Publications by authors named "Derek A Mann"

100Publications

Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.

Authors:
Arianna Bianchi Letizia Marchetti Zoe Hall Henrique Lemos Michele Vacca Hannah Paish Kile Green Bronte Elliott Dina Tiniakos João F Passos Diana Jurk Derek A Mann Caroline L Wilson

J Immunol 2021 Jan 13. Epub 2021 Jan 13.

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom;

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January 2021

Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.

Authors:
Jack Leslie Marina García Macia Saimir Luli Julie C Worrell William J Reilly Hannah L Paish Amber Knox Ben S Barksby Lucy M Gee Marco Y W Zaki Amy L Collins Rachel A Burgoyne Rainie Cameron Charlotte Bragg Xin Xu Git W Chung Colin D A Brown Andrew D Blanchard Carmel B Nanthakumar Morten Karsdal Stuart M Robinson Derek M Manas Gourab Sen Jeremy French Steven A White Sandra Murphy Matthias Trost Johannes L Zakrzewski Ulf Klein Robert F Schwabe Ingmar Mederacke Colin Nixon Tom Bird Laure-Anne Teuwen Luc Schoonjans Peter Carmeliet Jelena Mann Andrew J Fisher Neil S Sheerin Lee A Borthwick Derek A Mann Fiona Oakley

Nat Metab 2020 Dec 10. Epub 2020 Dec 10.

Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2020

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.

Authors:
Jack Leslie Marina García Macia Saimir Luli Julie C Worrell William J Reilly Hannah L Paish Amber Knox Ben S Barksby Lucy M Gee Marco Y W Zaki Amy L Collins Rachel A Burgoyne Rainie Cameron Charlotte Bragg Xin Xu Git W Chung Colin D A Brown Andrew D Blanchard Carmel B Nanthakumar Morten Karsdal Stuart M Robinson Derek M Manas Gourab Sen Jeremy French Steven A White Sandra Murphy Matthias Trost Johannes L Zakrzewski Ulf Klein Robert F Schwabe Ingmar Mederacke Colin Nixon Tom Bird Laure-Anne Teuwen Luc Schoonjans Peter Carmeliet Jelena Mann Andrew J Fisher Neil S Sheerin Lee A Borthwick Derek A Mann Fiona Oakley

Nat Metab 2020 11 9;2(11):1350-1367. Epub 2020 Nov 9.

Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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November 2020

Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI.

Authors:
Veronica Attard Cheuk Yin Li Alexander Self Derek A Mann Lee A Borthwick Phil O'Connor David J Deehan Nicholas S Kalson

Bone Joint J 2020 Oct;102-B(10):1331-1340

Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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October 2020

Anti-inflammatory treatment rescues memory deficits during aging in nfkb1 mice.

Authors:
Edward Fielder Clare Tweedy Caroline Wilson Fiona Oakley Fiona E N LeBeau João F Passos Derek A Mann Thomas von Zglinicki Diana Jurk

Aging Cell 2020 10 11;19(10):e13188. Epub 2020 Sep 11.

Biosciences Institute, Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

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October 2020

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

Authors:
Aitor Esparza-Baquer Ibone Labiano Omar Sharif Aloña Agirre-Lizaso Fiona Oakley Pedro M Rodrigues Ekaterina Zhuravleva Colm J O'Rourke Elizabeth Hijona Raul Jimenez-Agüero Ioana Riaño Ana Landa Adelaida La Casta Marco Y W Zaki Patricia Munoz-Garrido Mikel Azkargorta Felix Elortza Andrea Vogel Gernot Schabbauer Patricia Aspichueta Jesper B Andersen Sylvia Knapp Derek A Mann Luis Bujanda Jesus Maria Banales Maria Jesus Perugorria

Gut 2020 Sep 9. Epub 2020 Sep 9.

Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain

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September 2020

cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis.

Authors:
Julie C Worrell Jack Leslie Graham R Smith Marco Y W Zaki Hannah L Paish Amber Knox Michelle L James Tyrell N Cartwright Steven O'Reilly Gabriela Kania Oliver Distler Jörg H W Distler Ariane L Herrick Maria Jeziorska Lee A Borthwick Andrew J Fisher Jelena Mann Derek A Mann Fiona Oakley

Rheumatology (Oxford) 2020 12;59(12):3939-3951

Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne.

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December 2020

FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis.

Authors:
Jack Leslie Ben Jm Millar Alicia Del Carpio Pons Rachel A Burgoyne Joseph D Frost Ben S Barksby Saimir Luli Jon Scott A John Simpson Jack Gauldie Lynne A Murray Donna K Finch Alan M Carruthers John Ferguson Matthew A Sleeman David Rider Rachel Howarth Christopher Fox Fiona Oakley Andrew J Fisher Derek A Mann Lee A Borthwick

JCI Insight 2020 02 27;5(4). Epub 2020 Feb 27.

Newcastle Fibrosis Research Group and.

