cancer Res 2010 Mar 16;16(5):1642-51. Epub 2010 Feb 16.

Division of Hematologic Malignancies, Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834217PMC
March 2010

A review of the current use of rituximab in autoimmune diseases.

Int Immunopharmacol 2009 Jan 8;9(1):10-25. Epub 2008 Nov 8.

Center for Blistering Diseases, New England Baptist Hospital, Boston, MA 02120, USA.

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http://dx.doi.org/10.1016/j.intimp.2008.10.004DOI Listing
January 2009

Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.

J Immunol 2008 Oct;181(8):5501-9

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077557PMC
http://dx.doi.org/10.4049/jimmunol.181.8.5501DOI Listing
October 2008

Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis.

Cell Mol Biol Lett 2008 23;13(4):656-66. Epub 2008 Aug 23.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 190 Longwood Ave, Boston, MA, USA.

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http://dx.doi.org/10.2478/s11658-008-0030-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275671PMC
December 2008

Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.

Proc Natl Acad Sci U S A 2008 Apr 24;105(13):5172-6. Epub 2008 Mar 24.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0712131105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278190PMC
April 2008

Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy.

Cytokine 2008 Mar;41(3):315-21

Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.cyto.2007.12.007DOI Listing
March 2008

Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.

J Immunol 2007 Aug;179(3):1681-92

Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.179.3.1681DOI Listing
August 2007

TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3378-83. Epub 2007 Feb 20.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0611098104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805591PMC
February 2007

Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.

Cell Mol Biol Lett 2007 13;12(1):82-102. Epub 2006 Nov 13.

Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 30912, USA,

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http://dx.doi.org/10.2478/s11658-006-0048-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275707PMC
August 2007

Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.

Med Immunol 2006 May 18;5. Epub 2006 May 18.

Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1476-9433-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559620PMC
May 2006

Copolymer effects on microglia and T cells in the central nervous system of humanized mice.

Eur J Immunol 2005 Dec;35(12):3683-93

Center for Neurological Diseases, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02138, USA.

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http://dx.doi.org/10.1002/eji.200526121DOI Listing
December 2005

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.

Proc Natl Acad Sci U S A 2005 Feb 21;102(5):1620-5. Epub 2005 Jan 21.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0409022102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547868PMC
February 2005

Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.

J Reprod Immunol 2002 Oct-Nov;57(1-2):143-50

Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/s0165-0378(02)00040-2DOI Listing
May 2003

Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.

J Immunol 2002 Apr;168(8):3771-6

Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.4049/jimmunol.168.8.3771DOI Listing
April 2002