Dennis Selkoe

Dennis Selkoe

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Dennis Selkoe

Publications by authors named "Dennis Selkoe"

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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.

Proc Natl Acad Sci U S A 2019 Oct 23;116(41):20760-20769. Epub 2019 Sep 23.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1903216116DOI Listing
October 2019

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life.

Alzheimers Dement 2019 Sep 12;15(9):1183-1194. Epub 2019 Aug 12.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2019.06.3918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756967PMC
September 2019

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.

Ann Neurol 2019 Aug 22;86(2):215-224. Epub 2019 Jun 22.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25513
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http://dx.doi.org/10.1002/ana.25513DOI Listing
August 2019

Early network dysfunction in Alzheimer's disease.

Authors:
Dennis J Selkoe

Science 2019 08;365(6453):540-541

Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.aay5188DOI Listing
August 2019

A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family.

Neurobiol Aging 2019 Aug 7. Epub 2019 Aug 7.

Chair of Geriatric Medicine, University Essen, and Geriatric Centre Haus Berge, Contilia Group, Essen, Germany; Department of Neurology, Philipps-University Marburg, Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.07.002DOI Listing
August 2019

Alzheimer disease and aducanumab: adjusting our approach.

Authors:
Dennis J Selkoe

Nat Rev Neurol 2019 Jul;15(7):365-366

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41582-019-0205-1DOI Listing
July 2019

β-secretase inhibitors for Alzheimer's disease: heading in the wrong direction?

Authors:
Dennis Selkoe

Lancet Neurol 2019 Jul;18(7):624-626

Department of Neurology, Harvard Medical School, and Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30202-9DOI Listing
July 2019

Verubecestat for Prodromal Alzheimer's Disease.

N Engl J Med 2019 07;381(4):388

Brigham and Women's Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1906679DOI Listing
July 2019

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Brain 2019 May;142(5):1441-1457

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487330PMC
May 2019

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Alzheimers Dement 2019 Mar 9;15(3):487-496. Epub 2018 Nov 9.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, England. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476313PMC
March 2019

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.

J Cell Biol 2019 Feb 9;218(2):644-663. Epub 2019 Jan 9.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://www.jcb.org/lookup/doi/10.1083/jcb.201806205
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http://dx.doi.org/10.1083/jcb.201806205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363461PMC
February 2019

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Acta Neuropathol Commun 2018 11 8;6(1):121. Epub 2018 Nov 8.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s40478-018-0626-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225562PMC
November 2018

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.

Acta Neuropathol 2018 10 7;136(4):537-555. Epub 2018 Jul 7.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Rd, 9006, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-018-1880-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132948PMC
October 2018

Light at the End of the Amyloid Tunnel.

Authors:
Dennis J Selkoe

Biochemistry 2018 10 1;57(41):5921-5922. Epub 2018 Oct 1.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b00985
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http://dx.doi.org/10.1021/acs.biochem.8b00985DOI Listing
October 2018

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Neuron 2018 10;100(1):75-90.e5

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211795PMC
October 2018

Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.

EMBO Mol Med 2018 09;10(9)

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.15252/emmm.201808931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127891PMC
September 2018

Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.

iScience 2018 Aug 24;6:138-150. Epub 2018 Jul 24.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183010
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http://dx.doi.org/10.1016/j.isci.2018.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137707PMC
August 2018

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Nat Commun 2018 07 11;9(1):2676. Epub 2018 Jul 11.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-018-05068-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041266PMC
July 2018

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Int J Mol Sci 2018 Feb 27;19(3). Epub 2018 Feb 27.

Laboratory for Neurodegenerative Disease Research, Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/ijms19030663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877524PMC
February 2018

Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory.

Cell Rep 2017 08;20(6):1335-1347

Department of Biology, Boston University, Boston, MA 02215, USA; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584878PMC
August 2017

Showing transmitters the door: synucleins accelerate vesicle release.

Authors:
Dennis J Selkoe

Nat Neurosci 2017 04;20(5):629-631

Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4551DOI Listing
April 2017

Caspase-1 clipping causes complications for α-synuclein.

Proc Natl Acad Sci U S A 2016 Sep 22;113(36):9958-60. Epub 2016 Aug 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115; Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1610993113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018740PMC
September 2016

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Elife 2016 08 31;5. Epub 2016 Aug 31.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.17578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134833PMC
August 2016

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.

J Neurosci 2016 08;36(35):9041-56

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1523/JNEUROSCI.1023-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005718PMC
August 2016

The amyloid hypothesis of Alzheimer's disease at 25 years.

EMBO Mol Med 2016 06 1;8(6):595-608. Epub 2016 Jun 1.

Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

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http://dx.doi.org/10.15252/emmm.201606210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888851PMC
June 2016

Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

Bioorg Med Chem Lett 2016 May 12;26(9):2129-32. Epub 2016 Mar 12.