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February 2020

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.

Authors:
Eva Moran-Salvador Marina Garcia-Macia Ashwin Sivaharan Laura Sabater Marco Y W Zaki Fiona Oakley Amber Knox Agata Page Saimir Luli Jelena Mann Derek A Mann

Gastroenterology 2019 11 25;157(5):1398-1412.e9. Epub 2019 Jul 25.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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November 2019

Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery.

Authors:
Hannah L Paish Thomas Edward Baldock Colin S Gillespie Alicia Del Carpio Pons Derek A Mann David J Deehan Lee A Borthwick Nicholas S Kalson

J Orthop Res 2019 11 23;37(11):2316-2324. Epub 2019 Jul 23.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.

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November 2019

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices.

Authors:
Hannah L Paish Lee H Reed Helen Brown Mark C Bryan Olivier Govaere Jack Leslie Ben S Barksby Marina Garcia Macia Abigail Watson Xin Xu Marco Y W Zaki Laura Greaves Julia Whitehall Jeremy French Steven A White Derek M Manas Stuart M Robinson Gabriele Spoletini Clive Griffiths Derek A Mann Lee A Borthwick Michael J Drinnan Jelena Mann Fiona Oakley

Hepatology 2019 10 28;70(4):1377-1391. Epub 2019 May 28.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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October 2019

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Authors:
Mohsen Malehmir Dominik Pfister Suchira Gallage Marta Szydlowska Donato Inverso Elena Kotsiliti Valentina Leone Moritz Peiseler Bas G J Surewaard Dominik Rath Adnan Ali Monika Julia Wolf Hannah Drescher Marc E Healy Daniel Dauch Daniela Kroy Oliver Krenkel Marlene Kohlhepp Thomas Engleitner Alexander Olkus Tjeerd Sijmonsma Julia Volz Carsten Deppermann David Stegner Patrick Helbling César Nombela-Arrieta Anahita Rafiei Martina Hinterleitner Marcel Rall Florian Baku Oliver Borst Caroline L Wilson Jack Leslie Tracy O'Connor Christopher J Weston David H Adams Lozan Sheriff Ana Teijeiro Marco Prinz Ruzhica Bogeska Natasha Anstee Malte N Bongers Mike Notohamiprodjo Tobias Geisler Dominic J Withers Jerry Ware Derek A Mann Hellmut G Augustin Alexandros Vegiopoulos Michael D Milsom Adam J Rose Patricia F Lalor Josep M Llovet Roser Pinyol Frank Tacke Roland Rad Matthias Matter Nabil Djouder Paul Kubes Percy A Knolle Kristian Unger Lars Zender Bernhard Nieswandt Meinrad Gawaz Achim Weber Mathias Heikenwalder

Nat Med 2019 04 1;25(4):641-655. Epub 2019 Apr 1.

Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.

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April 2019

HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression.

Authors:
Tyrell N Cartwright Julie C Worrell Letizia Marchetti Catríona M Dowling Amber Knox Patrick Kiely Jelena Mann Derek A Mann Caroline L Wilson

Biochim Biophys Acta Gene Regul Mech 2018 10 10;1861(10):962-970. Epub 2018 Sep 10.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, UK. Electronic address:

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October 2018

Rapamycin improves healthspan but not inflammaging in nfκb1 mice.

Authors:
Clara Correia-Melo Jodie Birch Edward Fielder Dina Rahmatika Jennifer Taylor James Chapman Anthony Lagnado Bernadette M Carroll Satomi Miwa Gavin Richardson Diana Jurk Fiona Oakley Jelena Mann Derek A Mann Viktor I Korolchuk João F Passos

Aging Cell 2019 02 23;18(1):e12882. Epub 2018 Nov 23.

Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.

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February 2019

The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.

Authors:
Guillaume Wettstein Jean-Michel Luccarini Laurence Poekes Patrick Faye Francine Kupkowski Vanessa Adarbes Evelyne Defrêne Céline Estivalet Xavier Gawronski Ingrid Jantzen Alain Philippot Julien Tessier Pascale Tuyaa-Boustugue Fiona Oakley Derek A Mann Isabelle Leclercq Sven Francque Irena Konstantinova Pierre Broqua Jean-Louis Junien

Hepatol Commun 2017 08 19;1(6):524-537. Epub 2017 Jun 19.

Inventiva Daix France.

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August 2017

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.

Authors:
Maria J Perugorria Aitor Esparza-Baquer Fiona Oakley Ibone Labiano Ana Korosec Alexander Jais Jelena Mann Dina Tiniakos Alvaro Santos-Laso Ander Arbelaiz Riem Gawish Ana Sampedro Antonio Fontanellas Elizabeth Hijona Raul Jimenez-Agüero Harald Esterbauer Dagmar Stoiber Luis Bujanda Jesus María Banales Sylvia Knapp Omar Sharif Derek A Mann

Gut 2019 03 27;68(3):533-546. Epub 2018 Jan 27.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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March 2019

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis.

