Debra Crumrine

Debra Crumrine

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Debra Crumrine

Publications by authors named "Debra Crumrine"

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Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols.

Sci Rep 2019 Sep 13;9(1):13254. Epub 2019 Sep 13.

Division of Nephrology, Washington University School of Medicine, 4523 Clayton Ave., St. Louis, MO, 63110, United States.

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http://dx.doi.org/10.1038/s41598-019-49684-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744566PMC
September 2019

Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses.

J Invest Dermatol 2019 Jul 2. Epub 2019 Jul 2.

Department of Pediatrics, University of Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.06.134DOI Listing
July 2019

Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope.

J Invest Dermatol 2019 Apr 22;139(4):760-768. Epub 2018 Nov 22.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California, USA; Department of Dermatology, University of California-San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.005DOI Listing
April 2019

Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines.

Am J Pathol 2018 06 13;188(6):1419-1429. Epub 2018 Mar 13.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California; Department of Dermatology, University of California, San Francisco, San Francisco, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971224PMC
June 2018

Embryonic AP1 Transcription Factor Deficiency Causes a Collodion Baby-Like Phenotype.

J Invest Dermatol 2017 09 16;137(9):1868-1877. Epub 2017 May 16.

Departments of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.jid.2017.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572120PMC
September 2017

Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.

Int J Clin Exp Pathol 2015 1;8(4):3529-42. Epub 2015 Apr 1.

Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China ; Endocsrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, CA 94121, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466923PMC
April 2017

Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification.

J Invest Dermatol 2017 04 23;137(4):845-854. Epub 2016 Dec 23.

MRC Laboratory for Molecular Cell Biology, University College London, London, UK; Institute of Child Health, University College London, London, UK; Inherited Metabolic Diseases Unit, Great Ormond Street Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358661PMC
April 2017

Endoplasmic Reticulum Calcium Regulates Epidermal Barrier Response and Desmosomal Structure.

J Invest Dermatol 2016 09 31;136(9):1840-1847. Epub 2016 May 31.

Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070468PMC
http://dx.doi.org/10.1016/j.jid.2016.05.100DOI Listing
September 2016

Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.

Hum Mol Genet 2016 Jan 24;25(2):348-57. Epub 2015 Nov 24.

Department of Genetics, Department of Dermatology and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA,

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http://dx.doi.org/10.1093/hmg/ddv481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706118PMC
January 2016

Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin.

J Allergy Clin Immunol 2015 Nov 12;136(5):1268-76. Epub 2015 Jun 12.

Clinical Medicine, Trinity College Dublin, Dublin, Ireland; Pediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649901PMC
November 2015

Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F.

FEBS Lett 2015 Jul 9;589(15):1904-10. Epub 2015 Jun 9.

LIMES (Life and Medical Science Institute), Molecular Genetics, University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741282PMC
July 2015

Cellular basis of secondary infections and impaired desquamation in certain inherited ichthyoses.

JAMA Dermatol 2015 Mar;151(3):285-92

Dermatology Service, Department of Veterans Affairs Medical Center, University of California, San Francisco2Department of Dermatology, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamadermatol.2014.3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498571PMC
March 2015

Basis for enhanced barrier function of pigmented skin.

J Invest Dermatol 2014 Sep 14;134(9):2399-2407. Epub 2014 Apr 14.

Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, California, USA; Department of Dermatology, University of California, San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134407PMC
September 2014

Formation and functions of the corneocyte lipid envelope (CLE).

Biochim Biophys Acta 2014 Mar 27;1841(3):314-8. Epub 2013 Sep 27.

Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.bbalip.2013.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943821PMC
March 2014

Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.

J Invest Dermatol 2013 Feb 27;133(2):469-78. Epub 2012 Sep 27.

Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/jid.2012.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532566PMC
February 2013

The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis.

Exp Dermatol 2013 Jan 22;22(1):30-5. Epub 2012 Nov 22.

Department of Dermatology, Faculty of Medicine, Oita University, Yufu-shi, Oita, Japan.

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http://dx.doi.org/10.1111/exd.12047DOI Listing
January 2013

Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.

J Invest Dermatol 2012 Oct 24;132(10):2350-2359. Epub 2012 May 24.

Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535488
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http://dx.doi.org/10.1038/jid.2012.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434298PMC
October 2012

Cellular changes that accompany shedding of human corneocytes.

J Invest Dermatol 2012 Oct 28;132(10):2430-2439. Epub 2012 Jun 28.

Department of Veterans Affairs Medical Center and Department of Dermatology, Dermatology Service, University of California, San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447115PMC
October 2012

Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications.

Mol Genet Metab 2011 Dec 16;104(4):631-6. Epub 2011 Sep 16.

Department of Dermatology, VA Medical Center & University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.ymgme.2011.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224209PMC
December 2011

Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.

