Publications by authors named "Debra I Diz"

100Publications

Lower urinary α-Klotho is associated with lower angiotensin-(1-7) and higher blood pressure in young adults born preterm with very low birthweight.

J Clin Hypertens (Greenwich) 2020 Jun 31;22(6):1033-1040. Epub 2020 May 31.

Department of Pediatrics, Wake Forest School of Medicine and Brenner Children's Hospital, Winston Salem, North Carolina, USA.

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http://dx.doi.org/10.1111/jch.13897DOI Listing
June 2020

COVID-19, ACE2, and the cardiovascular consequences.

Am J Physiol Heart Circ Physiol 2020 05 31;318(5):H1084-H1090. Epub 2020 Mar 31.

Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1152/ajpheart.00217.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191628PMC
May 2020

The Role of Heart Rate Variability in Mindfulness-Based Pain Relief.

J Pain 2020 Mar - Apr;21(3-4):306-323. Epub 2019 Aug 1.

Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Anesthesiology, University of California San Diego, San Diego, California. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994350PMC
August 2019

Children with orthostatic intolerance exhibit elevated markers of inflammation in the dorsal medulla.

Am J Physiol Heart Circ Physiol 2019 08 21;317(2):H323-H329. Epub 2019 Jun 21.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1152/ajpheart.00680.2018DOI Listing
August 2019

Central ANG-(1-7) infusion improves blood pressure regulation in antenatal betamethasone-exposed sheep and reveals sex-dependent effects on oxidative stress.

Am J Physiol Heart Circ Physiol 2019 06 5;316(6):H1458-H1467. Epub 2019 Apr 5.

Department of Surgery, Hypertension, and Vascular Research and the Cardiovascular Sciences Center, Wake Forest University School of Medicine , Winston-Salem, North Carolina.

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https://www.physiology.org/doi/10.1152/ajpheart.00497.2018
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http://dx.doi.org/10.1152/ajpheart.00497.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620683PMC
June 2019

Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.

Clin Sci (Lond) 2019 01 8;133(1):55-74. Epub 2019 Jan 8.

Cardiovascular Sciences Center, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.

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http://clinsci.org/lookup/doi/10.1042/CS20171550
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http://dx.doi.org/10.1042/CS20171550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716381PMC
January 2019

Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.

J Cardiovasc Pharmacol 2019 03;73(3):143-148

Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC.

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http://Insights.ovid.com/crossref?an=00005344-900000000-9857
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http://dx.doi.org/10.1097/FJC.0000000000000645DOI Listing
March 2019

Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.

J Pediatr 2019 02 5;205:55-60.e1. Epub 2018 Nov 5.

Department of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC.

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http://dx.doi.org/10.1016/j.jpeds.2018.09.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561332PMC
February 2019

Renal function and blood pressure are altered in adolescents born preterm.

Pediatr Nephrol 2019 01 15;34(1):137-144. Epub 2018 Aug 15.

Department of Pediatrics, Wake Forest School of Medicine, One Medical Center Boulevard, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1007/s00467-018-4050-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237649PMC
January 2019

Chronic nausea and orthostatic intolerance: Diagnostic utility of orthostatic challenge duration, Nausea Profile Questionnaire, and neurohumoral measures.

Neurogastroenterol Motil 2018 11 13;30(11):e13433. Epub 2018 Aug 13.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://doi.wiley.com/10.1111/nmo.13433
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http://dx.doi.org/10.1111/nmo.13433DOI Listing
November 2018

Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure.

Clin Sci (Lond) 2018 09 16;132(17):1953-1962. Epub 2018 Sep 16.

Department of Surgery, Hypertension and Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC, U.S.A.

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http://dx.doi.org/10.1042/CS20180417DOI Listing
September 2018

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.

Nitric Oxide 2017 Sep 23;69:78-90. Epub 2017 May 23.

Sections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565697PMC
September 2017

No Brain Renin-Angiotensin System: Déjà vu All Over Again?

Hypertension 2017 06 10;69(6):1007-1010. Epub 2017 Apr 10.

From the Department of Pharmacology, UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (C.D.S.); and Department of Surgery, Hypertension and Vascular Research, Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston-Salem, NC (D.I.D., M.C.C.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497704PMC
June 2017

Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity.

Peptides 2017 04 10;90:10-16. Epub 2017 Feb 10.

The Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688182PMC
April 2017

Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression.

Front Physiol 2016 9;7:207. Epub 2016 Jun 9.

Department of Physiology and Pharmacology and Hypertension and Vascular Research Center, Wake Forest School of Medicine Winston-Salem, NC, USA.

