Dr Debprasad , Ph.D. - ICMR-Virus Unit - Scientist

Dr Debprasad

Ph.D.

ICMR-Virus Unit

Scientist

Kolkata, West Bengal | India

Main Specialties: Infectious Disease, Medical Toxicology, Pharmacology

Additional Specialties: Ethnopharmacology, Virology, Microbiology, Molecular Medicine

ORCID logohttps://orcid.org/0000-0002-7999-329X


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Dr Debprasad , Ph.D. - ICMR-Virus Unit - Scientist

Dr Debprasad

Ph.D.

Introduction

D. Chattopadhyay obtained his PhD from Jadavpur University in 1989 after MSc in Botany with Microbiology. He moved to London Hospital Medical College and then to Staten Serum Institute, Copenhagen for Post-Doc (1990-1992). Returning India he joined IICB as Sr Research Associate. In early 1993 he was offered a faculty position in a US University, but joined the RMRC (Regional Medical Research Centre) Port Blair as Research Officer to initiate work on validation of Traditional Ethnic Medicine of India. In 1997 he was transferred to the ICMR-Virus Unit Kolkata. In Aug 2016 he was selected as the Director of RMRC (National Institute of Traditional Medicine) Belgaum.

Dr Chattopadhyay initiate the scientific validation of Traditional Health care Practices of ethnic marginalized communities of Bay Islands India, by establishing personal contact with diverse tribes to unveil their knowledge (used the term “Ethnomedicine”). He has worked with tribes of Bay Islands, Gujrat, Jharkhand, Maharashtra, Rajasthan and West Bengal. In quest for identifying natural lead against difficult-to-treat diseases he conducted surveys on health-care practices of those tribes and scientifically validate the use of their age-old medicaments, safety, efficacy and mechanism at molecular level to translate traditional 'information into medical innovation'.

His group has documented and validated various traditional preparations demonstrating: (i) Anti-typhoid activity of a traditional formulation, (ii) wound-healing and anti-inflammatory activities; (iii) Isolated a compound that help to eliminate mycobacteria by enhancing immune responses in TB-infected mice; (iv) Sperm motility-inhibiting ability of an ethnomedicine; (v) Wound healing and anti-inflammatory activity of a folk-remedy; (vi) Antibacterial, antiinflammatory and related activities of two tribal medicines; (vii) Screened and validated four folk-medicines with isolation of active compounds against HSV. Isolated a pure alkaloid from one such medicament with potent anti-HSV activity and molecular mechanism of action in infected animal; (viii) Anti-inflammatory mechanism of a phyto-formulation from Andaman Islands and a traditional medicine of Jangalmohal, West Bengal; (ix) Iron-chelation, antioxidative and hepatoprotective activity of a Nutraceutical in iron-overloaded mice; useful to remove excess iron in Thalassemia; (x) A pheno-thiazine drug able to reverse antibiotic resistance in selected drug-resistant bacteria by altering membrane permeability.

He has also contributed in survey of major viral diseases to generate base-line information on prevalence of (i) Herpes Simplex, Human Immunodeficiency, Hepatitis B and Hepatitis C Viruses in seven Correctional Homes of West Bengal; (ii) among Antenatal mothers; and (iii) Dermatological Clinic Attendees of Calcutta Medical College Hospital; (iv) Role of Hepatitis E Virus in liver diseases; and (v) Japanese Encephalitis among children’s.

Several collaborative studies by his group revealed that: (i) An early secreted Antigen (ESAT-6) can promote robust immune responses by immuno-modulation in TB-infected mice; (ii) Anti-inflammatory potential of an analog by blocking pro-inflammatory cytokines; (iii) Management of oxidative stress by Coconut water; (iv) Ability of L-arginine to modulate host immunity in mice infected with falciparum malaria; (v) Redundant and regulatory role of TLRs, and its silencing to control Kala-azar; (vi) Designed an anti-HSV analog from natural compounds; (vii) Developed a synthetic anti-HSV agent; (viii) Designed chemosensor fluorescent probe for cell imaging, ATP, and Al+sensing in body fluid/ aqueous medium, that help to detect risk factor of water pollution and neuro-degenerative diseases; (ix) Identified early diagnostic marker of oral cancer.

