Publications by authors named "Deepak Voora"

59Publications

Modeling statin myopathy in a human skeletal muscle microphysiological system.

PLoS One 2020 25;15(11):e0242422. Epub 2020 Nov 25.

Duke Center for Applied Genomics & Precision Medicine, Durham, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242422PLOS
November 2020

Platelet reactivity in response to aspirin and ticagrelor in African-Americans and European-Americans.

J Thromb Thrombolysis 2020 Nov 6. Epub 2020 Nov 6.

Center for Applied Genomics & Precision Medicine, Duke University, 2187 CIEMAS, Campus Box 3382, Durham, NC, 27708, USA.

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http://dx.doi.org/10.1007/s11239-020-02327-wDOI Listing
November 2020

Identifying End Users' Preferences about Structuring Pharmacogenetic Test Orders in an Electronic Health Record System.

J Mol Diagn 2020 Oct;22(10):1264-1271

San Francisco VA Health Care System, San Francisco, California; Division of Hematology-Oncology, Department of Pediatrics University of California, San Francisco School of Medicine, San Francisco, California; Department of Medicine, and the Division of Medical Genetics, Department of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, California.

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http://dx.doi.org/10.1016/j.jmoldx.2020.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527867PMC
October 2020

Association of Hepatic Steatosis With Major Adverse Cardiovascular Events, Independent of Coronary Artery Disease.

Clin Gastroenterol Hepatol 2020 Jul 21. Epub 2020 Jul 21.

Cardiovascular Imaging Research Center, Massachusetts General Hospital, Boston, Massachusetts; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.

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http://dx.doi.org/10.1016/j.cgh.2020.07.030DOI Listing
July 2020

Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system.

Pharmacogenomics 2020 04 20;21(6):411-418. Epub 2020 Apr 20.

Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.2217/pgs-2019-0148DOI Listing
April 2020

Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.

Value Health 2020 01 25;23(1):61-73. Epub 2019 Sep 25.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jval.2019.08.002DOI Listing
January 2020

Genetic influences on aspirin response in patients undergoing percutaneous coronary intervention.

Cardiovasc Res 2019 08;115(10):1452-1453

Division of Cardiology, Duke University, Duke University Medical Center, 2301 Erwin Road, Durham, NC, USA.

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http://dx.doi.org/10.1093/cvr/cvz110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933505PMC
August 2019

Effects of Delivering SLCO1B1 Pharmacogenetic Information in Randomized Trial and Observational Settings.

Circ Genom Precis Med 2018 09;11(9):e002228

Department of Medicine (B.P., K.S., G.T., D.V.), Center for Applied Genomics & Precision Medicine, Duke University, Durham, NC. United States (S.B.H., M.D.M., D.V.).

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002228
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http://dx.doi.org/10.1161/CIRCGEN.118.002228DOI Listing
September 2018

Future directions in pharmacogenomics discovery in cardiovascular disease.

Pharmacogenomics 2018 04 23;19(5):375-377. Epub 2018 Mar 23.

Division of Cardiology, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.2217/pgs-2018-0002DOI Listing
April 2018

Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events.

BMC Med Genomics 2018 01 12;11(1). Epub 2018 Jan 12.

Center for Applied Genomics & Precision Medicine, Department of Medicine, Duke University, 101 Science Drive, 2187 CIEMAS, Durham, NC, 27708, UK.

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https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12920-017-0318-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767057PMC
January 2018

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2018 01 1;11(2):181-191. Epub 2017 Nov 1.

Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jcin.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775044PMC
January 2018

The need for sex-specific precision biomarkers for antiplatelet therapies.

Future Cardiol 2017 Sep 23;13(5):419-422. Epub 2017 Aug 23.

Department of Medicine, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.2217/fca-2017-0043DOI Listing
September 2017

Transcription Factor RUNX1 Regulates Platelet (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants.

Circulation 2017 Sep 4;136(10):927-939. Epub 2017 Jul 4.

From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591032PMC
September 2017

Assessing feasibility of delivering pharmacogenetic testing in a community pharmacy setting.

Pharmacogenomics 2017 Mar 22;18(4):327-335. Epub 2017 Feb 22.

Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, 304 Research Drive, Box 90141, Durham, NC 27708, USA.

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http://dx.doi.org/10.2217/pgs-2016-0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558549PMC
March 2017

Circulating extracellular vesicles containing miRNAs may have utility as early biomarkers for cardiac injury.

