Denis De Keukeleire

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Denis De Keukeleire

Publications by authors named "Denis De Keukeleire"

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52Publications

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Metabolism of hop-derived bitter acids.

J Agric Food Chem 2013 Aug 12;61(33):7916-24. Epub 2013 Aug 12.

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University (UGent), Ghent, Belgium.

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August 2013

Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.

Endocr Metab Immune Disord Drug Targets 2011 Sep;11(3):247-61

Ghent University (UGent), Department of Physiology, Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ledeganckstraat, Ghent, Belgium.

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September 2011

Bioavailability of hop-derived iso-α-acids and reduced derivatives.

Food Funct 2011 Jul 17;2(7):412-22. Epub 2011 Jun 17.

UGent-Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.

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July 2011

Reactivity of beer bitter acids toward the 1-hydroxyethyl radical as probed by spin-trapping electron paramagnetic resonance (EPR) and electrospray ionization-tandem mass spectrometry (ESI-MS/MS).

J Agric Food Chem 2011 Apr 14;59(8):4183-91. Epub 2011 Mar 14.

Instituto de Química de São Carlos (IQSC), Universidade de São Paulo, São Carlos, São Paulo, Brazil.

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April 2011

Quantification of xanthohumol, isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin in hop extracts and derived capsules using secondary standards.

Talanta 2010 Dec 1;83(2):448-56. Epub 2010 Oct 1.

Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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December 2010

Disposition of hop prenylflavonoids in human breast tissue.

Mol Nutr Food Res 2010 Jul;54 Suppl 2:S284-94

Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Ghent University-UGent, Belgium.

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July 2010

Disposition of soy isoflavones in normal human breast tissue.

Am J Clin Nutr 2010 Apr 17;91(4):976-84. Epub 2010 Feb 17.

Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering and the Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.

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April 2010

Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Apr 24;878(13-14):949-56. Epub 2010 Feb 24.

Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Harelbekestraat 72, B-9000 Gent, Belgium.

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April 2010

Transport of hop bitter acids across intestinal Caco-2 cell monolayers.

J Agric Food Chem 2010 Apr;58(7):4132-40

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, UGent-Ghent University, Ghent, Belgium.

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April 2010

Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.

Mol Nutr Food Res 2009 Sep;53(9):1143-55

Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, Gent, Belgium.

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September 2009

Evaluation of a low-cost adsorbent for removal of toxic metal ions from wastewater of an electroplating factory.

J Environ Manage 2009 Aug 17;90(11):3340-4. Epub 2009 Jun 17.

Laboratório de Análise Traço, Departamento de Química Analítica e Físico Química, Universidade Federal do Ceará, Campus do Pici, Centro de Ciências, Bloco 940-CEP: 60451-970 Fortaleza, Ceará, Brazil.

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August 2009

Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.

J Nat Prod 2009 Jun;72(6):1220-30

Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Gent, Belgium.

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June 2009

Removal of some polycyclic aromatic hydrocarbons from petrochemical wastewater using low-cost adsorbents of natural origin.

Bioresour Technol 2008 Jul 25;99(10):4515-9. Epub 2007 Oct 25.

Departamento de Química Analítica e Físico Química, Universidade Federal do Ceará, Campus do Pici, Centro de Ciências, Bloco 940, CEP: 60451-970 Fortaleza, CE, Brazil.

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July 2008

Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem.

J Agric Food Chem 2008 Jun 22;56(12):4806-12. Epub 2008 May 22.

Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Ghent University (UGent), Coupure Links 653, B-9000 Gent, Belgium.

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June 2008

Simultaneous analysis of riboflavin and aromatic amino acids in beer using fluorescence and multivariate calibration methods.

Anal Chim Acta 2008 Apr 6;613(2):207-17. Epub 2008 Mar 6.

Faculty of Commodity Science, The Poznań University of Economics, al. Niepodległości 10, 60-967 Poznań, Poland.

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April 2008

HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotes.

J Agric Food Chem 2007 Sep 21;55(19):7767-76. Epub 2007 Aug 21.

Biology Centre of the ASCR, v.v.i. Institute of Plant Molecular Biology, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic.

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September 2007

Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities.

J Agric Food Chem 2007 Aug 26;55(17):7002-9. Epub 2007 Jul 26.

Institute of Plant Breeding, Seed Science, and Population Genetics, Department of Plant Breeding and Biotechnology, University of Hohenheim, 70593 Stuttgart, Germany.

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August 2007

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

J Biol Chem 2007 Feb 6;282(7):4253-64. Epub 2006 Dec 6.

Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Molecular Biology, Ghent University-UGent, K. L. Ledeganckstraat 35, B-9000 Gent, Belgium.

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February 2007

Efficient extraction of high-quality total RNA from various hop tissues (Humulus lupulus L.).

