Publications by authors named "Derek L Stemple"

72Publications

The gene regulatory basis of genetic compensation during neural crest induction.

PLoS Genet 2019 06 14;15(6):e1008213. Epub 2019 Jun 14.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594659PMC
June 2019

In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.

Cell Rep 2017 06;19(13):2782-2795

Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494305PMC
June 2017

Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution.

Proc Natl Acad Sci U S A 2016 08 4;113(34):E5014-23. Epub 2016 Aug 4.

Section of Hematology-Oncology and Stem Cell Transplant, Department of Pediatrics, The University of Chicago, Chicago, IL 60637;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1607602113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003237PMC
August 2016

Identification of a plant isoflavonoid that causes biliary atresia.

Sci Transl Med 2015 May;7(286):286ra67

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aaa1652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784984PMC
May 2015

Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling.

Dev Biol 2015 Jan 3;397(2):212-24. Epub 2014 Dec 3.

Sequencing Technology Development, The Genome Analysis Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2014.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294769PMC
January 2015

New insights into the maternal to zygotic transition.

Development 2014 Oct;141(20):3834-41

The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.102368DOI Listing
October 2014

A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

PLoS Genet 2014 Jul 10;10(7):e1004450. Epub 2014 Jul 10.

Department of Haematology, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091788PMC
July 2014

Zebrafish models of cancer: progress and future challenges.

Curr Opin Genet Dev 2014 Feb 27;24:38-45. Epub 2013 Dec 27.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gde.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003353PMC
February 2014

The emerging use of zebrafish to model metabolic disease.

Dis Model Mech 2013 Sep;6(5):1080-8

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dmm.biologists.org/cgi/doi/10.1242/dmm.011346
Publisher Site
http://dx.doi.org/10.1242/dmm.011346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759328PMC
September 2013

Multi-allelic phenotyping--a systematic approach for the simultaneous analysis of multiple induced mutations.

Methods 2013 Aug 23;62(3):197-206. Epub 2013 Apr 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2013.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770900PMC
August 2013

The zebrafish reference genome sequence and its relationship to the human genome.

Authors:
Kerstin Howe Matthew D Clark Carlos F Torroja James Torrance Camille Berthelot Matthieu Muffato John E Collins Sean Humphray Karen McLaren Lucy Matthews Stuart McLaren Ian Sealy Mario Caccamo Carol Churcher Carol Scott Jeffrey C Barrett Romke Koch Gerd-Jörg Rauch Simon White William Chow Britt Kilian Leonor T Quintais José A Guerra-Assunção Yi Zhou Yong Gu Jennifer Yen Jan-Hinnerk Vogel Tina Eyre Seth Redmond Ruby Banerjee Jianxiang Chi Beiyuan Fu Elizabeth Langley Sean F Maguire Gavin K Laird David Lloyd Emma Kenyon Sarah Donaldson Harminder Sehra Jeff Almeida-King Jane Loveland Stephen Trevanion Matt Jones Mike Quail Dave Willey Adrienne Hunt John Burton Sarah Sims Kirsten McLay Bob Plumb Joy Davis Chris Clee Karen Oliver Richard Clark Clare Riddle David Elliot David Eliott Glen Threadgold Glenn Harden Darren Ware Sharmin Begum Beverley Mortimore Beverly Mortimer Giselle Kerry Paul Heath Benjamin Phillimore Alan Tracey Nicole Corby Matthew Dunn Christopher Johnson Jonathan Wood Susan Clark Sarah Pelan Guy Griffiths Michelle Smith Rebecca Glithero Philip Howden Nicholas Barker Christine Lloyd Christopher Stevens Joanna Harley Karen Holt Georgios Panagiotidis Jamieson Lovell Helen Beasley Carl Henderson Daria Gordon Katherine Auger Deborah Wright Joanna Collins Claire Raisen Lauren Dyer Kenric Leung Lauren Robertson Kirsty Ambridge Daniel Leongamornlert Sarah McGuire Ruth Gilderthorp Coline Griffiths Deepa Manthravadi Sarah Nichol Gary Barker Siobhan Whitehead Michael Kay Jacqueline Brown Clare Murnane Emma Gray Matthew Humphries Neil Sycamore Darren Barker David Saunders Justene Wallis Anne Babbage Sian Hammond Maryam Mashreghi-Mohammadi Lucy Barr Sancha Martin Paul Wray Andrew Ellington Nicholas Matthews Matthew Ellwood Rebecca Woodmansey Graham Clark James D Cooper James Cooper Anthony Tromans Darren Grafham Carl Skuce Richard Pandian Robert Andrews Elliot Harrison Andrew Kimberley Jane Garnett Nigel Fosker Rebekah Hall Patrick Garner Daniel Kelly Christine Bird Sophie Palmer Ines Gehring Andrea Berger Christopher M Dooley Zübeyde Ersan-Ürün Cigdem Eser Horst Geiger Maria Geisler Lena Karotki Anette Kirn Judith Konantz Martina Konantz Martina Oberländer Silke Rudolph-Geiger Mathias Teucke Christa Lanz Günter Raddatz Kazutoyo Osoegawa Baoli Zhu Amanda Rapp Sara Widaa Cordelia Langford Fengtang Yang Stephan C Schuster Nigel P Carter Jennifer Harrow Zemin Ning Javier Herrero Steve M J Searle Anton Enright Robert Geisler Ronald H A Plasterk Charles Lee Monte Westerfield Pieter J de Jong Leonard I Zon John H Postlethwait Christiane Nüsslein-Volhard Tim J P Hubbard Hugues Roest Crollius Jane Rogers Derek L Stemple