Ann Transl Med 2016 Oct;4(Suppl 1):S60

Duke Center for Applied Genomics & Precision Medicine, Durham, NC, USA.

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http://dx.doi.org/10.21037/atm.2016.10.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104591PMC
October 2016

Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease.

Clin Chem 2017 Jan 18;63(1):177-185. Epub 2016 Nov 18.

Department of Medicine and and

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http://dx.doi.org/10.1373/clinchem.2016.255232DOI Listing
January 2017

Rationale and design of the SLCO1B1 genotype guided statin therapy trial.

Pharmacogenomics 2016 Nov 3;17(17):1873-1880. Epub 2016 Nov 3.

Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.2217/pgs-2016-0065DOI Listing
November 2016

Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer.

EBioMedicine 2016 Sep 14;11:157-164. Epub 2016 Aug 14.

Duke Center for Applied Genomics & Precision Medicine, Duke University, Durham, NC, United States; Department of Medicine, Duke University, Durham, NC, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049978PMC
http://dx.doi.org/10.1016/j.ebiom.2016.08.021DOI Listing
September 2016

Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects.

J Am Coll Cardiol 2016 Mar;67(10):1211-1213

Duke Molecular Physiology Institute, Duke University, Durham, North Carolina; Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.01.022DOI Listing
March 2016

Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.

Atherosclerosis 2015 Nov 5;243(1):30-7. Epub 2015 Sep 5.

Peking University Clinical Research Institute, Beijing, China; Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China. Electronic address:

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http://www.atherosclerosis-journal.com/article/S002191501530
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https://www.sciencedirect.com/journal/atherosclerosis/vol/24
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https://linkinghub.elsevier.com/retrieve/pii/S00219150153009
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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.034DOI Listing
November 2015

Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.

PLoS One 2015 20;10(7):e0132259. Epub 2015 Jul 20.

Center for Applied Genomics and Precision Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132259PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507878PMC
April 2016

Gene Expression Signatures and the Spectrum of Coronary Artery Disease.

J Cardiovasc Transl Res 2015 Aug 19;8(6):339-52. Epub 2015 Jun 19.

Department of Medicine, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1007/s12265-015-9640-6DOI Listing
August 2015

Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

Eur Heart J 2015 Aug 2;36(29):1901-12. Epub 2015 May 2.

Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, level 1, SE-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1093/eurheartj/ehv116DOI Listing
August 2015

SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.

Pharmacogenomics 2015 ;16(5):449-58

Duke Center for Applied Genomics & Precision Medicine, Duke University, 101 Science Drive, Durham, NC 27705, USA.

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http://dx.doi.org/10.2217/pgs.15.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719145PMC
January 2016

Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.

Pharmgenomics Pers Med 2015 9;8:43-61. Epub 2015 Feb 9.

Program for Personalized and Genomic Medicine and Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.2147/PGPM.S52900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397717PMC
April 2015

Module-based association analysis for omics data with network structure.

PLoS One 2015 30;10(3):e0122309. Epub 2015 Mar 30.

Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, 27695, United States of America; Department of Statistics, North Carolina State University, Raleigh, North Carolina, 27695, United States of America; Department of Statistics, National Cheng-Kung University, Taiwan, R.O.C.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378989PMC
March 2016

Expression quantitative trait locus analysis identifies novel genes for statin myopathy.

Authors:
Deepak Voora

Circ Cardiovasc Genet 2014 Apr;7(2):220-1

Division of Cardiology, Genomic Medicine, Institute for Genome Science & Policy, Duke University, Durham, NC.

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000611DOI Listing
April 2014

A freeze on tailored antiplatelet therapy?

Circulation 2014 May 9;129(21):2088-90. Epub 2014 Apr 9.

From the Department of Medicine, Center for Personalized and Precision Medicine, Duke University, Durham, NC (D.V.); and Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH (R.C.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.009930DOI Listing
May 2014

Platelet RNA as a novel biomarker for the response to antiplatelet therapy.

Future Cardiol 2014 Jan;10(1):9-12

Duke Clinical Research Institute, Durham, NC, USA.

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http://dx.doi.org/10.2217/fca.13.90DOI Listing
January 2014

Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.

J Thorac Cardiovasc Surg 2014 Apr 21;147(4):1368-1375.e3. Epub 2013 Nov 21.

Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC.

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https://linkinghub.elsevier.com/retrieve/pii/S00225223130116
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http://dx.doi.org/10.1016/j.jtcvs.2013.09.067DOI Listing
April 2014

Delivering pharmacogenetic testing in a primary care setting.

