Denise M Scholtens

Denise M Scholtens

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Denise M Scholtens

Denise M Scholtens

Publications by authors named "Denise M Scholtens"

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The interplay among psychological distress, the immune system, and brain tumor patient outcomes.

Curr Opin Behav Sci 2019 Aug 26;28:44-50. Epub 2019 Feb 26.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.

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http://dx.doi.org/10.1016/j.cobeha.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487487PMC
August 2019

Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers.

Sci Rep 2019 Jun 20;9(1):8946. Epub 2019 Jun 20.

Department of Neurological Surgery, Northwestern University, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1038/s41598-019-45346-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586617PMC
June 2019

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Authors:
Nicole M Warrington Robin N Beaumont Momoko Horikoshi Felix R Day Øyvind Helgeland Charles Laurin Jonas Bacelis Shouneng Peng Ke Hao Bjarke Feenstra Andrew R Wood Anubha Mahajan Jessica Tyrrell Neil R Robertson N William Rayner Zhen Qiao Gunn-Helen Moen Marc Vaudel Carmen J Marsit Jia Chen Michael Nodzenski Theresia M Schnurr Mohammad H Zafarmand Jonathan P Bradfield Niels Grarup Marjolein N Kooijman Ruifang Li-Gao Frank Geller Tarunveer S Ahluwalia Lavinia Paternoster Rico Rueedi Ville Huikari Jouke-Jan Hottenga Leo-Pekka Lyytikäinen Alana Cavadino Sarah Metrustry Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Natalia Vilor-Tejedor Peter K Joshi Jodie N Painter Ioanna Ntalla Ronny Myhre Niina Pitkänen Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Rebecca C Richmond Ana Espinosa Sheila J Barton Hazel M Inskip John W Holloway Loreto Santa-Marina Xavier Estivill Wei Ang Julie A Marsh Christoph Reichetzeder Letizia Marullo Berthold Hocher Kathryn L Lunetta Joanne M Murabito Caroline L Relton Manolis Kogevinas Leda Chatzi Catherine Allard Luigi Bouchard Marie-France Hivert Ge Zhang Louis J Muglia Jani Heikkinen Camilla S Morgen Antoine H C van Kampen Barbera D C van Schaik Frank D Mentch Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Gibran Hemani Susan M Ring Amanda J Bennett Kyle J Gaulton Juan Fernandez-Tajes Natalie R van Zuydam Carolina Medina-Gomez Hugoline G de Haan Frits R Rosendaal Zoltán Kutalik Pedro Marques-Vidal Shikta Das Gonneke Willemsen Hamdi Mbarek Martina Müller-Nurasyid Marie Standl Emil V R Appel Cilius E Fonvig Caecilie Trier Catharina E M van Beijsterveldt Mario Murcia Mariona Bustamante Sílvia Bonas-Guarch David M Hougaard Josep M Mercader Allan Linneberg Katharina E Schraut Penelope A Lind Sarah E Medland Beverley M Shields Bridget A Knight Jin-Fang Chai Kalliope Panoutsopoulou Meike Bartels Friman Sánchez Jakob Stokholm David Torrents Rebecca K Vinding Sara M Willems Mustafa Atalay Bo L Chawes Peter Kovacs Inga Prokopenko Marcus A Tuke Hanieh Yaghootkar Katherine S Ruth Samuel E Jones Po-Ru Loh Anna Murray Michael N Weedon Anke Tönjes Michael Stumvoll Kim F Michaelsen Aino-Maija Eloranta Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Harri Niinikoski Katja Pahkala Olli T Raitakari Bo Jacobsson Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Grant W Montgomery Harry Campbell James F Wilson Tanja G M Vrijkotte Martine Vrijheid Eco J C N de Geus M Geoffrey Hayes Haja N Kadarmideen Jens-Christian Holm Lawrence J Beilin Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Andrew T Hattersley Tim D Spector Mika Kähönen Jorma S Viikari Terho Lehtimäki Dorret I Boomsma Sylvain Sebert Peter Vollenweider Thorkild I A Sørensen Hans Bisgaard Klaus Bønnelykke Jeffrey C Murray Mads Melbye Ellen A Nohr Dennis O Mook-Kanamori Fernando Rivadeneira Albert Hofman Janine F Felix Vincent W V Jaddoe Torben Hansen Charlotta Pisinger Allan A Vaag Oluf Pedersen André G Uitterlinden Marjo-Riitta Järvelin Christine Power Elina Hyppönen Denise M Scholtens William L Lowe George Davey Smith Nicholas J Timpson Andrew P Morris Nicholas J Wareham Hakon Hakonarson Struan F A Grant Timothy M Frayling Debbie A Lawlor Pål R Njølstad Stefan Johansson Ken K Ong Mark I McCarthy John R B Perry David M Evans Rachel M Freathy

