Dennis L Murphy

Dennis L Murphy

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Dennis L Murphy

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Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice.

Biol Res 2017 Sep 19;50(1):29. Epub 2017 Sep 19.

Laboratorio de Neurogenética, Centro de Neurobiología y Plasticidad Cerebral, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

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http://biolres.biomedcentral.com/articles/10.1186/s40659-017
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http://dx.doi.org/10.1186/s40659-017-0138-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605982PMC
September 2017

Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

Behav Pharmacol 2015 Jun;26(4):345-52

aDepartment of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai bDivision of Pharmacognosy, Phytochemistry, and Narcotics, National Institute of Health Sciences, Tokyo cDepartment of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan dDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio eLaboratory of Clinical Science, National Institute of Mental Health, Bethesda fMolecular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, USA gDepartment of Psychiatry, University of Wurzburg, Wurzburg, Germany hDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1097/FBP.0000000000000135DOI Listing
June 2015

Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment.

Behav Pharmacol 2015 Feb;26(1-2):167-79

Departments of aBiological Psychiatry bGynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai cDepartment of Molecular Psychiatry, Tokyo Institute of Psychiatry, Tokyo, Japan dDepartment of Psychiatry und Psychotherapy, University of Wurzburg, Wurzburg, Germany eClinical Neuropharmacology Section, Laboratory of Clinical Science, National Institute on Mental Health, Intramural Research Program, Bethesda fMolecular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/FBP.0000000000000120DOI Listing
February 2015

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.

Authors:
Dongmei Yu Carol A Mathews Jeremiah M Scharf Benjamin M Neale Lea K Davis Eric R Gamazon Eske M Derks Patrick Evans Christopher K Edlund Jacquelyn Crane Jesen A Fagerness Lisa Osiecki Patience Gallagher Gloria Gerber Stephen Haddad Cornelia Illmann Lauren M McGrath Catherine Mayerfeld Sampath Arepalli Cristina Barlassina Cathy L Barr Laura Bellodi Fortu Benarroch Gabriel Bedoya Berrió O Joseph Bienvenu Donald W Black Michael H Bloch Helena Brentani Ruth D Bruun Cathy L Budman Beatriz Camarena Desmond D Campbell Carolina Cappi Julio C Cardona Silgado Maria C Cavallini Denise A Chavira Sylvain Chouinard Edwin H Cook M R Cookson Vladimir Coric Bernadette Cullen Daniele Cusi Richard Delorme Damiaan Denys Yves Dion Valsama Eapen Karin Egberts Peter Falkai Thomas Fernandez Eduardo Fournier Helena Garrido Daniel Geller Donald L Gilbert Simon L Girard Hans J Grabe Marco A Grados Benjamin D Greenberg Varda Gross-Tsur Edna Grünblatt John Hardy Gary A Heiman Sian M J Hemmings Luis D Herrera Dianne M Hezel Pieter J Hoekstra Joseph Jankovic James L Kennedy Robert A King Anuar I Konkashbaev Barbara Kremeyer Roger Kurlan Nuria Lanzagorta Marion Leboyer James F Leckman Leonhard Lennertz Chunyu Liu Christine Lochner Thomas L Lowe Sara Lupoli Fabio Macciardi Wolfgang Maier Paolo Manunta Maurizio Marconi James T McCracken Sandra C Mesa Restrepo Rainald Moessner Priya Moorjani Jubel Morgan Heike Muller Dennis L Murphy Allan L Naarden Erika Nurmi William Cornejo Ochoa Roel A Ophoff Andrew J Pakstis Michele T Pato Carlos N Pato John Piacentini Christopher Pittenger Yehuda Pollak Scott L Rauch Tobias Renner Victor I Reus Margaret A Richter Mark A Riddle Mary M Robertson Roxana Romero Maria C Rosário David Rosenberg Stephan Ruhrmann Chiara Sabatti Erika Salvi Aline S Sampaio Jack Samuels Paul Sandor Susan K Service Brooke Sheppard Harvey S Singer Jan H Smit Dan J Stein Eric Strengman Jay A Tischfield Maurizio Turiel Ana V Valencia Duarte Homero Vallada Jeremy Veenstra-VanderWeele Susanne Walitza Ying Wang Mike Weale Robert Weiss Jens R Wendland Herman G M Westenberg Yin Yao Shugart Ana G Hounie Euripedes C Miguel Humberto Nicolini Michael Wagner Andres Ruiz-Linares Danielle C Cath William McMahon Danielle Posthuma Ben A Oostra Gerald Nestadt Guy A Rouleau Shaun Purcell Michael A Jenike Peter Heutink Gregory L Hanna David V Conti Paul D Arnold Nelson B Freimer S Evelyn Stewart James A Knowles Nancy J Cox David L Pauls

Am J Psychiatry 2015 Jan 31;172(1):82-93. Epub 2014 Oct 31.

