Publications by authors named "Denis Duboule"

100Publications

A complex regulatory landscape involved in the development of mammalian external genitals.

Elife 2020 Apr 17;9. Epub 2020 Apr 17.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.7554/eLife.52962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185996PMC
April 2020

The regulatory landscapes of developmental genes.

Development 2020 02 3;147(3). Epub 2020 Feb 3.

Swiss Institute for Cancer Research (ISREC), School of Life Sciences, Federal Institute of Technology, Lausanne, 1015 Lausanne, Switzerland

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http://dx.doi.org/10.1242/dev.171736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033717PMC
February 2020

Commentary on paper by Leroy C.

Authors:
Denis Duboule

Dev Biol 2019 10;454(1):1-14

School of Life Sciences, Federal Institute of Technology, Lausanne, 1015 Lausanne, Switzerland; Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland; Collège de France, Paris, France.

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http://dx.doi.org/10.1016/j.ydbio.2019.07.016DOI Listing
October 2019

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.

BMC Biol 2019 07 12;17(1):55. Epub 2019 Jul 12.

Laboratory of Developmental Genomics, Department of Genetics and Evolution, University of Geneva, 1211, Geneva 4, Switzerland.

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http://dx.doi.org/10.1186/s12915-019-0677-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626364PMC
July 2019

The constrained architecture of mammalian gene clusters.

Proc Natl Acad Sci U S A 2019 07 17;116(27):13424-13433. Epub 2019 Jun 17.

School of Life Sciences, Federal Institute of Technology, Lausanne, 1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1073/pnas.1904602116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613147PMC
July 2019

Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes.

Dev Cell 2019 02 17;48(3):383-395.e8. Epub 2019 Jan 17.

Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.12.004DOI Listing
February 2019

Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo.

BMC Res Notes 2018 Mar 27;11(1):193. Epub 2018 Mar 27.

Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1186/s13104-018-3307-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870235PMC
March 2018

Response to Peron et al.

Genet Med 2018 11;20(11):1481-1482

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/gim.2018.20DOI Listing
November 2018

Control of growth and gut maturation by genes and the associated lncRNA .

Proc Natl Acad Sci U S A 2017 10 17;114(44):E9290-E9299. Epub 2017 Oct 17.

Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland;

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http://dx.doi.org/10.1073/pnas.1712511114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676926PMC
October 2017

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock.

Genes Dev 2017 07;31(14):1406-1416

School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1101/gad.303123.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588924PMC
July 2017

Large scale genomic reorganization of topological domains at the HoxD locus.

Genome Biol 2017 08 7;18(1):149. Epub 2017 Aug 7.

School of Life Sciences, Ecole Polytechnique Fédérale, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1186/s13059-017-1278-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547506PMC
August 2017

Integration of Shh and Fgf signaling in controlling gene expression in cultured limb cells.

Proc Natl Acad Sci U S A 2017 03 7;114(12):3139-3144. Epub 2017 Mar 7.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1620767114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373353PMC
March 2017

Hotair Is Dispensible for Mouse Development.

PLoS Genet 2016 Dec 15;12(12):e1006232. Epub 2016 Dec 15.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1006232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157951PMC
December 2016

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus.

Genes Dev 2016 05 19;30(10):1172-86. Epub 2016 May 19.

Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland; School of Life Sciences, Federal Institute of Technology, Lausanne, 1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1101/gad.281055.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888838PMC
May 2016

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci.

Curr Top Dev Biol 2016 27;116:299-314. Epub 2016 Jan 27.

School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland; Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2015.11.022DOI Listing
August 2017

Visualizing the HoxD Gene Cluster at the Nanoscale Level.

Cold Spring Harb Symp Quant Biol 2015 14;80:9-16. Epub 2016 Jan 14.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland.

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http://symposium.cshlp.org/content/early/2016/01/14/sqb.2015
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http://symposium.cshlp.org/content/early/2016/01/14/sqb.2015
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http://symposium.cshlp.org/lookup/doi/10.1101/sqb.2015.80.02
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http://dx.doi.org/10.1101/sqb.2015.80.027177DOI Listing
January 2018

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states.

Proc Natl Acad Sci U S A 2015 Nov 26;112(45):13964-9. Epub 2015 Oct 26.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland

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http://dx.doi.org/10.1073/pnas.1517972112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653165PMC
November 2015

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model.

Mech Dev 2015 Nov 31;138 Pt 2:64-72. Epub 2015 Jul 31.

Department of Genetics and Evolution, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mod.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678112PMC
November 2015

Structure, function and evolution of topologically associating domains (TADs) at HOX loci.

FEBS Lett 2015 Oct 23;589(20 Pt A):2869-76. Epub 2015 Apr 23.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.04.024DOI Listing
October 2015

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.