Nat Genet 2019 05 1;51(5):804-814. Epub 2019 May 1.

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/s41588-019-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522365PMC
May 2019

Fat mass estimation in neonates: anthropometric models compared with air displacement plethysmography.

Br J Nutr 2019 Feb 16;121(3):285-290. Epub 2018 Nov 16.

3Department of Obstetrics and Gynecology,Maternal Infant Research Institute,Tufts Medical Center,800 Washington Street,Box 394,Boston,MA 02111,USA.

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http://dx.doi.org/10.1017/S0007114518003355DOI Listing
February 2019

Gestational Diabetes and Childhood Obesity-Reply.

JAMA 2019 02;321(7):708-709

Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.19754DOI Listing
February 2019

Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia.

J Pediatr 2018 12 10;203:144-149.e1. Epub 2018 Sep 10.

Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1016/j.jpeds.2018.07.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252151PMC
December 2018

The selected biomarker analysis in 5 types of uterine smooth muscle tumors.

Hum Pathol 2018 06 16;76:17-27. Epub 2017 Dec 16.

Department of Pathology, Northwestern University, Feinberg School of Medicine; Department of Gynecology and Obstetrics, Northwestern University, Feinberg School of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065267PMC
June 2018

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

Hum Mol Genet 2018 02;27(4):742-756

Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.

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http://dx.doi.org/10.1093/hmg/ddx429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886200PMC
February 2018

An Outcome-Weighted Network Model for Characterizing Collaboration.

PLoS One 2016 5;11(10):e0163861. Epub 2016 Oct 5.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163861PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051930PMC
June 2017

Genetic determinants of adiponectin regulation revealed by pregnancy.

Obesity (Silver Spring) 2017 05 20;25(5):935-944. Epub 2017 Mar 20.

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/oby.21805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404994PMC
May 2017

Transversions have larger regulatory effects than transitions.

BMC Genomics 2017 05 19;18(1):394. Epub 2017 May 19.

Center for Genomic and Computational Biology, Duke University Medical School, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1186/s12864-017-3785-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438547PMC
May 2017

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data.

BMC Bioinformatics 2017 Feb 2;18(1):84. Epub 2017 Feb 2.

Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1186/s12859-017-1501-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290663PMC
February 2017

Associations Between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy.

Hypertension 2016 12 24;68(6):1459-1466. Epub 2016 Oct 24.

From the Department of Paediatrics (C.J.P., N.S.M., G.P., I.A.H., C.L.A., K.K.O., D.B.D.), Medical Research Council Epidemiology Unit (K.K.O.), and Institute of Metabolic Science (D.B.D.), University of Cambridge, United Kingdom; Hospital Sant Joan de Déu, Servicio de Pediatría, Barcelona, Spain (N.S.M.); Divisão de Endocrinologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (G.P.); and Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine (M.G.H., W.L.L.) and Division of Biostatistics, Department of Preventive Medicine (M.N., D.M.S.), Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159231PMC
December 2016

Synuclein-γ (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease.

J Ovarian Res 2016 Nov 3;9(1):75. Epub 2016 Nov 3.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 303 E. Superior Street, 4-117, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1186/s13048-016-0281-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094138PMC
November 2016

Characterizing Teamwork in Cardiovascular Care Outcomes: A Network Analytics Approach.

