Denan Jin

Denan Jin

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Denan Jin

Denan Jin

Publications by authors named "Denan Jin"

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86Publications

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A novel hamster nonalcoholic steatohepatitis model induced by a high-fat and high-cholesterol diet.

Exp Anim 2018 May 1;67(2):239-247. Epub 2018 Jan 1.

Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka 569-8686, Japan.

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May 2018

Early urinary biomarkers of renal tubular damage by a high-salt intake independent of blood pressure in normotensive rats.

Clin Exp Pharmacol Physiol 2018 Mar 20;45(3):261-268. Epub 2017 Dec 20.

Department of Urology, Jichi Medical University Saitama Medical Center, Saitama, Japan.

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March 2018

Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis.

Front Pharmacol 2018 21;9:144. Epub 2018 Feb 21.

Department of Innovative Medicine, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan.

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February 2018

Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet.

J Pharmacol Sci 2017 Jul 20;134(3):139-146. Epub 2017 Jun 20.

Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki 569-8686, Japan.

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July 2017

Effects of Gelatin Hydrogel Containing Anti-Transforming Growth Factor-β Antibody in a Canine Filtration Surgery Model.

Int J Mol Sci 2017 May 5;18(5). Epub 2017 May 5.

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka 569-8686, Japan.

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May 2017

Periostin antisense oligonucleotide prevents adhesion formation after surgery in mice.

J Pharmacol Sci 2017 Feb 9;133(2):65-69. Epub 2017 Feb 9.

Department of Innovative Medicine, Osaka Medical College Graduate School of Medicine, Takatsuki, Japan.

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February 2017

Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats.

J Renin Angiotensin Aldosterone Syst 2016 Jan-Mar;17(1):1470320316633895. Epub 2016 Mar 23.

Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.

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December 2016

Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice.

Am J Physiol Heart Circ Physiol 2016 Aug 10;311(2):H313-25. Epub 2016 Jun 10.

Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo, Japan;

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August 2016

Improvement of cardiovascular remodelling by chymase inhibitor.

Clin Exp Pharmacol Physiol 2016 Apr;43(4):387-93

Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.

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April 2016

Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice.

J Pharmacol Sci 2015 Dec 26;129(4):233-9. Epub 2015 Nov 26.

Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki 569-8686, Japan.

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December 2015

Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model.

Invest Ophthalmol Vis Sci 2015 Apr;56(4):2601-5

Department of Ophthalmology Osaka Medical College, Takatsuki-City, Osaka, Japan.

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April 2015

Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.

J Pharmacol Sci 2014 17;125(4):386-93. Epub 2014 Jul 17.

Department of Pharmacology, Osaka Medical College, Japan.

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March 2015

Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.

Pharmacology 2014 17;93(1-2):47-56. Epub 2014 Jan 17.

Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.

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November 2014

Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats.

J Hypertens 2014 Aug;32(8):1637-48; discussion 1649

aDepartment of Pharmacology, Osaka Medical College, Osaka, Japan bDepartment of Pharmacology, Shanghai Jiao Tong University School of Medicine, Shanghai, China cLaboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo dHirakata Ryoikuen, Osaka, Japan.

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August 2014

Quantification of Candesartan in Mouse Plasma by MALDI-TOFMS and in Tissue Sections by MALDI-Imaging Using the Stable-Isotope Dilution Technique.

Mass Spectrom (Tokyo) 2013 1;2(1):A0021. Epub 2013 Jun 1.

Department of Clinical and Laboratory Medicine, Osaka Medical College.

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May 2014

Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats.

Hypertens Res 2013 Apr 29;36(4):342-8. Epub 2012 Nov 29.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan.

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April 2013

Outside fibroblasts play a key role in the development of inner neointima after the implantation of polytetrafluoroethylene grafts.

J Pharmacol Sci 2012 22;119(2):139-49. Epub 2012 May 22.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan.

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December 2012

Multiple mechanisms for the action of chymase inhibitors.

J Pharmacol Sci 2012 14;118(3):311-6. Epub 2012 Feb 14.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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September 2012

Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ.

J Pharmacol Sci 2011 18;116(3):309-15. Epub 2011 Jun 18.

Department of Pharmacology, Osaka Medical College, Takatsuki, Osaka, Japan.

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December 2011

Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model.

Invest Ophthalmol Vis Sci 2011 Sep 29;52(10):7672-80. Epub 2011 Sep 29.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan.

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September 2011

Targets of chymase inhibitors.

Expert Opin Ther Targets 2011 Apr 4;15(4):519-27. Epub 2011 Feb 4.

Osaka Medical College, Department of Pharmacology, Daigaku-machi 2-7, Takatsuki City, Osaka 569-8686, Japan.

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April 2011

Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats.

Hypertens Res 2011 Feb 25;34(2):245-52. Epub 2010 Nov 25.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki City, Osaka, Japan.

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February 2011

New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage.

J Pharmacol Sci 2010 27;113(4):301-9. Epub 2010 Jul 27.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan.

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December 2010

Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats.

Hypertens Res 2010 Sep 3;33(9):953-9. Epub 2010 Jun 3.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan.

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September 2010

Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.

Hepatol Res 2010 Aug 7;40(8):832-40. Epub 2010 Jul 7.

Departments of Pharmacology and General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.

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August 2010

Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats.

J Pharmacol Exp Ther 2010 Feb 8;332(2):684-9. Epub 2009 Dec 8.