Prep Biochem Biotechnol 2006 ;36(4):355-62

Department of Plant Genetics and Breeding, Agricultural Research Centre, Melle, Belgium.

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December 2006

Sequence analysis of a "true" chalcone synthase (chs_H1) oligofamily from hop (Humulus lupulus L.) and PAP1 activation of chs_H1 in heterologous systems.

J Agric Food Chem 2006 Oct;54(20):7606-15

Biological Centre AS CR, Institute of Plant Molecular Biology, Branisovska 31, 37005 Ceské Budejovice, Czech Republic.

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October 2006

Flavin-induced photodecomposition of sulfur-containing amino acids is decisive in the formation of beer lightstruck flavor.

Photochem Photobiol Sci 2006 Oct 13;5(10):961-9. Epub 2006 Sep 13.

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000, Ghent, Belgium.

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October 2006

A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.

Maturitas 2006 May;54(2):164-75

Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium.

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May 2006

Metabolism of the food-associated carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human intestinal microbiota.

J Agric Food Chem 2006 May;54(9):3454-61

Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.

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May 2006

Regioselective synthesis and estrogenicity of (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins.

Eur J Med Chem 2005 Oct 13;40(10):1042-51. Epub 2005 Jun 13.

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

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October 2005

A safety study of oral tangeretin and xanthohumol administration to laboratory mice.

In Vivo 2005 Jan-Feb;19(1):103-7

Department of Gynaecological Oncology, De Pintelaan 185, University Hospital Ghent, B-9000 Ghent, Belgium.

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August 2005

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin.

J Agric Food Chem 2005 Aug;53(16):6281-8

Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Gent University-UGent, Coupure Links 653, Gent, Belgium.

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August 2005

Fate of flavins in sensitized photodegradation of isohumulones and reduced derivatives: studies on formation of radicals via EPR combined with detailed product analyses.

Photochem Photobiol Sci 2005 May 22;4(5):412-9. Epub 2005 Mar 22.

Laboratory of Pharmacognosy and Phytochemistry, Ghent University, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, B-9000, Ghent, Belgium.

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May 2005

Photooxidative degradation of beer bittering principles: a key step on the route to lightstruck flavor formation in beer.

J Agric Food Chem 2005 Mar;53(5):1489-94

Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, B-9000 Ghent, Belgium.

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March 2005

Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum.

Fitoterapia 2005 Jan;76(1):35-40

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.

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January 2005

Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.

J Nat Prod 2004 Nov;67(11):1829-32

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

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November 2004

Photooxidative degradation of beer bittering principles: product analysis with respect to lightstruck flavour formation.

Photochem Photobiol Sci 2004 Sep 17;3(9):854-8. Epub 2004 Jun 17.

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.

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September 2004

Distribution of soy-derived phytoestrogens in human breast tissue and biological fluids.

Obstet Gynecol 2004 May;103(5 Pt 1):892-8

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium.

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May 2004

Riboflavin-sensitized photooxidation of isohumulones and derivatives.

Photochem Photobiol Sci 2004 Apr 9;3(4):337-40. Epub 2004 Mar 9.

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.

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April 2004

Dynamic coating for fast and reproducible determination of basic drugs by capillary electrophoresis with diode-array detection and mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Jan;799(2):323-30

Laboratory of Separation Sciences, Department of Organic Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 (S4), B-9000 Gent, Belgium.

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January 2004

Radicaloid-type oxidative decomposition of beer bittering agents revealed.

Chemistry 2003 Oct;9(19):4693-9

Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, 9000 Ghent, Belgium.

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October 2003

Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.).

J Agric Food Chem 2003 Jul;51(15):4436-41

Department of Plant Genetics and Breeding, Agricultural Research Centre, Caritasstraat 21, B-9090 Melle, Belgium.

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July 2003

Photolysis of hop-derived trans-iso-alpha-acids and trans-tetrahydroiso-alpha-acids: product identification in relation to the lightstruck flavour of beer.

Photochem Photobiol Sci 2003 Mar;2(3):306-14

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

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March 2003

2,5-Bis-(2-hydroxybenzoylamino)pentanoic acid, a salicylic acid-metabolite isolated from chicken: characterization and independent synthesis.

Bioorg Med Chem Lett 2003 Feb;13(3):335-7

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory for Medicinal Chemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.

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February 2003

Quantitation of soy-derived phytoestrogens in human breast tissue and biological fluids by high-performance liquid chromatography.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 Jan;784(1):137-44

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, B-9000, Ghent, Belgium.

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January 2003

Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) in relation to hops (Humulus lupulus L.).

Nat Prod Lett 2002 Feb;16(1):57-63

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Belgium.

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February 2002