Publications by authors named "Denis L J Lafontaine"

50Publications

HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA.

Nucleic Acids Res 2020 Sep 25. Epub 2020 Sep 25.

Université de Lorraine, CNRS, INSERM, IBSLor (UMS2008/US40), Epitranscriptomics and RNA Sequencing Core Facility, F54000 Nancy, France.

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http://dx.doi.org/10.1093/nar/gkaa769DOI Listing
September 2020

The nucleolus as a multiphase liquid condensate.

Nat Rev Mol Cell Biol 2020 Sep 1. Epub 2020 Sep 1.

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.

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http://dx.doi.org/10.1038/s41580-020-0272-6DOI Listing
September 2020

Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts.

Am J Hum Genet 2020 05 30;106(5):694-706. Epub 2020 Apr 30.

Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212298PMC
May 2020

Birth of Nucleolar Compartments: Phase Separation-Driven Ribosomal RNA Sorting and Processing.

Mol Cell 2019 12;76(5):694-696

RNA Molecular Biology, Université Libre de Bruxelles, Fonds de la Recherche Scientifique (F.R.S./FNRS), 6041 Gosselies, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.015DOI Listing
December 2019

Controlling the material properties and rRNA processing function of the nucleolus using light.

Proc Natl Acad Sci U S A 2019 08 9;116(35):17330-17335. Epub 2019 Aug 9.

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544;

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http://dx.doi.org/10.1073/pnas.1903870116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717270PMC
August 2019

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.

Nucleic Acids Res 2019 09;47(15):7719-7733

RNA Molecular Biology, ULB Cancer Research Center (U-CRC), Fonds de la Recherche Scientifique (F.R.S./FNRS), Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1093/nar/gkz619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735865PMC
September 2019

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.

Biochem Pharmacol 2019 01 20;159:74-81. Epub 2018 Nov 20.

Univ Lyon, Université Claude Bernard Lyon 1, Inserm U1052, CNRS UMR5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.11.014DOI Listing
January 2019

AlkAniline-Seq: Profiling of m G and m C RNA Modifications at Single Nucleotide Resolution.

Angew Chem Int Ed Engl 2018 12 16;57(51):16785-16790. Epub 2018 Nov 16.

Lorraine University, UMS2008 IBSLor CNRS-UL-INSERM, Biopôle UL, 9, Avenue de la Forêt de Haye, 54505, Vandoeuvre-les-Nancy, France.

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http://doi.wiley.com/10.1002/anie.201810946
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http://dx.doi.org/10.1002/anie.201810946DOI Listing
December 2018

Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics.

Nat Protoc 2018 10;13(10):2387-2406

RNA Molecular Biology, F.R.S./FNRS, Université Libre de Bruxelles, Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1038/s41596-018-0044-3DOI Listing
October 2018

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.

Structure 2018 03 8;26(3):416-425.e4. Epub 2018 Feb 8.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.009DOI Listing
March 2018

Identification of sites of 2'-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.

Sci Rep 2017 09 13;7(1):11490. Epub 2017 Sep 13.

RNA Molecular Biology and Center for Microscopy and Molecular Imaging (CMMI), Fonds National de la Recherche (F.R.S./FNRS) and Université Libre de Bruxelles (ULB), BioPark campus Gosselies, Belgium.

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http://dx.doi.org/10.1038/s41598-017-09734-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597630PMC
September 2017

Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.

PLoS Genet 2017 May 24;13(5):e1006804. Epub 2017 May 24.

Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1006804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464676PMC
May 2017

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function.

RNA Biol 2017 09 2;14(9):1138-1152. Epub 2016 Dec 2.

a Institute for Molecular Biology, University Medical Center Göttingen, Georg-August-University , Göttingen , Germany.

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http://dx.doi.org/10.1080/15476286.2016.1259781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699541PMC
September 2017

The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.

Oncotarget 2016 Sep;7(37):59519-59534

RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles (ULB), BioPark Campus, Gosselies, Belgium.