Till date he has published 126 research papers in reputed peer-reviewed academic Journal, with 14 Chapters, 4 Books (Impact: 377.7; Citation 2744; h-index 30; i10-index 60). Out of Seven Patents, four technologies are ready to transfer for clinical trial and two commercial farms has applied for trial. Moreover, he has published 57 popular science articles in well-known social Journals and newspapers. Co-editor of “New Look to Phytomedicine” (Academic Press) contributing three Chapters; (ii) Implemented several Task-force Extramural Projects funded by DST, DBT, ICMR etc; (iii) Delivered Plenary Lecture and Chaired Session in several National and International Conferences; (iv) Guest Editor and Editorial Board Member of several reputed peer-reviewed International Journals; and (v) Examiner, paper setter, Research Guide and Guest Faculty of reputed Universities.

Primary Affiliation: ICMR-Virus Unit - Kolkata, West Bengal , India

Specialties:

Additional Specialties:

Research Interests:


View Dr Debprasad ’s Resume / CV

Education

Jan 1984 - Jan 1989
Jadavpur University
Ph.D.
Department of Pharmaceutical Technology
Jan 1981 - Jan 1983
University of Burdwan
M.Sc.
Department of Botany
Jan 1977 - Jan 1979
Vidyasagar College
B.Sc.
Department of Botany

Experience

Publications

114Publications

908Reads

8Profile Views

173PubMed Central Citations

Diet and nutrition: An important risk factor in leprosy.

Microb Pathog 2019 Sep 4;137:103714. Epub 2019 Sep 4.

ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, India; ICMR-Virus Unit, ID & BG Hospital, General Block 4, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata, 700010, India. Electronic address:

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http://dx.doi.org/10.1016/j.micpath.2019.103714DOI Listing
September 2019
2.000 Impact Factor

Innate immune response in astrocytes infected with herpes simplex virus 1

Archives of Virology https://doi.org/10.1007/s00705-019-04197-x

Archives of Virology


Herpes simplex virus 1 (HSV-1), a double-stranded DNA virus, infects epithelial surfaces and establishes latency in the central nervous system, where astrocytes are a major immune cell type. Here, we report changes that occur in the expression of pathogen recognition receptors, such as Toll-like receptors, DNA and RNA sensors, interferons, and interferon-stimulated genes, when astrocytes are infected with HSV-1 strain F. We observed upregulation of Toll-like receptors 2, 6 and 9, MDA5, and DAI along with an increase in the expression of type I interferons and interferon-stimulated genes such as IFIT1, IFIT3 and RNase L. These genes encode proteins that mediate the antiviral immune response.

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May 2019

A Phenyl Thioether-Based Probe: Zn2+ Ion Sensor, Structure Determination and Live Cell Imaging

Chem select 2019: 4: 4472-4477

Chemistry Select

3,3’-((1Z,1’Z)-(((Propane-1,3-diylbis(sulfanediyl))bis(2,1-phenylene)) bis(azanyyldiene))bis(methanylylidene))bis(2-hydroxy-5-methylbenzaldehyde) (H2-SAP), characterized by different spectroscopic data, exhibits yellow emission (λem, 560 nm) when binds with Zn2+ in H2O-MeOH (1:9 v/v, HEPES buffer, pH 7.4) in a mixture of seventeen biologically important other metal ions. The limit of detection (LOD) is 9.0 nM which is far below the World Health Organization (WHO) recommended data. The composition of the complex, 1:1 Zn2+:SAP2

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May 2019
2 Reads

Fluorescein derived Schiff base as fluorimetric zinc (II) sensor via 'turn on' response and its application in live cell imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 2;212:222-231. Epub 2019 Jan 2.

Department of Chemistry, Tamralipta Mahavidyalaya, Purba Medinipur, West Bengal 721636, India. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2018.12.053DOI Listing
April 2019
1 Read
2.353 Impact Factor

Phytochemical Bergenin as an Adjunct Immunotherapy for Tuberculosis.

