Dennis C Ko

Dennis C Ko

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Dennis C Ko

Dennis C Ko

Publications by authors named "Dennis C Ko"

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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3.

Cell Host Microbe 2020 01 31;27(1):129-139.e4. Epub 2019 Dec 31.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Duke University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952535PMC
January 2020

Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.

Front Cell Infect Microbiol 2019 7;9:280. Epub 2019 Aug 7.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.

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http://dx.doi.org/10.3389/fcimb.2019.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693555PMC
August 2019

A real-time PCR assay for quantification of parasite burden in murine models of leishmaniasis.

PeerJ 2018 9;6:e5905. Epub 2018 Nov 9.

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.

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https://peerj.com/articles/5905
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http://dx.doi.org/10.7717/peerj.5905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231426PMC
November 2018

Methylthioadenosine Suppresses Salmonella Virulence.

Infect Immun 2018 09 22;86(9). Epub 2018 Aug 22.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/IAI.00429-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105896PMC
September 2018

An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Cell Host Microbe 2018 08;24(2):308-323.e6

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093297PMC
August 2018

Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.

Cell Rep 2018 06;23(12):3525-3536

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314477PMC
June 2018

Reply to Gilchrist et al.: Possible roles for in multiple infectious diseases.

Proc Natl Acad Sci U S A 2018 04 27;115(16):E3604-E3605. Epub 2018 Mar 27.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710;

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http://dx.doi.org/10.1073/pnas.1803533115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910875PMC
April 2018

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.

Cell 2017 03;169(1):72-84.e13

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Center for RNA Biology, Duke University, Durham, NC 27710, USA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456452PMC
March 2017

A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.

FEBS J 2017 02 9;284(3):402-413. Epub 2017 Jan 9.

Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, New Zealand.

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http://dx.doi.org/10.1111/febs.13976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296212PMC
February 2017

The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease.

PLoS Pathog 2016 07 21;12(7):e1005680. Epub 2016 Jul 21.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956310PMC
July 2016

Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.

J Biol Chem 2015 Nov 20;290(45):27321-31. Epub 2015 Aug 20.

From the Department of Nutritional Sciences and Rutgers Center for Lipid Research and

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http://dx.doi.org/10.1074/jbc.M115.667469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646368PMC
November 2015

CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.

Genome Biol 2015 Sep 15;16:190. Epub 2015 Sep 15.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, 27710, USA.

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http://genomebiology.com/2015/16/1/190
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http://dx.doi.org/10.1186/s13059-015-0722-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570686PMC
September 2015

Expression Divergence of Duplicate Genes in the Protein Kinase Superfamily in Pacific Oyster.

Evol Bioinform Online 2015 13;11(Suppl 1):57-65. Epub 2015 Sep 13.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.4137/EBO.S30230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573066PMC
September 2015

The marriage of quantitative genetics and cell biology: a novel screening approach reveals people have genetically encoded variation in microtubule stability.

Bioarchitecture 2014 Mar-Apr;4(2):58-61. Epub 2014 Mar 11.

Department of Molecular Genetics and Microbiology; School of Medicine; Duke University; Durham, NC USA.

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http://www.tandfonline.com/doi/full/10.4161/bioa.28481
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http://dx.doi.org/10.4161/bioa.28481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199813PMC
January 2015

An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.

PLoS One 2013 11;8(7):e67828. Epub 2013 Jul 11.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708926PMC
April 2014

Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS.

PLoS Pathog 2013 1;9(8):e1003424. Epub 2013 Aug 1.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of

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http://dx.doi.org/10.1371/journal.ppat.1003424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731241PMC
March 2014

A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death.

Mol Biol Cell 2014 Jan 30;25(1):76-86. Epub 2013 Oct 30.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710 Department of Medicine and Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27710 Department of Microbiology, University of Washington, Seattle, WA 98195 Departments of Medicine, Genome Sciences, and Immunology, University of Washington, Seattle, WA 98195.

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http://www.molbiolcell.org/doi/10.1091/mbc.e13-06-0294
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http://dx.doi.org/10.1091/mbc.E13-06-0294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873895PMC
January 2014

A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.

PLoS One 2011 1;6(11):e26993. Epub 2011 Nov 1.

Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026993PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206050PMC
March 2012

Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.

Mol Biol Cell 2010 Oct 25;21(20):3567-77. Epub 2010 Aug 25.

Department of Medicine, Immunology, Microbiology, and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1091/mbc.E10-06-0482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954121PMC
October 2010

Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease.

PLoS Genet 2005 Jul 25;1(1):81-95. Epub 2005 Jul 25.

Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.0010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183526PMC
July 2005

The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.

Proc Natl Acad Sci U S A 2003 Mar 18;100(5):2518-25. Epub 2003 Feb 18.

Department of Developmental Biology, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.

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http://dx.doi.org/10.1073/pnas.0530027100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151373PMC
March 2003