Proc Natl Acad Sci U S A 2015 Apr 30;112(15):4672-7. Epub 2015 Mar 30.

School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and

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http://dx.doi.org/10.1073/pnas.1504783112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403207PMC
April 2015

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci.

Science 2014 Nov;346(6212):1004-6

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1126/science.1257493DOI Listing
November 2014

The genetics of murine Hox loci: TAMERE, STRING, and PANTHERE to engineer chromosome variants.

Methods Mol Biol 2014 ;1196:89-102

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-1242-1_6DOI Listing
May 2015

Considerations when investigating lncRNA function in vivo.

Elife 2014 Aug 14;3:e03058. Epub 2014 Aug 14.

Chris P Ponting is in the MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132285PMC
http://dx.doi.org/10.7554/eLife.03058DOI Listing
August 2014

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci.

Elife 2014 Apr 29;3:e02557. Epub 2014 Apr 29.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017647PMC
http://dx.doi.org/10.7554/eLife.02557DOI Listing
April 2014

Evolving Hox activity profiles govern diversity in locomotor systems.

Dev Cell 2014 Apr 17;29(2):171-87. Epub 2014 Apr 17.

Howard Hughes Medical Institute, NYU Neuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024207PMC
April 2014

SnapShot: Hox gene regulation.

Cell 2014 Feb;156(4):856-856.e1

School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne 1015, Switzerland; Department of Genetics and Evolution, University of Geneva, Geneva 1211, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2014.01.060DOI Listing
February 2014

Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits.

PLoS Biol 2014 Jan 21;12(1):e1001773. Epub 2014 Jan 21.

Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland ; School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.1001773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897358PMC
January 2014

Snakes: hatching of a model system for Evo-Devo?

Int J Dev Biol 2014 ;58(10-12):727-32

Department of Genetics and Evolution, University of Geneva, Switzerland.

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http://dx.doi.org/10.1387/ijdb.150026ddDOI Listing
April 2016

A genetic approach to the recruitment of PRC2 at the HoxD locus.

PLoS Genet 2013 Nov 7;9(11):e1003951. Epub 2013 Nov 7.

National Research Center 'Frontiers in Genetics', Geneva, Switzerland ; School of Life Sciences, Federal Institute of Technology (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1003951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820793PMC
November 2013

Topology of mammalian developmental enhancers and their regulatory landscapes.

Nature 2013 Oct;502(7472):499-506

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nature12753DOI Listing
October 2013

Chromatin looping and organization at developmentally regulated gene loci.

Wiley Interdiscip Rev Dev Biol 2013 Sep-Oct;2(5):615-30. Epub 2013 Jan 3.

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Frale (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1002/wdev.103DOI Listing
March 2014

Combined function of HoxA and HoxB clusters in neural crest cells.

Dev Biol 2013 Oct 11;382(1):293-301. Epub 2013 Jul 11.

School of Life Sciences, Federal Institute of Technology (EPFL) Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2013.06.027DOI Listing
October 2013

Transgene- and locus-dependent imprinting reveals allele-specific chromosome conformations.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):11946-51. Epub 2013 Jul 1.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1073/pnas.1310704110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718164PMC
July 2013

A switch between topological domains underlies HoxD genes collinearity in mouse limbs.

Science 2013 Jun;340(6137):1234167

School of Life Sciences, Federal Institute of Technology, Lausanne, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.1234167DOI Listing
June 2013

Chromatin organization and global regulation of Hox gene clusters.

Philos Trans R Soc Lond B Biol Sci 2013 6;368(1620):20120367. Epub 2013 May 6.

National Research Centre 'Frontiers in Genetics', School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1098/rstb.2012.0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682730PMC
December 2013

Chromatin architectures and Hox gene collinearity.

Curr Top Dev Biol 2013 ;104:113-48

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/B978-0-12-416027-9.00004-8DOI Listing
March 2014

Duplications of hox gene clusters and the emergence of vertebrates.

Dev Biol 2013 Jun 15;378(2):194-9. Epub 2013 Mar 15.

Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2013.03.004DOI Listing
June 2013

Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus.

Proc Natl Acad Sci U S A 2012 Dec 7;109(50):20204-11. Epub 2012 Nov 7.

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1073/pnas.1217659109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528568PMC
December 2012

A genetic basis for altered sexual behavior in mutant female mice.

Curr Biol 2012 Sep 2;22(18):1676-80. Epub 2012 Aug 2.

National Research Centre Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.cub.2012.06.067DOI Listing
September 2012

Landscapes and archipelagos: spatial organization of gene regulation in vertebrates.

Trends Cell Biol 2012 Jul 2;22(7):347-54. Epub 2012 May 2.