Circ Cardiovasc Qual Outcomes 2016 11 8;9(6):670-678. Epub 2016 Nov 8.

From the Departments of Preventive Medicine (M.B.C., D.M.S., C.N.F., A.Y.W., G.S.K., F.S.A., N.D.S.), Emergency Medicine (S.J.G., E.S.P.), Family and Community Medicine (A.Y.W.), and Medicine (F.S.A., R.K.M.), Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.116.003041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217475PMC
November 2016

Genome-wide associations for birth weight and correlations with adult disease.

Authors:
Momoko Horikoshi Robin N Beaumont Felix R Day Nicole M Warrington Marjolein N Kooijman Juan Fernandez-Tajes Bjarke Feenstra Natalie R van Zuydam Kyle J Gaulton Niels Grarup Jonathan P Bradfield David P Strachan Ruifang Li-Gao Tarunveer S Ahluwalia Eskil Kreiner Rico Rueedi Leo-Pekka Lyytikäinen Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Jouke-Jan Hottenga Natalia Vilor-Tejedor Peter K Joshi Eileen Tai Hui Boh Ioanna Ntalla Niina Pitkänen Anubha Mahajan Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Michael Nodzenski Louise A Diver Krina T Zondervan Mariona Bustamante Pedro Marques-Vidal Josep M Mercader Amanda J Bennett Nilufer Rahmioglu Dale R Nyholt Ronald Ching Wan Ma Claudia Ha Ting Tam Wing Hung Tam Santhi K Ganesh Frank Ja van Rooij Samuel E Jones Po-Ru Loh Katherine S Ruth Marcus A Tuke Jessica Tyrrell Andrew R Wood Hanieh Yaghootkar Denise M Scholtens Lavinia Paternoster Inga Prokopenko Peter Kovacs Mustafa Atalay Sara M Willems Kalliope Panoutsopoulou Xu Wang Lisbeth Carstensen Frank Geller Katharina E Schraut Mario Murcia Catharina Em van Beijsterveldt Gonneke Willemsen Emil V R Appel Cilius E Fonvig Caecilie Trier Carla Mt Tiesler Marie Standl Zoltán Kutalik Sílvia Bonas-Guarch David M Hougaard Friman Sánchez David Torrents Johannes Waage Mads V Hollegaard Hugoline G de Haan Frits R Rosendaal Carolina Medina-Gomez Susan M Ring Gibran Hemani George McMahon Neil R Robertson Christopher J Groves Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Frank D Mentch Scott M MacKenzie Rebecca M Reynolds William L Lowe Anke Tönjes Michael Stumvoll Virpi Lindi Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Thorkild Ia Sørensen Harri Niinikoski Katja Pahkala Olli T Raitakari Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Mads Melbye Harry Campbell James F Wilson Martine Vrijheid Eco Jcn de Geus Dorret I Boomsma Haja N Kadarmideen Jens-Christian Holm Torben Hansen Sylvain Sebert Andrew T Hattersley Lawrence J Beilin John P Newnham Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Mika Kähönen Jorma S Viikari Terho Lehtimäki Peter Vollenweider Klaus Bønnelykke Hans Bisgaard Dennis O Mook-Kanamori Albert Hofman Fernando Rivadeneira André G Uitterlinden Charlotta Pisinger Oluf Pedersen Christine Power Elina Hyppönen Nicholas J Wareham Hakon Hakonarson Eleanor Davies Brian R Walker Vincent Wv Jaddoe Marjo-Riitta Jarvelin Struan Fa Grant Allan A Vaag Debbie A Lawlor Timothy M Frayling George Davey Smith Andrew P Morris Ken K Ong Janine F Felix Nicholas J Timpson John Rb Perry David M Evans Mark I McCarthy Rachel M Freathy

Nature 2016 10 28;538(7624):248-252. Epub 2016 Sep 28.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/nature19806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164934PMC
October 2016

Nipple Aspirate Fluid Hormone Concentrations and Breast Cancer Risk.

Horm Cancer 2016 Apr 22;7(2):127-36. Epub 2016 Feb 22.