J Invest Dermatol 2011 Sep 2;131(9):1845-52. Epub 2011 Jun 2.

Department of Dermatology, Faculty of Medicine, Oita University, Yufu-shi, Oita, Japan.

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http://dx.doi.org/10.1038/jid.2011.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156961PMC
September 2011

Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.

J Biol Chem 2011 Jul 10;286(27):24046-56. Epub 2011 May 10.

Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M111.251496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129186PMC
July 2011

Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders.

Dermatoendocrinol 2011 Apr 1;3(2):100-6. Epub 2011 Apr 1.

Dermatology Service; Department of Veterans Affairs Medical Center and Dermatology; University of California, San Francisco; San Francisco, CA USA.

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http://dx.doi.org/10.4161/derm.3.2.14831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117009PMC
April 2011

Inherited clinical disorders of lipid metabolism.

Curr Probl Dermatol 2010 14;39:30-88. Epub 2010 Sep 14.

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http://dx.doi.org/10.1159/000321084DOI Listing
January 2011

Inherited disorders of accelerated desquamation.

Curr Probl Dermatol 2010 14;39:89-97. Epub 2010 Sep 14.

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http://dx.doi.org/10.1159/000321085DOI Listing
January 2011

Inherited disorders of corneocyte proteins.

Curr Probl Dermatol 2010 14;39:98-131. Epub 2010 Sep 14.

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http://dx.doi.org/10.1159/000321086DOI Listing
January 2011

Appendix 1: ultrastructural and histochemical methods.

Authors:
Debra Crumrine

Curr Probl Dermatol 2010 14;39:132-6. Epub 2010 Sep 14.

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http://dx.doi.org/10.1159/000321087DOI Listing
January 2011

Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.

Arch Dermatol Res 2010 Aug 5;302(6):443-51. Epub 2010 Jan 5.

Department of Pediatrics, University of Nebraska Medical Center, 985456 Nebraska Medical Center, Omaha, NE 68198-5456, USA.

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http://dx.doi.org/10.1007/s00403-009-1022-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892059PMC
August 2010

PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation.

J Invest Dermatol 2010 Feb 13;130(2):511-9. Epub 2009 Aug 13.

Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153469
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http://dx.doi.org/10.1038/jid.2009.245DOI Listing
February 2010

pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.

J Invest Dermatol 2009 Jul 29;129(7):1719-29. Epub 2009 Jan 29.

Department of Dermatology, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/jid.2008.442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695842PMC
July 2009

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

J Invest Dermatol 2009 Jul 29;129(7):1824-35. Epub 2009 Jan 29.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/jid.2008.444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695850PMC
July 2009

IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development.

J Dermatol Sci 2009 May 11;54(2):88-98. Epub 2009 Feb 11.

Metabolism Section, Veterans Affairs Medical Center, and Departments of Dermatology and Medicine, University of California at San Francisco, United States.

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http://dx.doi.org/10.1016/j.jdermsci.2009.01.001DOI Listing
May 2009

The "caveolae brake hypothesis" and the epidermal barrier.

J Invest Dermatol 2009 Apr 13;129(4):927-36. Epub 2008 Nov 13.

Department of Dermatology, Free University of Brussels, Brussels, Belgium.

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http://dx.doi.org/10.1038/jid.2008.328DOI Listing
April 2009

Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.

J Invest Dermatol 2009 Feb 14;129(2):365-74. Epub 2008 Aug 14.

Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/jid.2008.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548956PMC
February 2009

Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.

J Invest Dermatol 2008 Apr 18;128(4):917-25. Epub 2007 Oct 18.

Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1038/sj.jid.5701099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671223PMC
April 2008

Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.

J Invest Dermatol 2008 Feb 23;128(2):370-7. Epub 2007 Aug 23.

Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/sj.jid.5701026DOI Listing
February 2008

Stratum corneum acidification is impaired in moderately aged human and murine skin.

J Invest Dermatol 2007 Dec 7;127(12):2847-56. Epub 2007 Jun 7.

Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran's Administration Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/sj.jid.5700913DOI Listing
December 2007

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease.

Nephrol Dial Transplant 2007 Nov 25;22(11):3268-72. Epub 2007 Jun 25.

Department of Dermatology, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, North Carolina, 27157, USA.

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http://ndt.oxfordjournals.org/content/22/11/3268.full.pdf
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http://ndt.oxfordjournals.org/cgi/doi/10.1093/ndt/gfm375
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http://dx.doi.org/10.1093/ndt/gfm375DOI Listing
November 2007

Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation.

J Biol Chem 2007 May 12;282(18):13211-9. Epub 2007 Mar 12.

Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1074/jbc.M611562200DOI Listing
May 2007

Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function.

