Publications by authors named "Dennis A Dougherty"

100Publications

Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABA Receptor.

ACS Med Chem Lett 2020 Nov 15;11(11):2204-2211. Epub 2020 Sep 15.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

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November 2020

Proline Residues Contribute to Efficient GABA Receptor Function.

ACS Chem Neurosci 2020 12 17;11(24):4215-4222. Epub 2020 Nov 17.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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December 2020

Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem.

Neuron 2019 11;104(3):431-432

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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November 2019

Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor.

J Am Chem Soc 2019 10 24;141(40):15840-15849. Epub 2019 Sep 24.

School of Chemistry , University of Bristol , Bristol BS8 1TS , United Kingdom.

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October 2019

Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT and nACh Receptors.

ACS Chem Neurosci 2019 07 5;10(7):3327-3333. Epub 2019 Jul 5.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , United Kingdom.

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July 2019

Binding Interactions of NS6740, a Silent Agonist of the 7 Nicotinic Acetylcholine Receptor.

Mol Pharmacol 2019 08 7;96(2):212-218. Epub 2019 Jun 7.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California

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August 2019

Charge-transfer heptamethine dyes for NIR singlet oxygen generation.

Chem Commun (Camb) 2019 May;55(38):5511-5514

Division of Chemistry and Chemical Engineering, California Institute of Technology, 164-30, Pasadena, CA 91125, USA.

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May 2019

A general strategy for visible-light decaging based on the quinone cis-alkenyl lock.

Chem Commun (Camb) 2019 Apr;55(34):4965-4968

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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April 2019

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

Biochemistry 2018 07 21;57(27):4036-4043. Epub 2018 Jun 21.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , U.K.

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July 2018

A triad of residues is functionally transferrable between 5-HT serotonin receptors and nicotinic acetylcholine receptors.

J Biol Chem 2018 02 3;293(8):2903-2914. Epub 2018 Jan 3.

From the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125

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February 2018

Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors.

eNeuro 2017 Mar-Apr;4(2). Epub 2017 Mar 30.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.

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July 2018

A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock.

J Am Chem Soc 2017 04 24;139(13):4655-4658. Epub 2017 Mar 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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April 2017

Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors.

Biochemistry 2017 04 21;56(13):1836-1840. Epub 2017 Mar 21.

Division of Chemistry and Chemical Engineering and ‡Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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April 2017

Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process.

J Am Chem Soc 2017 04 24;139(13):4729-4736. Epub 2017 Mar 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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April 2017

Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain.

Chembiochem 2016 07 2;17(14):1323-7. Epub 2016 Jun 2.

Beckman Institute and Division of Chemistry and Chemical Engineering, The California Institute of Technology, 1200 E. California Avenue, Pasadena, CA, 91125, USA.

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July 2016

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

J Biol Chem 2016 Mar 14;291(12):6272-80. Epub 2015 Dec 14.

the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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March 2016

Cation-π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation.

Phys Chem Chem Phys 2015 Nov;17(43):29262-70

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena CA 91125, USA.

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November 2015

An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.

Chem Biol 2015 Aug 23;22(8):1063-73. Epub 2015 Jul 23.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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August 2015

Ketamine inside neurons?

Am J Psychiatry 2015 Nov 17;172(11):1064-6. Epub 2015 Jul 17.

From the Division of Biology and Biological Engineering and the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, Calif.; and the Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Va.

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November 2015

Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.

Neuropharmacology 2015 Oct 20;97:376-82. Epub 2015 Apr 20.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA. Electronic address:

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October 2015

Allosteric activation of the 5-HT3AB receptor by mCPBG.

Neuropharmacology 2015 Apr 23;91:103-8. Epub 2014 Dec 23.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, USA. Electronic address:

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April 2015

Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs.

Chem Biol 2014 Dec;21(12):1700-6

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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December 2014

Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.

ACS Chem Biol 2014 Oct 5;9(10):2283-90. Epub 2014 Aug 5.

Division of Chemistry & Chemical Engineering and ‡Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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October 2014

In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool.

Chembiochem 2014 Aug 2;15(12):1710-20. Epub 2014 Jul 2.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (USA).

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August 2014

Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors.

Mol Pharmacol 2014 Sep 25;86(3):263-74. Epub 2014 Jun 25.

Divisions of Chemistry and Chemical Engineering (W.L., D.A.D.) and Biology and Biological Engineering (H.A.L.), California Institute of Technology, Pasadena, California

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September 2014

Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground.

