Dennis E Kyle

Dennis E Kyle

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Dennis E Kyle

Dennis E Kyle

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An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing.

Lab Chip 2020 Feb 14. Epub 2020 Feb 14.

Center for Global Health and Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA. and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.

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http://dx.doi.org/10.1039/c9lc00921cDOI Listing
February 2020

In vitro screening of the open source MMV Malaria and Pathogen Boxes to discover novel compounds with activity against .

Antimicrob Agents Chemother 2020 Feb 18. Epub 2020 Feb 18.

Center for Tropical and Emerging Global Diseases, Coverdell Center Rm 370B, 500 DW Brooks Drive, University of Georgia, Athens, GA 30602, US.

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http://dx.doi.org/10.1128/AAC.02233-19DOI Listing
February 2020

Conservation of Ancient Genetic Pathways for Intracellular Persistence Among Animal Pathogenic Bordetellae.

Front Microbiol 2019 11;10:2839. Epub 2019 Dec 11.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.

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http://dx.doi.org/10.3389/fmicb.2019.02839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917644PMC
December 2019

Protozoan persister-like cells and drug treatment failure.

Nat Rev Microbiol 2019 10 23;17(10):607-620. Epub 2019 Aug 23.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.

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http://dx.doi.org/10.1038/s41579-019-0238-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024564PMC
October 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

First evidence of polychaete intermediate hosts for Neospirorchis spp. marine turtle blood flukes (Trematoda: Spirorchiidae).

Int J Parasitol 2018 12 25;48(14):1097-1106. Epub 2018 Oct 25.

Center for Tropical & Emerging Global Diseases, University of Georgia, Coverdell Room 370B, 500 D.W. Brooks Drive, Athens, GA 30602, USA; Center for Global Health Infectious Diseases Research, University of South Florida, 3270 Spectrum Blvd, Tampa, FL 33612, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183023
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http://dx.doi.org/10.1016/j.ijpara.2018.08.002DOI Listing
December 2018

Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys.

Antimicrob Agents Chemother 2018 09 27;62(9). Epub 2018 Aug 27.

Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00582-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125511PMC
September 2018

Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae).

Parasitol Int 2018 Apr 31;67(2):150-158. Epub 2017 Oct 31.

Department of Molecular Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL 33612, USA; Department of Global Health, University of South Florida, 3720 Spectrum Blvd, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2017.10.012DOI Listing
April 2018

Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum.

Antimicrob Agents Chemother 2018 03 23;62(3). Epub 2018 Feb 23.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

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http://dx.doi.org/10.1128/AAC.01771-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826125PMC
March 2018

Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine.

Bioorg Med Chem Lett 2017 10 14;27(20):4597-4600. Epub 2017 Sep 14.

Department of Global Health, College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X173092
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http://dx.doi.org/10.1016/j.bmcl.2017.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311391PMC
October 2017

Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome That Are Transmissible through Mosquitoes.

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA

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http://dx.doi.org/10.1128/AAC.00689-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527649PMC
August 2017

Synthesis and Activity of a New Series of Antileishmanial Agents.

ACS Med Chem Lett 2017 Aug 31;8(8):797-801. Epub 2017 Jul 31.

Department of Chemistry, University of South Florida, CHE 205, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00039
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http://dx.doi.org/10.1021/acsmedchemlett.7b00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554902PMC
August 2017

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.

ACS Med Chem Lett 2017 Aug 10;8(8):802-807. Epub 2017 Jul 10.

Department of Chemistry, University of South Florida, CHE 205, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554901PMC
August 2017

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

J Med Chem 2016 07 12;59(14):6943-60. Epub 2016 Jul 12.

Department of Chemistry, University of South Florida , CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00759DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

Int J Parasitol Drugs Drug Resist 2016 Apr 12;6(1):85-92. Epub 2016 Feb 12.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805781PMC
April 2016

Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes.

Antimicrob Agents Chemother 2015 16;59(6):3156-67. Epub 2015 Mar 16.

Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00197-15
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http://dx.doi.org/10.1128/AAC.00197-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432152PMC
February 2016

Fitness of artemisinin-resistant Plasmodium falciparum in vitro.

J Antimicrob Chemother 2015 Oct 22;70(10):2787-96. Epub 2015 Jul 22.

Global Health Infectious Disease Research Program, College of Public Health, University of South Florida, Tampa, FL, USA

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http://dx.doi.org/10.1093/jac/dkv199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668880PMC
October 2015

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.

J Org Chem 2015 Aug 5;80(16):7849-55. Epub 2015 Aug 5.

