Deborah T Hung

Deborah T Hung

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Deborah T Hung

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A point of inflection and reflection on systems chemical biology.

ACS Chem Biol 2019 Oct 15. Epub 2019 Oct 15.

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http://dx.doi.org/10.1021/acschembio.9b00714DOI Listing
October 2019

Mutations in Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in .

Antimicrob Agents Chemother 2019 Sep 23;63(9). Epub 2019 Aug 23.

The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1128/AAC.00511-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709506PMC
September 2019

Defining the core essential genome of .

Proc Natl Acad Sci U S A 2019 May 29;116(20):10072-10080. Epub 2019 Apr 29.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1900570116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525520PMC
May 2019

Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions.

ACS Infect Dis 2019 Mar 31;5(3):336-344. Epub 2019 Jan 31.

Infectious Disease and Microbiome Program , Broad Institute of Harvard and MIT , 415 Main Street , Cambridge , Massachusetts 02142 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00369DOI Listing
March 2019

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.

Bioorg Med Chem Lett 2018 12 29;28(22):3529-3533. Epub 2018 Sep 29.

The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA; Department of Molecular Biology and Center for Integrative and Computational Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183077
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http://dx.doi.org/10.1016/j.bmcl.2018.09.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233306PMC
December 2018

Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate.

Antimicrob Agents Chemother 2018 11 24;62(11). Epub 2018 Oct 24.

The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1128/AAC.01281-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201135PMC
November 2018

Harnessing CRISPR Effectors for Infectious Disease Diagnostics.

ACS Infect Dis 2018 09 16;4(9):1278-1282. Epub 2018 Aug 16.

Infectious Disease and Microbiome Program , Broad Institute of Harvard and MIT , 415 Main Street , Cambridge , Massachusetts 02142 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00170DOI Listing
September 2018

The Expanding Diversity of Mycobacterium tuberculosis Drug Targets.

ACS Infect Dis 2018 05 15;4(5):696-714. Epub 2018 Feb 15.

Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00255DOI Listing
May 2018

Whole-organism phenotypic screening for anti-infectives promoting host health.

Nat Chem Biol 2018 04 19;14(4):331-341. Epub 2018 Mar 19.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41589-018-0018-3DOI Listing
April 2018

Continuous and High-Throughput Electromechanical Lysis of Bacterial Pathogens Using Ion Concentration Polarization.

Anal Chem 2018 01 15;90(1):872-880. Epub 2017 Dec 15.

Broad Institute of MIT and Harvard , Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b03746DOI Listing
January 2018

scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing.

Genome Biol 2017 10 27;18(1):200. Epub 2017 Oct 27.

Institute for Computational Medicine and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, 10016, USA.

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http://dx.doi.org/10.1186/s13059-017-1340-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658913PMC
October 2017

A perspective on single cell behavior during infection.

Gut Microbes 2016 11 22;7(6):518-525. Epub 2016 Sep 22.

a Broad Institute of MIT and Harvard , Cambridge , MA.

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http://dx.doi.org/10.1080/19490976.2016.1239001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153611PMC
November 2016

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.

Nat Rev Drug Discov 2016 09 29;15(9):589-590. Epub 2016 Jul 29.

Biomedical Advanced Research and Development Authority, Washington, DC 20201, USA.

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http://dx.doi.org/10.1038/nrd.2016.155DOI Listing
September 2016

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.

Nat Protoc 2016 08 21;11(8):1477-91. Epub 2016 Jul 21.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2016.090DOI Listing
August 2016

Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.

Cell Chem Biol 2016 06 16;23(6):666-77. Epub 2016 Jun 16.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920728PMC
June 2016

Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis.

ACS Infect Dis 2016 02 21;2(2):104-10. Epub 2015 Dec 21.

Department of Microbiology and Immunobiology, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsinfecdis.5b00119DOI Listing
February 2016

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Cell 2015 Sep 3;162(6):1309-21. Epub 2015 Sep 3.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cms/attachment/2035742002/2051265527/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501041
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http://dx.doi.org/10.1016/j.cell.2015.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578813PMC
September 2015

Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.

Lab Chip 2015 May;15(10):2297-307

Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c5lc00311cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437799PMC
May 2015

Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.

J Antibiot (Tokyo) 2014 Sep 23;67(9):645-54. Epub 2014 Jul 23.

1] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA [2] Broad Institute, Cambridge, MA, USA [3] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ja.2014.94DOI Listing
September 2014

Bacterial toxins and small molecules elucidate endosomal trafficking.

Trends Microbiol 2014 Feb 23;22(2):53-5. Epub 2013 Dec 23.

Infectious Disease Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2013.12.002DOI Listing
February 2014

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.

PLoS Pathog 2014 Feb 20;10(2):e1003946. Epub 2014 Feb 20.

The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America ; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930586PMC
February 2014

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

Bioorg Med Chem Lett 2013 Nov 19;23(22):6052-9. Epub 2013 Sep 19.

The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Center for Computational and Integrative, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Microbiology and Immunobiology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.09.035DOI Listing
November 2013

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Nat Chem Biol 2013 Jun 21;9(6):398-405. Epub 2013 Apr 21.

Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615456PMC
June 2013

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9932-7. Epub 2013 May 28.

Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.1302257110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683768PMC
June 2013

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.

Virulence 2013 May 5;4(4):273-83. Epub 2013 Apr 5.