Authors:
Buket Yiğit Marie Boyle Oğuz Özler Nihan Erden Faik Tutucu Timothy Hardy Christina Bergmann Joerg H W Distler Gupse Adalı Murat Dayangaç Derek A Mann Mujdat Zeybel Jelena Mann

Gut 2018 10 20;67(10):1907-1908. Epub 2018 Jan 20.

Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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October 2018

Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis.

Authors:
Nicholas S Kalson Tim M Brock Massimo Mangino Stella M Fabiane Derek A Mann Lee A Borthwick David J Deehan Frances M K Williams

PLoS One 2018 2;13(1):e0190120. Epub 2018 Jan 2.

Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.

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February 2018

Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2.

Authors:
Hannah L Paish Nicholas S Kalson Graham R Smith Alicia Del Carpio Pons Thomas E Baldock Nicholas Smith Katarzyna Swist-Szulik David J Weir Michelle Bardgett David J Deehan Derek A Mann Lee A Borthwick

Am J Pathol 2018 03 15;188(3):696-714. Epub 2017 Dec 15.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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March 2018

Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

Authors:
Jane Margetts Laura F Ogle Stephen L Chan Anthony W H Chan K C Allen Chan David Jamieson Catherine E Willoughby Derek A Mann Caroline L Wilson Derek M Manas Winnie Yeo Helen L Reeves

Br J Cancer 2018 01 9;118(2):248-257. Epub 2017 Nov 9.

Northern Centre for Cancer Care, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 7DN, UK.

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January 2018

Variant Histone H2afv reprograms DNA methylation during early zebrafish development.

Authors:
Bhavani Madakashira Laura Corbett Chi Zhang Pier Paoli John W Casement Jelena Mann Kirsten C Sadler Derek A Mann

Epigenetics 2017 09 24;12(9):811-824. Epub 2017 Nov 24.

b Fibrosis Group , Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , NE24HH.

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September 2017

Epigenetic reprogramming in liver fibrosis and cancer.

Authors:
Caroline L Wilson Derek A Mann Lee A Borthwick

Adv Drug Deliv Rev 2017 11 25;121:124-132. Epub 2017 Oct 25.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, UK. Electronic address:

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November 2017

The NF-κB1 is a key regulator of acute but not chronic renal injury.

Authors:
Amy Fearn Gerhard R Situmorang Christopher Fox Fiona Oakley Rachel Howarth Caroline L Wilson Agklinta Kiosia Michael G Robson Derek A Mann Anna Moles Neil S Sheerin

Cell Death Dis 2017 06 15;8(6):e2883. Epub 2017 Jun 15.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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June 2017

Cellular senescence drives age-dependent hepatic steatosis.

Authors:
Mikolaj Ogrodnik Satomi Miwa Tamar Tchkonia Dina Tiniakos Caroline L Wilson Albert Lahat Christoper P Day Alastair Burt Allyson Palmer Quentin M Anstee Sushma Nagaraja Grellscheid Jan H J Hoeijmakers Sander Barnhoorn Derek A Mann Thomas G Bird Wilbert P Vermeij James L Kirkland João F Passos Thomas von Zglinicki Diana Jurk

Nat Commun 2017 06 13;8:15691. Epub 2017 Jun 13.

Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

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June 2017

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.

Authors:
Müjdat Zeybel Saimir Luli Laura Sabater Timothy Hardy Fiona Oakley Jack Leslie Agata Page Eva Moran Salvador Victoria Sharkey Hidekazu Tsukamoto David C K Chu Uma Sharan Singh Mirco Ponzoni Patrizia Perri Daniela Di Paolo Edgar J Mendivil Jelena Mann Derek A Mann

Mol Ther 2017 01 4;25(1):218-231. Epub 2017 Jan 4.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4(th) Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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January 2017

Epigenetics in liver disease: from biology to therapeutics.

Authors:
Timothy Hardy Derek A Mann

Gut 2016 11 13;65(11):1895-1905. Epub 2016 Sep 13.

Fibrosis Laboratories, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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November 2016

Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription.

Authors:
Francesco Lanucara Connie Lam Jelena Mann Tom P Monie Stefano A P Colombo Stephen W Holman James Boyd Manohar C Dange Derek A Mann Michael R H White Claire E Eyers

Open Biol 2016 07;6(7)

Centre for Proteome Research, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK

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July 2016

Liver: Osteopontin and HMGB1: novel regulators of HSC activation.

Authors:
Lee A Borthwick Derek A Mann

Nat Rev Gastroenterol Hepatol 2016 06 14;13(6):320-2. Epub 2016 Apr 14.

Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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June 2016

A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo.

Authors:
Saimir Luli Daniela Di Paolo Patrizia Perri Chiara Brignole Stephen J Hill Helen Brown Jack Leslie H L Marshall Matthew C Wright Derek A Mann Mirco Ponzoni Fiona Oakley

J Hepatol 2016 07 9;65(1):75-83. Epub 2016 Apr 9.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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July 2016

TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury.