Nature 2013 Apr 17;496(7446):498-503. Epub 2013 Apr 17.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703927PMC
April 2013

Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism.

Am J Hum Genet 2013 Mar 7;92(3):415-21. Epub 2013 Feb 7.

Applied Human Molecular Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591853PMC
March 2013

Genetic analysis of Xenopus tropicalis.

Methods Mol Biol 2012 ;917:69-110

National Institute for Medical Research, London, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-992-1_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273174PMC
January 2013

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

J Pathol 2012 Nov 26;228(3):274-85. Epub 2012 Sep 26.

Randall Division of Cell and Molecular Biophysics, New Hunt's House, King's College London, Guy's Campus, London, SE1 1UL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089345PMC
November 2012

Incorporating RNA-seq data into the zebrafish Ensembl genebuild.

Genome Res 2012 Oct 12;22(10):2067-78. Epub 2012 Jul 12.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.137901.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460200PMC
October 2012

Image-based characterization of thrombus formation in time-lapse DIC microscopy.

Med Image Anal 2012 May 11;16(4):915-31. Epub 2012 Feb 11.

Computer Aided Medical Procedures, Technische Universität München (TUM), Garching bei München 85748, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13618415120003
Publisher Site
http://dx.doi.org/10.1016/j.media.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740235PMC
May 2012

Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studies.

Genesis 2012 Mar 27;50(3):316-24. Epub 2011 Dec 27.

Institute of Systems and Synthetic Biology, Genopole, CNRS, Université d'Evry Val d'Essonne, Genavenir 3-Genopole campus 3, 1 rue Pierre Fontaine, Evry, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvg.20822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503257PMC
March 2012

High-throughput target-selected gene inactivation in zebrafish.

Methods Cell Biol 2011 ;104:121-7

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-374814-0.00006-9DOI Listing
January 2012

The future of model organisms in human disease research.

Nat Rev Genet 2011 07 18;12(8):575-82. Epub 2011 Jul 18.

Medical Research Council Clinical Sciences Centre, Imperial College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrg3047DOI Listing
July 2011

Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies.

Hum Mol Genet 2011 May 11;20(9):1763-75. Epub 2011 Feb 11.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddr059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071672PMC
May 2011

Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.

J Cell Sci 2011 Feb 18;124(Pt 4):565-77. Epub 2011 Jan 18.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.071274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031369PMC
February 2011

The role of meis1 in primitive and definitive hematopoiesis during zebrafish development.

Haematologica 2011 Feb 3;96(2):190-8. Epub 2010 Nov 3.

Department of Haematology, University of Cambridge, Long Road, Cambridge CB2 0PT, UK.