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http://dx.doi.org/10.18632/oncotarget.11148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312328PMC
September 2016

Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.

Proc Natl Acad Sci U S A 2016 08 25;113(32):E4620-9. Epub 2016 Jul 25.

Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 9190401, Israel;

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http://dx.doi.org/10.1073/pnas.1512156113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987808PMC
August 2016

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress.

Nat Commun 2016 06 6;7:11390. Epub 2016 Jun 6.

RNA Molecular Biology, F.R.S./FNRS, Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1038/ncomms11390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897761PMC
June 2016

'View From A Bridge': A New Perspective on Eukaryotic rRNA Base Modification.

Trends Biochem Sci 2015 Oct;40(10):560-575

RNA Molecular Biology, FRS/FNRS, Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium; Center for Microscopy and Molecular Imaging, BioPark campus, B-6041 Charleroi-Gosselies, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.07.008DOI Listing
October 2015

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.

Mol Biol Cell 2015 Jun 7;26(11):2080-95. Epub 2015 Apr 7.

RNA Molecular Biology, Fonds de la Recherche Scientifique (FRS/FNRS), Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium Center for Microscopy and Molecular Imaging, B-6041 Charleroi-Gosselies, Belgium

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http://dx.doi.org/10.1091/mbc.E15-02-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472018PMC
June 2015

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.

Nucleic Acids Res 2015 Feb 4;43(4):2242-58. Epub 2015 Feb 4.

RNA Molecular Biology, F.R.S./FNRS, Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium Center for Microscopy and Molecular Imaging, B-6041 Charleroi-Gosselies, Belgium

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http://dx.doi.org/10.1093/nar/gkv075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344512PMC
February 2015

Noncoding RNAs in eukaryotic ribosome biogenesis and function.

Nat Struct Mol Biol 2015 Jan;22(1):11-9

RNA Molecular Biology, Fonds National de la Recherche Scientifique, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1038/nsmb.2939DOI Listing
January 2015

Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.

Proc Natl Acad Sci U S A 2014 Dec 8;111(51):E5518-26. Epub 2014 Dec 8.

Center for Microscopy and Molecular Imaging, B-6041 Charleroi-Gosselies, Belgium; and RNA Molecular Biology, Fonds de la Recherche Scientifique, Université Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium

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http://dx.doi.org/10.1073/pnas.1413089111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280632PMC
December 2014

Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging.

J Mater Chem B 2014 Jan 5;2(4):387-397. Epub 2013 Dec 5.

Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, B-7000 Mons, Belgium.

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http://dx.doi.org/10.1039/c3tb21480jDOI Listing
January 2014

Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?

Biochimie 2012 Jul 8;94(7):1521-32. Epub 2012 Feb 8.

Fonds de la Recherche Scientifique (FRS-FNRS), Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, Belgium.

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http://dx.doi.org/10.1016/j.biochi.2012.02.001DOI Listing
July 2012

The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.

Mol Cell Biol 2012 Jan 14;32(2):430-44. Epub 2011 Nov 14.

Fonds de la Recherche Scientifique, Université Libre de Bruxelles, Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1128/MCB.06019-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255765PMC
January 2012

The nucleolus: structure/function relationship in RNA metabolism.

Wiley Interdiscip Rev RNA 2010 Nov-Dec;1(3):415-31. Epub 2010 Sep 22.

Nuclei and cell cycle, Institut Jacques Monod-UMR 7592 CNRS, Université Paris Diderot, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1002/wrna.39DOI Listing
March 2012

A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.

PLoS One 2011 19;6(9):e24962. Epub 2011 Sep 19.

RNA Metabolism, Fonds de la Recherche Scientifique (FRS-FNRS), Université Libre de Bruxelles, Charleroi-Gosselies, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024962PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176313PMC
February 2012

The nucleolus: when 2 became 3.

Nucleus 2011 Jul-Aug;2(4):289-93. Epub 2011 Jul 1.