National Research Centre Frontiers in Genetics, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.tcb.2012.04.003DOI Listing
July 2012

A function for all posterior Hoxd genes during digit development?

Dev Dyn 2012 Apr 28;241(4):792-802. Epub 2012 Feb 28.

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/dvdy.23756DOI Listing
April 2012

Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters.

Development 2012 Mar 25;139(5):929-39. Epub 2012 Jan 25.

National Research Centre Frontiers in Genetics at Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/dev.076794DOI Listing
March 2012

A regulatory archipelago controls Hox genes transcription in digits.

Cell 2011 Nov;147(5):1132-45

National Research Centre, Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2011.10.023DOI Listing
November 2011

A genetic approach to the transcriptional regulation of Hox gene clusters.

Annu Rev Genet 2011 ;45:145-66

National Center of Competence in Research, Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1146/annurev-genet-102209-163429DOI Listing
February 2012

The dynamic architecture of Hox gene clusters.

Science 2011 Oct;334(6053):222-5

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale (EPFL), Lausanne, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1207194
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http://dx.doi.org/10.1126/science.1207194DOI Listing
October 2011

Analysis of the dynamics of limb transcriptomes during mouse development.

BMC Dev Biol 2011 Jul 29;11:47. Epub 2011 Jul 29.

School of Life Sciences, Ecole Polytechnique Fédérale, Station 19, Lausanne, 1215 Switzerland.

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http://dx.doi.org/10.1186/1471-213X-11-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160909PMC
July 2011

Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters.

Proc Natl Acad Sci U S A 2011 Jun 13;108(26):10632-7. Epub 2011 Jun 13.

National Research Centre Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1073/pnas.1102985108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127922PMC
June 2011

Structural and functional differences in the long non-coding RNA hotair in mouse and human.

PLoS Genet 2011 May 26;7(5):e1002071. Epub 2011 May 26.

School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1002071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102750PMC
May 2011

A regulatory 'landscape effect' over the HoxD cluster.

Dev Biol 2011 Mar 30;351(2):288-96. Epub 2010 Dec 30.

National Research Centre-Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2010.12.034DOI Listing
March 2011

Functional analysis of CTCF during mammalian limb development.

Dev Cell 2010 Dec;19(6):819-30

Department of Zoology and Animal Biology, University of Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.devcel.2010.11.009DOI Listing
December 2010

The evo-devo comet.

Authors:
Denis Duboule

EMBO Rep 2010 Jul;11(7):489

University of Geneva, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/embor.2010.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897126PMC
July 2010

The origin of digits: expression patterns versus regulatory mechanisms.

Dev Cell 2010 Apr;18(4):526-32

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.devcel.2010.04.002DOI Listing
April 2010

Additive and global functions of HoxA cluster genes in mesoderm derivatives.

Dev Biol 2010 May 18;341(2):488-98. Epub 2010 Mar 18.

National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2010.03.006DOI Listing
May 2010

Changes in Hox genes' structure and function during the evolution of the squamate body plan.

Nature 2010 Mar;464(7285):99-103

National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/nature08789DOI Listing
March 2010

Epigenetic regulation of vertebrate Hox genes: a dynamic equilibrium.

Epigenetics 2009 Nov 21;4(8):537-40. Epub 2009 Nov 21.

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland.

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http://dx.doi.org/10.4161/epi.4.8.10132DOI Listing
November 2009

The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.

Authors:
Denis Duboule

Int J Dev Biol 2009 ;53(5-6):717-23

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http://dx.doi.org/10.1387/ijdb.072558mrDOI Listing
September 2009

Epigenetic temporal control of mouse Hox genes in vivo.

Science 2009 Jun;324(5932):1320-3

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1126/science.1171468DOI Listing
June 2009

Uncoupling time and space in the collinear regulation of Hox genes.

PLoS Genet 2009 Mar 6;5(3):e1000398. Epub 2009 Mar 6.

Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642670PMC
March 2009

Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard.

Genome Res 2009 Apr 18;19(4):602-10. Epub 2009 Feb 18.

National Research Center "Frontiers in Genetics," Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1101/gr.087932.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665779PMC
April 2009

Conserved elements within open reading frames of mammalian Hox genes.

J Biol 2009 6;8(2):17. Epub 2009 Feb 6.

National Research Centre 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Switzerland.

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http://dx.doi.org/10.1186/jbiol116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687771PMC
September 2009

Rostral and caudal pharyngeal arches share a common neural crest ground pattern.

Development 2009 Feb;136(4):637-45

Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104, Strasbourg, France.

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http://dx.doi.org/10.1242/dev.028621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482666PMC
February 2009

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.

Mamm Genome 2008 Apr 5;19(4):272-8. Epub 2008 Apr 5.

Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.

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http://link.springer.com/10.1007/s00335-008-9106-0
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http://dx.doi.org/10.1007/s00335-008-9106-0DOI Listing
April 2008

Epigenetic regulation of Hox gene activation: the waltz of methyls.

Bioessays 2008 Mar;30(3):199-202

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/bies.20724DOI Listing
March 2008

Global control regions and regulatory landscapes in vertebrate development and evolution.

Adv Genet 2008 ;61:175-205

Developmental Biology Unit, EMBL, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/S0065-2660(07)00006-5DOI Listing
November 2008

Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd.

J Cell Sci 2008 Mar 5;121(Pt 5):571-7. Epub 2008 Feb 5.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh University, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1242/jcs.023234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258412PMC
March 2008

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness.

Genes Dev 2008 Feb;22(3):346-59

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1101/gad.1631708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2216694PMC
February 2008

Distinct roles and regulations for HoxD genes in metanephric kidney development.

PLoS Genet 2007 Dec;3(12):e232

Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland.

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http://dx.doi.org/10.1371/journal.pgen.0030232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151092PMC
December 2007

Differentiation and gene regulation.

Curr Opin Genet Dev 2007 Oct 23;17(5):369-72. Epub 2007 Oct 23.

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http://dx.doi.org/10.1016/j.gde.2007.10.001DOI Listing
October 2007

Hox gene function in vertebrate gut morphogenesis: the case of the caecum.

Development 2007 Nov 17;134(22):3967-73. Epub 2007 Oct 17.

National Research Centre 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/dev.010991DOI Listing
November 2007

Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity.

Novartis Found Symp 2007 ;284:130-7; discussion 138-41, 158-63

Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1002/9780470319390.ch9DOI Listing
September 2007

The role of Hox genes during vertebrate limb development.

Curr Opin Genet Dev 2007 Aug 20;17(4):359-66. Epub 2007 Jul 20.

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.gde.2007.05.011DOI Listing
August 2007

The rise and fall of Hox gene clusters.

Authors:
Denis Duboule

Development 2007 Jul 6;134(14):2549-60. Epub 2007 Jun 6.

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland.

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http://dx.doi.org/10.1242/dev.001065DOI Listing
July 2007

Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10.

Dev Biol 2007 Jun 1;306(2):883-93. Epub 2007 Apr 1.

Department of Zoology and Animal Biology and National Research Centre/Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2007.03.517DOI Listing
June 2007

Transgenic analysis of Hoxd gene regulation during digit development.

Dev Biol 2007 Jun 23;306(2):847-59. Epub 2007 Mar 23.

National Center for Competence in Research/Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.ydbio.2007.03.020DOI Listing
June 2007

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.

Nature 2006 Oct;443(7114):985-8

Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/nature05247DOI Listing
October 2006

A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development.

Proc Natl Acad Sci U S A 2006 Mar 13;103(12):4511-5. Epub 2006 Mar 13.

Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, Sciences III, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1073/pnas.0510544103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450202PMC
March 2006

Control of Hoxd genes' collinearity during early limb development.

Dev Cell 2006 Jan;10(1):93-103

Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.devcel.2005.11.014DOI Listing
January 2006

[A STRING lifts the veil on the mechanisms controlling Hox genes expression].

Med Sci (Paris) 2006 Jan;22(1):14-6

National Research Centre Frontiers in Genetics, Département de Zoologie et de Biologie animale, Université de Genève, Sciences III, quai Ernest Genève, Suisse.

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http://dx.doi.org/10.1051/medsci/200622114DOI Listing
January 2006

Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?

Int J Dev Biol 2006 ;50(1):3-15

European Union Network of Excellence Cells into Organs, University College London, UK.

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http://dx.doi.org/10.1387/ijdb.052095csDOI Listing
April 2006

HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside.

Genes Dev 2005 Dec;19(23):2862-76

National Research Centre Frontiers in Genetics and Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1101/gad.351105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315393PMC
December 2005

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes.

Nat Genet 2005 Aug 3;37(8):889-93. Epub 2005 Jul 3.

National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/ng1597DOI Listing
August 2005

Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.

Nature 2005 Jun;435(7045):1113-6

Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/nature03648DOI Listing
June 2005

Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia.

Development 2005 Jul;132(13):3055-67

National Research Center (NCCR Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/dev.01885DOI Listing
July 2005

Developmental biology: reproduction in clusters.

Nature 2005 Apr;434(7034):715-6

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http://dx.doi.org/10.1038/434715aDOI Listing
April 2005

Tracing microRNA patterns in mice.

Nat Genet 2004 Oct;36(10):1033-4

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http://dx.doi.org/10.1038/ng1004-1033DOI Listing
October 2004