Pharmgenomics Pers Med 2013 18;6:105-12. Epub 2013 Sep 18.

Duke Institute for Genome Sciences and Policy, Durham, NC, USA.

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http://dx.doi.org/10.2147/PGPM.S50598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791676PMC
October 2013

Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.

J Am Coll Cardiol 2013 Oct 3;62(14):1267-1276. Epub 2013 Jul 3.

Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina; Department of Medicine, Duke University, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.05.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786046PMC
October 2013

A transcriptomics-informed genetic association study identifies RHOA in simvastatin-induced low-density lipoprotein cholesterol lowering.

Authors:
Deepak Voora

Circ Cardiovasc Genet 2013 Feb;6(1):137-8

Division of Cardiology, Institute for Genome Science and Policy, Duke University, Durham, NC 27705, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.111.000070DOI Listing
February 2013

Building the evidentiary framework for pharmacogenetic testing: is it time to move beyond randomized controlled trials?

Authors:
Deepak Voora

Per Med 2013 Jan;10(1):1-3

Center for Personalized Medicine, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.2217/pme.12.105DOI Listing
January 2013

Clinical application of cardiovascular pharmacogenetics.

J Am Coll Cardiol 2012 Jul;60(1):9-20

Duke Institute for Genome Science & Policy, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.jacc.2012.01.067DOI Listing
July 2012

Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy.

J Thromb Thrombolysis 2012 Apr;33(3):246-57

Institute for Genome Sciences and Policy, Duke University, 905 S. Lasalle Dr., DUMC Box 3445, Durham, NC 27710, USA.

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http://dx.doi.org/10.1007/s11239-012-0683-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337886PMC
April 2012

A hub for bench-to-bedside pharmacogenomic-based research.

Pharmacogenomics 2011 Aug;12(8):1095-8

Institute for Genome Sciences & Policy, Center for Genomic Medicine, 101 Science Drive, Duke University, DUMC Box 3382, Durham, NC 27708, USA.

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http://dx.doi.org/10.2217/pgs.11.62DOI Listing
August 2011

The pharmacogenetics of antiplatelet agents: towards personalized therapy?

Nat Rev Cardiol 2011 Aug 9;8(10):560-71. Epub 2011 Aug 9.

Division of Cardiology, Duke University School of Medicine, 2400 Pratt Street, DUMC 3850, Durham, NC 27710, USA.

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http://dx.doi.org/10.1038/nrcardio.2011.111DOI Listing
August 2011

Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use.

Am Heart J 2011 Jul;162(1):166-72.e1

Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ahj.2011.03.026DOI Listing
July 2011

Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation.

J Cardiovasc Electrophysiol 2010 Aug 11;21(8):849-52. Epub 2010 Feb 11.

Duke Center for Atrial Fibrillation, Cardiac Electrophysiology Section of the Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2010.01729.xDOI Listing
August 2010

Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.

Circ Cardiovasc Genet 2008 Dec 9;1(2):100-6. Epub 2008 Dec 9.

Division of Cardiovascular Medicine, the Institute for Genome & Science Policy, and the Center for Human Genetics, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.795013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995295PMC
December 2008

The SLCO1B1*5 genetic variant is associated with statin-induced side effects.

J Am Coll Cardiol 2009 Oct;54(17):1609-16

Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1016/j.jacc.2009.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417133PMC
October 2009

Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays.

AMIA Annu Symp Proc 2009 Nov 14;2009:307-11. Epub 2009 Nov 14.

Division of Clinical Informatics, Department of Community and Family Medicine, Duke University, Durham, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815454PMC
November 2009

The pharmacogenetics of coumarin therapy.

Pharmacogenomics 2005 Jul;6(5):503-13

Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.2217/14622416.6.5.503DOI Listing
July 2005

Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype.

Thromb Haemost 2005 Apr;93(4):700-5

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1160/TH04-08-0542DOI Listing
April 2005

Use of pharmacogenetics to guide warfarin therapy.

Drugs Today (Barc) 2004 Mar;40(3):247-57

Departments of Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1358/dot.2004.40.3.820088DOI Listing
March 2004

Mesenteric vein thrombosis associated with intravaginal contraceptives: a case report and review of the literature.

J Thromb Thrombolysis 2003 Apr;15(2):105-8

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1023/b:thro.0000003323.80742.4dDOI Listing
April 2003