Derek M Dykxhoorn

Derek M Dykxhoorn

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Derek M Dykxhoorn

Derek M Dykxhoorn

Publications by authors named "Derek M Dykxhoorn"

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48Publications

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Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.

Differentiation 2018 May - Jun;101:16-24. Epub 2018 Mar 27.

Schiff Center for Liver Diseases, University of Miami Miller School of Medicine, Miami, FL 33136, United States.

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November 2018

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring.

J Vis Exp 2018 Nov 17(141). Epub 2018 Nov 17.

Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine; Vascular Biology Institute, University of Miami Leonard M. Miller School of Medicine; Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M. Miller School of Medicine;

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November 2018

Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Hypertension 2018 Apr 26;71(4):752-760. Epub 2018 Feb 26.

From the Interdisciplinary Stem Cell Institute (W.Z., H.W., J.W., M.M.B., C.T.P., C.D.), Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences (G.C.S., C.R.W.), and Department of Human Genetics, John P. Hussman Institute for Human Genomics (D.M.D.), University of Miami Miller School of Medicine, FL.

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April 2018

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.

Arterioscler Thromb Vasc Biol 2017 Feb 1;37(2):280-290. Epub 2016 Dec 1.

From the Department of Medicine (S.D., H.W., C.J., S.Z., X.C., Q.M., J.W., E.C., W.Z., C.J.M., D.T.J, C.D.) and John T. Macdonald Foundation Department of Human Genetics (D.M.D.), Miller School of Medicine, University of Miami, FL; and Department of Cardiology, The Affiliated Hospital of Qingdao University, China (X.C.).

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February 2017

Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells.

Neurosci Lett 2017 01 5;637:201-206. Epub 2016 Nov 5.

Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami FL, United States; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami FL, United States. Electronic address:

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January 2017

Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and the Road Ahead.

J Alzheimers Dis Parkinsonism 2016 Oct 25;6(5). Epub 2016 Oct 25.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, USA.

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October 2016

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.

Neurol Genet 2016 Jun 17;2(3):e79. Epub 2016 May 17.

John P. Hussman Institute for Human Genomics (H.N.C., B.W.K., S.R., K.L.H.-N., M.A.K., P.L.W., D.V.B., D.M.D., M.L.C., J.M.V., J.R.G., G.W.B., E.R.M., R.M.C., M.A.P.-V.), Department of Neurology (H.N.C., J.M.V., M.A.P.-V.), Dr. John T. Macdonald Foundation Department of Human Genetics (D.M.D., M.L.C., J.M.V., J.R.G., G.W.B., E.R.M., R.M.C.), Miller School of Medicine, University of Miami, FL; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (B.N.V., R.M.), Gertrude H. Sergievsky Center, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Pathology and Laboratory Medicine (B.A.D., G.D.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Department of Biology (R.L., G.S.B., M.A.P.-V.), North Carolina A&T State University, Greensboro, NC; Departments of Medicine, Neurology, Ophthalmology, Genetics & Genomics, Epidemiology, and Biostatistics (L.A.F.), Boston University, MA; and Department of Epidemiology and Biostatistics (J.L.H.), Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH.

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June 2016

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Exp Neurol 2016 Mar 31;277:171-177. Epub 2015 Dec 31.

Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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March 2016

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Exp Neurol 2015 Sep 20;271:241-50. Epub 2015 Jun 20.

Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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September 2015

hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells.

Mol Cell Neurosci 2015 Sep 16;68:244-57. Epub 2015 Aug 16.

Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, United States; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, United States. Electronic address:

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September 2015

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles.

ACS Nano 2015 Jul 10;9(7):6706-16. Epub 2015 Jun 10.

△Dr. John T Macdonald Foundation, Department of Human Genetics, Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida 33136, United States.

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July 2015

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology 2015 Mar 6;84(10):972-80. Epub 2015 Feb 6.

From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System (

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March 2015

The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells.

PLoS One 2012 26;7(12):e52106. Epub 2012 Dec 26.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA.

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July 2013

Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells.

Neurosci Lett 2012 May 7;516(1):9-14. Epub 2012 Mar 7.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 509, Miami, FL 33146, USA.

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May 2012

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.

J Clin Invest 2011 Jun 16;121(6):2401-12. Epub 2011 May 16.

Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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June 2011

MicroRNAs and metastasis: little RNAs go a long way.

Cancer Res 2010 Aug 27;70(16):6401-6. Epub 2010 Jul 27.

Dr John T Macdonald Foundation, Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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August 2010

Advances in cell-type specific delivery of RNAi-based therapeutics.

IDrugs 2010 May;13(5):325-31

University of Miami Miller School of Medicine, John P Hussman Institute for Human Genomics, 1501 NW 10th Avenue, Miami, FL 33136, USA.

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May 2010

Advances in synthetic siRNA delivery.

Discov Med 2010 May;9(48):418-30

Center of Excellence in Infectious Diseases, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.

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May 2010

Breaking down the barriers: siRNA delivery and endosome escape.

J Cell Sci 2010 Apr;123(Pt 8):1183-9

Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, Miami, FL 33136, USA.

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April 2010

miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

PLoS One 2009 Sep 29;4(9):e7181. Epub 2009 Sep 29.

Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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September 2009

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.

Nat Struct Mol Biol 2009 May 19;16(5):492-8. Epub 2009 Apr 19.

Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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May 2009

RNA interference as an anticancer therapy: a patent perspective.

Expert Opin Ther Pat 2009 Apr;19(4):475-91

The University of Miami Miller School of Medicine, Miami Institute for Human Genomics, The John T Macdonald Foundation, Department of Human Genetics, Miami, FL 33136, USA.

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April 2009

RNA interference and cancer: endogenous pathways and therapeutic approaches.

Adv Exp Med Biol 2008 ;615:299-329

Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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May 2008

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.

Cell 2008 May;133(4):681-92

Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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May 2008

Identification of host proteins required for HIV infection through a functional genomic screen.

Science 2008 Feb 10;319(5865):921-6. Epub 2008 Jan 10.

Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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February 2008

MicroRNAs in viral replication and pathogenesis.

DNA Cell Biol 2007 Apr;26(4):239-49

The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts, USA.

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April 2007

Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.

Annu Rev Biomed Eng 2006 ;8:377-402

CBR Institute for Biomedical Research, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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October 2006

Silencing viral infection.

PLoS Med 2006 Jul 25;3(7):e242. Epub 2006 Jul 25.

CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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July 2006

Knocking down disease with siRNAs.

Cell 2006 Jul;126(2):231-5

CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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July 2006

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.

Proc Natl Acad Sci U S A 2006 Apr 3;103(15):5953-8. Epub 2006 Apr 3.

CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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April 2006

P-bodies and RNAi: The missing link?

J RNAi Gene Silencing 2005 Dec 16;2(1):105-6. Epub 2005 Dec 16.

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December 2005

Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.

J Biol Chem 2005 Sep 28;280(38):32736-45. Epub 2005 Jul 28.

Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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September 2005

The silent revolution: RNA interference as basic biology, research tool, and therapeutic.

Annu Rev Med 2005 ;56:401-23

CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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July 2005

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.

Nat Biotechnol 2005 Jun 22;23(6):709-17. Epub 2005 May 22.

CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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June 2005

Killing the messenger: short RNAs that silence gene expression.

Nat Rev Mol Cell Biol 2003 Jun;4(6):457-67

Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-529, Cambridge, Massachusetts 02139, USA.

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June 2003

siRNA-directed inhibition of HIV-1 infection.

Nat Med 2002 Jul 3;8(7):681-6. Epub 2002 Jun 3.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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July 2002