Dennis A Smith

Dennis A Smith

UNVERIFIED PROFILE

Are you Dennis A Smith?   Register this Author

Register author
Dennis A Smith

Dennis A Smith

Publications by authors named "Dennis A Smith"

Are you Dennis A Smith?   Register this Author

65Publications

1394Reads

30Profile Views

Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines.

Chem Commun (Camb) 2019 Dec 20;55(97):14665-14668. Epub 2019 Nov 20.

School of Chemistry, National University of Ireland Galway, University Road, Galway, H91 TK33, Ireland and Department of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc08261aDOI Listing
December 2019

The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance.

Biomolecules 2019 Oct 31;9(11). Epub 2019 Oct 31.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9110675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921012PMC
October 2019

Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise.

Drug Metab Dispos 2019 06 25;47(6):665-672. Epub 2019 Mar 25.

4 The Maltings, Walmer, Kent, United Kingdom (D.A.S.); and Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, University of Manchester, Manchester, United Kingdom (M.R.).

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0859
Publisher Site
http://dx.doi.org/10.1124/dmd.118.085951DOI Listing
June 2019

Clearance in Drug Design.

J Med Chem 2019 Mar 17;62(5):2245-2255. Epub 2018 Oct 17.

Pharmacokinetics, Dynamics and Metabolism , Pfizer Inc. , Groton , Connecticut 06340 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b01263DOI Listing
March 2019

Importance of target-mediated drug disposition for small molecules.

Drug Discov Today 2018 12 19;23(12):2023-2030. Epub 2018 Jun 19.

Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13596446183008
Publisher Site
http://dx.doi.org/10.1016/j.drudis.2018.06.010DOI Listing
December 2018

Safety Assessment of Acyl Glucuronides-A Simplified Paradigm.

Drug Metab Dispos 2018 06 20;46(6):908-912. Epub 2018 Mar 20.

4 The Maltings, Walmer, Kent, United Kingdom (D.A.S.); Preclinical Safety Consulting Ltd., Loughborough, Leicestershire, United Kingdom (T.H.); and Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.118.080515DOI Listing
June 2018

Relevance of Half-Life in Drug Design.

J Med Chem 2018 05 17;61(10):4273-4282. Epub 2017 Nov 17.

Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.7b00969DOI Listing
May 2018

Selective Methylmagnesium Chloride Mediated Acetylations of Isosorbide: A Route to Powerful Nitric Oxide Donor Furoxans.

Org Lett 2018 05 26;20(10):3025-3029. Epub 2018 Apr 26.

School of Chemistry , National University of Ireland Galway , University Road , Galway , H91 TK33 , Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.8b01060DOI Listing
May 2018

Impact of target interactions on small-molecule drug disposition: an overlooked area.

Nat Rev Drug Discov 2018 04 23;17(4):299. Epub 2018 Feb 23.

Department of Chemistry, University of Capetown, Capetown, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2018.26DOI Listing
April 2018

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

A new phase of drug discovery? The rise of PK/PD means extremely challenging work at the coalface.

Authors:
Dennis A Smith

Bioanalysis 2015 ;7(12):1415-7

4 The Maltings, Walmer, Kent CT147AR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.15.79DOI Listing
April 2016

Volume of Distribution in Drug Design.

J Med Chem 2015 Aug 1;58(15):5691-8. Epub 2015 Apr 1.

§Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.5b00201DOI Listing
August 2015

New bioanalytical technologies and concepts: worth the fuss?

Authors:
Dennis A Smith

Bioanalysis 2013 Aug;5(16):1969-73

4 The Maltings, Walmer, Kent, CT14 7AR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.13.151DOI Listing
August 2013

Which metabolites circulate?

Drug Metab Dispos 2013 May 1;41(5):933-51. Epub 2013 Mar 1.

Pfizer, Inc., 10646 Science Center Drive, San Diego, CA 92121, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.112.050278DOI Listing
May 2013

Evolution of ADME science: where else can modeling and simulation contribute?

Authors:
Dennis A Smith

Mol Pharm 2013 Apr 22;10(4):1162-70. Epub 2013 Jan 22.

School of Biological Sciences, University of Liverpool, Liverpool, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/mp3005319DOI Listing
April 2013

Impact of the pharmaceutical sciences on health care: a reflection over the past 50 years.

J Pharm Sci 2012 Nov 21;101(11):4075-99. Epub 2012 Aug 21.

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jps.23295DOI Listing
November 2012

Are predictive biomarkers of toxicity worth having? An economic model.

Xenobiotica 2012 Jan 4;42(1):4-10. Epub 2011 Oct 4.

Sandwich Laboratories, Pfizer Global Research and Development, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/00498254.2011.616938DOI Listing
January 2012

Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

Xenobiotica 2012 Jan 12;42(1):46-56. Epub 2011 Oct 12.

