Dennis R Roop

Dennis R Roop

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Dennis R Roop

Dennis R Roop

Publications by authors named "Dennis R Roop"

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Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging.

J Invest Dermatol 2020 Apr 19;140(4):891-900.e10. Epub 2019 Sep 19.

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.08.446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080593PMC
April 2020

Loricrin: Past, Present, and Future.

Int J Mol Sci 2020 Mar 25;21(7). Epub 2020 Mar 25.

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.3390/ijms21072271DOI Listing
March 2020

Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata.

J Invest Dermatol 2020 Jan 10;140(1):29-37. Epub 2019 Jun 10.

Department of Dermatology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA; Gates Center for Regenerative Medicine, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.03.1142DOI Listing
January 2020

Loricrin Confers Photoprotective Function against UVB in Corneocytes.

J Invest Dermatol 2018 12 19;138(12):2684-2687. Epub 2018 Jun 19.

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.

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http://dx.doi.org/10.1016/j.jid.2018.06.164DOI Listing
December 2018

High-efficiency RNA-based reprogramming of human primary fibroblasts.

Nat Commun 2018 02 21;9(1):745. Epub 2018 Feb 21.

Department of Dermatology, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1038/s41467-018-03190-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821705PMC
February 2018

Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization.

Med Res Rev 2017 07 28;37(4):907-935. Epub 2016 Dec 28.

Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

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http://dx.doi.org/10.1002/med.21426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466503PMC
July 2017

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.

J Natl Cancer Inst 2017 01 15;109(1). Epub 2016 Sep 15.

Affiliations of authors: Division of Medical Oncology, Department of Medicine (SBK, PNL, BM, BCJ, JRE, CN, JK, MJG, JJM, NPJ, KG, EW, JR, JJA, WAM, ACT, AJ), Department of Biostatistics and Informatics (JK, DG, ACT), Department of Pathology (HS, XJW), Department of Dermatology (DRR), and Gates Center for Regenerative Medicine (DRR, XJW, AJ), University of Colorado Denver School of Medicine, Denver, CO; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD (BT, LMW); Department of Environmental Health Sciences, Yale School of Public Health, Yale School of Medicine, New Haven, CT (VV).

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http://dx.doi.org/10.1093/jnci/djw189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025278PMC
January 2017

Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease.

Pulm Circ 2016 Dec;6(4):483-497

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1086/688314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210051PMC
December 2016

Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin.

J Invest Dermatol 2016 08 7;136(8):1656-1663. Epub 2016 May 7.

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X163114
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068579PMC
http://dx.doi.org/10.1016/j.jid.2016.04.022DOI Listing
August 2016

Proteomic Analysis of Loricrin Knockout Mouse Epidermis.

J Proteome Res 2016 08 26;15(8):2560-6. Epub 2016 Jul 26.

Department of Dermatology, Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus , Aurora, Colorado 80045, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00108DOI Listing
August 2016

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.

Oral Oncol 2016 Feb 15;53:74-9. Epub 2015 Dec 15.

Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States; Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676309PMC
February 2016

Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.

J Invest Dermatol 2016 Jan;136(1):45-51

Institute of Laboratory Animal Science, Chinese Academy of Medical Science and Comparative Medical Center, Peking Union Medical College; Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China; Department of Pathology, Stony Brook University, Stony Brook, New York, USA; Department of Dermatology, Stony Brook University, Stony Brook, New York, USA; Department of Dermatology and Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

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http://dx.doi.org/10.1038/JID.2015.375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764097PMC
January 2016

MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.

Elife 2015 Jul 23;4. Epub 2015 Jul 23.

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Boulder, United States.

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http://dx.doi.org/10.7554/eLife.07004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536367PMC
July 2015

Differentiation of human induced pluripotent stem cells into a keratinocyte lineage.

Methods Mol Biol 2014 ;1195:1-12

Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Mail Stop 8320, 6511, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/7651_2013_64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096605PMC
February 2015

Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.

J Invest Dermatol 2015 Jan 22;135(1):170-180. Epub 2014 Aug 22.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268309PMC
January 2015

Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.

Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a015164. Epub 2014 Nov 3.

Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a015164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208713PMC
November 2014

Genetic manipulation of keratinocyte stem cells with lentiviral vectors.

Methods Mol Biol 2013 ;989:143-51

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1007/978-1-62703-330-5_12DOI Listing
September 2013

Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells.