J Biol Chem 2019 Apr 11; jbc.RA119.008005

Journal of Biological Chemistry

ABSTRACT

The widespread availability and use of modern synthetic therapeutic agents have led to a massive decline in ethnomedical therapies. However, these synthetic agents often possess toxicity leading to various adverse effects. For instance, antitubercular treatment (ATT) is toxic, lengthy, and severely impairs host immunity, resulting in post treatment vulnerability to reinfection and reactivation of tuberculosis (TB). Incomplete ATT enhances the risk for the generation of multidrug- or extensively drug-resistant (MDR or XDR, respectively) variants of Mycobacterium tuberculosis (M.tb), the TB-causing microbe. Therefore, a new therapeutic approach that minimizes these risks is urgently needed to combat this deadly disease and prevent future TB epidemics. Previously, we have shown that the phytochemical bergenin induces T helper 1 (Th1)- and Th17 cell–based protective immune responses and potently inhibits mycobacterial growth in a murine model of M.tb infection, suggesting bergenin as a potential adjunct agent to TB therapy. Here, we combined ATT therapy with bergenin and found that this combination reduces immune impairment and the length of treatment in mice. We observed that co-treatment with the anti-TM drug isoniazid and bergenin produces additive effects and significantly reduces bacterial loads compared with isoniazid treatment alone. The bergenin co-treatment also reduced isoniazid-induced immune impairment, promoted long-lasting, antigen-specific central memory T-cell responses, and acted as a self-propelled vaccine. Of note, bergenin treatment significantly reduced the bacterial burden of an MDR TB strain. These observations suggest that bergenin is a potent immunomodulatory agent that could be further explored as a potential adjunct to TB therapy.

JBC Papers in Press. Published on April 11, 2019 as Manuscript RA119.008005

The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.RA119.008005

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April 2019
2 Reads

An azine-based carbothioamide chemosensor for selective and sensitive turn-on-off sequential detection of Zn(II) and HPO, live cell imaging and INHIBIT logic gate.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jan 11;207:164-172. Epub 2018 Sep 11.

Department of Chemistry, Jadavpur University, Kolkata 700 032, India. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2018.09.019DOI Listing
January 2019
8 Reads
2.353 Impact Factor

Inbred mouse strains differentially susceptible to Leishmania donovani infection differ in their immune cell metabolism.

Cytokine 2018 12 6;112:12-15. Epub 2018 Jun 6.

Jagadis Bose National Science Talent Search (JBNSTS), Kolkata 700010, India. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.06.003DOI Listing
December 2018
14 Reads
2.664 Impact Factor

Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling.

Phytomedicine 2018 Dec 16;51:94-103. Epub 2018 Oct 16.

ICMR Virus Unit, ID and BG Hospital, General Block 4, 57 Dr. Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India.. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.10.016DOI Listing
December 2018
21 Reads
3.126 Impact Factor

Highly monodispersed gold nanoparticles synthesis and inhibition of herpes simplex virus infections.

Mater Sci Eng C Mater Biol Appl 2018 Aug 5;89:413-421. Epub 2018 Apr 5.

Department of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, West Bengal, India; School of Pharmaceutical Technology, Adamas University, Barasat-Barrackpore Road, Jagannathpur, North 24 Parganas, Kolkata 700 126, West Bengal, India. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2018.04.005DOI Listing
August 2018
6 Reads
3.090 Impact Factor

DAMP-TLR-cytokine axis dictates the fate of tumor.

Cytokine 2018 04 9;104:114-123. Epub 2017 Oct 9.

National Institute of Traditional Medicine, Belagavi, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2017.10.004DOI Listing
April 2018
17 Reads
1 Citation
2.664 Impact Factor

TLR11 or TLR12 silencing reduces Leishmania major infection.

Cytokine 2018 04 7;104:110-113. Epub 2017 Oct 7.

National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2017.10.005DOI Listing
April 2018
13 Reads
2.664 Impact Factor

A visible light excitable chromone appended hydrazide chemosensor for sequential sensing of Al+3 and F− in aqueous medium and in Vero cells

Sensors and Actuators B: Chemical 257: 545-552

Sensors and Actuators B: Chemical

A probe, quinoline-2-carboxylic acid (4-oxo-4H-chromen-3-ylmethylene)-hydrazide, (HL), acts as selective and specific fluorogenic sensor to Al+3 in the visible light (435 nm) excitation in presence of biologically available large number of cations and emission appears at (em) 520 nm. The limit of detection (LOD) for Al+3 is 7.6 nM in aqueous medium which is less than 10−3 times of WHO recommended data (7.41 mM). The Job’s plot and mass spectral data support 1:1 composition of the complex [Al(HL)(OH)H2O](NO3)2. The strongly emissive complex turns off upon addition of F− and is detected at the level of (LOD) 7.4 nM. Thus, F−, a harmful water pollutant, could be identified at much lower level of WHO recommended toxic limit (3.68 M). The absorption and emission spectral features of HL and its Al+3-complex have been explained by DFT computation of optimized geometries and calculation of molecular functions. The devised receptor is non-toxic and has been used in detecting Al+3 in the intracellular region of African green monkey kidney cells (Vero cells) and exhibits an INHIBIT logic gate with Al+3 and F− as chemical inputs by monitoring the emission mode at 520 nm.