Laboratory for Experimental Alzheimer Drugs (LEAD), Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Harvard Institutes of Medicine, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.03.040DOI Listing
May 2016

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

Bioorg Med Chem Lett 2016 May 15;26(9):2133-7. Epub 2016 Mar 15.

Laboratory for Experimental Alzheimer Drugs (LEAD), Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Harvard Institutes of Medicine, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.03.042DOI Listing
May 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Science 2016 May 31;352(6286):712-716. Epub 2016 Mar 31.

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1126/science.aad8373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094372PMC
May 2016

Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

Bioorg Med Chem Lett 2016 May 23;26(9):2138-41. Epub 2016 Mar 23.

Laboratory for Experimental Alzheimer Drugs (LEAD), Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Harvard Institutes of Medicine, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.03.077DOI Listing
May 2016

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Nat Rev Neurosci 2016 Apr;17(4):251-60

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrn.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701169PMC
April 2016

New insights into cellular α-synuclein homeostasis in health and disease.

Curr Opin Neurobiol 2016 Feb 15;36:15-22. Epub 2015 Aug 15.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2015.07.007DOI Listing
February 2016

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Proc Natl Acad Sci U S A 2016 Feb 22;113(5):E509-18. Epub 2015 Dec 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1512952113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747693PMC
February 2016

Editorial overview: Neurobiology of disease.

Curr Opin Neurobiol 2016 Feb 18;36:v-vii. Epub 2016 Jan 18.

Lieber Institute for Brain Development and Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2016.01.001DOI Listing
February 2016

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Neurobiol Dis 2016 Jan 22;85:111-121. Epub 2015 Oct 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778388PMC
January 2016

Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.

ACS Chem Neurosci 2016 Jan 18;7(1):40-5. Epub 2015 Nov 18.

Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720558PMC
January 2016

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.

J Cell Biol 2015 Dec;211(6):1157-76

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

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http://www.jcb.org/lookup/doi/10.1083/jcb.201502001
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http://dx.doi.org/10.1083/jcb.201502001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687875PMC
December 2015

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

PLoS One 2014 30;9(7):e103727. Epub 2014 Jul 30.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103727PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116227PMC
November 2015

Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol.

Neurobiol Dis 2015 Oct 6;82:152-163. Epub 2015 Jun 6.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640956PMC
October 2015

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Brain 2015 Sep 28;138(Pt 9):2659-71. Epub 2015 Jul 28.

1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/brain/awv202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625PMC
September 2015

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Cell Rep 2015 Sep 20;12(9):1414-29. Epub 2015 Aug 20.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558300PMC
September 2015

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Proc Natl Acad Sci U S A 2015 Aug 7;112(31):9596-601. Epub 2015 Jul 7.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1505953112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534262PMC
August 2015

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Nat Commun 2015 Jun 16;6:7314. Epub 2015 Jun 16.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms8314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490410PMC
June 2015

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Alzheimers Res Ther 2015 22;7(1):14. Epub 2015 Mar 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School Boston, 77 Avenue Louis Pasteur, Harvard Institute Medical, Room 730, Boston, MA 02115 USA.

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http://alzres.com/content/7/1/14
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http://dx.doi.org/10.1186/s13195-015-0100-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369838PMC
March 2015

A new method for quantitative immunoblotting of endogenous α-synuclein.

PLoS One 2013 20;8(11):e81314. Epub 2013 Nov 20.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835431PMC
January 2015

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Biochemistry 2015 Jan 23;54(2):279-92. Epub 2014 Dec 23.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/bi501188a
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http://dx.doi.org/10.1021/bi501188aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303315PMC
January 2015

Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies.

J Neurochem 2014 Oct 18;131(1):94-100. Epub 2014 Jun 18.

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/jnc.12772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177330PMC
October 2014

Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.

Am J Hematol 2014 Oct 21;89(10):974-7. Epub 2014 Jul 21.

Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533827PMC
October 2014

Defining the native state of α-synuclein.

Neurodegener Dis 2014 30;13(2-3):114-7. Epub 2013 Oct 30.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000355516DOI Listing
September 2014

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

J Biol Chem 2014 Aug 18;289(31):21490-507. Epub 2014 Jun 18.

From the Center for Neurologic Diseases, Department of Neurology, and

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http://dx.doi.org/10.1074/jbc.M113.545749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118111PMC
August 2014

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Hum Mol Genet 2014 Jul 12;23(13):3523-36. Epub 2014 Feb 12.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/hmg/ddu064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049307PMC
July 2014

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

Biochemistry 2014 Jul 30;53(27):4393-406. Epub 2014 Jun 30.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/bi500489jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216188PMC
July 2014

γ-Secretase: a horseshoe structure brings good luck.

Cell 2014 Jul;158(2):247-249

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.043DOI Listing
July 2014

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Neurology 2013 Oct 25;81(17):1531-7. Epub 2013 Sep 25.