J Med Chem 2014 Aug 10;57(15):6289-300. Epub 2014 Mar 10.

Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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August 2014

Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.

Neuropharmacology 2014 Feb 18;77:342-9. Epub 2013 Oct 18.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA. Electronic address:

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February 2014

The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.

Biophys J 2013 Aug;105(4):887-98

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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August 2013

An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.

Mol Pharmacol 2013 Aug 16;84(2):201-7. Epub 2013 May 16.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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August 2013

Key binding interactions for memantine in the NMDA receptor.

ACS Chem Neurosci 2013 Feb 7;4(2):255-60. Epub 2012 Dec 7.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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February 2013

Binding interactions with the complementary subunit of nicotinic receptors.

J Biol Chem 2013 Mar 24;288(10):6991-7. Epub 2013 Jan 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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March 2013

The cation-π interaction.

Acc Chem Res 2013 Apr 7;46(4):885-93. Epub 2012 Dec 7.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

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April 2013

A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way.

ACS Chem Neurosci 2012 Oct 20;3(10):753-60. Epub 2012 Jul 20.

Division of Biology and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2012

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.

Proc Natl Acad Sci U S A 2012 Oct 3;109(44):E3028-34. Epub 2012 Oct 3.

Department of Cellular and Molecular Medicine, Laboratory of Structural Neurobiology, Catholic University of Leuven, 3000 Leuven, Belgium.

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October 2012

Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.

Int J Mol Sci 2012 10;13(8):10022-40. Epub 2012 Aug 10.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA; E-Mails: (R.S.); (C.I.R.); (C.D.); (F.J.M.).

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September 2015

Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.

J Am Chem Soc 2012 Sep 31;134(36):14890-6. Epub 2012 Aug 31.

Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2012

Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis.

ACS Chem Biol 2012 Oct 15;7(10):1738-45. Epub 2012 Aug 15.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

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October 2012

Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.

J Am Chem Soc 2012 Jul 9;134(28):11474-80. Epub 2012 Jul 9.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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July 2012

Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.

Nano Lett 2012 Jul 8;12(7):3690-4. Epub 2012 Jun 8.

Division of Biology 156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.

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July 2012

Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor.

ACS Chem Biol 2012 May 14;7(5):841-6. Epub 2012 Feb 14.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 164-30, Pasadena, CA 91125, USA.

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May 2012

Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors.

Methods Mol Biol 2012 ;796:97-113

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.

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May 2012

Two amino acid residues contribute to a cation-π binding interaction in the binding site of an insect GABA receptor.

J Neurosci 2011 Aug;31(34):12371-6

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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August 2011

Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.

ACS Chem Biol 2011 Oct 28;6(10):1063-8. Epub 2011 Jul 28.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, 91125, United States.

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October 2011

Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit.

J Biol Chem 2011 Sep 13;286(37):32251-8. Epub 2011 Jul 13.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2011

Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes.

J Biol Chem 2011 Apr 22;286(16):14618-27. Epub 2011 Feb 22.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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April 2011

Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates.

Org Lett 2010 Sep;12(18):3990-3

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2010

Preparation of translationally competent tRNA by direct chemical acylation.

Org Lett 2010 Sep;12(17):3776-9

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2010

Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.

Proc Natl Acad Sci U S A 2010 Jul 28;107(30):13206-11. Epub 2010 Jun 28.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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July 2010

Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation.

Mol Pharmacol 2010 Jul 2;78(1):29-35. Epub 2010 Apr 2.

Division of Chemistry and Chemical Engineering, Division of Biology, California Institute of Technology, Pasadena, California, USA.

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July 2010

A gating charge transfer center in voltage sensors.

Science 2010 Apr;328(5974):67-73

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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April 2010

Chemical scale studies of the Phe-Pro conserved motif in the cys loop of Cys loop receptors.

J Biol Chem 2010 Mar 12;285(12):8976-84. Epub 2010 Jan 12.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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March 2010

An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels.

J Gen Physiol 2009 Dec 16;134(6):461-9. Epub 2009 Nov 16.

Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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December 2009

A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.

J Org Chem 2009 Dec;74(23):9241-4

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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December 2009

Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids.

Proc Natl Acad Sci U S A 2009 Jul 6;106(29):11919-24. Epub 2009 Jul 6.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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July 2009

Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor.

Chembiochem 2009 May;10(8):1385-91

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91106, USA.

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May 2009

Long-range coupling in an allosteric receptor revealed by mutant cycle analysis.