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http://dx.doi.org/10.3389/fphys.2016.00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899471PMC
July 2016

Programs to Recruit and Retain a More Diverse Workforce in Biomedical Sciences Research.

J Best Pract Health Prof Divers 2016 ;9(1):1188-1194

Department of Surgery, Hypertension and Vascular Research Center, Winston-Salem, North Carolina.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575820PMC
January 2016

Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options.

Am J Physiol Heart Circ Physiol 2016 Feb 25;310(3):H416-25. Epub 2015 Nov 25.

Neuroscience Graduate Program, Wake Forest Graduate School of Arts and Sciences, Winston-Salem, North Carolina; Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina; and

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http://dx.doi.org/10.1152/ajpheart.00583.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888538PMC
February 2016

Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults.

Am J Hypertens 2016 Apr 20;29(4):494-500. Epub 2015 Aug 20.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem, North Carolina, USA; Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA;

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http://dx.doi.org/10.1093/ajh/hpv139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850901PMC
April 2016

Gαi/o-dependent Ca(2+) mobilization and Gαq-dependent PKCα regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells.

Neurochem Int 2015 Nov 16;90:142-51. Epub 2015 Jul 16.

Cardiovascular Disease Research Program, Julius L Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA; Department of Biology, North Carolina Central University, Durham, NC 27707, USA; Department of Physiology and Pharmacology and Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01970186153001
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http://dx.doi.org/10.1016/j.neuint.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641771PMC
November 2015

Injury patterns associated with hypotension in pediatric trauma patients: A national trauma database review.

J Trauma Acute Care Surg 2015 Jun;78(6):1143-8

From the Departments of Pediatrics and Emergency Medicine (A.R.G.), General Surgery, Division of Surgical Sciences (D.I.D.), Biostatistical Sciences (J.A.T.), Emergency Medicine (C.D.M.), and General Surgery, Section of Pediatric Surgery (J.P.), Wake Forest University School of Medicine, Winston-Salem, North Carolina.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000658DOI Listing
June 2015

Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.

J Cardiovasc Pharmacol 2015 May;65(5):473-9

*Department of Physiology and Pharmacology, Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC; †Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC; and ‡Analytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, NC.

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http://dx.doi.org/10.1097/FJC.0000000000000216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424182PMC
May 2015

Mechanisms of human erythrocytic bioactivation of nitrite.

J Biol Chem 2015 Jan 3;290(2):1281-94. Epub 2014 Dec 3.

From the Department of Physics and the Translational Science Center Wake Forest University, Winston-Salem, North Carolina 27109, Hypertension and Vascular Research Center and Biomedical Engineering and

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http://dx.doi.org/10.1074/jbc.M114.609222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294492PMC
January 2015

Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats.

Am J Physiol Heart Circ Physiol 2014 Dec 26;307(11):H1539-46. Epub 2014 Sep 26.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina

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http://ajpheart.physiology.org/content/ajpheart/307/11/H1539
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http://ajpheart.physiology.org/content/ajpheart/early/2014/0
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0028
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http://dx.doi.org/10.1152/ajpheart.00282.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255011PMC
December 2014

Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance.

J Pediatr Gastroenterol Nutr 2014 Jul;59(1):39-43

*Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, University of Colorado, Aurora †Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition ‡Hypertension and Vascular Research Center §Neuroscience Graduate Program, Wake Forest Graduate School of Arts & Sciences ||Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1097/MPG.0000000000000305DOI Listing
July 2014

Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats.

Physiol Rep 2014 Aug 28;2(8). Epub 2014 Aug 28.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina Hypertension & Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.14814/phy2.12108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246581PMC
August 2014

Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea.

Exp Brain Res 2014 Aug 15;232(8):2645-50. Epub 2014 May 15.

Department of Child Psychiatry and Behavioral Sciences, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, B130, 13123 E. 16th Ave., Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/s00221-014-3981-2DOI Listing
August 2014

The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia.

J Renin Angiotensin Aldosterone Syst 2015 Sep 15;16(3):529-38. Epub 2014 Apr 15.

Department of Pediatrics, Wake Forest School of Medicine, USA Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.

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http://journals.sagepub.com/doi/10.1177/1470320314526940
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http://dx.doi.org/10.1177/1470320314526940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278943PMC
September 2015

Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep.

J Neurochem 2014 Jul 19;130(2):313-23. Epub 2014 Apr 19.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

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http://dx.doi.org/10.1111/jnc.12720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137327PMC
July 2014

Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways.

Front Endocrinol (Lausanne) 2014 Jan 9;4:201. Epub 2014 Jan 9.