From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888173PMC
October 2013

The therapeutics of Alzheimer's disease: where we stand and where we are heading.

Authors:
Dennis J Selkoe

Ann Neurol 2013 Sep;74(3):328-36

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ana.24001DOI Listing
September 2013

SnapShot: pathobiology of Alzheimer's disease.

Authors:
Dennis J Selkoe

Cell 2013 Jul;154(2):468-468.e1

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2013.07.003DOI Listing
July 2013

Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.

Glia 2013 Jun 28;61(6):985-1002. Epub 2013 Mar 28.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/glia.22490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981075PMC
June 2013

Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein.

Biochemistry 2013 May 2;52(19):3264-77. Epub 2013 May 2.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/bi400165fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809327PMC
May 2013

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

J Biol Chem 2013 Mar 14;288(9):6371-85. Epub 2013 Jan 14.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.403311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585072PMC
March 2013

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

Alzheimers Dement 2013 Mar 30;9(2):99-112. Epub 2013 Jan 30.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jalz.2012.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604133PMC
March 2013

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

Neuron 2013 Mar;77(5):929-41

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.12.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596823PMC
March 2013

Pancortins interact with amyloid precursor protein and modulate cortical cell migration.

Development 2012 Nov 19;139(21):3986-96. Epub 2012 Sep 19.

Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/dev.082909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472593PMC
November 2012

Alzheimer disease in 2020.

Cold Spring Harb Perspect Med 2012 Nov 1;2(11). Epub 2012 Nov 1.

Department of Neurology, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/cshperspect.a011585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543098PMC
November 2012

Preventing Alzheimer's disease.

Authors:
Dennis J Selkoe

Science 2012 Sep;337(6101):1488-92

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1228541DOI Listing
September 2012

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.

Cold Spring Harb Perspect Med 2012 Jul;2(7):a006338

Gladstone Institute of Neurological Disease and University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1101/cshperspect.a006338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385944PMC
July 2012

Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study.

Alzheimer Dis Assoc Disord 2012 Jan-Mar;26(1):50-4

Department of Epidemiology, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/WAD.0b013e31821764ceDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140548PMC
June 2012

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Jun;2(6):a006262

The Mental Health Research Institute, The University of Melbourne, Parkville 3010, Australia.

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http://dx.doi.org/10.1101/cshperspect.a006262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367542PMC
June 2012

Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.

Brain Pathol 2012 May 31;22(3):280-94. Epub 2011 Oct 31.

Department of Biochemistry and Molecular Biology, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00530.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253141PMC
May 2012

Effects of membrane lipids on the activity and processivity of purified γ-secretase.

Biochemistry 2012 May 19;51(17):3565-75. Epub 2012 Apr 19.

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/bi300303gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347702PMC
May 2012

Deciphering Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Jan;2(1):a011460

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a011460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253026PMC
January 2012

Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview.

Neurobiol Aging 2011 Dec;32 Suppl 1:S1-3

Department of Neurology, Knight Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.09.005DOI Listing
December 2011

Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.

Arch Neurol 2011 Nov;68(11):1385-92

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, HIM Room 730, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1001/archneurol.2011.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248784PMC
November 2011

Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies.

Arch Neurol 2011 Oct;68(10):1239-44

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1001/archneurol.2011.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211071PMC
October 2011

Resolving controversies on the path to Alzheimer's therapeutics.

Authors:
Dennis J Selkoe

Nat Med 2011 Sep 7;17(9):1060-5. Epub 2011 Sep 7.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2460DOI Listing
September 2011

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

Nature 2011 Aug 14;477(7362):107-10. Epub 2011 Aug 14.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature10324
Publisher Site
http://dx.doi.org/10.1038/nature10324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166366PMC
August 2011

Alzheimer's disease.

Authors:
Dennis J Selkoe

Cold Spring Harb Perspect Biol 2011 Jul 1;3(7). Epub 2011 Jul 1.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a004457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119915PMC
July 2011

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.

J Neurochem 2011 Jun 13;117(5):856-67. Epub 2011 Apr 13.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07253.xDOI Listing
June 2011

Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain.

Methods Mol Biol 2011 ;670:33-44

Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-60761-744-0_3DOI Listing
May 2011

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.

Proc Natl Acad Sci U S A 2011 Apr 18;108(14):5819-24. Epub 2011 Mar 18.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1017033108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078381PMC
April 2011

Plasma beta-amyloid level, cognitive reserve, and cognitive decline.

JAMA 2011 Apr;305(16):1655; author reply 1655-6

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http://dx.doi.org/10.1001/jama.2011.524DOI Listing
April 2011

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation.

Mol Neurodegener 2011 Jan 24;6:10. Epub 2011 Jan 24.

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.

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http://dx.doi.org/10.1186/1750-1326-6-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037337PMC
January 2011