Publications by authors named "Derek Klarin"

45Publications

The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.

PLoS Med 2020 Sep 11;17(9):e1003302. Epub 2020 Sep 11.

Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1003302DOI Listing
September 2020

Mendelian Randomization Study of ACLY and Cardiovascular Disease.

N Engl J Med 2020 08;383(7):e50

Verve Therapeutics, Cambridge, MA

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http://dx.doi.org/10.1056/NEJMc1908496DOI Listing
August 2020

Genetic predisposition to smoking in relation to 14 cardiovascular diseases.

Eur Heart J 2020 Apr 16. Epub 2020 Apr 16.

Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

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http://dx.doi.org/10.1093/eurheartj/ehaa193DOI Listing
April 2020

Concomitant carotid endarterectomy and cardiac surgery does not decrease postoperative stroke rates.

J Vasc Surg 2020 Aug 14;72(2):589-596.e3. Epub 2020 Feb 14.

Department of Cardiac Surgery, Massachusetts General Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jvs.2019.10.072DOI Listing
August 2020

Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy.

J Am Coll Cardiol 2019 12 11;74(22):2743-2754. Epub 2019 Nov 11.

Cardiology Division and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.09.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981240PMC
December 2019

Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2019 06;39(6):1253-1261

From the Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.Z., K.A., C.E., A.V.K., D.K., P.N.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312626
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http://dx.doi.org/10.1161/ATVBAHA.119.312626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531323PMC
June 2019

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:
Ayush Giri Jacklyn N Hellwege Jacob M Keaton Jihwan Park Chengxiang Qiu Helen R Warren Eric S Torstenson Csaba P Kovesdy Yan V Sun Otis D Wilson Cassianne Robinson-Cohen Christianne L Roumie Cecilia P Chung Kelly A Birdwell Scott M Damrauer Scott L DuVall Derek Klarin Kelly Cho Yu Wang Evangelos Evangelou Claudia P Cabrera Louise V Wain Rojesh Shrestha Brian S Mautz Elvis A Akwo Muralidharan Sargurupremraj Stéphanie Debette Michael Boehnke Laura J Scott Jian'an Luan Jing-Hua Zhao Sara M Willems Sébastien Thériault Nabi Shah Christopher Oldmeadow Peter Almgren Ruifang Li-Gao Niek Verweij Thibaud S Boutin Massimo Mangino Ioanna Ntalla Elena Feofanova Praveen Surendran James P Cook Savita Karthikeyan Najim Lahrouchi Chunyu Liu Nuno Sepúlveda Tom G Richardson Aldi Kraja Philippe Amouyel Martin Farrall Neil R Poulter Markku Laakso Eleftheria Zeggini Peter Sever Robert A Scott Claudia Langenberg Nicholas J Wareham David Conen Colin Neil Alexander Palmer John Attia Daniel I Chasman Paul M Ridker Olle Melander Dennis Owen Mook-Kanamori Pim van der Harst Francesco Cucca David Schlessinger Caroline Hayward Tim D Spector Marjo-Riitta Jarvelin Branwen J Hennig Nicholas J Timpson Wei-Qi Wei Joshua C Smith Yaomin Xu Michael E Matheny Edward E Siew Cecilia Lindgren Karl-Heinz Herzig George Dedoussis Joshua C Denny Bruce M Psaty Joanna M M Howson Patricia B Munroe Christopher Newton-Cheh Mark J Caulfield Paul Elliott J Michael Gaziano John Concato Peter W F Wilson Philip S Tsao Digna R Velez Edwards Katalin Susztak Christopher J O'Donnell Adriana M Hung Todd L Edwards

Nat Genet 2019 01 21;51(1):51-62. Epub 2018 Dec 21.

Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.

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http://www.nature.com/articles/s41588-018-0303-9
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http://dx.doi.org/10.1038/s41588-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102PMC
January 2019

Risk factor profile and anatomic features of previously asymptomatic patients presenting with carotid-related stroke.

J Vasc Surg 2018 11 24;68(5):1390-1395. Epub 2018 May 24.

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2018.01.064DOI Listing
November 2018

Heritability of Atrial Fibrillation.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA (L.-C.W., S.H.C., D.K., J.G.S. P.-R.L., M.C., C.R., O.L.H., C.N.-C., S.K., P.T.E., S.A.L.); Department of Cardiology, Clinical Sciences, Lund University, Sweden (J.G.S.); Department of Heart Failure and Valvular Disease, Skane University Hospital, Lund, Sweden (J.G.S.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (P.-R.L.); Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (K.L.L., J.D., E.J.B.); Boston University School of Public Health, Boston, MA (K.L.L., J.D., E.J.B.); Boston University School of Medicine, Boston, MA (E.J.B.); and Cardiovascular Research Center (L.-C.W., D.K., J.G.S., O.L.H., C.N.-C., S.K., P.T.E., S.A.L.) and Cardiac Arrhythmia Service (P.T.E., S.A.L.), Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966046PMC
December 2017

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.

Sci Rep 2017 09 12;7(1):11303. Epub 2017 Sep 12.

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-017-09396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595875PMC
September 2017

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 07;49(8):1286

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http://dx.doi.org/10.1038/ng0817-1286cDOI Listing
July 2017

Reply.

J Vasc Surg 2017 05;65(5):1550

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jvs.2016.12.096DOI Listing
May 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 Jun 17;49(6):946-952. Epub 2017 Apr 17.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585859PMC
June 2017

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.

Diabetes 2017 08 14;66(8):2310-2315. Epub 2017 Apr 14.

Center for Genomic Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db17-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521864PMC
August 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.

Circ Cardiovasc Genet 2017 Apr;10(2)

From the Center for Genomic Medicine (D.K., C.A.E., P.N., S.K.), Department of Surgery (D.K.), and Division of Vascular and Endovascular Surgery (M.E.C.), Massachusetts General Hospital, Harvard Medical School, Boston; and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (D.K., C.A.E., P.N., S.K.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395047PMC
April 2017

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.

JAMA 2017 02;317(6):626-634

Center for Genomic Medicine and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston2Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1001/jama.2016.21042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571980PMC
February 2017

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort.

Am J Cardiol 2017 Mar 18;119(6):881-885. Epub 2016 Dec 18.

Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.11.042DOI Listing
March 2017

Perioperative and long-term impact of chronic kidney disease on carotid artery interventions.

J Vasc Surg 2016 Nov;64(5):1295-1302

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2016.04.038DOI Listing
November 2016