Am J Physiol Regul Integr Comp Physiol 2006 Dec 20;291(6):R1657-62. Epub 2006 Jul 20.

Dermatology and Medical Services (Metabolism Section), Veteran Affairs Medical Center, 111F 4150 Clement St., San Francisco, CA 94121, USA.

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http://www.physiology.org/doi/10.1152/ajpregu.00010.2006
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http://dx.doi.org/10.1152/ajpregu.00010.2006DOI Listing
December 2006

Serine protease signaling of epidermal permeability barrier homeostasis.

J Invest Dermatol 2006 Sep 11;126(9):2074-86. Epub 2006 May 11.

Department of Dermatology and Medical Services (Metabolism), VA Medical Center, San Francisco, California, USA.

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http://dx.doi.org/10.1038/sj.jid.5700351DOI Listing
September 2006

Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome).

J Invest Dermatol 2006 Sep 1;126(9):2032-8. Epub 2006 Jun 1.

Department of Dermatology, University of California San Francisco, USA.

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http://dx.doi.org/10.1038/sj.jid.5700332DOI Listing
September 2006

Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis.

J Invest Dermatol 2006 Jun;126(6):1356-65

Department of Medicine, University of California San Francisco and VA Medical Center, San Francisco, California, USA. lilly.bourguignon.ucsf.edu

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http://dx.doi.org/10.1038/sj.jid.5700260DOI Listing
June 2006

Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate.

J Invest Dermatol 2005 Dec;125(6):1206-14

Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1532584
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http://dx.doi.org/10.1111/j.0022-202X.2005.23964.xDOI Listing
December 2005

Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity.

Arch Dermatol Res 2005 Sep 29;297(3):127-33. Epub 2005 Sep 29.

Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616-8588, USA.

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http://dx.doi.org/10.1007/s00403-005-0591-7DOI Listing
September 2005

Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity.

J Invest Dermatol 2005 Mar;124(3):587-95

Dermatology and Medical Services (Metabolism), VA Medical Center San Francisco, San Francisco, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1532217
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http://dx.doi.org/10.1111/j.0022-202X.2005.23589.xDOI Listing
March 2005

Functional consequences of a neutral pH in neonatal rat stratum corneum.

J Invest Dermatol 2004 Jul;123(1):140-51

Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1111/j.0022-202X.2004.22726.xDOI Listing
July 2004

Pathophysiologic basis for growth failure in children with ichthyosis: an evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure.

J Pediatr 2004 Jul;145(1):82-92

Department of Dermatolog, University of California San Francisco, and the Department of Veterans Affairs Medical Center, San Francisco, 94143, USA.

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http://dx.doi.org/10.1016/j.jpeds.2004.03.052DOI Listing
July 2004

Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.

J Invest Dermatol 2004 Feb;122(2):314-9

Department of Dermatology, University of California, San Francisco and Dermatology and Medical Services, VAMC, San Francisco, 94143, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2003.22258.xDOI Listing
February 2004

pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.

J Invest Dermatol 2003 Aug;121(2):345-53

University of California San Francisco Medical Center, Department of Dermatology, San Francisco, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1530367
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http://dx.doi.org/10.1046/j.1523-1747.2003.12365.xDOI Listing
August 2003

Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.

J Invest Dermatol 2003 May;120(5):728-37

Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12134.xDOI Listing
May 2003

Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.

J Invest Dermatol 2003 Mar;120(3):456-64

Dermatology and Medical Services (Metabolism), VA Medical Center San Francisco and Department of Dermatology, University of California San Francisco, San Francisco, California, U.S.A.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12053.xDOI Listing
March 2003

NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging.

J Biol Chem 2002 Dec 7;277(49):47399-406. Epub 2002 Sep 7.

Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1074/jbc.M204759200DOI Listing
December 2002

Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms.

J Invest Dermatol 2002 Dec;119(6):1269-74

Dermatology and Medical Services, Veterans Administration Medical Center and Departments of Dermatology and Medicine, University of California School of Medicine, San Francisco, CA 94121, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1530083
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http://dx.doi.org/10.1046/j.1523-1747.2002.19622.xDOI Listing
December 2002

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero.

J Invest Dermatol 2002 Dec;119(6):1298-303

Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2002.19605.xDOI Listing
December 2002

Modulations in epidermal calcium regulate the expression of differentiation-specific markers.

J Invest Dermatol 2002 Nov;119(5):1128-36

Dermatology and Medical Services, Veterans Administration Medical Center, University of California School of Medicine, San Francisco 94121, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2002.19512.xDOI Listing
November 2002

Basis for the permeability barrier abnormality in lamellar ichthyosis.

Exp Dermatol 2002 Jun;11(3):248-56

Dermatology Service & Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA.

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June 2002