Publications by authors named "Derek A Mann"

100Publications

Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI.

Bone Joint J 2020 Oct;102-B(10):1331-1340

Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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October 2020

Anti-inflammatory treatment rescues memory deficits during aging in nfkb1 mice.

Aging Cell 2020 10 11;19(10):e13188. Epub 2020 Sep 11.

Biosciences Institute, Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

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October 2020

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.

Gastroenterology 2019 11 25;157(5):1398-1412.e9. Epub 2019 Jul 25.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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November 2019

Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery.

J Orthop Res 2019 11 23;37(11):2316-2324. Epub 2019 Jul 23.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.

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November 2019

HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 10 10;1861(10):962-970. Epub 2018 Sep 10.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, UK. Electronic address:

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October 2018

Rapamycin improves healthspan but not inflammaging in nfκb1 mice.

Aging Cell 2019 02 23;18(1):e12882. Epub 2018 Nov 23.

Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.

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February 2019

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis.

Gut 2018 10 20;67(10):1907-1908. Epub 2018 Jan 20.

Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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October 2018

Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

Br J Cancer 2018 01 9;118(2):248-257. Epub 2017 Nov 9.

Northern Centre for Cancer Care, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 7DN, UK.

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January 2018

Variant Histone H2afv reprograms DNA methylation during early zebrafish development.

Epigenetics 2017 09 24;12(9):811-824. Epub 2017 Nov 24.

b Fibrosis Group , Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , NE24HH.

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September 2017

Epigenetic reprogramming in liver fibrosis and cancer.

Adv Drug Deliv Rev 2017 11 25;121:124-132. Epub 2017 Oct 25.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, UK. Electronic address:

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November 2017

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.

Mol Ther 2017 01 4;25(1):218-231. Epub 2017 Jan 4.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4(th) Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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January 2017

Epigenetics in liver disease: from biology to therapeutics.

Gut 2016 11 13;65(11):1895-1905. Epub 2016 Sep 13.

Fibrosis Laboratories, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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November 2016

Liver: Osteopontin and HMGB1: novel regulators of HSC activation.

Nat Rev Gastroenterol Hepatol 2016 06 14;13(6):320-2. Epub 2016 Apr 14.

Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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June 2016

A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo.

J Hepatol 2016 07 9;65(1):75-83. Epub 2016 Apr 9.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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July 2016

TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury.

J Immunol 2016 05 6;196(10):4298-310. Epub 2016 Apr 6.

Laboratory of Molecular and Cellular Biology, University of Crete Medical School, 71003 Heraklion, Crete, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research & Technology-Hellas, 70013 Heraklion, Crete, Greece; Laboratory of Translational Medicine and Experimental Therapeutics, University of Crete Medical School, 71003 Heraklion, Crete, Greece;

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May 2016

The Role of the Fibroblast in Inflammatory Upper Airway Conditions.

Am J Pathol 2016 Feb 10;186(2):225-33. Epub 2015 Dec 10.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2016

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

PLoS One 2015 13;10(11):e0142794. Epub 2015 Nov 13.

Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.

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June 2016

Fibrosis is a common outcome following total knee arthroplasty.

Sci Rep 2015 Nov 10;5:16469. Epub 2015 Nov 10.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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November 2015

Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.

J Hepatol 2015 Dec 8;63(6):1421-8. Epub 2015 Aug 8.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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December 2015

Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement.

PLoS One 2015 21;10(7):e0133629. Epub 2015 Jul 21.

Department of Orthopaedics, The Royal Victoria Infirmary and the Freeman Hospital, Newcastle upon Tyne, United Kingdom; Fibrosis Research Group, Institute of Cellular Medicine, University of Newcastle, Newcasltle upon Tyne, United Kingdom.

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May 2016

Epigenetic regulation of liver fibrosis.

Clin Res Hepatol Gastroenterol 2015 Sep 16;39 Suppl 1:S64-8. Epub 2015 Jul 16.

Fibrosis Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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September 2015

Emerging and disease-specific mechanisms of hepatic stellate cell activation.

