Deborah V Novack

Deborah V Novack

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Deborah V Novack

Deborah V Novack

Publications by authors named "Deborah V Novack"

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Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.

Sci Rep 2017 07 26;7(1):6630. Epub 2017 Jul 26.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, United States.

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http://dx.doi.org/10.1038/s41598-017-07014-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529467PMC
July 2017

Inflammatory osteolysis: a conspiracy against bone.

J Clin Invest 2017 Jun 1;127(6):2030-2039. Epub 2017 Jun 1.

Department of Medicine, Division of Bone and Mineral Diseases, and.

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http://dx.doi.org/10.1172/JCI93356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451216PMC
June 2017

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy.

Sci Adv 2017 May 17;3(5):e1602168. Epub 2017 May 17.

Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1126/sciadv.1602168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435415PMC
May 2017

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Proc Natl Acad Sci U S A 2017 04 27;114(15):3957-3962. Epub 2017 Mar 27.

Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1619863114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393217PMC
April 2017

Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.

J Bone Miner Res 2017 01 14;32(1):188-195. Epub 2016 Oct 14.

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977397PMC
January 2017

Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus.

J Bone Miner Res 2016 09 9;31(9):1774-82. Epub 2016 May 9.

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010446PMC
September 2016

Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis.

JCI Insight 2016 Aug;1(13)

Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/jci.insight.88839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996279PMC
August 2016

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

Bone 2016 Mar 31;84:289-298. Epub 2015 Dec 31.

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755825PMC
March 2016

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Cell Rep 2016 Jan 24;14(1):82-92. Epub 2015 Dec 24.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; ICCE Institute, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706805PMC
January 2016

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms.

J Bone Miner Res 2015 Dec 6;30(12):2287-99. Epub 2015 Aug 6.

Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1002/jbmr.2584
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http://dx.doi.org/10.1002/jbmr.2584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834842PMC
December 2015

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):15654-9. Epub 2015 Dec 7.

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1511285112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697402PMC
December 2015

Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.

J Bone Miner Res 2015 Oct 26;30(10):1852-63. Epub 2015 Aug 26.

Department of Orthopaedics, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580562PMC
October 2015

A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.

J Bone Miner Res 2015 Aug 21;30(8):1508-22. Epub 2015 May 21.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506715PMC
August 2015

NLRP12 provides a critical checkpoint for osteoclast differentiation.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10455-60. Epub 2015 Aug 3.

Musculoskeletal Research Center, Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1500196112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547270PMC
August 2015

Immunohistochemistry of skeletal tissues.

Methods Mol Biol 2015 ;1226:87-95

Musculoskeletal Research Center, Histology and Morphometry Core, Department of Orthopedics, Washington University School of Medicine, St. Louis, MO, USA.

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http://link.springer.com/10.1007/978-1-4939-1619-1_8
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http://dx.doi.org/10.1007/978-1-4939-1619-1_8DOI Listing
June 2015

Inhibition of CaMKK2 reverses age-associated decline in bone mass.

Bone 2015 Jun 25;75:120-7. Epub 2015 Feb 25.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737584PMC
June 2015

Response to: A rapid skeletal turnover in radiographic mimic of osteopetrosis might be secondary to systemic mastocytosis.

J Bone Miner Res 2015 May;30(5):946

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO,, USA; Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO,, USA.

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http://dx.doi.org/10.1002/jbmr.2455DOI Listing
May 2015

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

FASEB J 2015 Apr 4;29(4):1269-79. Epub 2014 Dec 4.

*Division of Bone and Mineral Diseases and Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; and Division of Allergy, Immunology, and Rheumatology, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1096/fj.14-264804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396608PMC
April 2015

Rapid skeletal turnover in a radiographic mimic of osteopetrosis.

J Bone Miner Res 2014 Dec;29(12):2601-9

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO, USA; Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391634PMC
December 2014

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

J Pathol 2014 Nov 28;234(3):375-85. Epub 2014 Aug 28.

Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.4403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194146PMC
November 2014

Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANK.

Bone 2014 Nov 23;68:153-61. Epub 2014 Jul 23.

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63131, USA,; Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189967PMC
November 2014

p38MAPK plays a crucial role in stromal-mediated tumorigenesis.

Cancer Discov 2014 Jun 26;4(6):716-29. Epub 2014 Mar 26.

Authors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TexasAuthors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TexasAuthors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas sheila.stewart@wust

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http://dx.doi.org/10.1158/2159-8290.CD-13-0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049323PMC
June 2014

Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure.

J Clin Endocrinol Metab 2013 Dec 24;98(12):4606-12. Epub 2013 Sep 24.