Second Department of Internal Medicine, Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan.

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February 2010

Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats.

Hypertens Res 2009 Oct 7;32(10):853-60. Epub 2009 Aug 7.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki City, Osaka, Japan.

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October 2009

Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes.

J Pharmacol Sci 2009 Aug 1;110(4):459-65. Epub 2009 Aug 1.

Department of Pharmacology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki City, Osaka, Japan.

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August 2009

Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

J Atheroscler Thromb 2009 Aug 27;16(4):480-9. Epub 2009 Aug 27.

Department of Pharmacology, Osaka Medical College,Takatsuki, Japan.

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August 2009

Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.

Atherosclerosis 2009 Jun 8;204(2):359-64. Epub 2008 Oct 8.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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June 2009

Possible roles of mast cell-derived chymase for skin rejuvenation.

Lasers Med Sci 2009 Mar 12;24(2):223-9. Epub 2008 Apr 12.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

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March 2009

Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo.

J Pharmacol Exp Ther 2009 Feb 5;328(2):540-8. Epub 2008 Nov 5.

Département de Pharmacologie, Facultéde médecine et des Sciences de Santé, Universitéde Sherbrooke, Sherbrooke, Quebec, Canada.

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February 2009

Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis.

Hepatol Res 2008 May 1;38(5):501-10. Epub 2007 Oct 1.

Departments of Pharmacology, and General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.

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May 2008

Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.

J Pharmacol Exp Ther 2008 Feb 16;324(2):422-6. Epub 2007 Nov 16.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan.

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February 2008

Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9.

J Mol Cell Cardiol 2007 Dec 16;43(6):670-6. Epub 2007 Aug 16.

Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatsuki, Osaka 569-8686, Japan.

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December 2007

Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters.

Eur J Pharmacol 2007 Oct 10;572(1):57-60. Epub 2007 Jul 10.

Department of Pharmacology, Osaka Medical College, Takatsuki City 589-8686, Japan.

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October 2007

Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.

Life Sci 2007 Sep 20;81(16):1291-300. Epub 2007 Sep 20.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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September 2007

Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters.

Eur J Pharmacol 2007 Jul 30;568(1-3):231-3. Epub 2007 Apr 30.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 589-8686, Japan.

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July 2007

Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits.

J Am Coll Cardiol 2007 Apr 21;49(13):1482-9. Epub 2007 Mar 21.

First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.

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April 2007

Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.

Pharmacol Ther 2006 Dec 11;112(3):668-76. Epub 2006 Jul 11.

Department of Pharmacology, Osaka Medical College, 2-7, Daigakumachi, Takatsuki City, Osaka 569-8686, Japan.

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December 2006

Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.

Pediatr Res 2006 Jul 11;60(1):77-82. Epub 2006 May 11.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan .

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July 2006

Expression of chymase-positive cells in gastric cancer and its correlation with the angiogenesis.

J Surg Oncol 2006 Jan;93(1):36-42; discussion 42-3

Department of Pharmacology Osaka Medical College, Takatsuki City, Osaka, Japan.

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January 2006

Eplerenone inhibits atherosclerosis in nonhuman primates.

Hypertension 2005 Nov 3;46(5):1135-9. Epub 2005 Oct 3.

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan.

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November 2005

The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.

Eur J Cardiothorac Surg 2005 Oct;28(4):617-21

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan.

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October 2005

The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet.

J Hypertens 2005 Oct;23(10):1879-86

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan.

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October 2005

Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs.

J Am Soc Nephrol 2005 Apr 2;16(4):1024-34. Epub 2005 Mar 2.

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.

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April 2005

Chymase as a novel target for the prevention of vascular diseases.

Trends Pharmacol Sci 2004 Oct;25(10):518-22

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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October 2004

Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis.

Eur J Pharmacol 2004 Oct;501(1-3):1-8

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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October 2004

Chymase-derived angiotensin II and arrhythmias after myocardial infarction.

Nihon Yakurigaku Zasshi 2004 08;124(2):77-82

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.

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August 2004

A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters.

Eur J Pharmacol 2004 Jun;493(1-3):173-6

Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 589-8686, Japan.

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June 2004

An antiarrhythmic effect of a chymase inhibitor after myocardial infarction.

J Pharmacol Exp Ther 2004 May 16;309(2):490-7. Epub 2004 Jan 16.

Department of Pharmacology, Osaka Medical College, Japan.

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May 2004

A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins.

J Pharmacol Sci 2004 Apr;94(4):443-8

Department of Pharmacology, Osaka Medical College, Osaka, Japan.

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April 2004

Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.

Hypertens Res 2004 Mar;27(3):213-9

Department of Pharmacology, Osaka Medical College, Takatsuki 569-8686, Japan.

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March 2004

Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.

Cardiovasc Res 2003 Nov;60(2):413-20

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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November 2003

Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins.

J Thorac Cardiovasc Surg 2002 Sep;124(3):621-5

Departments of Pharmacology and Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan.

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September 2002

Increased local angiotensin II formation in aneurysmal aorta.

Life Sci 2002 Sep;71(18):2195-205

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki City, Osaka 569-8686, Japan.

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September 2002

Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction.

Life Sci 2002 Jun;71(4):437-46

Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

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June 2002

Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters.

Jpn J Pharmacol 2002 Feb;88(2):183-8

Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan.

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February 2002