Deepak Nagrath

Deepak Nagrath

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Deepak Nagrath

Deepak Nagrath

Publications by authors named "Deepak Nagrath"

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42Publications

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Regulation of protein metabolism in cancer.

Mol Cell Oncol 2018 10;5(5):e1285384. Epub 2018 May 10.

Department of Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1080/23723556.2017.1285384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154860PMC
May 2018

The key role of extracellular vesicles in the metastatic process.

Biochim Biophys Acta Rev Cancer 2018 Jan 24;1869(1):64-77. Epub 2017 Nov 24.

Department of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800973PMC
January 2018

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

Nat Commun 2017 10 4;8(1):783. Epub 2017 Oct 4.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-017-00902-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627275PMC
October 2017

Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism.

Metab Eng 2017 09 11;43(Pt B):156-172. Epub 2017 Jan 11.

Laboratory for Systems Biology of Human Diseases, Rice University, Houston, TX 77005, USA; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2017.01.001DOI Listing
September 2017

Nitric Oxide: The Forgotten Child of Tumor Metabolism.

Trends Cancer 2017 09 18;3(9):659-672. Epub 2017 Aug 18.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679229PMC
September 2017

Glutaminolysis: A Hallmark of Cancer Metabolism.

Annu Rev Biomed Eng 2017 06 8;19:163-194. Epub 2017 Mar 8.

Laboratory for Systems Biology of Human Diseases, Rice University, Houston, Texas 77005.

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http://dx.doi.org/10.1146/annurev-bioeng-071516-044546DOI Listing
June 2017

The role of stromal cancer-associated fibroblasts in pancreatic cancer.

J Hematol Oncol 2017 03 28;10(1):76. Epub 2017 Mar 28.

Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.

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http://dx.doi.org/10.1186/s13045-017-0448-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371211PMC
March 2017

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

Cell Metab 2016 11;24(5):685-700

Laboratory for Systems Biology of Human Diseases, Rice University, Houston, TX 77005, USA; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.011DOI Listing
November 2016

Amplification of USP13 drives ovarian cancer metabolism.

Nat Commun 2016 11 28;7:13525. Epub 2016 Nov 28.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms13525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133706PMC
November 2016

Role of Increased n-acetylaspartate Levels in Cancer.

J Natl Cancer Inst 2016 Jan 26;108(6):djv426. Epub 2016 Jan 26.

Departments of Gynecologic Oncology and Reproductive Medicine (BZ, RAP, RR, TM, ASN, HJD, WH, CI, SYW, KMG, SP, LSM, AMN, GAP, AKS), Cancer Systems Imaging (NMZ, CRM, PKB), Biostatistics (MG), Cancer Medicine (CVP), Center for RNA Interference and Non-Coding RNA (CI, LSM, CRA, GLB, AKS), Cancer Biology (YS, MBE, GLB, AKS), Experimental Therapeutics (CRA, GLB), Bioinformatics and Computational Biology (YW, KAB), Melanoma Medical Oncology (MAD), and Pathology (JL), University of Texas M. D. Anderson Cancer Center, Houston, TX; Department of Nanomedicine and Bioengineering, UT Health, Houston, TX (GLB, AKS); Departments of Psychology, Urology, and Obstetrics and Gynecology, the University of Iowa, Iowa City, IA (SKL); Laboratory for Systems Biology of Human Diseases (LY, JB, AA, DN), Department of Chemical and Biomolecular Engineering (LY, JB, AA, DN), and Department of Bioengineering (DN), Rice University, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djv426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849357PMC
January 2016

Linking omentum and ovarian cancer: NO.

Oncoscience 2015 14;2(10):797-8. Epub 2015 Sep 14.

Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, and Department of Bioengineering, Rice University, Houston, TX.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671925PMC
http://dx.doi.org/10.18632/oncoscience.248DOI Listing
December 2015

Synthesis and biological evaluation of dimeric furanoid macroheterocycles: discovery of new anticancer agents.

J Am Chem Soc 2015 Apr 1;137(14):4766-70. Epub 2015 Apr 1.

‡Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jacs.5b00141DOI Listing
April 2015

Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells.

Cancer Res 2015 Jan 25;75(2):456-71. Epub 2014 Nov 25.

Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas. Department of Bioengineering, Rice University, Houston, Texas.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-1337DOI Listing
January 2015

Reply to: "Is the pathway of energy metabolism modified in advanced cirrhosis?".

J Hepatol 2014 Aug 2;61(2):453. Epub 2014 May 2.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine and Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186694PMC
August 2014

Modeling integrated cellular machinery using hybrid Petri-Boolean networks.

PLoS Comput Biol 2013 7;9(11):e1003306. Epub 2013 Nov 7.