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April 2018
56 Reads

Validation of a traditional preparation against multi-drug resistant Salmonella Typhi and its protective efficacy in S. Typhimurium infected mice.

Biomed Pharmacother 2018 Mar;99:286-289

National Institutes of Cholera and Enteric Diseases, Beliaghata, Kolkata 700010, India. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.01.057DOI Listing
March 2018
17 Reads
1 Citation
2.023 Impact Factor

Liaison between heme metabolism and bioenergetics pathways-a multimodal elucidation for early diagnosis of oral cancer.

Photodiagnosis Photodyn Ther 2018 Mar 4;21:263-274. Epub 2018 Jan 4.

Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology Shibpur, Howrah, 711103, India. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2018.01.002DOI Listing
March 2018
12 Reads
2.014 Impact Factor

Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice.

Biomed Pharmacother 2017 Mar 6;87:443-450. Epub 2017 Jan 6.

ICMR Virus Unit, ID & BG Hospital, GB-4, First Floor, 57 Dr Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India; Regional Medical Research Centre (ICMR), Nehru Nagar, Belagavi, Karnataka 590010, India. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2016.12.125DOI Listing
March 2017
9 Reads
2.023 Impact Factor

Pedilanthus tithymaloides Inhibits HSV Infection by Modulating NF-κB Signaling.

PLoS One 2015 25;10(9):e0139338. Epub 2015 Sep 25.

ICMR Virus Unit, ID and BG Hospital, General Block 4, 57 Dr Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583282PMC
June 2016
20 Reads
3.234 Impact Factor

Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis.

Adv Virol 2015 19;2015:537939. Epub 2015 Oct 19.

Department of Microbiology, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1155/2015/537939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628955PMC
November 2015
24 Reads
1 Citation

Protective effect of coconut water concentrate and its active component shikimic acid against hydroperoxide mediated oxidative stress through suppression of NF-κB and activation of Nrf2 pathway.

J Ethnopharmacol 2014 Aug 14;155(1):132-46. Epub 2014 May 14.

ICMR Virus Unit, ID & BG Hospital, GB-4, First Floor, 57 Dr. Suresh C Banerjee Road, Beliaghata, Kolkata 700010, West Bengal, India.

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http://dx.doi.org/10.1016/j.jep.2014.04.046DOI Listing
August 2014
22 Reads
3 Citations
3.000 Impact Factor

Prevalence of hepatitis E virus infection in West Bengal, India: a hospital-based study.

J Med Microbiol 2014 Jul 12;63(Pt 7):975-80. Epub 2014 May 12.

ICMR Virus Unit, ID & BG Hospital, Kolkata, West Bengal, India

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http://dx.doi.org/10.1099/jmm.0.072249-0DOI Listing
July 2014
5 Reads
1 Citation
2.250 Impact Factor

A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events.

Antiviral Res 2014 May 25;105:126-34. Epub 2014 Feb 25.

ICMR Virus Unit, ID and BG Hospital, General Block 4, 57 Dr. Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2014.02.007DOI Listing
May 2014
42 Reads
4 Citations
3.940 Impact Factor

Medicinal plants in the prevention and treatment of chronic diseases 2013.

Evid Based Complement Alternat Med 2014 26;2014:180981. Epub 2014 Mar 26.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

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http://dx.doi.org/10.1155/2014/180981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984767PMC
May 2014
7 Reads
1 Citation
1.880 Impact Factor

Evaluation of the wound healing activity of Shorea robusta, an Indian ethnomedicine, and its isolated constituent(s) in topical formulation.

J Ethnopharmacol 2013 Aug 6;149(1):335-43. Epub 2013 Jul 6.

ICMR Virus Unit, ID & BG Hospital, GB-4, First Floor, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata-700010, West Bengal, India.

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http://dx.doi.org/10.1016/j.jep.2013.06.045DOI Listing
August 2013
24 Reads
4 Citations
3.000 Impact Factor

Evaluation of an ethnomedicinal combination containing Semecarpus kurzii and Hernandia peltata used for the management of inflammation.

Pharm Biol 2013 Jun 25;51(6):677-85. Epub 2013 Mar 25.

Directorate of Seed Research, Kushmaur, Maunath Bhanjan, Uttar Pradesh, India.