Methods Mol Biol 2013 ;961:337-50

Department of Dermatology, Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1007/978-1-62703-227-8_22DOI Listing
June 2013

A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.

PLoS One 2012 30;7(11):e50634. Epub 2012 Nov 30.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511458PMC
May 2013

Aurora kinase-A deficiency during skin development impairs cell division and stratification.

J Invest Dermatol 2013 Jan 26;133(1):78-86. Epub 2012 Jul 26.

Department of Dermatology, University of Colorado, Denver, CO, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153596
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http://dx.doi.org/10.1038/jid.2012.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494779PMC
January 2013

Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.

Dev Cell 2012 Dec;23(6):1238-46

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Denver, CO 80045, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710685PMC
December 2012

Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance.

J Invest Dermatol 2012 Oct 24;132(10):2440-2450. Epub 2012 May 24.

Department of Dermatology, University of Colorado Denver, Aurora, Colorado, USA; Charles C Gates Regenerative Medicine and Stem Cell Biology, University of Colorado Denver, Aurora, Colorado, USA; Denver Veterans Affairs Medical Center, Denver, Colorado, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434242PMC
October 2012

Mimicking hair disorders by genetic manipulation of organ-cultured human hair follicles.

J Invest Dermatol 2012 Oct;132(10):2312-2314

Department of Dermatology and Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535470
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http://dx.doi.org/10.1038/jid.2012.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708693PMC
October 2012

Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.

J Invest Dermatol 2012 May;132(5):1317-20

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/jid.2011.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480207PMC
May 2012

Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

J Pathol 2011 Dec 26;225(4):479-89. Epub 2011 Sep 26.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/path.2971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302750PMC
December 2011

A fitness model for melanoma-initiating cells.

Pigment Cell Melanoma Res 2011 Jun;24(3):396-7

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http://dx.doi.org/10.1111/j.1755-148x.2011.00844.xDOI Listing
June 2011

Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage.

J Invest Dermatol 2011 Apr 9;131(4):857-64. Epub 2010 Dec 9.

Department of Dermatology, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1038/jid.2010.364DOI Listing
April 2011

Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.

J Invest Dermatol 2011 Feb 21;131(2):302-10. Epub 2010 Oct 21.

Dermatology and Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado at Denver, Aurora, Colorado 80045, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153515
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http://dx.doi.org/10.1038/jid.2010.306DOI Listing
February 2011

Altering cell fate: from thymus epithelium to skin stem cells.

Cell Stem Cell 2010 Oct;7(4):419-20

Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1016/j.stem.2010.09.007DOI Listing
October 2010

Are stem cell niches shared for skin cancers?

Pigment Cell Melanoma Res 2010 Aug 8;23(4):517-20. Epub 2010 Jun 8.

Department of Dermatology and the Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

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http://doi.wiley.com/10.1111/j.1755-148X.2010.00727.x
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http://dx.doi.org/10.1111/j.1755-148X.2010.00727.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137929PMC
August 2010

The effect of c-myc on stem cell fate influences skin tumor phenotype.

Mol Carcinog 2010 Apr;49(4):315-9

Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1002/mc.20617DOI Listing
April 2010

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.

Sci Signal 2010 Feb 23;3(110):ra13. Epub 2010 Feb 23.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/scisignal.2000634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905599PMC
February 2010

p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.

Exp Dermatol 2009 Dec;18(12):1016-21

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1111/j.1600-0625.2009.00894.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857403PMC
December 2009

Melanoma-initiating cells: a compass needed.

EMBO Rep 2009 Sep 14;10(9):965-72. Epub 2009 Aug 14.

Charles C Gates Regenerative Medicine and Stem Cell Program, Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/embor.2009.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750051PMC
September 2009

DeltaNp63 knockdown mice: A mouse model for AEC syndrome.

Am J Med Genet A 2009 Sep;149A(9):1942-7

Department of Dermatology and Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado-Denver, Aurora, CO 80045, USA.

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http://doi.wiley.com/10.1002/ajmg.a.32794
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http://dx.doi.org/10.1002/ajmg.a.32794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753548PMC
September 2009

Genetically engineered mouse models for skin research: taking the next step.

J Dermatol Sci 2008 Oct 3;52(1):1-12. Epub 2008 Jun 3.

Department of Dermatology and Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.jdermsci.2008.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701407PMC
October 2008

Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita.

