Derek W Abbott

Derek W Abbott

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Derek W Abbott

Derek W Abbott

Publications by authors named "Derek W Abbott"

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Human polymorphisms in Gsdmd alter the inflammatory response.

J Biol Chem 2020 Jan 27. Epub 2020 Jan 27.

Pathology, Case Western Reserve University, United States.

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http://dx.doi.org/10.1074/jbc.RA119.010604DOI Listing
January 2020

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

Immunity 2019 07 13;51(1):43-49.e4. Epub 2019 May 13.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106 USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640092PMC
July 2019

Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity.

Sci Signal 2018 07 17;11(539). Epub 2018 Jul 17.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44122, USA.

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http://dx.doi.org/10.1126/scisignal.aao3964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066185PMC
July 2018

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Proc Natl Acad Sci U S A 2018 06 11;115(26):6792-6797. Epub 2018 Jun 11.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106;

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http://dx.doi.org/10.1073/pnas.1800562115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042100PMC
June 2018

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Structure 2018 05 22;26(5):778-784.e3. Epub 2018 Mar 22.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932255PMC
May 2018

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides.

J Immunol 2016 08 6;197(4):1353-67. Epub 2016 Jul 6.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106; and Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1600699
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http://dx.doi.org/10.4049/jimmunol.1600699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976007PMC
August 2016

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity.

Science 2016 Jul 21;353(6297):399-403. Epub 2016 Jul 21.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Angie Fowler Adolescent and Young Adult Cancer Institute and University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051664PMC
http://dx.doi.org/10.1126/science.aae0477DOI Listing
July 2016

Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain.

J Immunol 2016 05 4;196(10):4291-7. Epub 2016 Apr 4.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106

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http://dx.doi.org/10.4049/jimmunol.1502631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868782PMC
May 2016

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.

Am J Pathol 2016 Apr 22;186(4):885-98. Epub 2016 Feb 22.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807926PMC
April 2016

An IκB Kinase-Regulated Feedforward Circuit Prolongs Inflammation.

Cell Rep 2015 Jul 16;12(4):537-44. Epub 2015 Jul 16.

Department of Pathology, Case Western Reserve University (CWRU) School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520735PMC
July 2015

In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.

J Biol Chem 2014 Oct 11;289(43):29651-64. Epub 2014 Sep 11.

From the Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4973,

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http://dx.doi.org/10.1074/jbc.M114.591388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207980PMC
October 2014

Myeloid glycosylation defects lead to a spontaneous common variable immunodeficiency-like condition with associated hemolytic anemia and antilymphocyte autoimmunity.

J Immunol 2014 Jun 2;192(12):5561-70. Epub 2014 May 2.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106

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http://dx.doi.org/10.4049/jimmunol.1400385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048762PMC
June 2014

RIP2 activity in inflammatory disease and implications for novel therapeutics.

J Leukoc Biol 2013 Nov 21;94(5):927-32. Epub 2013 Jun 21.

1.Case Western Reserve University School of Medicine, Wolstein Research Bldg., 2103 Cornell Rd., Room 6532, Cleveland, OH 44122, USA.

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http://dx.doi.org/10.1189/jlb.0213109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800061PMC
November 2013

Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):16999-7004. Epub 2013 Sep 30.

Departments of Medicine and Pathology, and Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122.

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http://dx.doi.org/10.1073/pnas.1311657110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801018PMC
October 2013

Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

Cell Rep 2013 Jul 18;4(2):352-61. Epub 2013 Jul 18.

Department of Pathology, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843603PMC
July 2013

A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling.

Mol Cell Biol 2013 Jan 29;33(1):146-58. Epub 2012 Oct 29.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1128/MCB.01049-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536315PMC
January 2013

Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease.

Biochim Biophys Acta 2012 Nov 11;1823(11):2022-8. Epub 2012 Apr 11.

Department of Pathology, Case Western Reserve University, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01674889120008
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http://dx.doi.org/10.1016/j.bbamcr.2012.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404158PMC
November 2012

IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.

Mol Cell Biol 2012 Jul 30;32(13):2479-89. Epub 2012 Apr 30.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1128/MCB.00106-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434482PMC
July 2012

TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.

J Immunol 2012 Feb 6;188(3):1019-26. Epub 2012 Jan 6.

Department of Pathology, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.4049/jimmunol.1102181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262948PMC
February 2012

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

Nat Immunol 2011 Jul 17;12(9):834-43. Epub 2011 Jul 17.

Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ni.2066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205447PMC
July 2011

A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.

J Biol Chem 2011 Jan 19;286(3):1938-50. Epub 2010 Nov 19.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M110.189308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023490PMC
January 2011

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

Genes Dev 2010 Dec;24(23):2666-77

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1101/gad.1964410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994040PMC
December 2010

Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice.

J Immunol 2010 Nov 6;185(9):5561-8. Epub 2010 Oct 6.

Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.0903938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228636PMC
November 2010

CpG-B oligodeoxynucleotides inhibit TLR-dependent and -independent induction of type I IFN in dendritic cells.

J Immunol 2010 Apr 24;184(7):3367-76. Epub 2010 Feb 24.

Department of Pathology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903079
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http://dx.doi.org/10.4049/jimmunol.0903079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892962PMC
April 2010

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Curr Biol 2009 Aug 9;19(15):1255-63. Epub 2009 Jul 9.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.cub.2009.06.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741418PMC
August 2009

MEKK4 sequesters RIP2 to dictate NOD2 signal specificity.

Curr Biol 2008 Sep 4;18(18):1402-8. Epub 2008 Sep 4.

Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1016/j.cub.2008.07.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581469PMC
September 2008

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

Mol Cell Biol 2007 Nov 20;27(21):7451-61. Epub 2007 Aug 20.

Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01101-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169042PMC
November 2007

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Mol Cell Biol 2007 Sep 11;27(17):6012-25. Epub 2007 Jun 11.

Department of Pathology, Case Western Reserve University School of Medicine, Room 5123 Wolstein Research Building, Cleveland, OH 44106, and Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1128/MCB.00270-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952158PMC
September 2007

NODing off and Ramping up.

Inflamm Bowel Dis 2005 Sep;11(9):860-1

Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/01.mib.0000171284.39894.18DOI Listing
September 2005

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Genes Dev 2005 Jul 28;19(14):1692-704. Epub 2005 Jun 28.

Division of Infectious Diseases, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1311105
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http://dx.doi.org/10.1101/gad.1311105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176007PMC
July 2005

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.

Curr Biol 2004 Dec;14(24):2217-27

Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.cub.2004.12.032DOI Listing
December 2004

A rapid method for determining protein kinase phosphorylation specificity.

Nat Methods 2004 Oct;1(1):27-9

Division of Signal Transduction, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nmeth708DOI Listing
October 2004

Cervical cancer screening: from the Papanicolaou smear to the vaccine era.

J Clin Oncol 2003 May;21(10 Suppl):224s-230s

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2003.01.116DOI Listing
May 2003