Authors:
Dimitra Vyrla Georgios Nikolaidis Fiona Oakley Maria J Perugorria Philip N Tsichlis Derek A Mann Aristides G Eliopoulos

J Immunol 2016 05 6;196(10):4298-310. Epub 2016 Apr 6.

Laboratory of Molecular and Cellular Biology, University of Crete Medical School, 71003 Heraklion, Crete, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research & Technology-Hellas, 70013 Heraklion, Crete, Greece; Laboratory of Translational Medicine and Experimental Therapeutics, University of Crete Medical School, 71003 Heraklion, Crete, Greece;

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May 2016

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease.

Authors:
Timothy Hardy Mujdat Zeybel Christopher P Day Christian Dipper Steven Masson Stuart McPherson Elsbeth Henderson Dina Tiniakos Steve White Jeremy French Derek A Mann Quentin M Anstee Jelena Mann

Gut 2017 07 21;66(7):1321-1328. Epub 2016 Mar 21.

Fibrosis Laboratories, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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July 2017

The Role of the Fibroblast in Inflammatory Upper Airway Conditions.

Authors:
Stephen L Ball Derek A Mann Janet A Wilson Andrew J Fisher

Am J Pathol 2016 Feb 10;186(2):225-33. Epub 2015 Dec 10.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2016

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

Authors:
Laura Corbett Jelena Mann Derek A Mann

PLoS One 2015 13;10(11):e0142794. Epub 2015 Nov 13.

Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.

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June 2016

Fibrosis is a common outcome following total knee arthroplasty.

Authors:
Nicole Abdul David Dixon Andrew Walker Joanna Horabin Nick Smith David J Weir Nigel T Brewster David J Deehan Derek A Mann Lee A Borthwick

Sci Rep 2015 Nov 10;5:16469. Epub 2015 Nov 10.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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November 2015

A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.

Authors:
David Dixon Jonathon Coates Alicia del Carpio Pons Joanna Horabin Andrew Walker Nicole Abdul Nicholas S Kalson Nigel T Brewster David J Weir David J Deehan Derek A Mann Lee A Borthwick

Sci Rep 2015 Nov 10;5:16466. Epub 2015 Nov 10.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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November 2015

Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.

Authors:
Caroline L Wilson Lindsay B Murphy Jack Leslie Stuart Kendrick Jeremy French Christopher R Fox Neil S Sheerin Andrew Fisher John H Robinson Dina G Tiniakos Douglas A Gray Fiona Oakley Derek A Mann

J Hepatol 2015 Dec 8;63(6):1421-8. Epub 2015 Aug 8.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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December 2015

Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement.

Authors:
Frances M Williams Nicholas S Kalson Stella M Fabiane Derek A Mann David J Deehan

PLoS One 2015 21;10(7):e0133629. Epub 2015 Jul 21.

Department of Orthopaedics, The Royal Victoria Infirmary and the Freeman Hospital, Newcastle upon Tyne, United Kingdom; Fibrosis Research Group, Institute of Cellular Medicine, University of Newcastle, Newcasltle upon Tyne, United Kingdom.

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May 2016

Epigenetic regulation of liver fibrosis.

Authors:
Agata Page Derek A Mann

Clin Res Hepatol Gastroenterol 2015 Sep 16;39 Suppl 1:S64-8. Epub 2015 Jul 16.

Fibrosis Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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September 2015

Emerging and disease-specific mechanisms of hepatic stellate cell activation.

Authors:
Michael C Wallace Scott L Friedman Derek A Mann

Semin Liver Dis 2015 May 14;35(2):107-18. Epub 2015 May 14.

Fibrosis Laboratory, Institute of Cellular Medicine, New Castle University, Newcastle upon Tyne, United Kingdom.

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May 2015

Novel therapeutic targets in primary biliary cirrhosis.

Authors:
Jessica K Dyson Gideon M Hirschfield David H Adams Ulrich Beuers Derek A Mann Keith D Lindor David E J Jones

Nat Rev Gastroenterol Hepatol 2015 Mar 3;12(3):147-58. Epub 2015 Feb 3.

Institute of Cellular Medicine, 3rd Floor William Leech Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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March 2015

How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis?

Authors:
Stephen L Ball Monika I Suwara Lee A Borthwick Janet A Wilson Derek A Mann Andrew J Fisher

Ann Otol Rhinol Laryngol 2015 Jun 23;124(6):437-42. Epub 2014 Dec 23.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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June 2015

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells.

Authors:
Agata Page Pier P Paoli Stephen J Hill Rachel Howarth Raymond Wu Soo-Mi Kweon Jeremy French Steve White Hidekazu Tsukamoto Derek A Mann Jelena Mann

J Hepatol 2015 Feb 20;62(2):388-97. Epub 2014 Oct 20.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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February 2015

The mechanisms of HSC activation and epigenetic regulation of HSCs phenotypes.