Semin Liver Dis 2015 May 14;35(2):107-18. Epub 2015 May 14.

Fibrosis Laboratory, Institute of Cellular Medicine, New Castle University, Newcastle upon Tyne, United Kingdom.

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May 2015

Novel therapeutic targets in primary biliary cirrhosis.

Nat Rev Gastroenterol Hepatol 2015 Mar 3;12(3):147-58. Epub 2015 Feb 3.

Institute of Cellular Medicine, 3rd Floor William Leech Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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March 2015

How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis?

Ann Otol Rhinol Laryngol 2015 Jun 23;124(6):437-42. Epub 2014 Dec 23.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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June 2015

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells.

J Hepatol 2015 Feb 20;62(2):388-97. Epub 2014 Oct 20.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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February 2015

The mechanisms of HSC activation and epigenetic regulation of HSCs phenotypes.

Curr Pathobiol Rep 2014 Dec 27;2(4):163-170. Epub 2014 Sep 27.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4 Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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December 2014

Epigenetics in liver disease.

Authors:
Derek A Mann

Hepatology 2014 Oct 7;60(4):1418-25. Epub 2014 May 7.

Fibrosis Research Laboratories, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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October 2014

Epigenetic modifications as new targets for liver disease therapies.

J Hepatol 2013 Dec 4;59(6):1349-53. Epub 2013 Jun 4.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2013

The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice.

Am J Pathol 2013 Jun 4;182(6):2109-20. Epub 2013 Apr 4.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2013

An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury.

HPB (Oxford) 2013 Aug 27;15(8):581-7. Epub 2012 Dec 27.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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August 2013

Epigenetic regulation of wound healing and fibrosis.

Curr Opin Rheumatol 2013 Jan;25(1):101-7

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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January 2013

Serotonin paracrine signaling in tissue fibrosis.

Biochim Biophys Acta 2013 Jul 29;1832(7):905-10. Epub 2012 Sep 29.

Fibrosis Laboratories, Institute of Cellular Medicine, 4th Floor, William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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July 2013

The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

Am J Pathol 2012 Jun 21;180(6):2293-308. Epub 2012 Apr 21.

Tissue Fibrosis & Repair Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2012

Clinical evidence for the regression of liver fibrosis.

J Hepatol 2012 May 13;56(5):1171-1180. Epub 2012 Jan 13.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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May 2012

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect.

Hepatology 2012 Apr 1;55(4):1271-81. Epub 2012 Mar 1.

Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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April 2012

Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways.

Cancer Microenviron 2012 Apr 27;5(1):45-57. Epub 2011 Jul 27.

Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, NE2 4HH.

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April 2012

Epigenetic cell fate regulation of hepatic stellate cells.

Hepatol Res 2011 Jul 19;41(7):675-82. Epub 2011 Apr 19.

Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California Keck School of Medicine Greater Los Angeles Healthcare System, Los Angeles, California, USA Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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July 2011

Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.

Biochim Biophys Acta 2011 May 18;1813(5):731-41. Epub 2011 Feb 18.

Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

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May 2011

Counter-selection recombineering of the baculovirus genome: a strategy for seamless modification of repeat-containing BACs.

Nucleic Acids Res 2010 Sep 9;38(16):e166. Epub 2010 Jul 9.

Pharmaceutical Science Division, King's College London, London SE1 9NH, UK.

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September 2010

The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes.

J Hepatol 2010 Sep 2;53(3):519-27. Epub 2010 Jun 2.

Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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September 2010

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.

Ann Rheum Dis 2010 Jul 6;69(7):1315-20. Epub 2010 May 6.

Musculoskeletal Research Group, Institute of Cellular Medicine, University of Newcastle, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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July 2010

The PXR is a drug target for chronic inflammatory liver disease.

J Steroid Biochem Mol Biol 2010 May 21;120(2-3):137-48. Epub 2010 Apr 21.

Institute of Cellular Medicine, University of Newcastle, Upon Tyne, UK.

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May 2010

Fibrogenic signalling in hepatic stellate cells.