The Hypertension and Vascular Research Center, Wake Forest University School of Medicine , Winston-Salem, NC , USA.

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http://dx.doi.org/10.3389/fendo.2013.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886117PMC
January 2014

Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming.

Peptides 2014 Feb 16;52:74-81. Epub 2013 Dec 16.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157337PMC
February 2014

Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep.

Am J Physiol Regul Integr Comp Physiol 2013 Oct 15;305(7):R679-88. Epub 2013 Aug 15.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina;

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http://dx.doi.org/10.1152/ajpregu.00321.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798802PMC
October 2013

Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats.

Cardiovasc Endocrinol 2012 Sep;1(3):49-58

Department of Anesthesiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, USA ; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, USA ; Hypertension and Vascular Research Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1097/XCE.0b013e32835a2159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685869PMC
September 2012

Nitric-oxide synthase knockout modulates Ca²⁺-sensing receptor expression and signaling in mouse mesenteric arteries.

J Pharmacol Exp Ther 2013 Jul 2;346(1):38-47. Epub 2013 May 2.

Cardiovascular & Metabolic Diseases Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA.

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http://dx.doi.org/10.1124/jpet.113.205534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684838PMC
July 2013

Increased constrictor tone induced by ouabain treatment in rats.

J Cardiovasc Pharmacol 2013 Aug;62(2):174-83

Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC 27101, USA.

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http://dx.doi.org/10.1097/FJC.0b013e3182955d33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893306PMC
August 2013

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep.

Peptides 2013 Jun 26;44:25-31. Epub 2013 Mar 26.

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, NC, United States.

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http://dx.doi.org/10.1016/j.peptides.2013.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690463PMC
June 2013

Response to Angiotensin-(1-7) and Bradykinin in Baroreceptor Reflex Sensitivity in Hypertension.

Hypertension 2013 Feb;61(2):e20

Hypertension and Vascular Research CenterWake Forest University School of Medicine Winston-Salem, NC, USA.

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http://dx.doi.org/10.1161/hypertensionaha.111.00571DOI Listing
February 2013

The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains.

Int J Hypertens 2013 21;2013:136028. Epub 2013 Jan 21.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1155/2013/136028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564433PMC
February 2013

Brain renin-angiotensin system in the nexus of hypertension and aging.

Hypertens Res 2013 Jan 18;36(1):5-13. Epub 2012 Oct 18.

The Hypertension and Vascular Research Center, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 271157-1032, USA.

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http://dx.doi.org/10.1038/hr.2012.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816955PMC
January 2013

Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats.

Hypertension 2012 Nov 8;60(5):1257-65. Epub 2012 Oct 8.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.196782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491885PMC
November 2012

The brain renin-angiotensin system and cardiovascular responses to stress: insights from transgenic rats with low brain angiotensinogen.

J Appl Physiol (1985) 2012 Dec 13;113(12):1929-36. Epub 2012 Sep 13.

The Hypertension & Vascular Research Center and the Departments of General Surgery and Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/japplphysiol.00569.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544491PMC
December 2012

Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system.

Am J Physiol Regul Integr Comp Physiol 2012 Oct 22;303(8):R799-806. Epub 2012 Aug 22.

The Hypertension and Vascular Research Center, Wake Forest Univ. School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/ajpregu.00566.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469665PMC
October 2012

Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment.

Radiat Res 2012 Jul 12;178(1):46-56. Epub 2012 Jun 12.

Department of Molecular Medicine and Translational Science, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422865PMC
http://dx.doi.org/10.1667/rr2731.1DOI Listing
July 2012

Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function.

J Cardiovasc Pharmacol 2012 May;59(5):472-8

Hypertension and Vascular Research Center and Department of General Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1097/FJC.0b013e31824ba490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349073PMC
May 2012

In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats.

J Cardiovasc Pharmacol 2012 Aug;60(2):150-7

Radiation Oncology Department †Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1097/FJC.0b013e3182588b32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419797PMC
August 2012

Identification and characterization of novel perivascular adventitial cells in the whole mount mesenteric branch artery using immunofluorescent staining and scanning confocal microscopy imaging.

Int J Cell Biol 2012 19;2012:172746. Epub 2012 Feb 19.

Cardiovascular Disease Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA.

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http://dx.doi.org/10.1155/2012/172746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296306PMC
August 2012

Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure.

Hypertension 2012 Feb 3;59(2):453-8. Epub 2012 Jan 3.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Hanes Building, 6th floor, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.185876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157309PMC
February 2012

Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats.

Hypertens Res 2011 Dec 22;34(12):1257-62. Epub 2011 Sep 22.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1038/hr.2011.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160904PMC
December 2011

Fludrocortisone improves nausea in children with orthostatic intolerance (OI).