From the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston; the Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Mass.; the Department of Psychiatry, University of California, San Francisco; the Department of Neurology, Massachusetts General Hospital, Boston; the Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston; the Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago; the Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam; the Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles; the Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Md.; the Genomic and Bioinformatic Unit, Filarete Foundation, Milan, Italy; the Department of Health Sciences, Graduate School of Nephrology, University of Milan, Milan; the Toronto Western Research Institute, University Health Network, Toronto; Hospital for Sick Children, Toronto; Università Vita-Salute San Raffaele, Milan; the Herman Dana Division of Child and Adolescent Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem; Universidad de Antioquia, Universidad Pontificia Bolivariana, Medellín, Colombia; the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore; the Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; the Child Study Center and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; North Shore-Long Island Jewish Medical Center and North Shore-Lo

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http://dx.doi.org/10.1176/appi.ajp.2014.13101306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282594PMC
January 2015

Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice.

Psychopharmacology (Berl) 2014 Oct 13;231(21):4119-33. Epub 2014 Apr 13.

Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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http://dx.doi.org/10.1007/s00213-014-3554-xDOI Listing
October 2014

Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.

Authors:
Lauren M McGrath Dongmei Yu Christian Marshall Lea K Davis Bhooma Thiruvahindrapuram Bingbin Li Carolina Cappi Gloria Gerber Aaron Wolf Frederick A Schroeder Lisa Osiecki Colm O'Dushlaine Andrew Kirby Cornelia Illmann Stephen Haddad Patience Gallagher Jesen A Fagerness Cathy L Barr Laura Bellodi Fortu Benarroch O Joseph Bienvenu Donald W Black Michael H Bloch Ruth D Bruun Cathy L Budman Beatriz Camarena Danielle C Cath Maria C Cavallini Sylvain Chouinard Vladimir Coric Bernadette Cullen Richard Delorme Damiaan Denys Eske M Derks Yves Dion Maria C Rosário Valsama Eapen Patrick Evans Peter Falkai Thomas V Fernandez Helena Garrido Daniel Geller Hans J Grabe Marco A Grados Benjamin D Greenberg Varda Gross-Tsur Edna Grünblatt Gary A Heiman Sian M J Hemmings Luis D Herrera Ana G Hounie Joseph Jankovic James L Kennedy Robert A King Roger Kurlan Nuria Lanzagorta Marion Leboyer James F Leckman Leonhard Lennertz Christine Lochner Thomas L Lowe Gholson J Lyon Fabio Macciardi Wolfgang Maier James T McCracken William McMahon Dennis L Murphy Allan L Naarden Benjamin M Neale Erika Nurmi Andrew J Pakstis Michele T Pato Carlos N Pato John Piacentini Christopher Pittenger Yehuda Pollak Victor I Reus Margaret A Richter Mark Riddle Mary M Robertson David Rosenberg Guy A Rouleau Stephan Ruhrmann Aline S Sampaio Jack Samuels Paul Sandor Brooke Sheppard Harvey S Singer Jan H Smit Dan J Stein Jay A Tischfield Homero Vallada Jeremy Veenstra-VanderWeele Susanne Walitza Ying Wang Jens R Wendland Yin Yao Shugart Euripedes C Miguel Humberto Nicolini Ben A Oostra Rainald Moessner Michael Wagner Andres Ruiz-Linares Peter Heutink Gerald Nestadt Nelson Freimer Tracey Petryshen Danielle Posthuma Michael A Jenike Nancy J Cox Gregory L Hanna Helena Brentani Stephen W Scherer Paul D Arnold S Evelyn Stewart Carol A Mathews James A Knowles Edwin H Cook David L Pauls Kai Wang Jeremiah M Scharf

J Am Acad Child Adolesc Psychiatry 2014 Aug 24;53(8):910-9. Epub 2014 Jun 24.