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http://dx.doi.org/10.3109/13880209.2012.762405DOI Listing
June 2013
27 Reads
1.340 Impact Factor

Anti-herpes virus activities of Achyranthes aspera: an indian ethnomedicine, and its triterpene acid.

Microbiol Res 2013 May 5;168(4):238-44. Epub 2012 Dec 5.

ICMR Virus Unit, ID & BG Hospital, GB-4, First Floor, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata 700 010, India.

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http://dx.doi.org/10.1016/j.micres.2012.11.002DOI Listing
May 2013
8 Reads
7 Citations
2.561 Impact Factor

Exploring the anti-inflammatory activity of a novel 2-phenylquinazoline analog with protection against inflammatory injury.

Toxicol Appl Pharmacol 2012 Oct 7;264(2):182-91. Epub 2012 Aug 7.

Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata-700032, West Bengal, India.

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http://dx.doi.org/10.1016/j.taap.2012.07.032DOI Listing
October 2012
8 Reads
1 Citation
3.705 Impact Factor

Medicinal plants in the prevention and treatment of chronic diseases.

Evid Based Complement Alternat Med 2012 18;2012:458274. Epub 2012 Sep 18.

Moulay Ismail Unversity, BP 21, Errachidia 52000, Morocco.

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http://dx.doi.org/10.1155/2012/458274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457723PMC
October 2012
13 Reads
1 Citation
1.880 Impact Factor

Animal models as tools to investigate antidiabetic and anti-inflammatory plants.

Evid Based Complement Alternat Med 2012 29;2012:142087. Epub 2012 Jul 29.

Moulay Ismail University, BP 21, Errachidia 52000, Morocco.

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http://dx.doi.org/10.1155/2012/142087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414199PMC
September 2012
8 Reads
18 Citations
1.880 Impact Factor

Mycobacterium tuberculosis directs T helper 2 cell differentiation by inducing interleukin-1β production in dendritic cells.

J Biol Chem 2012 Sep 18;287(40):33656-63. Epub 2012 Jul 18.

International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India.

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http://dx.doi.org/10.1074/jbc.M112.375154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460463PMC
September 2012
13 Reads
12 Citations
4.573 Impact Factor

Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation.

J Ethnopharmacol 2012 Aug 7;142(3):714-22. Epub 2012 Jun 7.

Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.

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http://dx.doi.org/10.1016/j.jep.2012.05.048DOI Listing
August 2012
26 Reads
9 Citations
3.000 Impact Factor

Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity.

Evid Based Complement Alternat Med 2012 10;2012:254849. Epub 2012 May 10.

ICMR Virus Unit, ID and BG Hospital, GB 4, First Floor, 57 Dr. Suresh C Banerjee Road, Beliaghata, Kolkata 700010, India.

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http://www.hindawi.com/journals/ecam/2012/254849/
Publisher Site
http://dx.doi.org/10.1155/2012/254849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358043PMC
August 2012
12 Reads
4 Citations
1.880 Impact Factor

Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands.

Virol J 2012 May 24;9:98. Epub 2012 May 24.

ICMR Virus Unit, ID & BG Hospital, General Block 4, First floor, 57 Dr Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India.

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http://dx.doi.org/10.1186/1743-422X-9-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430555PMC
May 2012
49 Reads
5 Citations
2.181 Impact Factor

Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.

PLoS Pathog 2011 Nov 10;7(11):e1002378. Epub 2011 Nov 10.

Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

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http://dx.doi.org/10.1371/journal.ppat.1002378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213116PMC
November 2011
47 Reads
56 Citations

Recent advancements for the evaluation of anti-viral activities of natural products.

N Biotechnol 2009 Jun 5;25(5):347-68. Epub 2009 Apr 5.

ICMR Virus Unit, I.D. & B.G. Hospital, GB-4, First Floor, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata 700010, India.

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http://dx.doi.org/10.1016/j.nbt.2009.03.007DOI Listing
June 2009
7 Reads
13 Citations
2.900 Impact Factor

Ethnomedicines and ethnomedicinal phytophores against herpesviruses.

Biotechnol Annu Rev 2008 ;14:297-348

ICMR Virus Unit, I.D. & B.G. Hospital Campus, Beliaghata, Kolkata 700 010, India.

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http://dx.doi.org/10.1016/S1387-2656(08)00012-4DOI Listing
October 2008
6 Reads
8 Citations

Antivirals of ethnomedicinal origin: structure-activity relationship and scope.