Broad Institute of MIT and Harvard, Cambridge, MA USA.

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http://dx.doi.org/10.4161/viru.23987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710330PMC
May 2013

How antibiotics kill bacteria: new models needed?

Nat Med 2013 May;19(5):544-5

M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.3198DOI Listing
May 2013

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

ACS Chem Biol 2013 Apr 4;8(4):812-22. Epub 2013 Feb 4.

Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1021/cb300555nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638717PMC
April 2013

The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence.

J Bacteriol 2012 Dec 28;194(23):6537-47. Epub 2012 Sep 28.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1128/JB.01168-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497526PMC
December 2012

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.

Proc Natl Acad Sci U S A 2012 Dec;109(52):E3629-30

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535640PMC
http://dx.doi.org/10.1073/pnas.1209419110DOI Listing
December 2012

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Proc Natl Acad Sci U S A 2012 Jul 9;109(30):12147-52. Epub 2012 Jul 9.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1203735109
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http://dx.doi.org/10.1073/pnas.1203735109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409745PMC
July 2012

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.

Virulence 2011 Nov-Dec;2(6):553-8. Epub 2011 Nov 1.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.4161/viru.2.6.17987DOI Listing
March 2012

Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2012 Mar 12;56(3):1591-4. Epub 2011 Dec 12.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/AAC.06027-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294900PMC
March 2012

Systematics-guided bioprospecting for bioactive microbial natural products.

Antonie Van Leeuwenhoek 2012 Jan 16;101(1):55-66. Epub 2011 Nov 16.

Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1007/s10482-011-9671-1DOI Listing
January 2012

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.

Mol Microbiol 2011 Sep 29;81(5):1390-401. Epub 2011 Jul 29.

Section of Molecular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2011.07770.x
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http://dx.doi.org/10.1111/j.1365-2958.2011.07770.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041151PMC
September 2011

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

J Bacteriol 2011 Jun 22;193(12):2989-99. Epub 2011 Apr 22.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1128/JB.01546-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133189PMC
June 2011

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

Crit Rev Biochem Mol Biol 2011 Feb;46(1):41-66

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.tandfonline.com/doi/full/10.3109/10409238.2010.53
Publisher Site
http://dx.doi.org/10.3109/10409238.2010.538663DOI Listing
February 2011

The fast track to multidrug resistance.

Mol Cell 2010 Feb;37(3):297-8

Infectious Disease Initiative, The Broad Institute, Cambridge, MA 02141, USA; Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.01.027DOI Listing
February 2010

Targeting multiple biofilm pathways.

Chem Biol 2009 Dec;16(12):1216-8

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.chembiol.2009.12.003DOI Listing
December 2009

Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.

Sci Transl Med 2009 Dec;1(11):11ps13

Infectious Disease Initiative, The Broad Institute, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000550DOI Listing
December 2009

Productive steps toward an antimicrobial targeting virulence.

Curr Opin Microbiol 2009 Oct 22;12(5):490-6. Epub 2009 Jul 22.

Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.mib.2009.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763366PMC
October 2009

Chemical tools for dissecting bacterial physiology and virulence.

Biochemistry 2009 Sep;48(37):8776-86

Infectious Disease Initiative, The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/bi9009083DOI Listing
September 2009

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.

Infect Immun 2009 Apr 21;77(4):1293-303. Epub 2009 Jan 21.

Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.

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http://dx.doi.org/10.1128/IAI.01181-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663173PMC
April 2009

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nat Methods 2009 Jan 14;6(1):67-9. Epub 2008 Dec 14.

Broad Institute of Massachusetts Institute of Technology and Harvard University, 320 Charles Street, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.1038/nmeth.1286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613166PMC
January 2009

Targeting virulence: a new paradigm for antimicrobial therapy.

Nat Chem Biol 2007 Sep;3(9):541-8

Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge St., Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nchembio.2007.24DOI Listing
September 2007

Virstatin inhibits dimerization of the transcriptional activator ToxT.

Proc Natl Acad Sci U S A 2007 Feb 5;104(7):2372-7. Epub 2007 Feb 5.

Department of Microbiology and Molecular Genetics, Harvard Medical School, Armenise Building, Room 425, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0611643104
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http://dx.doi.org/10.1073/pnas.0611643104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892951PMC
February 2007

Chemical biology and bacteria: not simply a matter of life or death.

Curr Opin Chem Biol 2006 Aug 30;10(4):321-6. Epub 2006 Jun 30.

Department of Microbiology and Molecular Genetics, Harvard Medical School, USA; Division of Infectious Disease, Brigham and Women's Hospital, USA.

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http://dx.doi.org/10.1016/j.cbpa.2006.06.016DOI Listing
August 2006

Bile acids stimulate biofilm formation in Vibrio cholerae.

Mol Microbiol 2006 Jan;59(1):193-201

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2005.04846.x
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http://dx.doi.org/10.1111/j.1365-2958.2005.04846.xDOI Listing
January 2006

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Science 2005 Oct 13;310(5748):670-4. Epub 2005 Oct 13.

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1116739DOI Listing
October 2005

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.

Proc Natl Acad Sci U S A 2005 Feb 7;102(8):3028-33. Epub 2005 Feb 7.

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0409559102
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http://dx.doi.org/10.1073/pnas.0409559102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549475PMC
February 2005