Massachusetts General Hospital, Boston; Brigham and Womens Hospital, Boston; Harvard-MIT Broad Institute, Boston. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2014.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218748PMC
August 2014

Characterization of SLITRK1 variation in obsessive-compulsive disorder.

PLoS One 2013 21;8(8):e70376. Epub 2013 Aug 21.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America ; Department of Neuroscience, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749144PMC
April 2014

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.

Pflugers Arch 2014 Jan 13;466(1):25-42. Epub 2013 Dec 13.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.

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http://link.springer.com/10.1007/s00424-013-1410-1
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http://dx.doi.org/10.1007/s00424-013-1410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930102PMC
January 2014

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

Authors:
Lea K Davis Dongmei Yu Clare L Keenan Eric R Gamazon Anuar I Konkashbaev Eske M Derks Benjamin M Neale Jian Yang S Hong Lee Patrick Evans Cathy L Barr Laura Bellodi Fortu Benarroch Gabriel Bedoya Berrio Oscar J Bienvenu Michael H Bloch Rianne M Blom Ruth D Bruun Cathy L Budman Beatriz Camarena Desmond Campbell Carolina Cappi Julio C Cardona Silgado Danielle C Cath Maria C Cavallini Denise A Chavira Sylvain Chouinard David V Conti Edwin H Cook Vladimir Coric Bernadette A Cullen Dieter Deforce Richard Delorme Yves Dion Christopher K Edlund Karin Egberts Peter Falkai Thomas V Fernandez Patience J Gallagher Helena Garrido Daniel Geller Simon L Girard Hans J Grabe Marco A Grados Benjamin D Greenberg Varda Gross-Tsur Stephen Haddad Gary A Heiman Sian M J Hemmings Ana G Hounie Cornelia Illmann Joseph Jankovic Michael A Jenike James L Kennedy Robert A King Barbara Kremeyer Roger Kurlan Nuria Lanzagorta Marion Leboyer James F Leckman Leonhard Lennertz Chunyu Liu Christine Lochner Thomas L Lowe Fabio Macciardi James T McCracken Lauren M McGrath Sandra C Mesa Restrepo Rainald Moessner Jubel Morgan Heike Muller Dennis L Murphy Allan L Naarden William Cornejo Ochoa Roel A Ophoff Lisa Osiecki Andrew J Pakstis Michele T Pato Carlos N Pato John Piacentini Christopher Pittenger Yehuda Pollak Scott L Rauch Tobias J Renner Victor I Reus Margaret A Richter Mark A Riddle Mary M Robertson Roxana Romero Maria C Rosàrio David Rosenberg Guy A Rouleau Stephan Ruhrmann Andres Ruiz-Linares Aline S Sampaio Jack Samuels Paul Sandor Brooke Sheppard Harvey S Singer Jan H Smit Dan J Stein E Strengman Jay A Tischfield Ana V Valencia Duarte Homero Vallada Filip Van Nieuwerburgh Jeremy Veenstra-Vanderweele Susanne Walitza Ying Wang Jens R Wendland Herman G M Westenberg Yin Yao Shugart Euripedes C Miguel William McMahon Michael Wagner Humberto Nicolini Danielle Posthuma Gregory L Hanna Peter Heutink Damiaan Denys Paul D Arnold Ben A Oostra Gerald Nestadt Nelson B Freimer David L Pauls Naomi R Wray S Evelyn Stewart Carol A Mathews James A Knowles Nancy J Cox Jeremiah M Scharf

PLoS Genet 2013 Oct 24;9(10):e1003864. Epub 2013 Oct 24.

Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812053PMC
October 2013

Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity.

Philos Trans R Soc Lond B Biol Sci 2013 25;368(1615):20120435. Epub 2013 Feb 25.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1098/rstb.2012.0435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638387PMC
September 2013

An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.

Psychopharmacology (Berl) 2013 Jun 17;227(4):685-95. Epub 2013 Feb 17.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10-3D41, MSC 1264, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00213-013-2988-xDOI Listing
June 2013

miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells.

Int J Neuropsychopharmacol 2013 Apr 8;16(3):621-9. Epub 2012 May 8.

Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1017/S1461145712000454DOI Listing
April 2013

5HTTLPR: White Knight or Dark Blight?

ACS Chem Neurosci 2013 Jan;4(1):13-5

Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States.

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http://dx.doi.org/10.1021/cn3002224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547485PMC
January 2013

Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.

Brain 2012 Jun 10;135(Pt 6):1926-36. Epub 2012 May 10.

Controlled Substance Staff, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA.

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http://dx.doi.org/10.1093/brain/aws104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359755PMC
June 2012

Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study.

Int J Neuropsychopharmacol 2012 Apr 25;15(3):349-61. Epub 2011 Mar 25.

University of Ottawa Institute of Mental Health Research (IMHR), Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1017/S1461145711000484DOI Listing
April 2012

Phenomenological features and clinical impact of affective disorders in OCD: a focus on the bipolar disorder and OCD connection.

Depress Anxiety 2012 Mar 22;29(3):226-33. Epub 2011 Nov 22.

University of Miami, Coral Gables, Florida 33146, USA.

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http://dx.doi.org/10.1002/da.20908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322278PMC
March 2012

Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity.

J Abnorm Psychol 2011 Aug;120(3):700-7

Department of Psychology, University of Miami, 5665 Ponce de Leon Boulevard, Coral Gables, FL 33146, USA.

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http://dx.doi.org/10.1037/a0024159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169010PMC
August 2011

Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.

BMC Pharmacol 2011 Apr 7;11. Epub 2011 Apr 7.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2210-11-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080299PMC
April 2011

Separation anxiety disorder in OCD.

Depress Anxiety 2011 Mar 9;28(3):256-62. Epub 2011 Feb 9.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 1629 Thames Street, Baltimore, MD 21287, USA.

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http://doi.wiley.com/10.1002/da.20773
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http://dx.doi.org/10.1002/da.20773DOI Listing
March 2011

Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.

Curr Opin Pharmacol 2011 Feb 23;11(1):3-10. Epub 2011 Mar 23.

Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.coph.2011.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487694PMC
February 2011

Psychiatric symptoms associated with focal hand dystonia.

Mov Disord 2010 Oct;25(13):2249-52

Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/mds.23250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082988PMC
October 2010

The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis.

Psychopharmacology (Berl) 2010 Sep 13;212(1):13-23. Epub 2009 Oct 13.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1007/s00213-009-1694-1DOI Listing
September 2010

Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice.

Cereb Cortex 2010 Aug 23;20(8):1955-63. Epub 2009 Dec 23.

Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, MD 20852-9411, USA.

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http://dx.doi.org/10.1093/cercor/bhp266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912649PMC
August 2010

Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts.

Dialogues Clin Neurosci 2010 ;12(2):131-48

Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181955PMC
August 2010

Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset.

Brain Imaging Behav 2010 Mar 12;4(1):35-45. Epub 2009 Dec 12.

Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Veterans Affairs Medical Center 830 Chalkstone Ave., Providence, RI 02908, USA.

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http://dx.doi.org/10.1007/s11682-009-9083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018344PMC
March 2010

Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT).

Br J Pharmacol 2010 Feb 27;159(4):879-87. Epub 2010 Jan 27.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00578.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829213PMC
February 2010

Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.

Int J Neuropsychopharmacol 2009 Sep 11;12(8):1055-65. Epub 2009 Mar 11.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1017/S146114570900011XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095PMC
September 2009

Exploration of anxiety sensitivity and distress tolerance as vulnerability factors for hoarding behaviors.

Depress Anxiety 2009 ;26(4):343-53

Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/da.20469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770430PMC
August 2009

Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice.

Neuropsychopharmacology 2009 Jun 14;34(7):1695-709. Epub 2009 Jan 14.

Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2008.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700347PMC
June 2009

Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.

J Immunol 2009 Jun;182(12):7430-9

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.0900039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901060PMC
June 2009

Predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis.

Depress Anxiety 2008 ;25(8):680-8

Section on Socio-Environmental Studies, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892-8408, USA.

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http://doi.wiley.com/10.1002/da.20444
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http://dx.doi.org/10.1002/da.20444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730946PMC
March 2009

Involvement of insula and cingulate cortices in control and suppression of natural urges.

