Publications by authors named "Dennis P Hughes"

28Publications

Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy.

Paediatr Drugs 2015 Aug;17(4):257-71

Department of Pediatrics-Research, The Children's Cancer Hospital at MD Anderson Cancer Center, Unit 853, MOD 1.021d, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s40272-015-0134-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516866PMC
August 2015

Health disparities are important determinants of outcome for children with solid tumor malignancies.

J Pediatr Surg 2015 Jan 26;50(1):161-6. Epub 2014 Oct 26.

Department of Health Services Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.jpedsurg.2014.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408987PMC
January 2015

Effect of concurrent metastatic disease on survival in children and adolescents undergoing lung resection for metastatic osteosarcoma.

J Pediatr Surg 2015 Jan 28;50(1):157-60; discussion 160. Epub 2014 Oct 28.

Department of Pediatric Surgery, The University of Texas Medical School at Houston, Houston, Texas; Department of Pediatrics, Children's Cancer Hospital at the University of Texas M.D. Anderson Cancer Center, Houston, Texas; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jpedsurg.2014.10.038DOI Listing
January 2015

New, tolerable γ-secretase inhibitor takes desmoid down a notch.

Clin Cancer Res 2015 Jan 21;21(1):7-9. Epub 2014 Oct 21.

Department of Pathology and Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306586PMC
January 2015

Developmental pathways hijacked by osteosarcoma.

Adv Exp Med Biol 2014 ;804:93-118

The College of Natural Sciences, The University of Texas at Austin, Austin, TX, USA.

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http://dx.doi.org/10.1007/978-3-319-04843-7_5DOI Listing
September 2014

Understanding the role of Notch in osteosarcoma.

Adv Exp Med Biol 2014 ;804:67-92

The Children's Cancer Hospital at MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-3-319-04843-7_4DOI Listing
September 2014

Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression.

Front Oncol 2013 Sep 17;3:230. Epub 2013 Sep 17.

Department of Pediatrics - Research, UT MD Anderson Cancer Center , Houston, TX , USA.

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http://dx.doi.org/10.3389/fonc.2013.00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775316PMC
September 2013

Complications in the surgical treatment of pediatric melanoma.

J Pediatr Surg 2013 Jun;48(6):1249-53

Department of Pediatric Surgery, The University of Texas Medical School at Houston, Houston, TX 77030-1439, USA.

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http://dx.doi.org/10.1016/j.jpedsurg.2013.03.018DOI Listing
June 2013

Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors.

Carcinogenesis 2012 Sep 4;33(9):1674-83. Epub 2012 Jul 4.

Department of Sarcoma Medical Oncology, University of Texas-MD Anderson Cancer Center Houston, TX, USA.

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http://dx.doi.org/10.1093/carcin/bgs221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514902PMC
September 2012

Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma.

Cancer 2012 Oct 13;118(20):5140-54. Epub 2012 Mar 13.

Department of Pediatrics Research, Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://doi.wiley.com/10.1002/cncr.27496
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http://dx.doi.org/10.1002/cncr.27496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414637PMC
October 2012

Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo.

Cancer 2010 Jul;116(13):3233-43

Department of Pediatrics Research, Children's Cancer Hospital, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.25073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923448PMC
July 2010

Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected].

Mol Cancer Ther 2010 May 20;9(5):1111-9. Epub 2010 Apr 20.

Department of Pediatrics Research, Children's Cancer Hospital, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868119PMC
May 2010

How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize.

Cancer Treat Res 2009 ;152:479-96

Children's Cancer Hospital, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1007/978-1-4419-0284-9_28DOI Listing
October 2010

Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions.

Curr Oncol Rep 2009 Nov;11(6):446-53

Department of Pediatrics Research, Unit 853, Children's Cancer Hospital, The University of Texas, M. D. Anderson Cancer Center, PO Box 301402, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s11912-009-0061-zDOI Listing
November 2009

Strategies for the targeted delivery of therapeutics for osteosarcoma.

Expert Opin Drug Deliv 2009 Dec;6(12):1311-21

The Children's Cancer Hospital at MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 853, Houston, TX 77030, USA.

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http://dx.doi.org/10.1517/17425240903280422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163784PMC
December 2009

Novel agents in development for pediatric sarcomas.

Curr Opin Oncol 2009 Jul;21(4):332-7

Department of Pediatrics-Research, The Children's Cancer Hospital at M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1097/CCO.0b013e32832c94e2DOI Listing
July 2009

Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.

Cancer Res 2009 Mar 10;69(6):2461-70. Epub 2009 Mar 10.

Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University Heidelberg and DKFZ (German Cancer Research Center), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3236DOI Listing
March 2009

Critical role of notch signaling in osteosarcoma invasion and metastasis.

Clin Cancer Res 2008 May;14(10):2962-9

Department of Pediatrics Research, Children's Cancer Hospital, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830718PMC
May 2008

Primary tuberculosis of bone mimicking a lytic bone tumor.

J Pediatr Hematol Oncol 2007 Mar;29(3):198-202

University of Texas Health Science Center at Houston Medical School, Department of Pathology, The Children's Cancer Hospital at MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1097/MPH.0b013e31803b959fDOI Listing
March 2007

Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin.

Cancer Res 2006 May;66(9):4913-21

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3507DOI Listing
May 2006

Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition.

Pediatr Blood Cancer 2006 May;46(5):614-23

Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/pbc.20454DOI Listing
May 2006

[Chimeric T cell receptor N29gamma redirect T lymphocytes response specific to p185HER2 in A murine model of metastatic breast cancer].

Ai Zheng 2004 Nov;23(11 Suppl):1370-5

Department of Hepatobiliary Oncology,Cancer Center, Sun Yat-sen University, Guangzhou,Guangdong,510060, PRChina.

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November 2004

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.

Cancer Res 2004 Mar;64(6):2047-53

Department of Pediatrics and Infectious Diseases, Division of Pediatric Hematology/Oncology, University of Michigan Medical Center, L2110 Women's Hospital, 0238, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0238, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-3096DOI Listing
March 2004