Mini Rev Med Chem 2007 Mar;7(3):275-301

ICMR Virus Unit, I.D. & B.G. Hospital Campus, GB 4, (East Wing, First Floor), 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata 700 010, India.

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March 2007
5 Reads
1 Citation
2.903 Impact Factor

Sperm motility inhibiting activity of a phytosterol from Alstonia macrophylla Wall ex A. DC. leaf extract: a tribal medicine.

Indian J Exp Biol 2005 Nov;43(11):1104-9

ICMR Virus Unit, Infectious Diseases & Beliaghata General Hospital, General Block 4, 1st Floor, 57 Dr. Suresh Chandra Banerjee Road, Kolkata 700 010, India.

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November 2005
11 Reads
0.840 Impact Factor

Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands.

J Pharm Pharm Sci 2005 Oct 6;8(3):558-64. Epub 2005 Oct 6.

ICMR Virus Unit, Infectious Diseases & Beliaghata General Hospital, Beliaghata, Kolkata.

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October 2005
7 Reads
1 Citation
1.681 Impact Factor

A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract.

Contraception 2005 May;71(5):372-8

ICMR Virus Unit, Infectious Diseases and Beliaghata General Hospital, Beliaghata, Kolkata 700010, India.

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https://linkinghub.elsevier.com/retrieve/pii/S00107824040030
Publisher Site
http://dx.doi.org/10.1016/j.contraception.2004.11.006DOI Listing
May 2005
6 Reads
3 Citations
2.340 Impact Factor

CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands.

Fitoterapia 2004 Dec;75(7-8):673-82

ICMR Virus Unit Calcutta, Infectious Diseases and Beliaghata General Hospital, GB 4, 1st Floor, 57, Dr Suresh Banerjee Road, Kolkata 700 010, India.

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http://dx.doi.org/10.1016/j.fitote.2004.08.002DOI Listing
December 2004
10 Reads
2.220 Impact Factor

CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge.

J Ethnopharmacol 2003 Mar;85(1):99-105

ICMR Virus Unit Calcutta, Infectious Diseases & Beliaghata General Hospital, GB 4, 1st Floor, 57 Dr. Suresh Chandra Banerjee Road, Kolkata 700 010, India.

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http://dx.doi.org/10.1016/s0378-8741(02)00379-3DOI Listing
March 2003
11 Reads
1 Citation
3.000 Impact Factor

Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.

J Ethnopharmacol 2002 Oct;82(2-3):229-37

ICMR Virus Unit Calcutta, I.D. and B.G. Hospital, GB 4, 57 Dr. Suresh Chandra Banerjee Road, Beliaghata, Kolkata, India.

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http://dx.doi.org/10.1016/s0378-8741(02)00165-4DOI Listing
October 2002
8 Reads
11 Citations
3.000 Impact Factor

[Ecological study of Ixodes ricinus (Linné, 1758) (Acarina, Ixodoides) in southeastern France].

Acta Trop 1975 ;32(3):232-58

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March 1976
2 Reads
2.270 Impact Factor

Review of drug treatment for Down's syndrome persons.

Authors:
J B Share

Am J Ment Defic 1976 Jan;80(4):388-93

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January 1976
10 Reads

Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp.

Am J Obstet Gynecol 1976 Jan;124(2):193-5

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http://dx.doi.org/10.1016/s0002-9378(16)33297-5DOI Listing
January 1976
21 Reads
4.704 Impact Factor

Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.

Authors:
K S Bose R H Sarma

Biochem Biophys Res Commun 1975 Oct;66(4):1173-9

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http://dx.doi.org/10.1016/0006-291x(75)90482-9DOI Listing
October 1975
44 Reads
2.297 Impact Factor

Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake.

Biochem Biophys Res Commun 1975 Oct;66(4):1338-43

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http://dx.doi.org/10.1016/0006-291x(75)90506-9DOI Listing
October 1975
17 Reads
2.297 Impact Factor

Acid-base balance in amphibian gastric mucosa.

Am J Physiol 1975 Sep;229(3):721-30

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http://dx.doi.org/10.1152/ajplegacy.1975.229.3.721DOI Listing
September 1975
122 Reads

Effect of pH on ionic exchange and function in rat and rabbit myocardium.