Authors:
Agata Page Derek A Mann Jelena Mann

Curr Pathobiol Rep 2014 Dec 27;2(4):163-170. Epub 2014 Sep 27.

Institute of Cellular Medicine, Faculty of Medical Sciences, 4 Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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December 2014

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Authors:
Diana Jurk Caroline Wilson João F Passos Fiona Oakley Clara Correia-Melo Laura Greaves Gabriele Saretzki Chris Fox Conor Lawless Rhys Anderson Graeme Hewitt Sylvia Lf Pender Nicola Fullard Glyn Nelson Jelena Mann Bart van de Sluis Derek A Mann Thomas von Zglinicki

Nat Commun 2014 Jun 24;2:4172. Epub 2014 Jun 24.

1] Institute for Ageing and Health, Newcastle University, NE4 5PL, UK [2].

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June 2014

Epigenetics in liver disease.

Authors:
Derek A Mann

Hepatology 2014 Oct 7;60(4):1418-25. Epub 2014 May 7.

Fibrosis Research Laboratories, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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October 2014

Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.

Authors:
Caroline L Wilson Jelena Mann Meagan Walsh Maria J Perrugoria Fiona Oakley Matthew C Wright Chiara Brignole Daniela Di Paolo Patrizia Perri Mirco Ponzoni Michael Karin Derek A Mann

PLoS One 2014 8;9(1):e83391. Epub 2014 Jan 8.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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September 2014

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.

Authors:
Anna Moles Lindsay Murphy Caroline L Wilson Jayashree Bagchi Chakraborty Christopher Fox Eek Joong Park Jelena Mann Fiona Oakley Rachel Howarth John Brain Steven Masson Michael Karin Ekihiro Seki Derek A Mann

J Hepatol 2014 Apr 11;60(4):782-91. Epub 2013 Dec 11.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK. Electronic address:

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April 2014

Epigenetic modifications as new targets for liver disease therapies.

Authors:
Müjdat Zeybel Derek A Mann Jelena Mann

J Hepatol 2013 Dec 4;59(6):1349-53. Epub 2013 Jun 4.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2013

The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice.

Authors:
Nicola Fullard Anna Moles Steven O'Reilly Jacob M van Laar David Faini Julie Diboll Nick J Reynolds Derek A Mann Julia Reichelt Fiona Oakley

Am J Pathol 2013 Jun 4;182(6):2109-20. Epub 2013 Apr 4.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2013

An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury.

Authors:
Stuart M Robinson Jelena Mann Derek M Manas Derek A Mann Steven A White

HPB (Oxford) 2013 Aug 27;15(8):581-7. Epub 2012 Dec 27.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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August 2013

Epigenetic regulation of wound healing and fibrosis.

Authors:
Jelena Mann Derek A Mann

Curr Opin Rheumatol 2013 Jan;25(1):101-7

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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January 2013

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice.

Authors:
Maria J Perugorria Lindsay B Murphy Nicola Fullard Jayashree B Chakraborty Dimitra Vyrla Caroline L Wilson Fiona Oakley Jelena Mann Derek A Mann

Hepatology 2013 Mar;57(3):1238-49

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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March 2013

Serotonin paracrine signaling in tissue fibrosis.

Authors:
Derek A Mann Fiona Oakley

Biochim Biophys Acta 2013 Jul 29;1832(7):905-10. Epub 2012 Sep 29.

Fibrosis Laboratories, Institute of Cellular Medicine, 4th Floor, William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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July 2013

Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.

Authors:
Anna Moles Ana M Sanchez Paul S Banks Lindsay B Murphy Saimir Luli Lee Borthwick Andrew Fisher Steven O'Reilly Jacob M van Laar Steven A White Neil D Perkins Alastair D Burt Derek A Mann Fiona Oakley

Hepatology 2013 Feb 8;57(2):817-28. Epub 2013 Jan 8.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2013

Multigenerational epigenetic adaptation of the hepatic wound-healing response.

Authors:
Müjdat Zeybel Timothy Hardy Yi K Wong John C Mathers Christopher R Fox Agata Gackowska Fiona Oakley Alastair D Burt Caroline L Wilson Quentin M Anstee Matt J Barter Steven Masson Ahmed M Elsharkawy Derek A Mann Jelena Mann

Nat Med 2012 Sep;18(9):1369-77

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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September 2012

The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand.

Authors:
Christine Richter Sylvia Messerschmidt Gerlinde Holeiter Jessica Tepperink Sylvia Osswald Andrea Zappe Marcus Branschädel Verena Boschert Derek A Mann Peter Scheurich Anja Krippner-Heidenreich

Mol Cell Biol 2012 Jul 30;32(13):2515-29. Epub 2012 Apr 30.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom.