Pfizer Inc, Groton, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/00498254.2011.621985DOI Listing
January 2012

Why do metabolites circulate?

Xenobiotica 2012 Jan 24;42(1):107-26. Epub 2011 Nov 24.

School of Biomedical Sciences, University of Liverpool, Liverpool, UK.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/00498254.2011.63
Publisher Site
http://dx.doi.org/10.3109/00498254.2011.630110DOI Listing
January 2012

Discovery and ADMET: Where are we now.

Authors:
Dennis A Smith

Curr Top Med Chem 2011 ;11(4):467-81

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global R & D, Sandwich, Kent CT139NJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802611794480909DOI Listing
July 2011

Multiple factors govern the association between pharmacology and toxicity in a class of drugs: toward a unification of class effect terminology.

Chem Res Toxicol 2011 Apr 10;24(4):463-74. Epub 2011 Mar 10.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Sandwich, Kent, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx100408vDOI Listing
April 2011

Managing the challenge of chemically reactive metabolites in drug development.

Nat Rev Drug Discov 2011 Apr;10(4):292-306

MRC Centre for Drug Safety Science, Division of Molecular & Clinical Pharmacology, The Institute of Translational Medicine, University of Liverpool, Liverpool L693GE, UK. ac.uk

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd3408DOI Listing
April 2011

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.

Nat Rev Drug Discov 2010 12;9(12):929-39

Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9UJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd3287DOI Listing
December 2010

Does validation stagnate innovation?

Authors:
Dennis A Smith

Bioanalysis 2010 Aug;2(8):1349-50

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.10.63DOI Listing
August 2010

Metabolites: have we MIST out the importance of structure and physicochemistry?

Bioanalysis 2010 Jul;2(7):1223-33

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.10.92DOI Listing
July 2010

P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.

Expert Opin Drug Metab Toxicol 2010 May;6(5):603-19

Pfizer Global Research & Development, Department of Pharmacokinetics, Dynamics & Metabolism, 10646 Science Center Drive, San Diego, CA 92121, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17425251003610640DOI Listing
May 2010

Immunomodulatory therapies and the risk of opportunistic infections.

Curr Opin Drug Discov Devel 2010 Jan;13(1):20-2

View Article

Download full-text PDF

Source
January 2010

Will biomedical innovation change the future of healthcare?

Drug Discov Today 2009 Nov 30;14(21-22):1037-44. Epub 2009 Jul 30.

Worldwide Medicinal Chemistry, Sandwich Laboratories, IPC 326, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2009.07.008DOI Listing
November 2009

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity.

Chem Biol Interact 2009 Apr 26;179(1):60-7. Epub 2008 Sep 26.

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2008.09.022DOI Listing
April 2009

Dogma driven science, the need to establish a common base line.

Authors:
Dennis A Smith

Chem Biol Interact 2009 Apr 1;179(1):68-70. Epub 2008 Nov 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2008.10.020DOI Listing
April 2009

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Chem Res Toxicol 2009 Feb;22(2):357-68

Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, San Diego, California 92121, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx8004357
Publisher Site
http://dx.doi.org/10.1021/tx8004357DOI Listing
February 2009

Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment.

Chem Res Toxicol 2009 Feb;22(2):267-79

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx800415jDOI Listing
February 2009

Pharmacogenomics and adverse drug reactions; prospective screening for risk identification.

Curr Opin Drug Discov Devel 2009 Jan;12(1):27-30

View Article

Download full-text PDF

Source
January 2009

Does human pharmacokinetic prediction add significant value to compound selection in drug discovery research?

Curr Opin Drug Discov Devel 2009 Jan;12(1):61-71

Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich Laboratories, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
January 2009

Ethnic variation in drug response: implications for the development and regulation of drugs.

Curr Opin Drug Discov Devel 2008 Jan;11(1):29-31

View Article

Download full-text PDF

Source
January 2008

The sulfonamide group as a structural alert: A distorted story?

Curr Opin Drug Discov Devel 2008 Jan;11(1):72-9

Sandwich Laboratories, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK.

View Article

Download full-text PDF

Source
January 2008

Pharmaceutical R&D in the spotlight: why is there still unmet medical need?

Drug Discov Today 2007 Dec 23;12(23-24):998-1006. Epub 2007 Oct 23.

Strategic Management, IPC 326, Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13596446070035
Publisher Site
http://dx.doi.org/10.1016/j.drudis.2007.08.013DOI Listing
December 2007

Do prodrugs deliver?

Authors:
Dennis A Smith

Curr Opin Drug Discov Devel 2007 Sep;10(5):550-9

Sandwich Laboratories, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK.