J Dermatol Sci 2008 Sep 20;51(3):151-7. Epub 2008 May 20.

Department of Dermatology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.

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http://dx.doi.org/10.1016/j.jdermsci.2008.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587483PMC
September 2008

Sorting out the p63 signaling network.

J Invest Dermatol 2008 Jul;128(7):1617-9

Department of Dermatology and Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/jid.2008.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854628PMC
July 2008

Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium.

Stem Cells 2008 May 28;26(5):1298-306. Epub 2008 Feb 28.

Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1634/stemcells.2007-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091843PMC
May 2008

Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.

Dev Biol 2008 May 21;317(1):187-95. Epub 2008 Feb 21.

Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.

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http://dx.doi.org/10.1016/j.ydbio.2008.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435508PMC
May 2008

Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

J Invest Dermatol 2008 Feb 13;128(2):270-9. Epub 2007 Sep 13.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1038/sj.jid.5701038DOI Listing
February 2008

Mechanisms regulating epithelial stratification.

Annu Rev Cell Dev Biol 2007 ;23:93-113

Department of Dermatology and Charles C. Gates Program in Regenerative Medicine and Stem Cell Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80010, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.cellbio.23.
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http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123357DOI Listing
December 2007

Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.

Mol Carcinog 2007 Dec;46(12):949-57

Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/mc.20334DOI Listing
December 2007

Double-inducible gene activation system for caspase 3 and 9 in epidermis.

Genesis 2007 Apr;45(4):194-9

Center for Molecular Development and Disease, Texas A and M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/dvg.20288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566959PMC
April 2007

Conflicting roles for p63 in skin development and carcinogenesis.

Cell Cycle 2007 Feb 3;6(3):269-73. Epub 2007 Feb 3.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.4161/cc.6.3.3792DOI Listing
February 2007

Oct-4: the almighty POUripotent regulator?

J Invest Dermatol 2007 Feb;127(2):260-2

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1533267
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http://dx.doi.org/10.1038/sj.jid.5700654DOI Listing
February 2007

p63 induces key target genes required for epidermal morphogenesis.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3255-60. Epub 2007 Feb 20.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0611376104
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http://dx.doi.org/10.1073/pnas.0611376104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805532PMC
February 2007

Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function.

J Cell Sci 2006 Dec 14;119(Pt 23):4901-12. Epub 2006 Nov 14.

Department of Dermatology, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1242/jcs.03282DOI Listing
December 2006

An unexpected role for keratin 10 end domains in susceptibility to skin cancer.

J Cell Sci 2006 Dec 21;119(Pt 24):5067-76. Epub 2006 Nov 21.

Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.03298
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http://dx.doi.org/10.1242/jcs.03298DOI Listing
December 2006

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

Dev Biol 2006 Nov 21;299(1):122-36. Epub 2006 Jul 21.

Departments of Medicine and Biological Chemistry, University of California, Irvine, CA 92697-4030, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.07.015DOI Listing
November 2006

Keratin 6 is not essential for mammary gland development.

Breast Cancer Res 2006 21;8(3):R29. Epub 2006 Jun 21.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/bcr1504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557733PMC
September 2006

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.

Proc Natl Acad Sci U S A 2006 May 19;103(22):8435-40. Epub 2006 May 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.0602477103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482510PMC
May 2006

Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.

Cancer Res 2006 Apr;66(8):3981-6

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-06-0027DOI Listing
April 2006

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.

Genes Dev 2006 Apr;20(8):1028-42

Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA, and Department of Biochemistry, University of Lausanne, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472299PMC
http://dx.doi.org/10.1101/gad.1406006DOI Listing
April 2006

TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis.

Dev Biol 2006 Jan 1;289(1):253-61. Epub 2005 Dec 1.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.10.041DOI Listing
January 2006

P63 deficiency: a failure of lineage commitment or stem cell maintenance?

J Investig Dermatol Symp Proc 2005 Nov;10(2):118-23

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1087-0024.2005.200416.xDOI Listing
November 2005

Asymmetric cell division in skin development: a new look at an old observation.

Dev Cell 2005 Oct;9(4):444-6

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.devcel.2005.09.009DOI Listing
October 2005

Mouse models in preclinical studies for pachyonychia congenita.