Clin Auton Res 2011 Dec 28;21(6):419-23. Epub 2011 Jul 28.

Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1007/s10286-011-0130-xDOI Listing
December 2011

The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat.

J Cardiovasc Pharmacol 2011 Oct;58(4):367-73

Department of Life Sciences and Biomedical Research Infrastructure Center, Winston-Salem State University, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1097/FJC.0b013e31822555caDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188661PMC
October 2011

Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis.

Am J Physiol Heart Circ Physiol 2011 Jun 1;300(6):H2206-13. Epub 2011 Apr 1.

The Hypertension & Vascular Research Center, Wake Forest Univ. School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/ajpheart.01263.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119102PMC
June 2011

Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure.

Am J Physiol Endocrinol Metab 2011 Jun 8;300(6):E979-85. Epub 2011 Mar 8.

Hypertension and Vascular Research Center, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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June 2011

Angiotensin peptides and central autonomic regulation.

Curr Opin Pharmacol 2011 Apr 28;11(2):131-7. Epub 2011 Feb 28.

The Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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April 2011

Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney.

Hypertension 2011 Mar 10;57(3):620-6. Epub 2011 Jan 10.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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March 2011

Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide.

Am J Physiol Renal Physiol 2010 Nov 1;299(5):F983-90. Epub 2010 Sep 1.

Wake Forest Univ. Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/ajprenal.00371.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980408PMC
November 2010

Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus.

Am J Physiol Heart Circ Physiol 2010 Sep 18;299(3):H763-71. Epub 2010 Jun 18.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA.

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September 2010

Acute AT(1)-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone.

Am J Physiol Heart Circ Physiol 2010 Aug 11;299(2):H541-7. Epub 2010 Jun 11.

Hypertension and Vascular Research Center, Wake Forest Univ. School of Medicine, Hanes Bldg., 6th floor, Medical Center Blvd., Winston-Salem, NC 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930394PMC
August 2010

Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities.

Eur J Pharmacol 2010 Jul 4;638(1-3):108-14. Epub 2010 May 4.

Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907528PMC
July 2010

Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus.

Hypertension 2010 Jan 30;55(1):166-71. Epub 2009 Nov 30.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821807PMC
January 2010

Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus.

Hypertension 2009 Nov 21;54(5):1001-8. Epub 2009 Sep 21.

Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789663PMC
November 2009

The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy.

Endocrinology 2009 Sep 11;150(9):4316-25. Epub 2009 Jun 11.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736074PMC
September 2009

Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep.

Am J Physiol Regul Integr Comp Physiol 2009 Aug 10;297(2):R446-52. Epub 2009 Jun 10.

Dept. of Obstetrics and Gynecology, Wake Forest Univ. School of Medicine, Winston Salem, NC 27157, USA.

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http://dx.doi.org/10.1152/ajpregu.00023.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724228PMC
August 2009

Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats.

Am J Physiol Regul Integr Comp Physiol 2009 Jul 29;297(1):R111-5. Epub 2009 Apr 29.

Hypertension and Vascular Research Center, Wake Forest University Health Science, Winston-Salem, North Carolina 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711698PMC
July 2009

Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production.

Am J Physiol Renal Physiol 2009 Jun 25;296(6):F1484-93. Epub 2009 Feb 25.

Hypertension and Vascular Research Center, Wake Forest Univ. School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692453PMC
June 2009

Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats.

Pharmacol Res 2009 Apr 31;59(4):263-8. Epub 2008 Dec 31.

Department of Biochemistry, Faculty of Medicine, Kuwait University, Kuwait.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682227PMC
April 2009

The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment.

Int J Radiat Oncol Biol Phys 2009 Feb 10;73(2):499-505. Epub 2008 Dec 10.

Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2008.09.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631653PMC
February 2009

Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension.

Hypertension 2009 Feb 1;53(2):404-8. Epub 2008 Dec 1.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Hanes Building, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.124339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674380PMC
February 2009

Future directions in cardiovascular pharmacology: examples from the Renin-Angiotensin system.

Authors:
Debra I Diz

Mol Interv 2008 Oct;8(5):222-5

Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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October 2008

Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats.

J Cardiovasc Pharmacol 2008 Jun;51(6):542-8

Hypertension & Vascular Research Center, Division of Surgical Sciences, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676577PMC
June 2008

Lewis K. Dahl memorial lecture: the renin-angiotensin system and aging.

Authors:
Debra I Diz

Hypertension 2008 Jul 12;52(1):37-43. Epub 2008 May 12.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.108985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701673PMC
July 2008

Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function.

