Denis Tvorogov

Denis Tvorogov

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Denis Tvorogov

Denis Tvorogov

Publications by authors named "Denis Tvorogov"

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21Publications

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Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.

Proc Natl Acad Sci U S A 2015 Oct 1;112(42):13063-8. Epub 2015 Oct 1.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FI-00290 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1517810112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620883PMC
October 2015

The βc receptor family - Structural insights and their functional implications.

Cytokine 2015 Aug 14;74(2):247-58. Epub 2015 May 14.

Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666150006
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http://dx.doi.org/10.1016/j.cyto.2015.02.005DOI Listing
August 2015

Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties.

Stem Cell Res 2015 May 9;14(3):380-95. Epub 2015 Apr 9.

Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia, Australia; Co-operative Research Centre for Biomarker Translation, La Trobe University, Melbourne, Victoria, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.04.002DOI Listing
May 2015

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Circulation 2014 May 19;129(19):1962-71. Epub 2014 Feb 19.

Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002779DOI Listing
May 2014

Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period.

Circ Res 2014 Feb 15;114(5):806-22. Epub 2014 Jan 15.

From the Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco (L.-C.Y., P.B., D.M.M.); Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden (C.T., L.C.-W.); Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki and University of Helsinki, Helsinki, Finland (D.T., A.A., K.A.); Department of Pathology, Boston Children's Hospital, Harvard University, MA (S.O.V.), and Department of Cell Biology, ImClone Systems, Eli Lilly and Company, New York (B.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.303119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969887PMC
February 2014

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12960-5. Epub 2013 Jul 22.

Translational Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1301415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740881PMC
August 2013

The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.

Sci Signal 2013 Jul 2;6(282):ra52. Epub 2013 Jul 2.

Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scisignal.2003905DOI Listing
July 2013

Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

Cancer Res 2012 Jul 16;72(14):3512-21. Epub 2012 May 16.

Molecular/Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Research Programs Unit, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1070DOI Listing
July 2012

PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1.

Blood 2012 Jul 24;120(1):232-5. Epub 2012 May 24.

MediCity Research Laboratory, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1182/blood-2012-01-406876DOI Listing
July 2012

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Nat Cell Biol 2011 Sep 11;13(10):1202-13. Epub 2011 Sep 11.

Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Research Programs Unit and Department of Pathology, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261765PMC
http://dx.doi.org/10.1038/ncb2331DOI Listing
September 2011

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Blood 2011 Feb 8;117(5):1507-15. Epub 2010 Dec 8.

Molecular Cancer Biology Program, Research Programs Unit, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2010-08-301549DOI Listing
February 2011

Cell death or survival promoted by alternative isoforms of ErbB4.

Mol Biol Cell 2010 Dec 13;21(23):4275-86. Epub 2010 Oct 13.

Department of Medical Biochemistry and Genetics, and Medicity Research Laboratory, University of Turku, Turku, Finland; Department of Oncology, Turku University Hospital, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1091/mbc.E10-04-0332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993754PMC
December 2010

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Cancer Cell 2010 Dec 2;18(6):630-40. Epub 2010 Dec 2.

Institute for Molecular Medicine Finland, Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ccr.2010.11.001DOI Listing
December 2010

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

Am J Pathol 2010 Oct 19;177(4):2124-33. Epub 2010 Aug 19.

Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2353/ajpath.2010.091301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947305PMC
October 2010

The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels.

Microvasc Res 2009 Dec 9;78(3):278-85. Epub 2009 Jul 9.

Department of Medical Biochemistry and Genetics, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.mvr.2009.06.010DOI Listing
December 2009

Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

J Biol Chem 2009 Feb 19;284(9):5582-91. Epub 2008 Dec 19.

MediCity Research Laboratory and Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1074/jbc.M805438200DOI Listing
February 2009

Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion.

J Cell Sci 2005 Feb 18;118(Pt 3):601-10. Epub 2005 Jan 18.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1242/jcs.01643DOI Listing
February 2005

EGF-dependent association of phospholipase C-gamma1 with c-Cbl.

Exp Cell Res 2002 Jul;277(1):86-94

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1006/excr.2002.5545DOI Listing
July 2002