Dennis C Sgroi

Dennis C Sgroi

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Dennis C Sgroi

Dennis C Sgroi

Publications by authors named "Dennis C Sgroi"

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82Publications

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Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Cell 2019 Jun 25;177(7):1903-1914.e14. Epub 2019 Apr 25.

Molecular Pathology Unit, Massachusetts General Hospital Research Institute, Charlestown, MA 02129, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570580PMC
June 2019

A Novel Breast Cancer Index for Prediction of Distant Recurrence in HR Early-Stage Breast Cancer with One to Three Positive Nodes.

Clin Cancer Res 2017 Dec 22;23(23):7217-7224. Epub 2017 Sep 22.

Massachusetts General Hospital, Department of Pathology, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1688DOI Listing
December 2017

Biomarkers for Early-Stage Breast Cancer: Clinical Utility for Extended Adjuvant Treatment Decisions.

J Clin Oncol 2016 11;34(32):3941-3942

Dennis C. Sgroi, Massachusetts General Hospital, Charlestown and Boston, MA; and Adam Brufsky, University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2016.67.2949DOI Listing
November 2016

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 12-2016. An 8-Year-Old Boy with an Enlarging Mass in the Right Breast.

N Engl J Med 2016 Apr;374(16):1565-74

From the Departments of Pediatrics (M.M., A.M.F.), Radiology (P.S.), Pediatric Surgery (D.P.R.), and Pathology (D.C.S.), Massachusetts General Hospital, and the Departments of Pediatrics (M.M., A.M.F.), Radiology (P.S.), Pediatric Surgery (D.P.R.), and Pathology (D.C.S.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1503831DOI Listing
April 2016

Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS).

Breast Cancer Res Treat 2014 Jan 18;143(2):343-50. Epub 2013 Dec 18.

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital and Harvard Medical School , Boston, MA, USA,

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http://dx.doi.org/10.1007/s10549-013-2813-6DOI Listing
January 2014

The molecular pathology of breast cancer progression.

J Pathol 2011 Jan 16;223(2):307-17. Epub 2010 Nov 16.

Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.2808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069504PMC
January 2011

Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.

PLoS One 2010 Jul 13;5(7):e11499. Epub 2010 Jul 13.

Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011499PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903480PMC
July 2010

Preinvasive breast cancer.

Authors:
Dennis C Sgroi

Annu Rev Pathol 2010 ;5:193-221

Department of Pathology, Molecular Pathology Research Unit, Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.pathol.4.11
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http://dx.doi.org/10.1146/annurev.pathol.4.110807.092306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918415PMC
March 2010

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.

Methods Mol Biol 2009 ;560:87-98

Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/978-1-59745-448-3_8DOI Listing
December 2009

Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.

Mol Cancer Res 2009 Aug 11;7(8):1304-9. Epub 2009 Aug 11.

Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239295PMC
August 2009

Case records of the Massachusetts General Hospital. Case 25-2009. A 36-year-old woman with hormone-receptor-positive breast cancer.

N Engl J Med 2009 Aug;361(7):699-707

Division of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcpc0902224DOI Listing
August 2009

Breast cancer SRC activity: bad to the bone.

Authors:
Dennis C Sgroi

Cancer Cell 2009 Jul;16(1):1-2

Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.06.010DOI Listing
July 2009

Gene expression profiling of the tumor microenvironment during breast cancer progression.

Breast Cancer Res 2009 2;11(1):R7. Epub 2009 Feb 2.

bioTheranostics, Inc, 11025 Roselle Street, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1186/bcr2222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687710PMC
June 2009

Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers.

PLoS Comput Biol 2008 Aug 1;4(8):e1000138. Epub 2008 Aug 1.

Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1000138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453235PMC
August 2008

Re-evaluating early breast neoplasia.

Breast Cancer Res 2008 8;10(1):302. Epub 2008 Feb 8.

Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1186/bcr1853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374963PMC
June 2008

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.

J Clin Endocrinol Metab 2008 Mar 11;93(3):1046-53. Epub 2007 Dec 11.

Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1210/jc.2007-0931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266961PMC
March 2008

The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.