Biophys J 2009 Apr;96(8):3168-78

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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April 2009

Nicotine binding to brain receptors requires a strong cation-pi interaction.

Nature 2009 Mar 1;458(7237):534-7. Epub 2009 Mar 1.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

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March 2009

Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors.

Biophys J 2009 Jan;96(1):226-37

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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January 2009

An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.

J Biol Chem 2008 Dec 24;283(51):35638-43. Epub 2008 Oct 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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December 2008

A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.

J Neurosci 2008 Oct;28(43):10937-42

School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

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October 2008

A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor.

J Am Chem Soc 2008 Oct 10;130(40):13216-8. Epub 2008 Sep 10.

Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2008

New insights into the therapeutic inhibition of voltage-gated sodium channels.

Channels (Austin) 2008 Jan-Feb;2(1):1-3. Epub 2008 Apr 1.

Department of Anesthesiology, University of British Columbia, Vancouver, British Columbia, Canada.

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November 2008

Cys-loop neuroreceptors: structure to the rescue?

Chem Rev 2008 May 1;108(5):1642-53. Epub 2008 May 1.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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May 2008

Physical organic chemistry on the brain.

J Org Chem 2008 May 16;73(10):3667-73. Epub 2008 Apr 16.

Division of Chemistry and Chemical Engineering California Institute of Technology, Pasadena, CA 91125, USA.

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May 2008

Confirming the revised C-terminal domain of the MscL crystal structure.

Biophys J 2008 Jun 7;94(12):4662-7. Epub 2008 Mar 7.

Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.

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June 2008

Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels.

Circ Res 2008 Jan 25;102(1):86-94. Epub 2007 Oct 25.

Department of Molecular Physiology & Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, PA, USA.

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January 2008

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation.

RNA 2007 Oct 13;13(10):1703-14. Epub 2007 Aug 13.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2007

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency.

RNA 2007 Oct 13;13(10):1715-22. Epub 2007 Aug 13.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2007

1-Oxo-5-hydroxytryptamine: a surprisingly potent agonist of the 5-HT3 (serotonin) receptor.

Org Lett 2007 Aug 18;9(17):3205-7. Epub 2007 Jul 18.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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August 2007

Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.

J Biol Chem 2007 Sep 2;282(36):26210-6. Epub 2007 Jul 2.

Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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September 2007

Calcium block of single sodium channels: role of a pore-lining aromatic residue.

Biophys J 2007 Oct 1;93(7):2341-9. Epub 2007 Jun 1.

Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, Pennsylvania, USA.

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October 2007

Cation-pi interactions involving aromatic amino acids.

J Nutr 2007 06;137(6 Suppl 1):1504S-1508S; discussion 1516S-1517S

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2007

A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block.

J Biol Chem 2007 Mar 19;282(11):8044-51. Epub 2007 Jan 19.

Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.

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March 2007

Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor.

Biochemistry 2007 Jan;46(3):630-9

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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January 2007

Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis.

ACS Chem Biol 2006 May;1(4):227-34

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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May 2006

A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels.

J Gen Physiol 2006 Dec;128(6):649-57

Department of Molecular Physiology and Biophysics, Jefferson Medical College, Philadelphia, PA 19107, USA.

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December 2006

Reconstitution of ion channels in agarose-supported silicon orifices.

Biosens Bioelectron 2007 May 13;22(11):2577-84. Epub 2006 Nov 13.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.

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May 2007

In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression.

Proc Natl Acad Sci U S A 2006 Jun 25;103(23):8650-5. Epub 2006 May 25.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2006

Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance.

Biophys J 2006 May 24;90(10):3555-69. Epub 2006 Feb 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, USA.

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May 2006

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

Nature 2005 Nov;438(7065):248-52

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.

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November 2005

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.

J Biol Chem 2005 Dec 10;280(50):41655-66. Epub 2005 Oct 10.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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December 2005

Caged phosphoproteins.

J Am Chem Soc 2005 Jan;127(3):846-7

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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January 2005

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.

J Am Chem Soc 2005 Jan;127(1):350-6

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

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January 2005

Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

J Neurosci 2004 Oct;24(41):9097-104

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2004

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.

Proc Natl Acad Sci U S A 2004 Jul 24;101(27):10195-200. Epub 2004 Jun 24.

Division of Chemistry and Chemical Engineering, 1200 East California Boulevard, California Institute of Technology, Pasadena, CA 91125, USA.

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July 2004

Cys-loop receptors: new twists and turns.

Trends Neurosci 2004 Jun;27(6):329-36

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2004