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July 2012

The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

Authors:
Aaron Gardner Andrew J Fisher Christine Richter Gail E Johnson Elizabeth J Moisey Malcolm Brodlie Christopher Ward Anja Krippner-Heidenreich Derek A Mann Lee A Borthwick

Am J Pathol 2012 Jun 21;180(6):2293-308. Epub 2012 Apr 21.

Tissue Fibrosis & Repair Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2012

Seamless replacement of Autographa californica multiple nucleopolyhedrovirus gp64 with each of five novel type II alphabaculovirus fusion sequences generates pseudotyped virus that fails to transduce mammalian cells.

Authors:
Marcel Westenberg Helen M Soedling Nisha Hirani Linda J Nicholson Derek A Mann Colin T Dolphin

J Gen Virol 2012 Jul 4;93(Pt 7):1583-1590. Epub 2012 Apr 4.

Pharmaceutical Science Research Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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July 2012

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans.

Authors:
James Pritchett Emma Harvey Varinder Athwal Andrew Berry Cliff Rowe Fiona Oakley Anna Moles Derek A Mann Nicoletta Bobola Andrew D Sharrocks Brian J Thomson Abed M Zaitoun William L Irving Indra N Guha Neil A Hanley Karen Piper Hanley

Hepatology 2012 Sep;56(3):1108-16

Endocrinology and Diabetes Group, School of Biomedicine, University of Manchester, Manchester, United Kingdom.

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September 2012

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation.

Authors:
Maria Jesus Perugorria Caroline L Wilson Mujdat Zeybel Meagan Walsh Shilu Amin Stuart Robinson Steven A White Alastair D Burt Fiona Oakley Hidekazu Tsukamoto Derek A Mann Jelena Mann

Hepatology 2012 Sep;56(3):1129-39

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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September 2012

Clinical evidence for the regression of liver fibrosis.

Authors:
Elizabeth L Ellis Derek A Mann

J Hepatol 2012 May 13;56(5):1171-1180. Epub 2012 Jan 13.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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May 2012

The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis.

Authors:
Silvia Gaspar-Pereira Nicola Fullard Paul A Townsend Paul S Banks Elizabeth L Ellis Christopher Fox Aidan G Maxwell Lindsay B Murphy Adam Kirk Ralf Bauer Jorge H Caamaño Nichola Figg Roger S Foo Jelena Mann Derek A Mann Fiona Oakley

Am J Pathol 2012 Mar 30;180(3):929-939. Epub 2011 Dec 30.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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March 2012

Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Authors:
Mohammad R Ebrahimkhani Fiona Oakley Lindsay B Murphy Jelena Mann Anna Moles Maria J Perugorria Elizabeth Ellis Anne F Lakey Alastair D Burt Angela Douglass Matthew C Wright Steven A White Fabrice Jaffré Luc Maroteaux Derek A Mann

Nat Med 2011 Nov 27;17(12):1668-73. Epub 2011 Nov 27.

Fibrosis Laboratory, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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November 2011

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect.

Authors:
Melissa D Yang Yi-Ming Chiang Reiichi Higashiyama Kinji Asahina Derek A Mann Jelena Mann Clay C C Wang Hidekazu Tsukamoto

Hepatology 2012 Apr 1;55(4):1271-81. Epub 2012 Mar 1.

Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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April 2012

Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways.

Authors:
Lee A Borthwick Aaron Gardner Anthony De Soyza Derek A Mann Andrew J Fisher

Cancer Microenviron 2012 Apr 27;5(1):45-57. Epub 2011 Jul 27.

Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, NE2 4HH.

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April 2012

Epigenetic cell fate regulation of hepatic stellate cells.

Authors:
Hidekazu Tsukamoto Nian-Ling Zhu Kinji Asahina Derek A Mann Jelena Mann

Hepatol Res 2011 Jul 19;41(7):675-82. Epub 2011 Apr 19.

Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California Keck School of Medicine Greater Los Angeles Healthcare System, Los Angeles, California, USA Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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July 2011

Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.

Authors:
Sawako Nakachi Tetsuro Nakazato Chie Ishikawa Ryuichiro Kimura Derek A Mann Masachika Senba Hiroaki Masuzaki Naoki Mori

Biochim Biophys Acta 2011 May 18;1813(5):731-41. Epub 2011 Feb 18.

Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

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May 2011

Opposing putative roles for canonical and noncanonical NFκB signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells.

Authors:
Chunbo Yang Stuart P Atkinson Felipe Vilella Maria Lloret Lyle Armstrong Derek A Mann Majlinda Lako

Stem Cells 2010 Nov;28(11):1970-80

Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle Upon Tyne, United Kingdom.

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November 2010

Counter-selection recombineering of the baculovirus genome: a strategy for seamless modification of repeat-containing BACs.

Authors:
Marcel Westenberg Helen M Soedling Derek A Mann Linda J Nicholson Colin T Dolphin

Nucleic Acids Res 2010 Sep 9;38(16):e166. Epub 2010 Jul 9.

Pharmaceutical Science Division, King's College London, London SE1 9NH, UK.