Cellular Biology Unit, GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, Liège, Belgium.

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http://dx.doi.org/10.4161/nucl.2.4.16806DOI Listing
January 2013

Nucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.

J Struct Biol 2011 May 16;174(2):352-9. Epub 2011 Feb 16.

Cellular Biology Unit, GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, B36, 4000 Liège, Belgium.

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http://dx.doi.org/10.1016/j.jsb.2011.02.003DOI Listing
May 2011

[< Catch me if you can >: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms].

Med Sci (Paris) 2010 Mar;26(3):259-66

Fonds de la recherche scientifique (FRS-FNRS), Métabolisme de l'ARN, Institut de biologie et de médecine moléculaires (IBMM), Université Libre de Bruxelles (ULB), avenue des Professeurs Jeener et Brachet, 12, B-6041 Gosselies, Belgique.

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http://dx.doi.org/10.1051/medsci/2010263259DOI Listing
March 2010

A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes.

Trends Biochem Sci 2010 May 22;35(5):267-77. Epub 2010 Jan 22.

Fonds de la Recherche Scientifique (FRS-F.N.R.S.), Institut de Biologie et de Médecine Moléculaire (IBMM), Université Libre de Bruxelles (ULB), Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1016/j.tibs.2009.12.006DOI Listing
May 2010

The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance.

RNA 2009 Mar 13;15(3):406-19. Epub 2009 Jan 13.

Fonds de la Recherche Scientifique (FRS-FNRS), AcadémieWallonie-Bruxelles, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, Charleroi-Gosselies, B-6041 Belgium.

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http://dx.doi.org/10.1261/rna.1402709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657017PMC
March 2009

TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.

RNA 2008 Oct 28;14(10):2061-73. Epub 2008 Aug 28.

Fonds de la Recherche Scientifique (FRS-FNRS), Académie Wallonie-Bruxelles, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, Charleroi-Gosselies, B-6041, Belgium.

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http://dx.doi.org/10.1261/rna.1176708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553727PMC
October 2008

Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.

Mol Cell Biol 2008 Jun 31;28(11):3686-99. Epub 2008 Mar 31.

Department of Biochemistry and Molecular Biology, University of Georgia, Davison Life Sciences Complex, Green Street, Athens, GA 30602, USA.

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http://dx.doi.org/10.1128/MCB.01115-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423305PMC
June 2008

Is ribosome synthesis controlled by pol I transcription?

Cell Cycle 2007 Jan 9;6(1):11-5. Epub 2007 Jan 9.

CEA, Laboratoire Régulation de l'Expression des Gènes et Epigénétique, Service de Biologie Integrative et Génétique Moléculaire, Gif sur Yvette, France.

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http://dx.doi.org/10.4161/cc.6.1.3649DOI Listing
January 2007

Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.

Mol Cell Biol 2005 Jul;25(13):5523-34

Fonds National de la Recherche Scientifique, Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1128/MCB.25.13.5523-5534.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156982PMC
July 2005

Birth of a nucleolus: the evolution of nucleolar compartments.

Trends Cell Biol 2005 Apr;15(4):194-9

Laboratory of Cell and Tissue Biology, Department of Life Sciences, Faculty of Sciences, Université de Liège, Liège, Belgium.

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http://dx.doi.org/10.1016/j.tcb.2005.02.007DOI Listing
April 2005

The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.

Mol Cell Biol 2004 Sep;24(18):7976-86

Fonds National de la Recherche Scientifique, Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi-Gosselies, Belgium.

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http://dx.doi.org/10.1128/MCB.24.18.7976-7986.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515057PMC
September 2004

Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.

RNA 2004 Apr;10(4):645-56

F.N.R.S., Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi-Gosselies, Belgium. LBME du CNRS, 31062 Toulouse cedex 04, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370555PMC
http://dx.doi.org/10.1261/rna.5162204DOI Listing
April 2004