Cereb Cortex 2009 Jan 9;19(1):218-23. Epub 2008 May 9.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/cercor/bhn074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638741PMC
January 2009

Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.

Psychopharmacology (Berl) 2008 Dec 19;201(2):203-18. Epub 2008 Aug 19.

Laboratory of Clinical Science (LCS), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), 10 Center Drive, Building 10-3D41, MSC 1264, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1007/s00213-008-1268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584159PMC
December 2008

Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disorders.

Behav Pharmacol 2008 Sep;19(5-6):377-84

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892-1264, USA.

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http://dx.doi.org/10.1097/FBP.0b013e32830dc09bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743519PMC
September 2008

Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research?

Prog Neuropsychopharmacol Biol Psychiatry 2008 Jul 23;32(5):1172-8. Epub 2007 Dec 23.

Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, Maryland 20892-1264, USA.

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http://dx.doi.org/10.1016/j.pnpbp.2007.12.010DOI Listing
July 2008

Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse.

Eur J Pharmacol 2008 Jul 7;589(1-3):225-7. Epub 2008 Jun 7.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA.

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http://dx.doi.org/10.1016/j.ejphar.2008.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527649PMC
July 2008

Perspectives on genetic animal models of serotonin toxicity.

Neurochem Int 2008 Mar-Apr;52(4-5):649-58. Epub 2007 Sep 1.

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1016/j.neuint.2007.08.015DOI Listing
June 2008

Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research.

Behav Brain Res 2008 Apr 22;188(2):243-9. Epub 2007 Nov 22.

Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1016/j.bbr.2007.11.011DOI Listing
April 2008

Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.

J Clin Invest 2008 Apr;118(4):1544-52

Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8548, USA.

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http://www.jci.org/articles/view/33374
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http://dx.doi.org/10.1172/JCI33374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2260909PMC
April 2008

A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.

Hum Mol Genet 2008 Mar 30;17(5):717-23. Epub 2007 Nov 30.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/hmg/ddm343DOI Listing
March 2008

The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression.

Neural Plast 2007 ;2007:52087

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1155/2007/52087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233771PMC
March 2008

SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.

Psychiatr Genet 2008 Feb;18(1):31-9

Laboratory of Clinical Science, Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, Maryland 20892-1264, USA.

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http://dx.doi.org/10.1097/YPG.0b013e3282f08a06DOI Listing
February 2008

Targeting the murine serotonin transporter: insights into human neurobiology.

Nat Rev Neurosci 2008 Feb;9(2):85-96

Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrn2284DOI Listing
February 2008

Analyzing grooming microstructure in neurobehavioral experiments.

Nat Protoc 2007 ;2(10):2538-44

Laboratory of Clinical Science, National Institute of Mental Health, NIMH/NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nprot.2007.367DOI Listing
January 2008

A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder.

Neuropsychopharmacology 2007 Dec 21;32(12):2543-51. Epub 2007 Mar 21.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/sj.npp.1301394DOI Listing
December 2007

A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.

Psychopharmacology (Berl) 2007 Dec 22;195(2):147-66. Epub 2007 Aug 22.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00213-007-0910-0DOI Listing
December 2007

Do traumatic events influence the clinical expression of compulsive hoarding?

Behav Res Ther 2007 Nov 17;45(11):2581-92. Epub 2007 Jun 17.

Department of Psychology, Florida State University, Tallahassee, FL 32306-1270, USA.

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http://dx.doi.org/10.1016/j.brat.2007.06.005DOI Listing
November 2007

Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

Eur J Pharmacol 2007 Oct 27;572(2-3):120-8. Epub 2007 Jun 27.

Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2007.06.022DOI Listing
October 2007

Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.

Neuropharmacology 2007 Oct 27;53(5):643-56. Epub 2007 Jul 27.

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2007.07.009DOI Listing
October 2007

Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice.

Brain Res 2007 Sep 14;1169:87-97. Epub 2007 Jul 14.

Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Dr. MSC 1264, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.07.009DOI Listing
September 2007

An investigation of traumatic life events and obsessive-compulsive disorder.

Behav Res Ther 2007 Jul 25;45(7):1683-91. Epub 2006 Oct 25.

Department of Psychology, Florida State University, Tallahassee, FL 32306-1270, USA.

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http://dx.doi.org/10.1016/j.brat.2006.08.018DOI Listing
July 2007

Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies.