Clin Cancer Res 2007 Nov;13(21):6327-34

Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0310DOI Listing
November 2007

HOXB13 promotes ovarian cancer progression.

Proc Natl Acad Sci U S A 2007 Oct 17;104(43):17093-8. Epub 2007 Oct 17.

Molecular Pathology Research Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0707938104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040435PMC
October 2007

A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.

Genes Dev 2007 Sep 17;21(17):2131-6. Epub 2007 Aug 17.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1561507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950852PMC
September 2007

The Spemann organizer gene, Goosecoid, promotes tumor metastasis.

Proc Natl Acad Sci U S A 2006 Dec 1;103(50):18969-74. Epub 2006 Dec 1.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.0608636103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1748161PMC
December 2006

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon.

Proc Natl Acad Sci U S A 2006 Aug 7;103(33):12405-10. Epub 2006 Aug 7.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0605579103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533802PMC
August 2006

Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.

Proc Natl Acad Sci U S A 2006 Feb 6;103(7):2316-21. Epub 2006 Feb 6.

Cancer Center and Department of Pathology, Molecular Pathology Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0508776103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413705PMC
February 2006

Novel role for PDEF in epithelial cell migration and invasion.

Cancer Res 2005 Dec;65(24):11572-80

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919290PMC
December 2005

Case records of the Massachusetts General Hospital. Case 24-2005. A 58-year-old woman with early-stage estrogen-receptor-positive breast cancer.

N Engl J Med 2005 Aug;353(6):617-22

Department of Hematology, Massachusetts General Hospital, USA.

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http://dx.doi.org/10.1056/NEJMcpc059018DOI Listing
August 2005

Mapping molecular networks using proteomics: a vision for patient-tailored combination therapy.

J Clin Oncol 2005 May;23(15):3614-21

US Food and Drug Administration-National Cancer Institute Clinical Proteomics Program, Office of Cellular and Gene Therapy, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA.

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http://dx.doi.org/10.1200/JCO.2005.02.509DOI Listing
May 2005

Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling.

J Proteome Res 2004 May-Jun;3(3):604-12

Barnett Institute, Department of Chemistry, Northeastern University, 341 Mugar Building, 360 Huntington Avenue, Boston, Massachusetts 02115, USA.

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December 2004

Laser Capture Microdissection: a rising tool in genetic profiling of cancer.

Expert Rev Mol Diagn 2004 Jul;4(4):429-30

Dana Farber Cancer Institute and Harvard Medical School, Department of Medical Oncology, Boston, MA 02115, USA.

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http://dx.doi.org/10.1586/14737159.4.4.429DOI Listing
July 2004

Sclerosing lesions of the breast.

Semin Diagn Pathol 2004 Feb;21(1):42-7

James Homer Wright Pathology Laboratories, Molecular Pathology Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA.

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February 2004

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.

Nat Cell Biol 2003 Aug;5(8):733-40

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb1026DOI Listing
August 2003

In situ gene expression analysis of cancer using laser capture microdissection, microarrays and real time quantitative PCR.

Cancer Biol Ther 2002 Jul-Aug;1(4):354-8

Cancer Genetics Branch, NHGRI-NIH, Bethesda, MD 20892, USA.

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July 2003

Laser capture microdissection and advanced molecular analysis of human breast cancer.

J Mammary Gland Biol Neoplasia 2003 Jul;8(3):335-45

Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

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July 2003

Proteomics of human breast ductal carcinoma in situ.

Cancer Res 2002 Nov;62(22):6740-9

Women's Cancers Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA.

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November 2002

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.

Genes Dev 2002 Sep;16(17):2252-63

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.988902
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http://dx.doi.org/10.1101/gad.988902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186663PMC
September 2002

Selective loss of heterozygosity in multiple breast cancers from a carrier of mutations in both BRCA1 and BRCA2.

Cancer Res 2002 May;62(10):2741-3

Center for Cancer Risk Analysis, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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May 2002

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

J Biol Chem 2002 Mar 8;277(13):10912-21. Epub 2002 Jan 8.

Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M111751200DOI Listing
March 2002