View Article

Download full-text PDF

Source
September 2007

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs.

Drug Metab Rev 2007 ;39(1):17-43

Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Inc., Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03602530600952172DOI Listing
June 2007

Communicating the risks and benefits of medicines.

Drug Discov Today 2007 May 23;12(9-10):355-64. Epub 2007 Mar 23.

Strategic Management, Sandwich Laboratories, Pfizer Global Research and Development, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S135964460700103
Publisher Site
http://dx.doi.org/10.1016/j.drudis.2007.03.003DOI Listing
May 2007

Biomarkers: the pièce de résistance of innovative medicines.

Curr Opin Drug Discov Devel 2007 Jan;10(1):22-4

View Article

Download full-text PDF

Source
January 2007

Metabolites and safety: What are the concerns, and how should we address them?

Chem Res Toxicol 2006 Dec;19(12):1570-9

Pharmacokinetics, Dynamics, and Drug Metabolism, Global Research and Development, Pfizer, Inc., Groton, Connecticut 06340, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx0602012
Publisher Site
http://dx.doi.org/10.1021/tx0602012DOI Listing
December 2006

R&D technology investments: misguided and expensive or a better way to discover medicines?

Drug Discov Today 2006 Sep;11(17-18):775-84

Strategic Management Group, Sandwich Laboratories, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S135964460600283
Publisher Site
http://dx.doi.org/10.1016/j.drudis.2006.07.007DOI Listing
September 2006

Commentary on variability in vitamin K antagonist metabolism.

Authors:
Dennis A Smith

Expert Opin Drug Metab Toxicol 2006 Feb;2(1):1-2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17425255.2.1.1DOI Listing
February 2006

Editorial overview: safety of drugs can never be absolute.

Curr Opin Drug Discov Devel 2006 Jan;9(1):26-8

View Article

Download full-text PDF

Source
January 2006

Drug withdrawals and the lessons within.

Curr Opin Drug Discov Devel 2006 Jan;9(1):38-46

Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent, CT13 9NJ, UK.

View Article

Download full-text PDF

Source
January 2006

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing.

Drug Metab Dispos 2005 Oct 28;33(10):1409-17. Epub 2005 Jun 28.

Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Inc., Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.105.005041DOI Listing
October 2005

Oral delivery of G protein-coupled receptor modulators: an explanation for the observed class difference.

Bioorg Med Chem Lett 2005 Aug;15(16):3658-64

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.05.042DOI Listing
August 2005

Keynote review: Is declining innovation in the pharmaceutical industry a myth?

Drug Discov Today 2005 Aug;10(15):1031-9

Strategic Management Group, Laboratories, Pfizer Global Research and Development, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1359-6446(05)03524-5DOI Listing
August 2005

Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.

Drug Metab Dispos 2005 Apr 13;33(4):587-95. Epub 2005 Jan 13.

Department of Pharmacokinetics, Dynamics and Metabolism (IPC 664), Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.104.002626DOI Listing
April 2005

Editorial overview: safety/toxicity threshold concepts in drug discovery and development.

Curr Opin Drug Discov Devel 2005 Jan;8(1):24-6

View Article

Download full-text PDF

Source
January 2005

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Drug Metab Dispos 2004 Nov 10;32(11):1201-8. Epub 2004 Aug 10.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.104.000794DOI Listing
November 2004

Is pharmaceutical R&D just a game of chance or can strategy make a difference?

Drug Discov Today 2004 Jan;9(1):18-26

IPC 924, Sandwich Laboratories, PGRD, Ramsgate Road, Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1359-6446(04)02951-4DOI Listing
January 2004

Linking toxicity and chemistry: think globally, but act locally?

Curr Opin Drug Discov Devel 2004 Jan;7(1):33-5

View Article

Download full-text PDF

Source
January 2004

Hello Drug Discovery, I am from Insilico, take me to your President.

Authors:
Dennis A Smith

Drug Discov Today 2002 Nov;7(21):1080-1

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(02)02485-6DOI Listing
November 2002

Should scientific innovation be managed?

Drug Discov Today 2002 Sep;7(18):941-5

Discovery, Pfizer Sandwich Laboratories, IPC 475 Ramsgate Road, Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(02)02404-2DOI Listing
September 2002

'This is your captain speaking'.

Authors:
Dennis A Smith

Drug Discov Today 2002 Jul;7(13):705-6

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(02)02341-3DOI Listing
July 2002

Discovery, innovation and the cyclical nature of the pharmaceutical business.

Drug Discov Today 2002 May;7(10):563-8

Discovery Strategic Planning, Sandwich Laboratories, Pfizer Global R&D, Sandwich, Kent, UK CT13 9NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(02)02266-3DOI Listing
May 2002