†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.joc.5b01264DOI Listing
August 2015

4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.

Curr Top Med Chem 2014 ;14(14):1693-705

Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Ave., Tampa, Florida 33620, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479281PMC
http://dx.doi.org/10.2174/1568026614666140808124638DOI Listing
May 2015

Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.

Antimicrob Agents Chemother 2015 Apr 20;59(4):2037-44. Epub 2015 Jan 20.

Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA

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http://dx.doi.org/10.1128/AAC.05122-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356813PMC
April 2015

Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum.

Antimicrob Agents Chemother 2014 Aug 9;58(8):4773-81. Epub 2014 Jun 9.

Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia Malaria Drug Resistance and Chemotherapy, Queensland Institute of Medical Research, Brisbane, Australia

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http://dx.doi.org/10.1128/AAC.02647-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135995PMC
August 2014

Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines.

J Med Chem 2014 Jun 17;57(12):5141-56. Epub 2014 Jun 17.

Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/jm5000408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216219PMC
June 2014

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

Org Lett 2014 May 29;16(10):2630-3. Epub 2014 Apr 29.

Department of Chemistry and Center for Drug Discovery and Innovation and §Department of Global Health, University of South Florida , Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/ol500792xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127331PMC
May 2014

Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum.

Pharm Biol 2014 Mar 23;52(3):398-401. Epub 2013 Oct 23.

Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey , New Brunswick, NJ , USA .

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http://dx.doi.org/10.3109/13880209.2013.837077DOI Listing
March 2014

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.

Antimicrob Agents Chemother 2013 Dec 30;57(12):6187-95. Epub 2013 Sep 30.

Department of Global Health, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1128/AAC.00492-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837905PMC
December 2013

Real-time PCR to quantify Leishmania donovani in hamsters.

J Parasitol 2013 Feb 27;99(1):145-50. Epub 2012 Aug 27.

Department of Global Health, University of South Florida, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1645/GE-3221.1DOI Listing
February 2013

4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Antimicrob Agents Chemother 2013 Jan 5;57(1):417-24. Epub 2012 Nov 5.

Department of Global Health, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1128/AAC.00793-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535941PMC
January 2013

Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

Int J Parasitol Drugs Drug Resist 2012 Dec 27;2:249-255. Epub 2012 Jan 27.

Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia ; Malaria Drug Resistance and Chemotherapy, Queensland Institute of Medical Research, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.ijpddr.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572751PMC
December 2012

Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro.

Antimicrob Agents Chemother 2012 Sep 18;56(9):4685-92. Epub 2012 Jun 18.

Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1128/AAC.01061-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421852PMC
September 2012

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.

Org Lett 2012 Aug 13;14(15):3878-81. Epub 2012 Jul 13.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/ol301607qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449157PMC
August 2012

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

J Med Chem 2012 May 18;55(9):4205-19. Epub 2012 Apr 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm201642zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349818PMC
May 2012

Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii.

Mar Drugs 2012 Apr 28;10(4):762-74. Epub 2012 Mar 28.

Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery and Delivery, University of South Florida, Tampa, FL 33620, USA.

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http://dx.doi.org/10.3390/md10040762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366674PMC
April 2012

Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei.

PLoS One 2011 24;6(10):e26689. Epub 2011 Oct 24.

Department of Global Health, University of South Florida, Tampa, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026689PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200358PMC
February 2012

Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition.

Antimicrob Agents Chemother 2012 Jan 10;56(1):428-31. Epub 2011 Oct 10.

Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05456-11
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http://dx.doi.org/10.1128/AAC.05456-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256014PMC
January 2012

Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum.

Antimicrob Agents Chemother 2012 Jan 14;56(1):302-14. Epub 2011 Nov 14.

Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1128/AAC.05540-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256069PMC
January 2012

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

J Med Chem 2011 Dec 23;54(24):8321-7. Epub 2011 Nov 23.

Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/jm200718mDOI Listing
December 2011

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.

Bioorg Med Chem 2011 Oct 22;19(19):5756-62. Epub 2011 Aug 22.

Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery and Delivery, South Florida, Tampa, FL 33620, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.08.033DOI Listing
October 2011

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.

J Med Chem 2011 Jul 16;54(13):4399-426. Epub 2011 Jun 16.

Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/jm200015aDOI Listing
July 2011

Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure.

Malar J 2011 Mar 8;10:56. Epub 2011 Mar 8.

Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.

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http://dx.doi.org/10.1186/1475-2875-10-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060839PMC
March 2011

Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure.