Cell Mol Neurobiol 2006 Jul-Aug;26(4-6):755-80. Epub 2006 Sep 22.

Laboratory of Clinical Science, NIMH, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1007/s10571-006-9048-6DOI Listing
April 2007

The developing use of heterozygous mutant mouse models in brain monoamine transporter research.

Trends Pharmacol Sci 2007 Mar 2;28(3):122-7. Epub 2007 Feb 2.

Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Drive, 1264 Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1016/j.tips.2007.01.002DOI Listing
March 2007

Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice.

Behav Genet 2007 Jan;37(1):214-22

Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10519-006-9129-9DOI Listing
January 2007

Cerebrospinal fluid monoamine metabolite levels in human newborn infants born in winter differ from those born in summer.

Psychiatry Res 2006 Dec 30;145(2-3):189-97. Epub 2006 Oct 30.

Division of Psychiatry, Department of Clinical Sciences, University of Umeå, SE-901 85 Umeå, Sweden.

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http://dx.doi.org/10.1016/j.psychres.2005.11.008DOI Listing
December 2006

Ethanol-related behaviors in serotonin transporter knockout mice.

Alcohol Clin Exp Res 2006 Dec;30(12):1957-65

Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2006.00241.xDOI Listing
December 2006

The hoarding dimension of OCD: psychological comorbidity and the five-factor personality model.

Behav Res Ther 2006 Oct 4;44(10):1503-12. Epub 2006 Jan 4.

The Catholic University of America, Adult OCD Unit, NIMH, 10 Center Drive MSC 1264, 10/3D41, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.brat.2005.11.009DOI Listing
October 2006

Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia.

Neuroreport 2006 Aug;17(12):1347-51

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892-1264, USA.

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http://dx.doi.org/10.1097/01.wnr.0000230514.08962.76DOI Listing
August 2006

Vulnerability to mild predator stress in serotonin transporter knockout mice.

Behav Brain Res 2006 Jun 20;170(1):126-40. Epub 2006 Mar 20.

Department of Psychology, Memorial University, 232 Elizabeth Avenue, St. John's, Nfld, Canada A1B 3X9.

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http://dx.doi.org/10.1016/j.bbr.2006.02.012DOI Listing
June 2006

Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism.

Am J Med Genet B Neuropsychiatr Genet 2006 Jun;141B(4):403-8

Department of Psychiatry, University Hospital, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1002/ajmg.b.30309DOI Listing
June 2006

BDNF in anxiety and depression.

Science 2006 Jun;312(5780):1598-9; author reply 1598-9

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http://dx.doi.org/10.1126/science.312.5780.1598DOI Listing
June 2006

Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl.

Mol Pharmacol 2005 Nov 12;68(5):1408-14. Epub 2005 Aug 12.

School of Pharmacy, Taipei Medical University, 250 Wu-Xing Street, Taipei 110, Taiwan.

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http://dx.doi.org/10.1124/mol.105.012302DOI Listing
November 2005

Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter.

Neuropharmacology 2005 Nov 23;49(6):798-810. Epub 2005 Sep 23.

Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2005.08.010DOI Listing
November 2005

(+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter.

J Pharmacol Exp Ther 2005 Sep 18;314(3):953-60. Epub 2005 May 18.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824-1317, USA.

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http://dx.doi.org/10.1124/jpet.105.087080DOI Listing
September 2005

Serotonergic-like progenitor cells propagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT.

FASEB J 2005 Sep 21;19(11):1537-9. Epub 2005 Jun 21.

Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892-1264, USA.

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http://dx.doi.org/10.1096/fj.04-3657fjeDOI Listing
September 2005

5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter.

Psychopharmacology (Berl) 2005 Jun 15;180(1):12-20. Epub 2005 Apr 15.

Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Building 9, Room 1S128, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00213-005-2231-5DOI Listing
June 2005

Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity.

Psychiatry Res 2005 Jun;135(2):121-32

Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892-2670, USA.

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http://dx.doi.org/10.1016/j.psychres.2005.03.003DOI Listing
June 2005

Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice.

Proc Natl Acad Sci U S A 2005 Apr 4;102(15):5582-7. Epub 2005 Apr 4.

Laboratory of Cerebral Metabolism, National Institute of Mental Health, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0501509102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556265PMC
April 2005