J Investig Dermatol Symp Proc 2005 Oct;10(1):37-46

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1087-0024.2005.10206.xDOI Listing
October 2005

Inducible mouse models for inherited skin diseases: implications for skin gene therapy.

Cells Tissues Organs 2004 ;177(3):160-8

Department of Dermatology, University of Köln, Köln, Germany.

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http://dx.doi.org/10.1159/000079990DOI Listing
March 2005

Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes.

J Invest Dermatol 2004 Dec;123(6):1120-6

Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23492.xDOI Listing
December 2004

Genetic pathways required for epidermal morphogenesis.

Eur J Cell Biol 2004 Dec;83(11-12):625-9

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1078/0171-9335-00387DOI Listing
December 2004

The role of keratins in epidermal development and homeostasis--going beyond the obvious.

J Invest Dermatol 2004 Nov;123(5):x-xi

Departments of Molecular & Cellular Biology and Dermatology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23495.xDOI Listing
November 2004

p63 and epithelial appendage development.

Differentiation 2004 Oct;72(8):364-70

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1432-0436.2004.07208002.xDOI Listing
October 2004

Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease.

J Investig Dermatol Symp Proc 2004 Sep;9(3):261-8

Departments of Molecular and Cellular Biology, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1087-0024.2004.09312.xDOI Listing
September 2004

Development of transgenic mice that inducibly express an active form of c-Src in the epidermis.

Mol Carcinog 2004 Aug;40(4):189-200

Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA.

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http://dx.doi.org/10.1002/mc.20027DOI Listing
August 2004

Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.

Cancer Res 2004 Aug;64(15):5054-8

Departments of Molecular and Cellular Biology and Dermatology, Baylor College of Medicine, Room T 713, One Baylor Plaza, Houston, TX 77030, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-1488DOI Listing
August 2004

c-Myc and epidermal stem cell fate determination.

J Dermatol 2004 May;31(5):368-75

Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1346-8138.2004.tb00687.xDOI Listing
May 2004

Transgenic mouse models provide new insights into the role of p63 in epidermal development.

Cell Cycle 2004 Apr 1;3(4):411-3. Epub 2004 Apr 1.

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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April 2004

IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.

Nature 2004 Apr;428(6983):660-4

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA.

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http://dx.doi.org/10.1038/nature02421DOI Listing
April 2004

The role of p63 in development and differentiation of the epidermis.

J Dermatol Sci 2004 Feb;34(1):3-9

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jdermsci.2003.10.003DOI Listing
February 2004

Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

J Biol Chem 2004 Jan 10;279(2):1197-205. Epub 2003 Oct 10.

Department of Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M310589200DOI Listing
January 2004

p63 is the molecular switch for initiation of an epithelial stratification program.

Genes Dev 2004 Jan 16;18(2):126-31. Epub 2004 Jan 16.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1165104
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http://dx.doi.org/10.1101/gad.1165104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC324418PMC
January 2004

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.

Nat Genet 2003 Nov 28;35(3):238-45. Epub 2003 Sep 28.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1038/ng1248DOI Listing
November 2003

Use of laser capture microscopy in the analysis of mouse models of human diseases.

Methods Enzymol 2002 ;356:207-15

Department of Dermatology, University of Cologne, 50924 Cologne, Germany.

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http://dx.doi.org/10.1016/s0076-6879(02)56934-2DOI Listing
December 2002

Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.

J Investig Dermatol Symp Proc 2002 Dec;7(1):41-5

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2002.19639.xDOI Listing
December 2002

Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.

J Biol Chem 2002 Nov 25;277(48):46131-9. Epub 2002 Sep 25.

Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M208675200DOI Listing
November 2002

The epidermis as a bioreactor: topically regulated cutaneous delivery into the circulation.

Hum Gene Ther 2002 Jun;13(9):1075-80

Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA.

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http://dx.doi.org/10.1089/104303402753812476DOI Listing
June 2002

K14-GLp65 transactivator induces transgene expression in embryonic epidermis.

Genesis 2002 Feb;32(2):189-90

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/gene.10063DOI Listing
February 2002

In utero activation of K5.CrePR1 induces gene deletion.

Genesis 2002 Feb;32(2):191-2

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/gene.10064DOI Listing
February 2002

Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system.

J Invest Dermatol 2002 Jan;118(1):102-9

Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-8025, USA.

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http://dx.doi.org/10.1046/j.0022-202x.2001.01661.xDOI Listing
January 2002