Department of Computer Science, Rice University, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820535PMC
July 2014

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration.

Am J Physiol Endocrinol Metab 2012 Oct 14;303(8):E1036-52. Epub 2012 Aug 14.

Laboratory for Systems Biology of Human Diseases, Rice University, Houston, Texas 77251-1892, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00151.2012
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http://dx.doi.org/10.1152/ajpendo.00151.2012DOI Listing
October 2012

Optimality and thermodynamics determine the evolution of transcriptional regulatory networks.

Mol Biosyst 2012 Feb 10;8(2):511-530. Epub 2011 Nov 10.

Massachusetts General Hospital and the Harvard Medical School, Shriners Hospitals for Children, 51 Blossom Street, Boston, MA 02114.

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http://dx.doi.org/10.1039/c1mb05177fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964374PMC
February 2012

Metabolic profiling based quantitative evaluation of hepatocellular metabolism in presence of adipocyte derived extracellular matrix.

PLoS One 2011 16;6(5):e20137. Epub 2011 May 16.

Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095641PMC
October 2011

Metabolomics for mitochondrial and cancer studies.

Biochim Biophys Acta 2011 Jun 21;1807(6):650-63. Epub 2011 Mar 21.

Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Rice University, 6100 Main St, Houston, TX 77005, USA.

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http://dx.doi.org/10.1016/j.bbabio.2011.03.006DOI Listing
June 2011

Characterization and modeling of nonlinear hydrophobic interaction chromatographic systems.

J Chromatogr A 2011 Mar 6;1218(9):1219-26. Epub 2011 Jan 6.

Department of Chemical and Biomolecular Engineering, Rice University, TX, USA.

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http://dx.doi.org/10.1016/j.chroma.2010.12.111DOI Listing
March 2011

Soft constraints-based multiobjective framework for flux balance analysis.

Metab Eng 2010 Sep 27;12(5):429-45. Epub 2010 May 27.

Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA.

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http://dx.doi.org/10.1016/j.ymben.2010.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922426PMC
September 2010

Adipocyte-derived basement membrane extract with biological activity: applications in hepatocyte functional augmentation in vitro.

FASEB J 2010 Jul 16;24(7):2364-74. Epub 2010 Mar 16.

Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1096/fj.09-135095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887257PMC
July 2010

Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo.

Metab Eng 2009 Jul-Sep;11(4-5):274-83. Epub 2009 Jun 7.

Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.ymben.2009.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814076PMC
November 2009

Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel.

Tissue Eng Part A 2008 Feb;14(2):227-36

Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1089/tea.2007.0143DOI Listing
February 2008

Integrated energy and flux balance based multiobjective framework for large-scale metabolic networks.

Ann Biomed Eng 2007 Jun 29;35(6):863-85. Epub 2007 Mar 29.

Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s10439-007-9283-0DOI Listing
June 2007

Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures.

Biotechnol Bioeng 2007 May;97(1):188-99

Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1002/bit.21225DOI Listing
May 2007

Effect of pH changes on water release values in hydrophobic interaction chromatographic systems.

J Chromatogr A 2005 Jun;1079(1-2):229-35

Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590, USA.

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http://dx.doi.org/10.1016/j.chroma.2005.04.005DOI Listing
June 2005

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model.

Metab Eng 2005 Mar;7(2):88-103

Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom Street, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109671760400074
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http://dx.doi.org/10.1016/j.ymben.2004.09.003DOI Listing
March 2005

Use and optimization of a dual-flowrate loading strategy to maximize throughput in protein-a affinity chromatography.

Biotechnol Prog 2004 May-Jun;20(3):830-40

Purification Process Development, Amgen Inc., Seattle, Washington, USA.

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http://dx.doi.org/10.1021/bp0342654DOI Listing
December 2004

A hybrid model framework for the optimization of preparative chromatographic processes.

Biotechnol Prog 2004 Jan-Feb;20(1):162-78

Howard P. Isermann Department of Chemical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, USA.

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http://dx.doi.org/10.1021/bp034026gDOI Listing
October 2004

Evaluation of selectivity changes in HIC systems using a preferential interaction based analysis.

Biotechnol Bioeng 2004 Aug;87(3):354-63

Howard P. Isermann Department of Chemical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, USA.

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http://doi.wiley.com/10.1002/bit.20120
Publisher Site
http://dx.doi.org/10.1002/bit.20120DOI Listing
August 2004

Modeling of adsorption in hydrophobic interaction chromatography systems using a preferential interaction quadratic isotherm.

J Chromatogr A 2003 Mar;989(1):47-54

Howard P. Isermann Department of Chemical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.

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http://dx.doi.org/10.1016/s0021-9673(02)02047-2DOI Listing
March 2003