Am J Physiol 1975 Sep;229(3):570-81

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http://dx.doi.org/10.1152/ajplegacy.1975.229.3.570DOI Listing
September 1975
10 Reads

Studies on synergism between penicillin and bromodiphenhydramine hydrochloride

Indian Journal of Experimental Biology 28, 253-258

Indian Journal of Experimental Biology

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5 Reads

Antibacterial activity of local anesthetics procaine and lignocaine

Indian Journal of Medical Research 87: 506-508

Indian Journal of Medical Research

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10 Reads

Ethnomedicinal Phytophores in Disease Management.

Authors:
Chattopadhyay D

Vol 3 (Special Issue 1), 1-75. ISBN 978-4-903313-35-1

Internat J Biomedical & Pharmaceutical Sciences

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6 Reads

Ethnomedicines in Antiviral Drug Discovery

International J Biomedical Pharmaceutical Sciences 3(1): 1-25

International J Biomedical Pharmaceutical Sciences

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8 Reads

Antivirals of Ethnomedicinal origin: Structure activity relationship and scope

Mini Review in Medicinal Chemistry 7(3): 275-301

Mini Review in Medicinal Chemistry

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7 Reads

Advances in Phytomedicine: Ethnomedicine and Drug Discovery (Book Review)

Drug Discovery Today 8(10): 535

Drug Discovery Today

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8 Reads

Viruses, the acellular parasites of cellular hosts: Biology and Pathology with special reference to HIV

Indian J Sex Transmitted Dis & AIDS 20: 54-60

Indian J Sex Transmitted Dis & AIDS

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8 Reads

Antibacterial property of a phenothiazine and its synergism with aminoglycoside antibiotics

Journal of Chemotherapy Infectious Diseases & Malignancy Suppl 1: 154-157

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8 Reads

Anti-HSV activity and mode of action study of α-pyrone carboxamide

Royal Society of Chemistry Advances 4(33): 17354-17363

Royal Society of Chemistry Advances

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11 Reads

Scientific validation of antiviral potential of a tribal folklore: A drug development initiative

Authors:
Chattopadhyay D

J Antivirals & Antiretrovirals 6(2): 2

J Antivirals & Antiretrovirals

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6 Reads

Molecular comparison of HEV isolates from Sewage and Humans at Western India.

World Academy of Science, Engineering & Technology, International Science Index, Medical and Health

World Academy of Science, Engineering & Technology, International Science Index, Medical and Health Sciences 2(8): 436

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6 Reads

An efficient Vanillinyl Schiff base as a turn on fluorescent probe for Zinc (II) and Cell imaging

Royal Society of Chemistry Advances 5(61): 48997-49005

Royal Society of Chemistry Advances

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19 Reads

Role and Scope of ethnomedicinal plants in the development of Antivirals

Authors:
Chattopadhyay D

PharmacologyOnline Newsletter 3: 64-72

PharmacologyOnline Newsletter

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11 Reads

Iron-chelating property of Phytic acid in Thalassaemia: An in vitro study

British Biotechnology Journal 4(8): 858-864.

British Biotechnology Journal

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9 Reads

Editorial: Medicinal Plants in the Prevention and Treatment of Chronic Diseases 2013.

Evidence-Based Complementary and Alternative Medicine 2014, Article ID 180981, 3 pages

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7 Reads

Animal models as tools to investigate Antidiabetic and Antiinflammatory Plants

Evidence-Based Complementary & Alternative Medicine 2012, Article ID 142087

Evidence-Based Complementary & Alternative Medicine

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5 Reads

Medicinal Plants in the Prevention and Treatment of Chronic Diseases, Editorial.

Evidence-Based Complementary & Alternative Medicine 2012, Article ID 458274, 2 pages

Evidence-Based Complementary & Alternative Medicine

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6 Reads

Immuno-metabolic changes in herpes virus infection

Cytokines 2019 Mar; 112: 52-62

Cytokines


Recent evidences indicate that change in cellular metabolic pathways can alter immune response and function of the host; emphasizing the role of metabolome in health and diseases. Human Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) causes diseases from asymptomatic to highly prevalent oral and genital herpes, recurrent blisters or neurological complications. Immune responses against HSV are complex with delicate interplay between innate signaling pathways and adaptive immune responses. The innate response involves the induction of protective IFN-1; while Natural Killer (NK) cells and plasmacytoid Dendritic Cells (pDC) confer in vivo adaptive anti-HSV response along with humoral and cellular components in controlling infection and latency. Metabolic changes lead to up-/down-regulation of several cytokines and chemokines like IFN-γ, IL-2, IL-4, IL-10 and MIP1β in HSV infection and recurrences. Recently, the viral protein ICP0 has been identified as an attenuator of TLR signaling, that inhibit innate responses to HSV. This review will summarize the role of metabolome in innate and adaptive effectors in infection, pathogenesis and immune control of HSV, highlighting the delicate interplay between the metabolic changes and immunity