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September 2010

The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes.

Authors:
Ahmed M Elsharkawy Fiona Oakley Feng Lin Graham Packham Derek A Mann Jelena Mann

J Hepatol 2010 Sep 2;53(3):519-27. Epub 2010 Jun 2.

Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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September 2010

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.

Authors:
Catherine Potter Heather J Cordell Anne Barton Ann K Daly Kimme L Hyrich Derek A Mann Ann W Morgan Anthony G Wilson John D Isaacs

Ann Rheum Dis 2010 Jul 6;69(7):1315-20. Epub 2010 May 6.

Musculoskeletal Research Group, Institute of Cellular Medicine, University of Newcastle, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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July 2010

The PXR is a drug target for chronic inflammatory liver disease.

Authors:
Karen Wallace David E Cowie Dimitrios K Konstantinou Stephen J Hill Torunn E Tjelle Andrew Axon Matthew Koruth Steven A White Harald Carlsen Derek A Mann Matthew C Wright

J Steroid Biochem Mol Biol 2010 May 21;120(2-3):137-48. Epub 2010 Apr 21.

Institute of Cellular Medicine, University of Newcastle, Upon Tyne, UK.

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May 2010

Fibrogenic signalling in hepatic stellate cells.

Authors:
Derek A Mann Fabio Marra

J Hepatol 2010 Jun 20;52(6):949-50. Epub 2010 Mar 20.

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Catherine Cookson Building, Medical School, Newcastle University, UK.

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June 2010

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

Authors:
Veronika Souslova Paul A Townsend Jelena Mann Chris M van der Loos Anna Motterle Fulvio D'Acquisto Derek A Mann Shu Ye

PLoS One 2010 Mar 25;5(3):e9902. Epub 2010 Mar 25.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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March 2010

Role of nuclear factor kappaB in liver health and disease.

Authors:
Stuart M Robinson Derek A Mann

Clin Sci (Lond) 2010 Mar 30;118(12):691-705. Epub 2010 Mar 30.

Cell Signalling Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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March 2010

The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation.

Authors:
Roben G Gieling Ahmed M Elsharkawy Jorge H Caamaño David E Cowie Matthew C Wright Mohammad R Ebrahimkhani Alastair D Burt Jelena Mann Pradip Raychaudhuri Hsiou-Chi Liou Fiona Oakley Derek A Mann

Hepatology 2010 Mar;51(3):922-31

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Cookson Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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March 2010

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

Authors:
Jinsheng Guo Feng Hong Johnny Loke Steven Yea Chooi Ling Lim Ursula Lee Derek A Mann Martin J Walsh John J Sninsky Scott L Friedman

J Biol Chem 2010 Feb 17;285(8):5428-37. Epub 2009 Dec 17.

Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA.

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February 2010

NF-kappaB signalling: embracing complexity to achieve translation.

Authors:
Jayashree Bagchi Chakraborty Derek A Mann

J Hepatol 2010 Feb 24;52(2):285-91. Epub 2009 Nov 24.

Liver Research Group, Institute of Cellular Medicine, 4th Floor, Catherine Cookson Building, Medical School, Newcastle University, UK.

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February 2010

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.

Authors:
Jelena Mann David C K Chu Aidan Maxwell Fiona Oakley Nian-Ling Zhu Hidekazu Tsukamoto Derek A Mann

Gastroenterology 2010 Feb 17;138(2):705-14, 714.e1-4. Epub 2009 Oct 17.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2010

Transcriptional regulation of hepatic stellate cells.

Authors:
Jelena Mann Derek A Mann

Adv Drug Deliv Rev 2009 Jul 22;61(7-8):497-512. Epub 2009 Apr 22.

Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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July 2009

Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.

Authors:
Hiroshi Kudo Yutaka Yata Terumi Takahara Kengo Kawai Yasuhiro Nakayama Masami Kanayama Takeshi Oya Seiichi Morita Masakiyo Sasahara Derek A Mann Toshiro Sugiyama

Liver Int 2009 Aug 6;29(7):988-96. Epub 2009 Apr 6.

Third Department of Internal Medicine, University of Toyama, Toyama, Japan.

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August 2009

Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.

Authors:
Fiona Oakley Victoria Teoh Gemma Ching-A-Sue Ramon Bataller Jordi Colmenero Julie R Jonsson Aristides G Eliopoulos Martha R Watson Derek Manas Derek A Mann

Gastroenterology 2009 Jun 18;136(7):2334-2344.e1. Epub 2009 Mar 18.

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 2009

Fibrosis and cirrhosis reversibility - molecular mechanisms.

Authors:
Roben G Gieling Alastair D Burt Derek A Mann

Clin Liver Dis 2008 Nov;12(4):915-37, xi

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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November 2008

Wound healing and local neuroendocrine regulation in the injured liver.