J Hepatol 2010 Jun 20;52(6):949-50. Epub 2010 Mar 20.

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Catherine Cookson Building, Medical School, Newcastle University, UK.

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June 2010

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

PLoS One 2010 Mar 25;5(3):e9902. Epub 2010 Mar 25.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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March 2010

Role of nuclear factor kappaB in liver health and disease.

Clin Sci (Lond) 2010 Mar 30;118(12):691-705. Epub 2010 Mar 30.

Cell Signalling Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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March 2010

The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation.

Hepatology 2010 Mar;51(3):922-31

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Cookson Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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March 2010

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

J Biol Chem 2010 Feb 17;285(8):5428-37. Epub 2009 Dec 17.

Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA.

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February 2010

NF-kappaB signalling: embracing complexity to achieve translation.

J Hepatol 2010 Feb 24;52(2):285-91. Epub 2009 Nov 24.

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Catherine Cookson Building, Medical School, Newcastle University, UK.

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February 2010

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.

Gastroenterology 2010 Feb 17;138(2):705-14, 714.e1-4. Epub 2009 Oct 17.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2010

Transcriptional regulation of hepatic stellate cells.

Adv Drug Deliv Rev 2009 Jul 22;61(7-8):497-512. Epub 2009 Apr 22.

Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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July 2009

Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.

Gastroenterology 2009 Jun 18;136(7):2334-2344.e1. Epub 2009 Mar 18.

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2009

Fibrosis and cirrhosis reversibility - molecular mechanisms.

Clin Liver Dis 2008 Nov;12(4):915-37, xi

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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November 2008

Wound healing and local neuroendocrine regulation in the injured liver.

Expert Rev Mol Med 2008 Apr 29;10:e11. Epub 2008 Apr 29.

Cell signalling, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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April 2008

Epigenetic regulation of hepatic stellate cell activation.

J Gastroenterol Hepatol 2008 Mar;23 Suppl 1:S108-11

Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.

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March 2008

Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain.

J Neuropathol Exp Neurol 2008 Mar;67(3):223-30

Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.

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March 2008

Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis.

J Biol Chem 2008 May 22;283(20):14063-71. Epub 2008 Feb 22.

Centre for Human Development, Stem Cells & Regeneration.

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May 2008

The function of serotonin within the liver.

J Hepatol 2008 Apr 28;48(4):666-75. Epub 2008 Jan 28.

Hepatic Fibrosis Group, The Queensland Institute of Medical Research, PO Royal Brisbane and Women's Hospital, Brisbane, Qld 4029, Australia.

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April 2008

NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.

J Hepatol 2008 Apr 31;48(4):589-97. Epub 2008 Jan 31.

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.

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April 2008

Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis.

Hepatology 2007 Aug;46(2):590-7

Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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August 2007

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation.

Hepatology 2006 Dec;44(6):1432-40

Liver Group, Division of Infection, Inflammation & Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK.

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December 2006

Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic.

Int J Biochem Cell Biol 2007 7;39(4):695-714. Epub 2006 Oct 7.

Liver Group, Division of Infection, Inflammation & Repair, University of Southampton, Southampton SO16 6YD, United Kingdom.

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June 2007

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis.

Am J Pathol 2006 Sep;169(3):861-76

Liver Research Group, Divison of Infection, Inflammation and Repair, University of Southampton School of Medicine, and Southampton General Hospital, UK.

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September 2006

NF-kappaB: a signal for cancer.

J Hepatol 2005 Apr;42(4):610-1

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK.

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April 2005

Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.

J Immunol 2005 Nov;175(10):6560-9

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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November 2005

RNA interference mediated in human primary cells via recombinant baculoviral vectors.

Mol Ther 2005 Apr;11(4):638-44

Department of Oncology, Guy's, King's and St Thomas' School of Medicine, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.

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April 2005

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

Gastroenterology 2005 Jan;128(1):108-20

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK.

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January 2005

Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2.

J Biol Chem 2004 Jun 29;279(23):24530-9. Epub 2004 Mar 29.

Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.

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June 2004