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November 0001
2 Reads

Water soluble sulfaguanidine based Schiff base as a “Turn-on” fluorescent probe for intracellular recognition of Zn2+ in living cells and exploration for biological activities

Polyhedron 2019 Mar 1:https://doi.org/10.1016/j.poly.2019.02.042

Polyhedron


(E)-N-(diaminomethylene)-4-(3,5-dichloro-2-hydroxybenzylideneamino)benzene (HL), a sulfaguanidine (SGN) appended Schiff base, acts as fluorescent ‘turn-on’ Zn2+ sensor in aqueous medium and limit of detection (LOD) is 37.13 nM which is much lower than the WHO recommended value (76 µM) in the drinking water. The composition of the complex has been supported by Job’s plot and mass spectral analysis. HL is weakly emissive which may be due to excited state induced proton transfer; however, binding with Zn2+ may stop this quenching and induce the chelation enhancement of fluorescence (CHEF) at 514 nm in presence of large number of biologically important cations. The complex shows much higher antibacterial efficiency than HL and sulfaguanidine (SGN) (MIC of SGN, >1000 μg/ml; HL, >1000 μg/ml and that of [ZnL2(H2O)] is 64 μg/ml for Escherichia coli). In living cells (African Monkey Vero Cells) the trace quantity of Zn2+ has been detected using the probe (HL). MTT assay confirms that the probe is non-toxic upto 200 μg/ml (774 µM). Both Density Functional Theory and molecular docking (PDB id, 5EVA) computation have been used to explain the electronic properties and to forecast the interaction of metal–ligand complex with target protein β-lactamase in bacterial cells.

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November -0001
2 Reads

Fluorescein derived Schiff base as fluorimetric zinc (II) sensor via ‘turn on’ response and its application in live cell imaging

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2019 Feb; 212: 222–231

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy


A novel Schiff base L composed of fluorescein hydrazine and a phenol functionalized moiety has been designed and prepared via cost-effective condensation reaction. The L is utilized for selective sensing of Zn2+ over other environmental and biological relevant metal ions in aqueous alcoholic solution under physiological pH range. The binding of Zn2+ to the receptor L is found to causes ~23 fold fluorescence enhancement of L. The 1:1  inding mode of the metal complex is established by combined UV–Vis, fluorescence, and HRMS (high-resolution mass spectroscopy) spectroscopic methods. The binding constant (Ka) for complexation and the limit of detection (LOD) of Zn2+ is calculated to be 2.86 × 104M−1 and 1.59 μM, respectively. Further photophysical investigations including steady-state, time-resolved fluorescence analysis and spectral investigations including NMR (nuclear magnetic resonance), IR (infrared spectroscopy) suggest introduction of CHEF (chelation enhance fluorescence) with the suppression of C_N isomerization and PET (photo-induced electron transfer)mechanism for the strong fluorescent response towards Zn2+. Finally, the sensor L is successfully employed to monitor a real-time detection of Zn2+ by means of TLC (thin layer chromatography) based paper strip. The L is used in the cell imaging study using African green monkey kidney cells (Vero cells) for the determination of exogenous Zn2+ by Immunofluorescence Assay (IFA) process.

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November -0001
2 Reads

Top co-authors

Durbadal Ojha
Durbadal Ojha

ID & BG Hospital

13
Hemanta Mukherjee
Hemanta Mukherjee

ID & BG Hospital

8
Asit B Mandal
Asit B Mandal

Infectious Diseases & Beliaghata General Hospital

7
Paromita Bag
Paromita Bag

ID and BG Hospital

7
Supriya Mondal
Supriya Mondal

Murshidabad Medical College

4
Gobardhan Das
Gobardhan Das

Robert Wood Johnson Medical School

4
Ved Prakash Dwivedi
Ved Prakash Dwivedi

National Institute of Plant Genome Research

4
Amalesh Samanta
Amalesh Samanta

Jadavpur University

4
Pulok K Mukherjee
Pulok K Mukherjee

Jadavpur University

3