Authors:
Mohammad R Ebrahimkhani Ahmed M Elsharkawy Derek A Mann

Expert Rev Mol Med 2008 Apr 29;10:e11. Epub 2008 Apr 29.

Cell signalling, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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April 2008

Epigenetic regulation of hepatic stellate cell activation.

Authors:
Derek A Mann Jelena Mann

J Gastroenterol Hepatol 2008 Mar;23 Suppl 1:S108-11

Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.

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March 2008

Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain.

Authors:
Sandra J Campbell Daniel C Anthony Fiona Oakley Harald Carlsen Ahmed M Elsharkawy Rune Blomhoff Derek A Mann

J Neuropathol Exp Neurol 2008 Mar;67(3):223-30

Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.

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March 2008

Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis.

Authors:
Karen Piper Hanley Fiona Oakley Sarah Sugden David I Wilson Derek A Mann Neil A Hanley

J Biol Chem 2008 May 22;283(20):14063-71. Epub 2008 Feb 22.

Centre for Human Development, Stem Cells & Regeneration.

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May 2008

The function of serotonin within the liver.

Authors:
Richard G Ruddell Derek A Mann Grant A Ramm

J Hepatol 2008 Apr 28;48(4):666-75. Epub 2008 Jan 28.

Hepatic Fibrosis Group, The Queensland Institute of Medical Research, PO Royal Brisbane and Women's Hospital, Brisbane, Qld 4029, Australia.

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April 2008

NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.

Authors:
Martha R Watson Karen Wallace Roben G Gieling Derek M Manas Ellis Jaffray Ronald T Hay Derek A Mann Fiona Oakley

J Hepatol 2008 Apr 31;48(4):589-97. Epub 2008 Jan 31.

Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.

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April 2008

Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis.

Authors:
Ahmed M Elsharkawy Derek A Mann

Hepatology 2007 Aug;46(2):590-7

Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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August 2007

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation.

Authors:
David E Smart Karen Green Fiona Oakley Jonathan B Weitzman Moshe Yaniv Gary Reynolds Jelena Mann Harry Millward-Sadler Derek A Mann

Hepatology 2006 Dec;44(6):1432-40

Liver Group, Division of Infection, Inflammation & Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK.

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December 2006

Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic.

Authors:
Ajay K Muddu Indra Neil Guha Ahmed M Elsharkawy Derek A Mann

Int J Biochem Cell Biol 2007 7;39(4):695-714. Epub 2006 Oct 7.

Liver Group, Division of Infection, Inflammation & Repair, University of Southampton, Southampton SO16 6YD, United Kingdom.

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June 2007

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis.

Authors:
Richard G Ruddell Fiona Oakley Ziafat Hussain Irene Yeung Lesley J Bryan-Lluka Grant A Ramm Derek A Mann

Am J Pathol 2006 Sep;169(3):861-76

Liver Research Group, Divison of Infection, Inflammation and Repair, University of Southampton School of Medicine, and Southampton General Hospital, UK.

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September 2006

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

Authors:
Emma L Haughton Steven J Tucker Carylyn J Marek Elaine Durward Val Leel Zainab Bascal Tanya Monaghan Matthew Koruth Elaina Collie-Duguid Derek A Mann Julie E Trim Matthew C Wright

Gastroenterology 2006 Jul;131(1):194-209

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland.

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July 2006

NF-kappaB: a signal for cancer.

Authors:
Derek A Mann Fiona Oakley

J Hepatol 2005 Apr;42(4):610-1

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK.

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April 2005

Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.

Authors:
Jelena Mann Claire N Patrick Mark S Cragg Jamie Honeychurch Derek A Mann Mark Harris

J Immunol 2005 Nov;175(10):6560-9

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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November 2005

RNA interference mediated in human primary cells via recombinant baculoviral vectors.

Authors:
Linda J Nicholson Marie Philippe Alan J Paine Derek A Mann Colin T Dolphin

Mol Ther 2005 Apr;11(4):638-44

Department of Oncology, Guy's, King's and St Thomas' School of Medicine, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.

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April 2005

Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.

Authors:
Fiona Oakley Jelena Mann Sarah Nailard David E Smart Narendra Mungalsingh Christothea Constandinou Shakir Ali Susan J Wilson Harry Millward-Sadler John P Iredale Derek A Mann

Am J Pathol 2005 Mar;166(3):695-708

Liver Group, Southampton General Hospital, Southampton SO16 6YD UK.

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March 2005

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

Authors:
Fiona Oakley Muriel Meso John P Iredale Karen Green Carylyn J Marek Xiaoying Zhou Michael J May Harry Millward-Sadler Matthew C Wright Derek A Mann

Gastroenterology 2005 Jan;128(1):108-20

Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK.

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January 2005

Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2.

Authors:
Marie Bertrand-Philippe Richard G Ruddell Michael J P Arthur James Thomas Narendra Mungalsingh Derek A Mann

J Biol Chem 2004 Jun 29;279(23):24530-9. Epub 2004 Mar 29.

Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.

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June 2004