MD, Shriners Hospital for Children, 2001 South Lindbergh Boulevard, St Louis, MO 63131.

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http://dx.doi.org/10.1210/jc.2013-1811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287393PMC
December 2013

Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

J Exp Med 2013 Oct 14;210(11):2257-71. Epub 2013 Oct 14.

Department of Orthopedics, 2 Department of Surgery, 3 Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1084/jem.20130281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804931PMC
October 2013

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.

Bone 2013 Sep 10;56(1):163-73. Epub 2013 Jun 10.

Dept. of Molecular Microbiology and Immunology, St. Louis University, Saint Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.bone.2013.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966133PMC
September 2013

Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.

J Bone Miner Res 2013 Jul;28(7):1599-610

James Graham Brown Cancer Center and Owensboro Cancer Research Program, University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1002/jbmr.1890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688641PMC
July 2013

Creation and preliminary characterization of a leptin knockout rat.

Endocrinology 2012 Nov 4;153(11):5622-8. Epub 2012 Sep 4.

Sigma Advanced Genetic Engineering Labs, Sigma-Aldrich Corp., St. Louis, Missouri 63146, USA.

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http://dx.doi.org/10.1210/en.2012-1462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473197PMC
November 2012

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.

Cancer Res 2011 Jul 20;71(14):4799-808. Epub 2011 May 20.

Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138866PMC
July 2011

Osteoclast motility: putting the brakes on bone resorption.

Ageing Res Rev 2011 Jan 27;10(1):54-61. Epub 2009 Sep 27.

Department of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.arr.2009.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888603PMC
January 2011

Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases.

J Bone Miner Res 2008 Oct;23(10):1698-707

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St Louis, Missouri 63131-3597, USA.

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http://www.pedrad.org/Portals/5/Events/2008/Osteopetrosis.pd
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http://doi.wiley.com/10.1359/jbmr.080511
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http://dx.doi.org/10.1359/jbmr.080511DOI Listing
October 2008

The osteoclast: friend or foe?

Annu Rev Pathol 2008 ;3:457-84

Department of Pathology and Immunology, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA

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http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.151431DOI Listing
May 2008

Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts.

J Biol Chem 2007 Nov 9;282(45):33098-106. Epub 2007 Aug 9.

Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1074/jbc.M611781200DOI Listing
November 2007

Estrogen and bone: osteoclasts take center stage.

Authors:
Deborah V Novack

Cell Metab 2007 Oct;6(4):254-6

Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041310700267
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http://dx.doi.org/10.1016/j.cmet.2007.09.007DOI Listing
October 2007

Damaging fatigue loading stimulates increases in periosteal vascularity at sites of bone formation in the rat ulna.

Calcif Tissue Int 2007 Jun 6;80(6):391-9. Epub 2007 Jun 6.

Orthopedic Research Laboratory, Department of Orthopedic Surgery, Washington University, 1 Barnes-Jewish Hospital Plaza, Suite 11300 WP, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s00223-007-9031-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680514PMC
June 2007

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

J Clin Invest 2006 Nov 19;116(11):2869-79. Epub 2006 Oct 19.

Department of Orthopaedic Surgery and Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI28775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616195PMC
November 2006

Mapping autosomal dominant progressive limb-girdle myopathy with bone fragility to chromosome 9p21-p22: a novel locus for a musculoskeletal syndrome.

Hum Genet 2005 Dec 22;118(3-4):508-14. Epub 2005 Oct 22.

Division of Genetics and Metabolism, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Fegan 10, Boston, MA, 02115, USA.

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http://link.springer.com/10.1007/s00439-005-0075-z
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http://dx.doi.org/10.1007/s00439-005-0075-zDOI Listing
December 2005

M-CSF mediates TNF-induced inflammatory osteolysis.

J Clin Invest 2005 Dec 17;115(12):3418-27. Epub 2005 Nov 17.

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI26132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283943PMC
December 2005

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.

J Clin Invest 2005 Oct 22;115(10):2742-51. Epub 2005 Sep 22.

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI24921
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http://dx.doi.org/10.1172/JCI24921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224296PMC
October 2005

Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice.

Circulation 2004 Mar 8;109(12):1564-9. Epub 2004 Mar 8.

Department of Surgery, Washington University School of Medicine, St Louis, Mo, USA.

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http://dx.doi.org/10.1161/01.CIR.0000121733.68724.FFDOI Listing
March 2004

Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice.

Proc Natl Acad Sci U S A 2003 May 13;100(11):6730-5. Epub 2003 May 13.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1137612100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164515PMC
May 2003