View Article

Download full-text PDF

Source
http://www.haematologica.org/cgi/doi/10.3324/haematol.2010.0
Publisher Site
http://dx.doi.org/10.3324/haematol.2010.027698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031685PMC
February 2011

Organ-specific requirements for Hdac1 in liver and pancreas formation.

Dev Biol 2008 Oct 21;322(2):237-50. Epub 2008 Jul 21.

National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2008.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710974PMC
October 2008

Zebrafish genome project: bringing new biology to the vertebrate genome field.

Zebrafish 2007 ;4(4):239-51

Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/zeb.2007.9979DOI Listing
March 2008

Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis.

Dev Biol 2007 Aug 25;308(2):368-78. Epub 2007 May 25.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2007.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994576PMC
August 2007

Genetic screens for mutations affecting development of Xenopus tropicalis.

PLoS Genet 2006 Jun 9;2(6):e91. Epub 2006 Jun 9.

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom.

View Article

Download full-text PDF

Source
https://dx.plos.org/10.1371/journal.pgen.0020091
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.0020091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475704PMC
June 2006

DNA detection using recombination proteins.

PLoS Biol 2006 Jul;4(7):e204

ASM Scientific Ltd, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.0040204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475771PMC
July 2006

Genetic and genomic prospects for Xenopus tropicalis research.

Semin Cell Dev Biol 2006 Feb 20;17(1):146-53. Epub 2006 Jan 20.

Vertebrate Development and Genetics, The Morgan Building, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2005.11.009DOI Listing
February 2006

Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation.

Dev Biol 2006 Jan;289(1):64-76

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2005.10.006DOI Listing
January 2006

Multiple mutations in mouse Chd7 provide models for CHARGE syndrome.

Hum Mol Genet 2005 Nov 5;14(22):3463-76. Epub 2005 Oct 5.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddi375DOI Listing
November 2005

Structure and function of the notochord: an essential organ for chordate development.

Authors:
Derek L Stemple

Development 2005 Jun;132(11):2503-12

Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.01812DOI Listing
June 2005

Zebrafish notochordal basement membrane: signaling and structure.

Curr Top Dev Biol 2005 ;65:229-53

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0070-2153(04)65009-5DOI Listing
March 2005

The notochord.

Authors:
Derek L Stemple

Curr Biol 2004 Oct;14(20):R873-4

Vertebrate Development and Genetics (Team 31), Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2004.09.065DOI Listing
October 2004

Differential requirements for COPI transport during vertebrate early development.

Dev Cell 2004 Oct;7(4):547-58

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S153458070400283
Publisher Site
http://dx.doi.org/10.1016/j.devcel.2004.07.020DOI Listing
October 2004

Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish.

Dev Biol 2004 Sep;273(1):23-37

Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309-0347, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2004.05.019DOI Listing
September 2004

Nodal signaling and vertebrate germ layer formation.

Birth Defects Res C Embryo Today 2003 Nov;69(4):325-32

Vertebrate Development and Genetics (Team31), Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdrc.10027DOI Listing
November 2003

TILLING--a high-throughput harvest for functional genomics.

Authors:
Derek L Stemple

Nat Rev Genet 2004 Feb;5(2):145-50

Vertebrate Development and Genetics (Team 31), Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrg1273
Publisher Site
http://dx.doi.org/10.1038/nrg1273DOI Listing
February 2004

Lefty antagonism of Squint is essential for normal gastrulation.

Curr Biol 2002 Dec;12(24):2129-35

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

View Article

Download full-text PDF

Source
http://www.ucl.ac.uk/zebrafish-group/publications/Feldman200
Web Search
http://dx.doi.org/10.1016/s0960-9822(02)01361-1DOI Listing
December 2002

Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.

Development 2002 Jul;129(14):3505-12

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

View Article

Download full-text PDF

Source
July 2002

Zebrafish mutants identify an essential role for laminins in notochord formation.

Development 2002 Jul;129(13):3137-46

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

View Article

Download full-text PDF

Source
July 2002

Pioneering work in vertebrate neural development.

Authors:
Derek L Stemple

Dev Cell 2002 Jun;2(6):687-8

Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1534-5807(02)00192-2DOI Listing
June 2002