J Infect Dis 2010 Nov;202(9):1362-8

Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Australian Army Malaria Institute, Brisbane, Australia.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/6564
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http://dx.doi.org/10.1086/656476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949454PMC
November 2010

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

J Med Chem 2010 Oct;53(19):7076-94

Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, USA.

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http://dx.doi.org/10.1021/jm1007903DOI Listing
October 2010

Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro.

Antimicrob Agents Chemother 2010 Aug 26;54(8):3395-401. Epub 2010 Apr 26.

Drug Resistance and Diagnostics, Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks, Enoggera, Qld 4051, Australia.

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http://aac.asm.org/cgi/doi/10.1128/AAC.01421-09
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http://dx.doi.org/10.1128/AAC.01421-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916312PMC
August 2010

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Antimicrob Agents Chemother 2010 Jun 29;54(6):2455-64. Epub 2010 Mar 29.

Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Australia.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00947-09
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http://dx.doi.org/10.1128/AAC.00947-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876417PMC
June 2010

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.

J Med Chem 2010 May;53(10):4187-97

Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1021/jm100265sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418807PMC
May 2010

Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity.

J Nat Prod 2010 Jan;73(1):60-6

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/np900622mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834186PMC
January 2010

Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.

Antimicrob Agents Chemother 2009 Aug 8;53(8):3592-4. Epub 2009 Jun 8.

Tropical Medicine Research, Malaria Drug and Vaccine Evaluation Center/Gorgas Memorial Institute of Health Studies, Panama, Panama.

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http://dx.doi.org/10.1128/AAC.00471-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715646PMC
August 2009

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review.

Curr Drug Targets 2009 Mar;10(3):178-92

Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.2174/138945009787581177DOI Listing
March 2009

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

J Nat Prod 2009 Jan;72(1):14-7

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/np8003529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760338PMC
January 2009

Malaria: progress, perils, and prospects for eradication.

J Clin Invest 2008 Apr;118(4):1266-76

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1172/JCI33996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276780PMC
April 2008

Malaria causal prophylactic activity of imidazolidinedione derivatives.

J Med Chem 2007 Nov 30;50(24):6226-31. Epub 2007 Oct 30.

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1021/jm7009815DOI Listing
November 2007

Synthesis and antimalarial activity of new isotebuquine analogues.

J Med Chem 2007 Feb 1;50(4):889-96. Epub 2007 Feb 1.

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA.

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http://dx.doi.org/10.1021/jm061232xDOI Listing
February 2007

Artemisone--a highly active antimalarial drug of the artemisinin class.

Angew Chem Int Ed Engl 2006 Mar;45(13):2082-8

Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China.

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http://dx.doi.org/10.1002/anie.200503071DOI Listing
March 2006

Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests.

J Infect Dis 2005 Sep 21;192(5):870-7. Epub 2005 Jul 21.

Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/4320
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http://dx.doi.org/10.1086/432010DOI Listing
September 2005

Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate.

Chembiochem 2005 Apr;6(4):659-67

Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China.

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http://doi.wiley.com/10.1002/cbic.200400366
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April 2005

Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum.

Antimicrob Agents Chemother 2004 Mar;48(3):954-60

Armed Forces Research Institute of Medical Sciences. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1128/aac.48.3.954-960.2004DOI Listing
March 2004

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.

Antimicrob Agents Chemother 2003 Nov;47(11):3500-5

Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Enoggera, Qld, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC253797PMC
http://dx.doi.org/10.1128/aac.47.11.3500-3505.2003DOI Listing
November 2003

A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal.

J Chem Inf Comput Sci 2002 Sep-Oct;42(5):1212-20

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910-7500, USA.

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http://dx.doi.org/10.1021/ci0200265DOI Listing
November 2002

Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores.

Antimicrob Agents Chemother 2002 Aug;46(8):2627-32

Parasitology Department, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127369PMC
http://dx.doi.org/10.1128/aac.46.8.2627-2632.2002DOI Listing
August 2002

Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents.

J Med Chem 2002 Aug;45(16):3491-6

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1021/jm020104fDOI Listing
August 2002

Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.

J Med Chem 2002 Jun;45(13):2741-8

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1021/jm010549oDOI Listing
June 2002

Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro.

J Nat Prod 2002 Apr;65(4):614-5

Department of Parasitology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910-7500, USA.

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http://dx.doi.org/10.1021/np0105275DOI Listing
April 2002

Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.

Antimicrob Agents Chemother 2002 Mar;46(3):787-96

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127479PMC
http://dx.doi.org/10.1128/aac.46.3.787-796.2002DOI Listing
March 2002