Department of Surgery, Northwestern University Feinberg School of Medicine, 303 E. Superior Street, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s12672-016-0252-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807603PMC
April 2016

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

JAMA 2016 Mar;315(11):1129-40

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom.

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http://dx.doi.org/10.1001/jama.2016.1975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811305PMC
March 2016

Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.

Curr Diab Rep 2016 Feb;16(2):15

Division of Endocrinology, Metabolism, and Molecular Medicine and Department of Medicine, Northwestern University Feinberg School of Medicine, Rubloff Building 420 E. Superior St., 12th Floor, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s11892-015-0709-zDOI Listing
February 2016

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.

Genome Res 2015 Aug 17;25(8):1206-14. Epub 2015 Jun 17.

Program in Computational Biology and Bioinformatics, Duke University, Durham, North Carolina 27710, USA; Department of Biostatistics and Bioinformatics, Duke University Medical School, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gr.190090.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510004PMC
August 2015

Node sampling for protein complex estimation in bait-prey graphs.

Stat Appl Genet Mol Biol 2015 Aug;14(4):391-411

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http://dx.doi.org/10.1515/sagmb-2015-0007DOI Listing
August 2015

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.

Nat Commun 2015 Feb 4;6:6069. Epub 2015 Feb 4.

1] Center for Genomic &Computational Biology, Duke University School of Medicine, Durham, North Carolina 27708, USA [2] Department of Biostatistics &Bioinformatics, Duke University Medical School, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncomms7069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318120PMC
February 2015

Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data.

Bioinformatics 2014 Nov 29;30(22):3287-8. Epub 2014 Jul 29.

Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

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http://bioinformatics.oxfordjournals.org/content/early/2014/
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http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btu509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221120PMC
November 2014

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.

J Clin Endocrinol Metab 2014 Nov 19;99(11):E2377-86. Epub 2014 Aug 19.

Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago (R.C.), Department of Preventive Medicine (S.E.B., J.R., A.C.R., L.P.L., D.M.S.), Division of Endocrinology, Metabolism & Molecular Medicine (L.L.A., M.U., B.E.M., M.G.H., W.L.L.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; and PhD (cand) (S.B.), University of Washington, Seattle, Washington 355852.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2013-4221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223445PMC
November 2014

Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns.

Transl Res 2014 Aug 25;164(2):153-7. Epub 2014 Jan 25.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Jesse Brown Veterans Affairs Medical Center, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2014.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156825PMC
August 2014

Hormonal determinants of nipple aspirate fluid yield among breast cancer cases and screening controls.

Cancer Epidemiol Biomarkers Prev 2013 Dec 18;22(12):2277-84. Epub 2013 Sep 18.

Authors' Affiliations: Departments of Preventive Medicine, Surgery, Radiology, Pathology, and Obstetrics and Gynecology, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center of Northwestern University and Department of Pathology, University of Illinois at Chicago, Chicago, Illinois; and Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101805PMC
December 2013

Breast ductal lavage for assessment of breast cancer biomarkers.

Horm Cancer 2010 Aug;1(4):197-204

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://link.springer.com/10.1007/s12672-010-0021-y
Publisher Site
http://dx.doi.org/10.1007/s12672-010-0021-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082955PMC
August 2010

A network model of a cooperative genetic landscape in brain tumors.

JAMA 2009 Jul;302(3):261-75

Department of Neurological Surgery, Northwestern Brain Tumor Institute and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3015, USA.

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http://dx.doi.org/10.1001/jama.2009.997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447713PMC
July 2009

Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma.

Lab Invest 2008 Jun 24;88(6):602-14. Epub 2008 Mar 24.

Department of Chemical and Biochemical Engineering, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/labinvest.2008.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849305PMC
June 2008

Array-based multiplex analysis of DNA methylation in breast cancer tissues.

J Mol Diagn 2008 Jan 28;10(1):93-101. Epub 2007 Dec 28.

Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA.

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http://dx.doi.org/10.2353/jmoldx.2008.070077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175548PMC
January 2008