Future Cardiol 2008 May;4(3):237-45

Wake Forest University School of Medicine, The Hypertension & Vascular Research Center, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929677PMC
May 2008

Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.

Am J Physiol Heart Circ Physiol 2008 May 28;294(5):H2363-70. Epub 2008 Mar 28.

Cardiovascular Disease Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA.

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http://dx.doi.org/10.1152/ajpheart.01042.2007DOI Listing
May 2008

Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats.

Exp Physiol 2008 May 20;93(5):694-700. Epub 2008 Mar 20.

The Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1113/expphysiol.2007.040261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704611PMC
May 2008

Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen.

Hypertension 2008 May 17;51(5):1326-31. Epub 2008 Mar 17.

Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.106005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483961PMC
May 2008

Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia.

Hypertension 2008 Apr 7;51(4):1066-72. Epub 2008 Feb 7.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705753PMC
April 2008

Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats.

Am J Nephrol 2008 20;28(1):25-33. Epub 2007 Sep 20.

Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait.

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http://dx.doi.org/10.1159/000108758DOI Listing
December 2007

Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats.

Am J Physiol Heart Circ Physiol 2007 Sep 6;293(3):H1327-33. Epub 2007 Jul 6.

The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/ajpheart.00457.2007DOI Listing
September 2007

Aging and the brain renin-angiotensin system: insights from studies in transgenic rats.

Cleve Clin J Med 2007 Feb;74 Suppl 1:S95-8

Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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February 2007

Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging.

Endocrine 2006 Oct;30(2):167-74

The Hypertension & Vascular Disease Center and Physiology/Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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October 2006

Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells.

Am J Physiol Cell Physiol 2007 May 31;292(5):C1895-905. Epub 2007 Jan 31.

Cardiovascular Disease Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George St., Durham, NC 27707, USA.

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http://dx.doi.org/10.1152/ajpcell.00404.2006DOI Listing
May 2007

Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction.

Am J Physiol Heart Circ Physiol 2007 Jan;292(1):H666-72

Dept. of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P. O. Box 24923, Safat 13110, Kuwait.

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http://dx.doi.org/10.1152/ajpheart.00372.2006DOI Listing
January 2007

Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment.

Int J Radiat Oncol Biol Phys 2007 Jan;67(1):6-9

Department of Radiation Oncology, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2006.09.036DOI Listing
January 2007

Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen.

Am J Physiol Heart Circ Physiol 2007 Mar 3;292(3):H1412-9. Epub 2006 Nov 3.

Hypertension & Vascular Disease Center, Wake Forest Univ School of Medicine, Winston-Salem, NC 27157-1032, USA.

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http://dx.doi.org/10.1152/ajpheart.00984.2006DOI Listing
March 2007

Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II.

Am J Physiol Renal Physiol 2007 Jan 8;292(1):F82-91. Epub 2006 Aug 8.

Department of Obstetrics and Gynecology, Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1095, USA.

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http://dx.doi.org/10.1152/ajprenal.00139.2006DOI Listing
January 2007

Adventitial neuronal somata.

J Vasc Res 2006 20;43(3):278-88. Epub 2006 Apr 20.

Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA.

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http://dx.doi.org/10.1159/000092765DOI Listing
December 2006

Approaches to establishing angiotensin II as a neurotransmitter revisited.

Authors:
Debra I Diz

Hypertension 2006 Mar 30;47(3):334-6. Epub 2006 Jan 30.

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http://dx.doi.org/10.1161/01.HYP.0000203146.72879.c3DOI Listing
March 2006

Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat.

Am J Physiol Renal Physiol 2006 Jun 10;290(6):F1497-506. Epub 2006 Jan 10.

Hypertension and Vascular Disease Ctr., Wake Forest Univ. Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157-1095, USA.

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http://dx.doi.org/10.1152/ajprenal.00317.2005DOI Listing
June 2006

Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain.

Hypertension 2006 Feb 27;47(2):230-7. Epub 2005 Dec 27.

Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA.

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http://dx.doi.org/10.1161/01.HYP.0000200259.01947.bbDOI Listing
February 2006

Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects.

Int J Radiat Oncol Biol Phys 2006 Jan;64(1):6-12

Department of Radiation Oncology, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2005.08.033DOI Listing
January 2006

Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems.

Physiol Genomics 2005 Nov 30;23(3):311-7. Epub 2005 Aug 30.

Hypertension and Vascular Disease Center, Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00163.2005DOI Listing
November 2005

Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii.

Hypertension 2005 Aug 11;46(2):333-40. Epub 2005 Jul 11.

The Hypertension and Vascular Disease Center, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.

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August 2005